Congrats to our fearless leader @mayoonthebrain.bsky.social for her promotion to Associate Professor!! 👏

... and the latest good news from the PaCT Lab below ⬇️

6️⃣ Another paper from @anadeutsch.bsky.social along with PhD student Luis Contreras -> conducting a scoping review of mystical experiences ✨ and mood symptoms in psychedelic clinical trials 💊

doi.org/10.1177/2045...

Functional neuroimaging of fatty acid amide hydrolase inhibition in posttraumatic stress disorder: a randomized clinical trial - Translational Psychiatry Translational Psychiatry - Functional neuroimaging of fatty acid amide hydrolase inhibition in posttraumatic stress disorder: a randomized clinical trial

5️⃣ Postdoc @ryanntansey.bsky.social expands on our previous FAAHi for PTSD clinical trial 💊 by delving into the neuroimaging (task + resting state fMRI) results 🧠

www.nature.com/articles/s41...

Individual and additive effects of childhood maltreatment and substance use disorder histories on baseline and stress-induced changes in peripheral stress biomarkers - Psychopharmacology Background Exposure to childhood maltreatment (CM) has serious consequences on the health of affected individuals, potentially elevating vulnerability to various psychopathologies, including substance...

4️⃣ Here's the FIRST first author publication 🎉 from PhD student (and former MSc student) @abby-lunge.bsky.social where she looked at the relationship between childhood maltreatment history & adulthood SUDs on blood 🩸 markers of stress

doi.org/10.1007/s002...

The effect of methamphetamine and 3,4-methylenedioxymethamphetamine on peripheral endocannabinoid concentrations: a study in healthy adults - Psychopharmacology Rationale Stimulant drugs such as methamphetamine (MA) and 3,4-methylenedioxymethamphetamine (MDMA) can impact neurobiological systems implicated in stress, reward processing, and drug use. Although r...

3️⃣ PhD student @anadeutsch.bsky.social investigates how eCBs in the blood 🩸 change following methamphetamine and MDMA in this publication!

doi.org/10.1007/s002...

Effects of acute alcohol administration on endocannabinoids and relation to subjective effects - Psychopharmacology Rationale Harmful alcohol use remains a significant global public health challenge. Examining variability in the acute subjective effects of alcohol and related neurobiological mechanisms may advance ...

2️⃣ Lab postdoc Gavin Petrie explores the role of eCBs in the subjective effects of alcohol intake (yes, we did give our participants alcoholic beverages for this study 🍷 🥂 🍺)

doi.org/10.1007/s002...

<em>Journal of Child Psychology and Psychiatry</em> | ACAMH Pediatric Journal | Wiley Online Library Background The endocannabinoid (eCB) system, the primary target of cannabis, has gained significant attention as a potential novel therapeutic approach for treating a range of psychiatric disorders ...

1️⃣ FIRST UP: we have this very comprehensive review from @ryanntansey.bsky.social and @marcdferger.bsky.social with @hmarusak.bsky.social about the intersection of development, eCBs, and mental health!

doi.org/10.1111/jcpp...

‼️ 📝 It's time for a PaCT Lab publication round up! 📝 ‼️

What has the lab been getting up to in the past year or so (other than many great meals together)?

See this thread ⬇️

UCalgary scientists study optimal THC dosage for therapeutic use | Watch News Videos Online Watch UCalgary scientists study optimal THC dosage for therapeutic use Video Online, on GlobalNews.ca

Grateful to @globalnews.ca for visiting to discuss our upcoming trial led by @pact-lab.bsky.social postdoc Gavin Petrie with @cannabrain.bsky.social exploring dose-response effects of THC products from Avicanna, setting the stage for upcoming clinical trials using controlled THC dosing

The PaCT Lab is gearing up for the Calgary Stampede ;)

The efficacy of elevating anandamide via inhibition of fatty acid amide hydrolase (FAAH) combined with internet-delivered cognitive behavioral therapy in the treatment of post-traumatic stress disorde... Neuropsychopharmacology - The efficacy of elevating anandamide via inhibition of fatty acid amide hydrolase (FAAH) combined with internet-delivered cognitive behavioral therapy in the treatment of...

