Beyond the echo chamber: reframing AMR awareness efforts to reach the other 99.9% | Antimicrobial Stewardship & Healthcare Epidemiology | Cambridge Core Beyond the echo chamber: reframing AMR awareness efforts to reach the other 99.9% - Volume 5 Issue 1

Solving #AMR requires all of us. Here are 4 ways to break the echo chamber and reach the other 99.9%:

🧠 Better knowledge translation
👨‍👩‍👦 Public engagement
🌏 One Health partnerships
👩‍⚖️ Science–policy collaboration

Read more: doi.org/10.1017/ash....
#AMRAwareCA @ashejournal.bsky.social

#qotd #fightAMR

New episode! 🎙️
Collaboration between the micro lab and stewardship turns data into better care.

“There are a lot of subtleties in interpreting microbiology…” — Dr. Hannah Creager

🎧 asm.org/podcasts/let...
#LetsTalkMicro #AST #Stewardship #ID

Must read for all teams consulting infectious diseases #idsky #idmeded #meded #stewardship #voicesofID @cidjournal.bsky.social
academic.oup.com/cid/advance-...

The most anticipated RCT in ID
🔥SNAP RCT🔥The largest RCT 2 date in SA bactermia
N:1341
Cefazolin Vs ASPs ((flu)cloxacillin) for MSSA bacteremia
Cefazolin is non-inferior (90d mortality)& less AKI than ASPs
A practice-changer RCT that must change the guidelines
#ESCMIDGlobal #IDSky

$5 million boost for world-first trial tackling strep infections in both children and adults A major new clinical trial, the Streptococcal Adaptive Platform (STRAP), has received $5 million in funding from the Australian Government’s Medical Research Future Fund (MRFF) to improve treatment for life-threatening streptococcal infections across all age groups. Lead by researchers and clinicians from the Doherty Institute, Murdoch Children's Research Institute (MCRI), and other national and international partners.

SNAP is extending from S aureus to invasive streptococcal infections!

A new platform trial for iGAS and iSDSE

@gurujosh.bsky.social @joshosowicki.bsky.social @drmichaelmarks.bsky.social

www.doherty.edu.au/news-events/...

What is Antimicrobial Resistance (AMR) and how can you help combat it? We introduce the new campaign to Keep Antibiotics Working, fronted by our mascot Andi Biotic, and look at why we all need to be more aware of Antimicrobial Resistance (AMR).

Antibiotics don’t work on viruses. Don’t demand or misuse them. Always finish your prescription. Wash hands, stay vaccinated, and spread the word. Let’s #KeepAntibioticsWorking and fight #AMR together.

ukhsa.blog.gov.uk/2025/04/07/w...

Your wish is our command!

In this week’s episode, Alyssa & Callum discuss the essentials of fungal diagnostics with Professor Malcolm Richardson.

Half of them anyway. It’s a 2-parter. See you next week!

podcasts.apple.com/gb/podcast/i...

#IDSky #microsky

#IDsky
Fascinating StepUp trial looking at tx male partners for BV w/topical clinda & oral metronidazole in conjunction w/ tx female patients. Reduced recurrence rate from 63% to 35% by 12 wks.

We were always taught BV is not an STD, but perhaps it should be considered as such.

IV to oral antibiotic switch in patients with uncomplicated E. faecalis BSI showed shorter length of hospital stay and no significant increase in the risk of treatment failure—this could be a promising strategy for selected patients:
https://doi.org/10.1093/jacamr/dlaf004
#JACAMRNews

Hepatitis E virus Infection in Vietnamese Pregnant Women with Hepatitis B: Prevalence and Clinical Outcomes Hepatitis E virus (HEV) infection during pregnancy is associated with obstetric complications and adverse maternal and neonatal outcomes. This study aimed to determine the seroprevalence of HEV and RNA positivity in both healthy pregnant women and women co-infected with hepatitis B virus (HBV).

Hepatitis E virus Infection in Vietnamese Pregnant Women with Hepatitis B: Prevalence and Clinical Outcomes

✅ Just Accepted
#IDSky

When Can a MRSA Nares Swab Guide Antibiotic Stewardship? This Clinical Insights discusses how the methicillin-resistant Staphylococcus aureus (MRSA) nares swab may be used alongside disease prevalence and clinical factors to determine when MRSA coverage is ...

🆕🔥Clinical Insights #JAMAInternalMed
When Can a MRSA Nares Swab Guide Antibiotic Stewardship?
What the Nose Knows #idsky #medsky #AMSsky #EMIMCC
jamanetwork.com/journals/jam...

Basic morphology and resistance mechanisms of enterococci.

My pleasure to be his 40th follower!

(Tell him about the podcast).

(Also don’t tell him about @febrilepodcast.bsky.social, @sidpharm.bsky.social #Breakpoints, @letstalkmicro.bsky.social or #puscast with @danielgriffinmdphd.bsky.social, give him a chance to get into our stuff first!)

