Data Security — Unbreaking How the administration is breaking the government, and what that means for all of us.

This week, our Data Security team added 25 events to the timeline, shining a spotlight on the Trump administration’s efforts to grab yet more personal data from Americans.

Dr. Locci (Penn) addresses a full conference room of researchers from a podium. Slides are projected on screens behind her.

Today, the 2026 Penn Colton Center for #Autoimmunity Symposium brings together the Penn #autoimmune research community—spanning diverse disease areas and the full continuum of discovery—to share new insights in diagnosing, treating, and preventing autoimmune diseases.

Check this out! Should be a terrific meeting!

Tomorrow is the last day to submit an abstract for @keystonesymposia.bsky.social meeting Beyond Antibiotics: Emerging Strategies Combating Bacterial Infections.

It is going to be an amazing meeting and we have a few slots left!
keysym.us/KSBeyondAntibiotics26 #KSBeyondAntibiotics26

Dysbiosis is not a change in the microbiota composition, it is a change in the host environment and compositional changes are secondary to this underlying cause

Thanks for highlighting our work with the other outstanding recent discoveries

Tolerance to intestinal microbes and the developing fetus share similar immunological mechanisms Pregnancy is remarkable in that mothers tolerate the developing fetus expressing immunologically foreign paternal antigens. These foreign antigens stimulate rejection in other contexts, such as organ ...

Back story (link.growkudos.com/1pt9jbrx24g) behind our recent publication... Maternal Krüppel-like factor 2 (KLF2)+ CD4 T cells promote fertility and fetal tolerance | PNAS www.pnas.org/doi/10.1073/...

Enhancing Diabetic Wound Healing: A little help from Alcaligenes faecalis? #Microbiome #ActAgainstAmputation diabeticfootonline.c...

Natural maternal immunity protects neonates from Escherichia coli sepsis - Nature Neonatal sepsis caused by Escherichia coli is associated with reduced transfer of pathogen-specific maternal antibodies and, in a mouse model, can be prevented by maternal preconceptual&nbsp...

Another twist to why newborn babies more vulnerable to infection. Beyond immune cell immaturity, layering, active suppression... maternal pathogen-targeted antibodies still protect. Grateful @Nature sharing this hopefully uplifting glass half (99.9%)-full perspective www.nature.com/articles/s41...

Orlaith Keenan in the Zackular lab (@joeyzacks.bsky.social) defends her thesis tomorrow!

Why Do Women with IBD Face Higher Risk of Pregnancy Complications? @babiesresearch.bsky.social @cincyresearch.bsky.social
www.pnas.org/doi/10.1073/...
@pnas.org

scienceblog.cincinnatichildrens.org/why-do-women...

Christopher Penn wrote: Just remember that given the abundance of neurodivergent people in science, it's far more likely that autism causes vaccines.

A different perspective.
Always helpful.

Excited to see this story published! Congrats @jeylee.bsky.social and @abaumler.bsky.social!

❤️An important message from our CSO, EVP, & team captain Dr. Sue Furth! Dr. Furth + the Research Institute team will be joining April's I ♥ CHOP Run, Walk & Virtual Challenge presented by Philadelphia Insurance Companies. Join us, support, or learn more: chop.donordrive.com/teams/CHOPRe...

Natural maternal immunity protects neonates from Escherichia coli sepsis @cincyresearch.bsky.social @babiesresearch.bsky.social @nature.com
www.nature.com/articles/s41...

Felt good to Stand Up For Science today in Seattle🔬🧬🧪💪 @standupforscience.bsky.social

β-hydroxybutyrate supplementation is a promising, readily implementable strategy to improve CAR-T cell function against various cancers @cellcellpress.bsky.social
www.cell.com/cell/fulltex... @marcoruella.bsky.social @penncancer.bsky.social @maayanlevy.bsky.social @stanforduniversity.bsky.social

"The challenge now is not whether brutalism should be admired, but whether its underlying values can be taken seriously again..."

MDSCs at the Vaginal Mucosa - Mucosal Immunology Podcast

#MucosalMonday means a new podcast episode with @societymucosalimm.bsky.social! Join @marionbrunck.bsky.social @ashu-mangalam.bsky.social @kknoop.bsky.social for discussions, mysteries, and the latest research at MI! www.iheart.com/podcast/269-...

Ramadan Mubarak everyone

Antibody cocktails derived from pediatricians cooperatively neutralize and protect rodents against RSV and hMPV by targeting conserved epitopes
www.science.org/doi/10.1126/...

Regulatory T cells safeguard liver health during metabolic-associated steatohepatitis @pnas.org #Mathis @harvardmed.bsky.social
www.pnas.org/doi/10.1073/...

Congratulations @joeyzacks.bsky.social @pjplanet.bsky.social
And to all the authors. So excited to see this out!!!

Thrilled to share this study tracking Staph aureus carriage and transmission across the NICU using genomics! Work done w @pjplanet.bsky.social & @ahmedmicrobes.bsky.social and made possible by @centermicrobialmed.bsky.social.

Study co-led by the amazing @qianxuan.bsky.social & Lakshmi Srinivasan!

Over 3 years we performed WGS-based surveillance of S. aureus in the NICU at @childrensphila.bsky.social, sequencing both surveillance and bloodstream infection isolates, to understand how colonization, transmission, and persistence are associated with invasive infection in high-risk neonates.

The End of Books Coverage at the Washington Post Becca Rothfeld, a former critic at the Washington Post, on the death of the paper’s books section.

"I fielded mail from all manner of people...what they often evinced was better than interest, better even than bibliophilia; it was the rare & precious capacity to be interested in what they didn’t already know interested them. It was a willingness to be changed." www.newyorker.com/books/page-t...

Cool story! Congratulations on this preprint!

Taken together: The neonatal liver undergoes a developmentally hard-wired Treg wave facilitated by cDC1s needed to restrain activation and promote tolerance in conventional T cells that respond to both microbes and self in early life. (10/10)
Link: tinyurl.com/neoliver