#ThisWeekInNPP

Studies in animal models & healthy humans suggested that increasing the eCB ligand AEA (via FAAH inhibition) may be a novel PTSD treatment - but did it work? Find out in this recent paper from @mayoonthebrain.bsky.social @cannabrain.bsky.social @pact-lab.bsky.social & co

The undertaking of the century fresh off the press from my first postdoc in Sweden. Not what we hoped to find but that raises new questions on the topic of endocannabinoids and their relationship with PTSD #Cannabinerds

Dig in for some unexpected results & some great representation for the "cannabinoid" half of our lab 😏

What's been taking up a good chuck of the PaCT Lab's time & effort for the last couple years? Our paper on our clinical trial of FAAH inhibition for PTSD is finally OUT in @npp-journal.bsky.social !!! ✨💫

A HUGE effort from many individuals! See thread below for a summary!

‼️‼️ Have you checked out the commentary written by @mayoonthebrain.bsky.social & PaCT Lab postdoc Gavin Petrie yet?!?! You should do that NOW!

We're recruiting a new therapist(s) for ongoing & upcoming clinical trials with psilocybin-assisted psychotherapy at @ucalgary.bsky.social

Come join our diverse, growing @pact-lab.bsky.social team exploring evidence-based psychedelic interventions!

Ad here: careers.ucalgary.ca/jobs/1601602...

Are you interested in reducing your alcohol consumption? We are testing the effectiveness of psilocybin (the primary component of “magic mushrooms”) + psychotherapy for the reduction of alcohol consumption.

Apply through the link in our bio or contact our team at pactlab@ucalgary.ca

Amazing work from lab undergrad Georgia!

Dedicated federal funding from the Canadian Institutes of Health Research (CIHR) to support psilocybin-assisted psychotherapy trials has allowed our @pact-lab.bsky.social team to explore innovative approaches to substance use disorder treatment ⤵️

www.cihr.ca/e/54242.html

Endocannabinoid contributions to the perception of socially relevant, affective touch in humans - Neuropsychopharmacology Neuropsychopharmacology - Endocannabinoid contributions to the perception of socially relevant, affective touch in humans

Be sure to check out the original paper, featuring @madeleinejones.bsky.social @cannabrain.bsky.social @abby-lunge.bsky.social & other @pact-lab.bsky.social team members

www.nature.com/articles/s41...

Endocannabinoid contributions to the perception of socially relevant, affective touch in humans - Neuropsychopharmacology Neuropsychopharmacology - Endocannabinoid contributions to the perception of socially relevant, affective touch in humans

The first @pact-lab.bsky.social paper of 2025 is out now in @npp-journal.bsky.social 🤩

Led by @madeleinejones.bsky.social & @connorhaggarty.bsky.social
ft. @abby-lunge.bsky.social @cannabrain.bsky.social & others

www.nature.com/articles/s41...

‼️ NEW PAPER ALERT ‼️

From PaCT lab alum & current members @connorhaggarty.bsky.social @madeleinejones.bsky.social @abby-lunge.bsky.social & bluesky-less Dr. Gavin Petrie

You'll want to read this one if you're interested in social touch & endocannabinoids!

Casual (Hourly) Clinical Research Nurse, Psychiatry in Calgary, AB, ... Casual (Hourly) Clinical Research Nurse, Psychiatry in Calgary, AB, ...

The @pact-lab.bsky.social is hiring 🤩

We're looking for a nurse to support our psilocybin-assisted psychotherapy clinical trials for alcohol use disorder (ongoing) and concussion (upcoming) at UCalgary 🍄

More info here: careers.ucalgary.ca/jobs/1547185...

✨WE ARE HIRING✨

We are looking for a nurse who can support our psilocybin clinical trials for the treatment of persistent post-concussive syndrome and alcohol use disorder!

Apply at the link below! 👇
careers.ucalgary.ca/jobs/1547185...

Happy (belated) new year all! If you want to stay informed on what's going on in cutting edge Canadian neuroscience research being conducted by postdocs, signing up for this mailing list is a MUST 💫 🇨🇦

Happy holidays from the PaCT Lab!! ❄️

group photo of a wonderfully talented group of scientists + their friends/partners on a spiral-ish staircase

Such a fun time celebrating the holidays with @pact-lab.bsky.social (+friends) last night - I cannot overstate how grateful I am to work with such an amazing team 🤩

(I'm also verrrry happy we could all squeeze in on our 'prom stairs' for a photo 😂)

📢 Hey #ACNP24, we have not one but TWO posters from our trainees tonight!

Postdoc @ryanntansey.bsky.social will bet at poster 217 presenting fMRI results from our PTSD clinical trial!

& PhD student @anadeutsch.bsky.social will be at poster 188 talking about the effects of stimulants on eCBs!! 🧠🎉✨

If you’re at #ACNP24 and you’re interested in fMRI (both task + rest) in PTSD, (or also eCBs) swing by my poster tonight and let’s chat!! See you there :)