sn-RNA-seq analysis of wild-type and RTT rat brain. Nuclei were isolated from brains of wild-type rats and transgenic rats with loss of MECP2. (A) 10× single-cell RNA sequencing was performed, and single-cell profiles were obtained. (B) Gene expression profiles were plotted with UMAP, and several different neuronal subtypes were identified in various clusters as indicated. (C) A plot of DEGs between wild-type (WT) and RTT (MT) rat brain. (D) Plotted are the number of DEGs (upregulated and downregulated) in each neuronal subtype.

Abril Morales & co demonstrate that neurons lacking MECP2 show signs of elevated DNA damage and senescence transcriptional signatures, which could contribute to phenotypes in patients with Rett syndrome. doi.org/10.1242/dmm....

#RettSyndrome #DNADamage

I can’t stop replaying the #memories from our first-ever New York Memory Hub conference! So grateful to everyone who made it a success and inspired us with their research 🧠

So excited for you!!

Excited to share that I landed my dream job!🎉🎉🎉 The Pennington Lab will be opening at the University of British Columbia in January 2026!
@ubcpsych.bsky.social @dmcbrainhealth.bsky.social

Change-of-mind neuroeconomic decision-making is modulated by LINC00473 in medial prefrontal cortex in a sex-dependent manner Long non-coding RNA LINC00473 in mPFC alters change-of-mind re-evaluative decision-making behavior related to negative rumination.

New paper alert!🚨📝

Paper: tinyurl.com/2cycsy6d
Press release: tinyurl.com/yur3j2n8

How the brain 🧠 engages in change-of-mind decisions taps into cognitive biases that depend on sensitivity to sunk costs & regret - both of which may contribute to negative rumination…however…🧵👇1/6 #ScienceAdvances

Endlessly grateful to my wonderful PhD mentor Lucas Pozzo-Miller and all past and current lab members. This project was a team effort that I was so lucky to be a part of!

Destynie Medeiros

🏆 Congratulations to the 2024 Outstanding Paper Prize winner for Research Articles: ‪@destyniemedeiros.bsky.social‬, Karen Ayala-Baylon, Hailey Egido-Betancourt, Christopher Chapleau and Wei Li. Read our Editorial to learn more about the winners & their research. doi.org/10.1242/dmm....

Collage that includes three presenters on the left, and on the right is a group photo of Cai Lab attendees.

The Cai Lab is at @mpfneuro.bsky.social's Emerging Neurotechnology course this week, running a #Miniscope workshop. The course kicked off Monday with an AMAZING keynote by Nobel Laureate @stefanhelllabs.bsky.social.

Looking forward to the rest of the week’s activities! 🤓 #Neuroskyence

Congratulations to you and the lab! Well deserved!!

NIDA notice of award

I am so happy to share that our lab was awarded our first (!!!) R01, the Stephen Katz R01 through NIDA! This award will allow our lab to expand into the fields of reward and addiction, where we will examine the prefrontal GABAergic circuits of adaptive and maladaptive reward seeking! We're hiring!