Nigeria activates emergency response as Lassa fever kills 190 this year Nigeria has launched an emergency response centre after recording 190 deaths from Lassa fever, a viral hemorrhagic illness, the country's disease control agency said on Monday.

Nigeria Launches Emergency Response Center After Recording 190 Deaths From Lassa Fever

A viral hemorrhagic illness, Lassa fever has infected 1,154 people in six Nigerian states.

#IDSky

www.reuters.com/world/africa...

Derivation and Validation of an Electronic Health Record Penicillin Allergy De-Labeling Prevalence Measure With no standard method to capture penicillin allergy de-labeling prevalence across populations, we developed and validated a simple penicillin allergy de-

No standard method to capture penicillin allergy de-labeling
🆕💫 Dr.Blumenthal et Al developed & validated a simple penicillin allergy de-labeling measure from EHRs can be used to assess penicillin allergy de-labeling prevalence across hospital systems #idsky
academic.oup.com/cid/advance-...

Great to see a JAC article highlighted as a Top Infectious Diseases Articles From 2024 via @absteward.bsky.social

Diagnostic accuracy of LiquidArray MTB-XDR VER1.0 for the detection of Mycobacterium tuberculosis complex, fluoroquinolone, amikacin, ethambutol, and linezolid susceptibility Drug susceptibility testing (DST) is essential for starting people on effective tuberculosis (TB) regimens.

Diagnostic accuracy of LiquidArray MTB-XDR VER1.0 for the detection of Mycobacterium tuberculosis complex, fluoroquinolone, amikacin, ethambutol, and linezolid susceptibility

✅ Just Accepted
#IDSKy

Mycobacteroides abscessus Outbreak and Mitigation in a Cardiothoracic Transplant Population: The Problem with Tap Water Hospital outbreaks caused by Mycobacteroides abscessus complex are a major cause for concern in vulnerable patients such as the cardiothoracic transplant population.

🦠Outbreak report: Authors describe an outbreak investigation and mitigation steps undertaken to address an increase in healthcare-associated Mycobacteroides abscessus complex cases in an inpatient cardiothoracic transplant population #IDsky
www.journalofhospitalinfection.com/article/S019...

Comparing piperacillin/tazobactam to current guidelines for the treatment of open fractures: A systematic review Current guidelines call for the use of a first-generation cephalosporin with or without an aminoglycoside for the treatment of open fractures. Due to …

🆕️🔥Systematic review
4 retrospective studies N:752
The use of pip/tazo for open fractures does not differ from 1st G cephalosporins +/-aminoglycoside in regard to SSI,AKI,return to OR, 1-year mortality,non-union& development of resistant pathogens #idsky #medsky
www.sciencedirect.com/science/arti...

Struggling to keep up with the new (and upcoming) antibiotics for Gram-negatives? A quick reference guide!
#AMSsky #IDSky

Safety of Kidney Transplantation from Donors with HIV | NEJM Kidney transplantation from donors with human immunodeficiency virus (HIV) to recipients with HIV is an emerging practice. It has been performed since 2016 under the U.S. congressional HIV Organ Po...

Oh and an observational study:

www.nejm.org/doi/full/10....

Preventing New Gram-negative Resistance Through Beta-lactam De-escalation in Hospitalized Patients With Sepsis: A Retrospective Cohort Study Our findings suggest the antibiotic stewardship approach of de-escalating broad-spectrum beta-lactam antibiotic therapy is associated with a reduced risk o

You can start with BLINGIII and BALANCE etc, but this stewardship paper gets my vote. Real-world study looking at de-escalation in terms of spectrum score, demonstrating that narrowed spectrum at 72 hours reduces AMR. We knew, but now we have proof.

Hi #IDSky! I’m putting together my usual top 10 ID papers of this year list again (this time will post here not in the other world).

Please tell me your candidate papers - practice changing paradigm shifting or dogma challenging!

State-of-the-Art Review: Ocular Infections Collaborations between ophthalmologists and infectious disease specialists are critical for optimizing care of many patients with eye infections. We review

Peep this gem (pun intended):

academic.oup.com/cid/article/...

Sooo cute!

Efficacy and tolerability of high-dose cefalexin 45 mg/kg/dose (maximum 1.5 g) three times daily in children with bone and joint infections AbstractBackground. Cefalexin, a first-generation cephalosporin, is commonly used as oral continuation therapy for paediatric bone and joint infections (BJ

The standard four times daily cephalexin dose makes treatment adherence challenging
🆕️⚡️⚡️Retrospective #JAC
Efficacy and tolerability of high-dose cefalexin 45 mg/kg/dose (maximum 1.5 g) three times daily in children with bone and joint infections #idsky
academic.oup.com/jac/article-...

Hi #IDSky! Febrile is a cultured podcast about all things ID. We talk about clinical reasoning, diagnostics, abxs, and other interesting topics! 🦠 We love showcasing trainees and ID clinicians, and we cover both adult+pediatric topics/cases. We're ~4 years old and sponsored by @idsainfo.bsky.social