In today’s publication in Science we introduce Zincore: a novel protein of QRICH1 and SEPHS1 and functions as a transcriptional coregulator dedicated to zinc finger transcription factors. Here’s how we found it: 🧵 www.science.org/doi/10.1126/... 1/11
I think there is still much to learn about SRBD1, not only in mitosis but also regarding other potential functions.
Its similarity to Spt6/SUPT6H continues to intrigue me 🤔
3D render of a Zincore complex locking ZFP91 onto DNA, promoting gene activation. Made in Blender with Molecular Nodes.
📢 Ready for this? A new way to think about Gene Regulation!
🚨A new coregulator complex, Zincore, acts as a "MOLECULAR GRIP", stabilizing TFs at DNA binding sites across the genome!🧬
💪Proud to be part of this work led by @daaninthelab.bsky.social
Read more: science.org/doi/10.1126/science.adv2861
🚀 My first Cryo-EM structures are OUT on the PDB!
🎉Super excited about this milestone as PhD, it’s been a journey, and I’m grateful to finally have these as my first Cryo-EM structures! 🙌
🔁Thank you for sharing!❤️
Read @daaninthelab.bsky.social et. al.: www.science.org/doi/10.1126/...
⬇️ 2nd video
⚠️Don't forget! You have FREE alternatives!
🔖Reminder that @niaidnews.bsky.social offers 2000+ scientific and biomedical high-quality icons for free use! Check their full catalog: bioart.niaid.nih.gov
📢And if that’s not enough, you also have SciDraw and Bioicons! Comment if you want the websites.
I think there is still much to learn about SRBD1, not only in mitosis but also regarding other potential functions.
Its similarity to Spt6/SUPT6H continues to intrigue me 🤔
A metallic arm holding a protein, simulating a GPI-anchored protein attached to the surface of a membrane.
📢 Excited to announce that our Opinion paper on GPI-anchored proteins is now Published! 🎉
👀 If you're working in this field, be sure to check out our paper — we've highlighted some truly outstanding questions on the topic! ⚠️
www.cell.com/trends/cell-...
🚨 New strategy against colorectal cancer!
Dual GSK-3 & BCL-XL inhibition kills APC-mutant cells in organoid models, tipping the balance towards healthy cells—a promising way to halt early tumor growth 💪🧪
➡️Read more: www.nature.com/articles/s41...
Thank you! 😁
👀 Just updated my Google Scholar and... can’t believe one of my papers reached 100 citations! 🚀
💪🏼 It might not seem like much, but as a PhD student, it feels like a big achievement.
❤️ To all fellow PhDs, keep going, stay strong, and celebrate every milestone!🔁
Read it: www.jbc.org/article/S002...
Type VI inhibitor targeting both the catalytic site and the tunnel of Autotaxin (ATX). PDB ID: 9FXW
🚨New Article Out!!
📢 In our latest work, we propose a Three-Point Lock binding mode for ATX inhibitors 🔒
🚀 This approach may represent the final piece in the puzzle of known binding mode types — and could have therapeutic relevance
♥️ Thanks for your support
Read more here: doi.org/10.1016/j.bm...
Congratulations! 💪
Thank you! 😁
Really crazy work!! wow.. Congratulation! 👏🏼
Congratulation on your work! 👏🏼
This is amazing!! wow! 👏🏼
Such a satisfying structure to look at! hahaha
Congratulation on you preprint! 👏🏼
This looks impressive!! 👏🏼
Nice poster! 👏🏼
I hope your presentation went well! 💪🏼
Cool image!! and Congratulations on your preprint! 👏🏼
That is a huge structure... Congratulations! 👏🏼
Amazing resolution for Cryo-EM!! 👏🏼
Congratulations! 👏🏼
Congratulations! 👏🏼
🚀 My first Cryo-EM structures are OUT on the PDB!
🎉Super excited about this milestone as PhD, it’s been a journey, and I’m grateful to finally have these as my first Cryo-EM structures! 🙌
🔁Thank you for sharing!❤️
Read @daaninthelab.bsky.social et. al.: www.science.org/doi/10.1126/...
⬇️ 2nd video
This sounds really really interesting. I might have a look at folddisco
I get you.... I really do hahahaha
