Diverse modes of T cell receptor sequence convergence define unique functional and cellular phenotypes Single-cell techniques allow concurrent study of gene activity and T cell receptor (TCR) sequences, identifying connections between TCR structure and cell traits. Expanding on our CoNGA software, we p...

How much of the TCR repertoire can we make sense of? Can your TCR and GEX data be put in the context of other conditions/tissues? How many varieties of T cells are in the repertoire zoo? All these questions (& more) addressed in our latest preprint: MetaCoNGA www.biorxiv.org/content/10.1... . a 🧵

www.biomedcentral.com/collections/...

We're still accepting submissions for the 'T cell responses to influenza' collection, which I'm guest editing with BMC Immunology. Please feel free to reach out if you're interested and would like to learn more.

Retroelement-specific tissue resident T cells control tissue resilience and predisposition to inflammation
papers.ssrn.com/sol3/papers....
@belkaidlab.bsky.social

Excited to announce a call for submissions for a special collection on T cell responses to influenza that I'm guest editing! If you're doing research in this area, I encourage you to submit your work. Feel free to reach out for information. #BMCimmunology #Tcells

LCK–co-receptor association ensures T cell lineage fidelity and maximizes epitope-specific TCR diversity LCK-mutant mice help define the role of LCK–co-receptor association in T cell development and immune responses.

Our paper is out!
LCK–co-receptor association ensures T cell lineage fidelity and maximizes epitope-specific TCR diversity | Science Immunology www.science.org/doi/10.1126/...

Integrating single-cell RNA and T cell/B cell receptor sequencing with mass cytometry reveals dynamic trajectories of human peripheral immune cells from birth to old age - Nature Immunology In this Resource, authors profile peripheral immune cells from a total of 220 healthy volunteers from birth to over 90 years. This revealed that T cells were most affected by aging with divergent agin...

Dynamic trajectories of human peripheral immune cells from birth to old age
@natimmunol.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/s41...

Snow day!

TLS_Finder: An algorithm for Identifying Tertiary Lymphoid Structures Using Immune Cell Spatial Coordinates www.biorxiv.org/content/10....

Great day of talks and insights on the NIH Influenza Immunity imprinting meeting

Inspired by @rodrahimi.bsky.social 's noble efforts linking immunologists together over here, let's try and get more specifically TCR/BCR/AIRR/repertoire chat going with this starter park
go.bsky.app/Gi2dcGd
Drop me a beep to get added or suggest others!

I’d like to join too!