If you're not a subscriber, you will have just missed our Spring 2026 Newsletter, but don't worry - you can find it here and click subscribe to make sure you don't miss out next time!
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Back in November, our Horizon Scanning Working Group held its second workshop designed to build a UK community around the latest advances in genome engineering technologies:
nmgn.mrc.ukri.org/news/horizon...
Stealth BioTherapeutics has today announced an award from our Business Engagement Fund to support a new collaboration to evaluate the effects of their compound SBT-589 on biomarkers of disease in a mouse model of Leigh syndrome, a rare mitochondrial disorder:
nmgn.mrc.ukri.org/news/busines...
Clinicians and researchers with an interest in #mitochondrial disease: Queen Square Advances in Mitochondrial Medicine (5 May 2026) is a CPD-approved course covering pre-clinical & translational research, and the latest updates in NHS diagnostic testing. Registration: www.ucl.ac.uk/brain-scienc...
Earlier this month we held a hugely successful hackathon focused on the spatial analysis software MuSpAn to conduct a deep dive study on the progression of liver metastases from colorectal cancer.
Read more:
nmgn.mrc.ukri.org/news/muspan-...
Our Best Models Working Group can offer advice on the use of a range of model systems.
The next in our series of #MeetTheExpert posts features Owen Sansom, whose group has created advanced mouse models matching a variety of human colorectal cancer subtypes.
nmgn.mrc.ukri.org/working-grou...
Our Best Models Working Group can offer advice on the use of a range of model systems.
The next in our series of #MeetTheExpert posts features Laura Greaves, whose group investigates the role of age-related mitochondrial DNA mutations in cancer biology
nmgn.mrc.ukri.org/working-grou...
MAPK-driven epithelial cell plasticity underlies colorectal cancer therapeutic resistance:
Members of our Cancer Cluster contributed to a recent paper that provides insight into resistance to therapy and suggests strategies that may improve therapeutic efficacy
nmgn.mrc.ukri.org/news/mapk-dr...
Our Best Models Working Group can offer advice on the use of a range of model systems.
The next in our series of posts highlighting our diverse expertise features Prof Robin Williams, whose group uses Dictyostelium to identify the proteins targeted by drugs
nmgn.mrc.ukri.org/working-grou...
Fresh insights reveal how cancer gene mutations drive tumour growth:
Andrew Wood (lead of our Degron Cluster) has co-led a team that created a comprehensive map that shows how hundreds of possible mutations in a key cancer gene influence tumour growth
nmgn.mrc.ukri.org/news/fresh-i...
Our Best Models Working Group can offer advice on the use of a range of model systems.
The next in our series highlighting our diverse expertise features Dr Andrew Wood, whose lab uses genome editing and targeted protein degradation to study genetic disease using cell lines, organoids, and mice.
Our Best Models Working Group can offer advice on the use of a range of model systems.
The next in our series of posts highlighting our diverse expertise features Dr Alex Whitworth, whose group uses Drosophila models of neurodegenerative diseases.
nmgn.mrc.ukri.org/working-grou...
The MRC National Mouse Genetics Network’s Best Models Working Group connects researchers with the right expertise in biological models and computational tools as part of our commitment to the #3Rs.
nmgn.mrc.ukri.org/working-grou...
#MeetTheExpert
A study led by Owen Sansom, Director of the National Mouse Genetics Network, has identified the protein NPM1 as a potential therapeutic target in liver and bowel cancers:
www.bbc.co.uk/news/article...
The National Mouse Genetics Network has contributed to a new briefing from the UK Parliamentary Office of Science and Technology (POST) that examines the development and use of emerging technologies as alternatives to animals in life sciences research.
nmgn.mrc.ukri.org/news/mary-ly...
10 days left to apply for this position at #LancasterUniversity working on the #MURIDAE project @mrcmousenetwork.bsky.social
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Still time to apply to join this incredible team and contribute to our understanding of neurodevelopmental disorders. #PreclinicalResearch #Genetics
📢 Job Alert 📢
Post-doc position at #LancasterUniversity working on the #MURIDAE project @mrcmousenetwork.bsky.social
Working with #genetic #preclinical models for #schizophrenia 🧠🧬🐭
Please repost!
www.jobs.ac.uk/job/DPW471/s...
Our Best Models Working Group can offer advice on the use of a range of model systems.
The next in our series of posts highlighting our diverse expertise features Dr Alex Benedetto, a Senior Lecturer in Integrative Physiology, who works with C. elegans.
nmgn.mrc.ukri.org/working-grou...
Our Best Models Working Group can offer advice on the use of a range of model systems.
The next in our series of posts highlighting our diverse expertise features Prof Karen Liu, who works on congenital anomalies arising during embryonic development.
nmgn.mrc.ukri.org/working-grou...
Great talk by Claire and Rosie this afternoon @mrcmousenetwork.bsky.social meeting!
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Great two days in York with the MRC National Mouse Genetics Network. Always a pleasure to be invited to share MitoCluster's work, thank you!
@mrcmousenetwork.bsky.social @jellevda.bsky.social @lauragreaves.bsky.social @robpitceathly.bsky.social
Just heading home from our @mrcmousenetwork.bsky.social MRC NMGN Science Meeting 2025 in York where our Congenital Anomalies Cluster shared updates on our clinical VUS & phenotyping pipelines at the podium! Great discussions! #FunctionalGenomics #RareDisease #CongenitalAnomalies
Our Best Models Working Group can offer advice on the use of a range of model systems.
The next in our series of posts highlighting our diverse expertise features Dr Xiao Fu, who uses integrative data science and computational modelling approaches to study cancer.
We plan to facilitate replacement training at the @mrcharwell.bsky.social Advance training centre and our Best Models Working Group provides a forum for researchers to learn about alternative models and connect with experts in other systems
nmgn.mrc.ukri.org/about/replac...
We welcome the government’s effort to provide a clear roadmap for the phasing out of the use of animals in research, while maintaining scientific rigour and safety standards.
Our Best Models Working Group can offer advice on the use of a range of model systems.
Next in our series highlighting the diverse expertise of our Working Group are Prof Matthew Guille and Dr Annie Godwin who work with Xenopus to recreate novel human gene variants thought to cause disease.
Our Best Models Working Group can offer advice on the use of a range of model systems.
Over the coming weeks, we will be highlighting the diverse expertise of our Working Group, starting with Julia Cordero, an expert in the use of Drosophila to study intestinal biology.
#MeetTheExpert
