‼️ Register for the GRC Systems Chemistry 2026‼️
‼️External funding will allow us to provide financial assistance to a number of attendees‼️
June 21 – 26, 2026, Portland, Maine (USA)
Last chance to be part of an exciting program
👉 Register now: www.grc.org/systems-chem...
#systemschemistry #GRC
Publishing powerpoint presentations? I see dark times ahead
Roeland Nolte top row second from the left; Nico Sommerdijk front row on the right?
oh no, not at all. Because most of these academic rankings are meaningless (what do they tell us about quality of education or research, in particular on the individual or group level) and because they are easily gamed.
This ranking is definitely in the top-10 of most pointless rankings.
Good luck Dave
Killjoy hier: 'Onthullen' dat FvD 'flirt' met extreemrechts is echt geen flex. Het levert applaus op en vaste een journalistieke prijs. Want onze sector houdt van vorm. Maar we zijn al jaren te laat met dit soort 'bewijzen'; waar blijft het bestrijden? We zijn lui en laat.
Importantly, we demonstrate this strategy on a real chemotherapeutic agent (gemcitabine) in 3D glioblastoma tumor models, highlighting its translational potential.
Outstanding work by Juncheng Liu, Bing Xu, and Mark de Geus, and a great collaboration with Antonia Denkova.
Here, we show that the well known benzylboronic acid caging group, traditionally removed using H₂O₂, can be rapidly and selectively uncaged by clinically relevant doses of ionizing radiation in the presence of organochlorides. This process is further enhanced through arylamine catalysis.
Ionizing radiation used in radiotherapy generates reactive oxygen species capable of removing specially designed caging groups (for a recent review, see: www.nature.com/articles/s41...).
Excited to announce our new publication on ionizing radiation–triggered uncaging of benzylboronic acid–caged chemotherapeutics, now published in Chemical Science (open access):
pubs.rsc.org/en/content/a...
graag ook bij TU Delft
@tudelfttnw.bsky.social @tudelftlibrary.bsky.social
congrats, well done
12/10 would recommend
happy b-day Wikipedia!
Bravo 💪🏾
Recent contributions from our group on this topic:
doi.org/10.1039/D5SC....
doi.org/10.1021/acsa....
doi.org/10.31635/ccs....
Many thanks to prof. Zhibo Liu (Peking University), a giant in this field, for useful input during the review process. I’m also very grateful to the journal and its editor @stephengdavey.bsky.social for an involved, constructive and rewarding review and editing process.
We thought it would be useful to review the developments in this field and link these to the underlying radiation chemistry.
For us, this was a very insightful piece to research and write, it taught us a lot about the limits and opportunities in the field.
Recent years have seen considerable advances in combined radio-chemotherapy, where therapeutic dose radiation is used to locally release or activate chemotherapeutics. This mostly goes via the radiolysis of water, where the formed reactive species react with polymer nanocarriers or caged drugs.
Now out in @natrevchem.nature.com: The role of ionizing radiation-initiated reactions in targeted activation of chemotherapeutics
by Dr. Juncheng Liu
Another great collaboration with prof. Antonia Denkova (Department of Radiation Science and Technology).
Our new paper "A Versatile Strategy for Light-Driven Active Transport of Ions" is now online in @angewandtechemie.bsky.social!
shorturl.at/jr1wY
We used an azobenzene photoswitch to transport ions against their concentration gradients from one aqueous compartment to the other. This was achieved
These findings could have exciting implications for low dose-rate cancer treatments, including radionuclide therapy and brachytherapy.
Wonderful work from Bing Xu and Juncheng Liu, and a great collaboration with prof. Antonia Denkova
Open Access publication here: www.cell.com/cell-reports...
The ionized photosensitizer and superoxide then react to form singlet oxygen, a key cytotoxic species in PDT. We hypothesize that low dose-rate radiation leads to more spatially dispersed reactive oxygen species from water radiolysis, reducing recombination and boosting superoxide formation.
Bing’s work suggests a compelling mechanism: instead of generating triplets (as in classic PDT), ionizing radiation ionizes the photosensitizer and simultaneously produces superoxide radicals from dissolved oxygen.
Ionizing radiation, on the other hand, reaches deep into the body, as used in radiotherapy but also opening the door to deep-tissue photodynamic-like effects.
So, what’s going on here? In ordinary PDT, light-induced excitation of a photosensitizer such as Chlorin e6 will lead to singlet oxygen formation via the photosensitizer triplet state. Photodynamic therapy (PDT) is powerful, but limited by how poorly light penetrates tissue.
You probably know Photodynamic Therapy (PDT), but how about Radiodynamic Therapy?
Now out in Cell Reports Physical Science, Bing Xu shows how lowering the radiation dose rate on solutions of the photosensitizer Chlorin e6 leads to increased production of highly cytotoxic singlet oxygen.
Published a paper warning that something doesn't work as commonly accepted in SciRep some years ago, that journal has done some dubious things in the mean time though. I generally like the approach and integrity of CellRepPhysSci, I could imagine they might be up for something like this
Want to come to Maine? I wanted to contact your journal but GRC doesn't allow me to. Would be great to have you there
🔬 Registration Now Open!
GRC Systems Chemistry 2026
“Bridging Molecular Complexity and Multiscale Systems Integration”
📅 June 21 – 26, 2026
📍 Portland, Maine (USA)
www.grc.org/systems-chem...
Feel free to share this announcement with anyone who may be interested.
#GRC @systemschem-grc.bsky.social