Thanks Lisa!

Photodynamische Therapie eröffnet neue Behandlungsoptionen bei schnell wachsenden Tumoren Die photodynamische Therapie gegen Krebs basiert darauf, Patienten eine zunächst inaktive Substanz zu verabreichen, die erst im Tumor durch gezielte Lichtbestrahlung aktiviert wird.

Manche #Tumoren wachsen so schnell, dass das Gefäßwachstum nicht mithält und sich im Inneren sauerstoffarme Bereiche bilden. Forscher der @kargesgroup.bsky.social an der @ruhr-uni-bochum.de haben einen Wirkstoff entwickelt, der ihre Behandlung mit photodynamischer Therapie möglich machen soll.

Thanks Johannes!

Thanks!

Thanks Sven!

Excited to share that I got promoted to W3 Full Professor / Chair of Biophysics at the Faculty of Medicine at the Ruhr University Bochum. The group is now moving across campus into the newly built Center of Protein Diagnostics. news.rub.de/leute/2026-0...

Tumore unabhängig von Sauerstoff behandeln Die meisten Tumore wachsen so schnell, dass das Gefäßwachstum nicht mithält und sich im Inneren sauerstoffarme Bereiche bilden. Ein neuer Wirkstoff könnte ihre Behandlung mit photodynamischer Therapie...

Sauerstoffarme Bereiche von Tumoren überstehen oft die gängige Therapie. Ein neuer Wirkmechanismus ändert das.

Milestone of the lab was just published in @jacs.acspublications.org about Metal-to-Metal Electron Transfer in a Ruthenium Deferasirox Conjugate for Hydroxyl Radical Mediated Hypoxic Photodynamic Therapy. Congrats to @nmontesdeocas.bsky.social and Zisis ! pubs.acs.org/doi/10.1021/...

Cuproptose: Mit Kupfer gegen Krebs

Check out our radio interview at @deutschlandfunk.de.web.brid.gy about the light induced induction of cuproptosis in drug resistant cancer cells (in German) @ruhr-uni-bochum.de
www.deutschlandfunk.de/cuproptose-m...

I am delighted to congratulate my PhD student Nicolas @nmontesdeocas.bsky.social on his outstanding PhD defense, awarded summa cum laude. A remarkable milestone reflecting years of dedication, creativity, and rigorous research. Wishing him all the best for the exciting journey ahead!

Big thanks to the Ruhr University Bochum for highlighting our research findings!

Check out our article in Adv. Funct. Mater. about the Light Activated Induction of Cuproptosis with Copper Containing Polymeric Bodipy Nanoparticles. Congrats to Ricarda and @nmontesdeocas.bsky.social ! @ruhr-uni-bochum.de dx.doi.org/10.1002/adfm...

Haha. Thanks.

Check out our Review Article in @chemicalscience.rsc.org about the classification of Metal Complexes in Medicine: Structural Scaffolds vs Functional Centers. Congrats to @nmontesdeocas.bsky.social ! @ruhr-uni-bochum.de dx.doi.org/10.1039/D6SC...

Thanks but credit all goes to Juan for writing such an excellent proposal.

We are very much looking forward to welcoming you in Bochum @ruhr-uni-bochum.de . Congrats for receiving the prestigious MSCA Fellowship! 🎉

Encapsulation of a Cyclometalated Iridium(III) Photosensitizer into Nanosized Micelles for Oncosis-Inducing Photodynamic Therapy The reliance of many anticancer agents on apoptosis often limits their therapeutic efficacy and contributes to the development of drug resistance. To overcome these challenges, alternative mechanisms ...

Thrilled to share our latest collaboration with
@kargesgroup.bsky.social! Huge congrats to @antoniolinero.bsky.social & all co-authors, including
@nmontesdeocas.bsky.social. Exciting advances in photoactivated iridium nanomaterials & oncosis‑driven cancer cell death. doi.org/10.1021/acsa...

Thanks Enrique!

