Looking for a PhD on stem cells, microenvironment and gene regulation/alternative splicing. Join us for this great project with @whatchamacaulay.bsky.social

Packed house for the kickoff at #ISEH2025 🏯 this morning! We are excited to have you all join us here in Kumamoto.

Huge congratulations to Marine Sechi for leading the work, which was a joint effort with the Lo Celso lab. Many thanks to all our other collaborators for their contributions and support. @imperialimmuno.bsky.social @imperialcollegeldn.bsky.social

While in homeostasis Hoxb5+Vwf+ HSCs are not found in closer proximity to megakaryocytes, high megakaryopoiesis dynamics following platelet depletion leads to increased proximity to megakaryocytes, revealing previously unrecognized niche dynamics in HSC regulation during regeneration.

Intravital microscopy showed that Hoxb5+Vwf+ HSCs have a non-migratory behaviour in all situations investigated and independently of the proliferative state of HSCs.

Co-expression of Hoxb5-mKO2 and Vwf-GFP alone defines a population of cells highly enriched for hematopoietic stem cells. This double reporter strategy is stable in homeostasis, stress and ageing.

Immunofluorescence image of and Hoxb5+Vwf+ and an Hoxb5+Vwf- cells in the bone marrow niche

New Preprint 🚨. Our latest work is now available in biorXiv: A new double reporter strategy reveals a subset of non-migratory hematopoietic stem cells localized in a dynamic bone marrow niche. www.biorxiv.org/content/10.1...

We are back @ExRdFestival today! Test your pipetting skills (in our custom lab coats!), learn about #SickleCell with our quiz, see real blood cells through a microscope, or craft a message for #SCDwarriors at our art table: www.imperial.ac.uk/immunology-i...

A kinetics-based model of hematopoiesis reveals extrinsic regulation of skewed lineage output from stem cells Residing at the top of the hematopoietic hierarchy, long-term hematopoietic stem cells (HSCs) are capable of self-renewal and sustained blood cell regeneration. Over the past decades, single-cell and ...

New pre-print from Thomas Höfer, Daniel Hübschmann, @haas_lab and myself, with first authors @Esther_RCorrea @FloGrunschlager and Tamar Nizharadze doi.org/10.1101/2025... @DKFZ @NCT_HD @ChariteBerlin @hi_stem_lab BIH & MDC