It’s time to talk about epithelial geometry and cancer. How can the architecture of an epithelium affect how tumors will grow and spread? In this thread, @jorgealmagro.bsky.social

Fascinating #EpithelialMechanics thread by @jorgealmagro.bsky.social, exploring the connection between tissue geometry and tumor growth 👇

Yearly Fuchs lab picnic 🧺

The integrated stress response fine-tunes stem cell fate decisions upon serine deprivation and tissue injury Novak et al. discover that dietary serine impacts whether hair follicle stem cells (HFSCs) prioritize hair growth or skin repair after injury. HFSCs gauge metabolic stress using the ISR and accelerate...

New paper alert! We report in @cp-cellmetabolism.bsky.social how serine regulates stem cell fate in physiology and upon wounding.
Good work, Jesse and collabs!
www.cell.com/cell-metabol...

Decenas de sociedades científicas piden a la Comunidad de Madrid que impida la destrucción del Museo Olavide Las instituciones recuerdan al Gobierno de Isabel Díaz Ayuso que la colección, una joya de la medicina expulsada por la Universidad Complutense, pertenece a una consejería. EL PAÍS graba los preparativos del traslado

Dos decenas de sociedades científicas han solicitado a la Comunidad de Madrid que impida urgentemente el “riesgo de destrucción” del Museo Olavide, una joya de la historia de la medicina que incluye unas 700 figuras de cera de pacientes reales

It was heartwarming to join academic workers together in the fight against funding cuts, layoffs, and attacks to freedom of speech in our campuses. Scientists will not give up! @uaw.org

Los españoles son los europeos menos preocupados por la seguridad y defensa, según el Eurobarómetro La última encuesta de la UE subraya la importancia de mostrar “unidad” ante los desafíos globales

“…España, para cuyos ciudadanos la prioridad máxima debe ser la educación e investigación (40%, frente al 23% de media europea), mientras que la defensa cae al 20%”
elpais.com/internaciona...

Submitting my PhD paper after 7.5 years 🫣

Moby-Dick review — the Met sets sail with Jake Heggie’s sprawling epic The opera — newly staged in its Metropolitan Opera premiere — is as ambitious and frustrating as its source material

My thoughts on Heggie’s Moby-Dick at the Met, for @thetimes.com

www.thetimes.com/culture/clas...

Postdocs vs students @thefuchslab.bsky.social laser tag was barely a competition 😏

Yesterday we marched to oppose the hijacking of the NIH and the government by a nazi oligarch. Hands off the NIH!! No research, no cures ✊🏼

Great news! @greatysp.bsky.social @jorgealmagro.bsky.social

Congratulations to @jorgealmagro.bsky.social and @thefuchslab.bsky.social as well!! 🎊🎉🥳🥳 @rockefelleruniv.bsky.social @hhmi.bsky.social

Shaping epithelial tissues by stem cell mechanics in development and cancer - Nature Reviews Molecular Cell Biology Adult stem cells self-renew and differentiate to build, maintain and repair tissues. This Review discusses recent insights into the contribution of mechanical forces produced by epithelial stem cell a...

New #Review! 🥳

@jorgealmagro.bsky.social, @thefuchslab.bsky.social et al. discuss the role of stem cell mechanics during developmental processes and what happens when the mechanics of the stem cell niche are disrupted in cancer.

👉 go.nature.com/3EsJzJx

#StemCells #Mechanobiology #Cancer

Shaping epithelial tissues by stem cell mechanics in development and cancer - Nature Reviews Molecular Cell Biology Adult stem cells self-renew and differentiate to build, maintain and repair tissues. This Review discusses recent insights into the contribution of mechanical forces produced by epithelial stem cell a...

Very happy to see our review out in @natrevmcb.bsky.social!
Here we discuss how stem cells exert forces to sculpt tissues in development and homeostasis, and how stem cell mechanics go awry upon malignant transformation. Read it here 👇
www.nature.com/articles/s41...

Shaping epithelial tissues by stem cell mechanics in development and cancer - Nature Reviews Molecular Cell Biology Adult stem cells self-renew and differentiate to build, maintain and repair tissues. This Review discusses recent insights into the contribution of mechanical forces produced by epithelial stem cell a...

Our first 2025 paper!
We discuss in @natrevmcb.bsky.social how epithelial stem cells mechanically sculpt tissues, and how these forces are altered in cancer.
Great work from our former and current tumor mechanobiology experts Vince Fiore & @jorgealmagro.bsky.social 👏
www.nature.com/articles/s41...

Paper of the Week! Norepinephrine oscillation during sleep regulates blood/CSF flow and waste clearance
With @kevinng.bsky.social @fesubtil.bsky.social @rysazaman.bsky.social
www.cell.com/cell/abstrac...

What an exciting read 😍

The Caltech and JPL Disaster Relief Fund

Caltech has set up a disaster relief fund for Caltech and Jet Propulsion Lab community members affected by the fires. Many lived in Altadena, which has been very heavily damaged. Please consider giving.
giving.caltech.edu/areas-to-sup...

Reading a textbook may give answers to such essential questions 😅
From Kandel et al. “Principles of Neural Science” (5th edition, before Piezo was identified as the master mechanosensor)

The Vienna BioCenter Summer School 2025 call is now open for applications from talented undergrads. It is the perfect preparation for students who are interested in graduate study in the life sciences arena. 9-week research project, accommodation and stipend for successful candidates.

Kicking off 2025 Paper of the Week with @kevinng.bsky.social & @fesubtil.bsky.social. Today we discussed our friend @martinaparigi.bsky.social et al. recent paper in @nature.com. How do epithelia unlink necessary drivers of regeneration from malignant transformation?
www.nature.com/articles/s41...

Congratulations Jimmy and @paigearnold.bsky.social 👏🏼

Birding (and lynxing🤞🏼) with @atalavera.bsky.social somewhere in La Mancha…

Aida review — the Met’s tacky show is like a night in a Luxor casino Angel Blue’s impassioned singing as the heroine of Verdi’s opera is the highlight of a dispiriting night at the Metropolitan Opera in New York

My first review of 2025 - Michael Mayer’s new Aida at the Met, for @thetimes.com

www.thetimes.com/culture/clas...

Beyond genetics: driving cancer with the tumour microenvironment behind the wheel - Nature Reviews Cancer In their Review article, Fuchs and colleagues discuss how a single or a few mutations in adult cells can lead to invasive cancers without a high mutational burden, demonstrating that non-genetic ...

Cancers may arise in tissues with a low mutational burden. It’s up to the microenvironment! We discussed this in @natrevcancer.bsky.social
www.nature.com/articles/s41...

2024 was a year of exciting discoveries and scientific discussions! A thread 🪡 of this years’ publications from our lab 👇🏼

The Fuchs lab is now on Bsky and wishes you happy holidays!! 🎄

Nobel Laureates Urge Senate to Turn Down Kennedy’s Nomination Elevating Mr. Kennedy to secretary of H.H.S. “would put the public’s health in jeopardy,” more than 75 laureates wrote.

More than 75 Nobel Prize winners have signed a letter urging senators not to confirm RFK Jr.

The letter marks the first time in recent memory that Nobel laureates have banded together against a Cabinet choice. But Kennedy is a threat they could not ignore, one said. www.nytimes.com/2024/12/09/h...