Reactive Oxygen Species Detection with Fluorescent Probes: Limitations and Recommendations beyond DCFH-DA Reactive oxygen species (ROS) are highly reactive molecules derived from molecular oxygen that play critical roles in cellular signaling, homeostasis, and the regulation of various physiological and pathological processes. Accurate detection and quantification of ROS are essential for elucidating their roles in health and disease. Despite significant advances in ROS probe development, challenges persist due to their short lifetimes, high reactivity, and their chemical diversity. This perspective article provides a critical evaluation of the limitations of the most commonly applied probe molecule DCFH-DA. Capitalizing on this, recommendations with practical applications in the lab for the specific detection of hydrogen peroxide, hydroxyl radical, singlet oxygen, superoxide anion, and peroxynitrite are provided. By integrating current knowledge on ROS probe technologies, this work aims to guide researchers in reliably assessing ROS in complex biological systems, thereby facilitating a deeper understanding of ROS-mediated processes and their implications for disease research and therapeutic development.

Check out our perspective in J. Med. Chem. @acsmedi.bsky.social about the Limitations of DCFH-DA for the Detection of ROS and Recommendations for Probe Selection. @ruhr-uni-bochum.de dx.doi.org/10.1021/acs....

Happy to see this collaborative with Hui Chao and @kargesgroup.bsky.social out in @angewandtechemie.bsky.social. We designed Ir(III) complexes to trigger oncosis and activate the cyclic GMP–AMP synthase-stimulator of interferon genes pathway.
@chimieparistechpsl.bsky.social
doi.org/10.1002/anie...

Incredibly proud to congratulate @antoniolinero.bsky.social on defending his PhD! He did a fantastic job. It’s been an honor to accompany him on this journey and to share this achievement with @joseruizlab.bsky.social, @vanesafm-isqch.bsky.social, @giampaolobarone.bsky.social and Dolores Santana. 🎉

🎥 Honored to be featured in a TV interview with WDR! We talked about our research and its impact — full interview (in German) here 👉 at 14:55 min: www.ardmediathek.de/video/lokalz...

Proud to share our new @ChemRxiv preprint. We report on a novel Metal-to-Metal Electron Transfer Mechanism enabling Hydroxyl Radical Photoredox Catalysis in Hypoxic and Drug-Resistant Cancer Cells, addressing bottlenecks in photodynamic therapy. Please RT! chemrxiv.org/engage/chemr...

Check out our paper in @chemcomm.rsc.org about the Red-Light Excitation of Ru(II)-Pt(II) Tetranuclear Complex for Combined Photoactivated Chemotherapy and Photodynamic Therapy. Congrats to Pia, Eleni, Julia, and @nmontesdeocas.bsky.social ! @ruhr-uni-bochum.de dx.doi.org/10.1039/D5CC...

🚨 PhD Opportunity! 🚨
Join our group in Bioinorganic Chemistry to work on the synthesis & biological evaluation of metal complexes for anticancer therapy.
jobs.ruhr-uni-bochum.de/jobposting/8...

Check out our paper in @inorgchemfront.rsc.org about the Induction of Oncosis by Light Activation with an Ir(III) complex conjugated to Albumin. Congrats to Antonio, Zisis, and Lisa. Fantastic collaboration with @joseruizlab.bsky.social ! @ruhr-uni-bochum.de @um.es dx.doi.org/10.1039/D5QI...

Sterbende Tumorzellen machen Metastasen zur Zielscheibe Ein neuer Wirkstoff kann Krebszellen beseitigen und gleichzeitig das Immunsystem trainieren, solche Zellen überall im Körper zu vernichten.

👉 Ein von der @kargesgroup.bsky.social an der @ruhr-uni-bochum.de entwickelter neuer Wirkstoffkomplex tötet Krebszellen auf eine so geschickte Art, dass sie im Sterben dem #Immunsystem den Weg zu #Metastasen zeigt, die sich an entfernten Orten im Körper entwickeln.

Thanks Maniklal!

Check out our paper in J. Med. Chem. @acsbiol.bsky.social @acsmedi.bsky.social about the induction of immunogenic cell death by a gallium complex for chemoimmunotherapy. Congrats to Zisis and Yassin! @ruhr-uni-bochum.de
dx.doi.org/10.1021/acs....

Honored to be giving the plenary lecture for the Inorganic Devision at the Brazilian Chemistry Conference #48RASBQ