To be clear, I learned my tank lesson and do not want it or encourage it. I to back getting a qb when you get chances and believe in them regaurdless of overall team status as those opportunities come too infrequently.

With the bengals, I'm not jealous in their current state, but that was a second example of getting a qb first and then getting weapons later and having high success even if it was limited. It's still a sb appearance. However, they never did get protection for burrow.

Sorry Travis. I had quite a few messages and I think the point got lost. The pats didn't tank. I thought Eric was being sarcastic and was implying it was stupid to get a qb early in a rebuild. Pats didn't tank. They got maye with no weapons or oline and made a sb which showed qb first can work.

*not like you are married to Malik

I apologize then. It's the opposite of what people usually advocate for so I took your comment as sarcasm. Plus I fought two people today on it so I was starting to wonder if I was stupid for wanting a qb early in the rebuild. It's like you are married to Malik. He balls, he balls. If not, next guy.

I'm confused Eric. I thought you were being sarcastic at first, but this response seems more genuine and has a good point in it.

Maybe if Sully believes in Malik, he can get him to sign a one year deal with the packers to be backup again so that Miami can beef the team up a little bit to get it ready for him next year.

Bengals did it and got to a sb. Pats just got to a sb doing it. Being on an average team for a year won't kill a qb and the team will improve the next year. Also people act like Miami has no one. You just had a 2k rushing attack with no deep passing threat.

This looks great!

Excellent! I've been using the wrapper version of it. I'll read through this and switch over enthusiast I get a chance. Thanks for your work Talley.

I also don't like this idea of build a team and then get a qb. Qbs don't just manifest when you need them. They watched Malik for 2 years everyday. If you think that man can ball, then get him. How many times do intriguing backups shake free and you have a real chance at them? Just this one time?

Tua played awful last year and most of the guys that got cut did nearly nothing and they still got the 11th pick. You can't just tank in the nfl. Keep guys like brew and brooks and achane that are balling and get rid of the rest. That will reset the books and then start drafting well.

I was just talking to a pats fan (I love in new England) and he was like just tank and get arch manning. I was like 1, is arch even actually good? 2, it's super hard to be get number 1 and it you don't get that, it might be for nothing.

*that

I'm excited about this! Im going to read about it when they documentation comes out.

I mean playoff wins

I think you mean 2x as many dynasties and dolphins have paid wins :(

Sorry, I mean his chosen Qb. I can see Mike being a good hc for a different franchise to target and give him that second chance.

IMO Tua was good chosen Qb. I get he fell apart at an unprecedented rate which is why I'm more willing to give Mike a pass. With the said, while I like Mike and think he deserves more chances, I don't believe enough in him to compromise doing a full reset in order to give him that next chance.

This was helpful. I am asking because I am working on a project related to what you published and knew you would have helpful info. I do work with oxidative bleaching BTW. I actually suspect it's bubble formation that disrupts tissue and not oxidation itself.

I work with a bubble free oxidative agent and have published FFPE duodenal tissue having no detectable tissue loss after 40 cycles. In unpublished work I have seen 0.5um slices from a PF fixed cell spheroid with no support matrix, have no detectable loss after 10 cycles.

@kevin-dean.bsky.social thank you for the answer. Just to clarify, did you ever experimentally try it or did you hypothesize it won't be as robust and had success with the other method and never tried it?

Just read the paper and I'm impressed! I am curious though. You mentioned techniques like CyCIF and then used antibody stripping. Why is that? Did you ever try CYCIF?

This looks great! Such an underappreciated, but important topic. I am going to read it right now.

Perfect response. I just gdpted a question yesterday and I know the answer to it because I just published the paper on it and even though the paper exists online, it still omitted it. The internet embolden the stupid and unfortunately AI is doubling down on that.

My institution gave us all unlimited gdrives for long term storage so I have been uploading a ton of multiplex data sets and it's possible that it's unlimited size, but I hit an item count limit. So now I have about 2 months of work to take them off, make them until tar folders and re-upload. Fun!

That's true! The size has changed, but the struggle to store it has remained constant.

At this point, this is what Texas wants. It's Texas so I'm pretty sure they have more than enough boot straps laying around to pull themselves up by.

Woah, we got that sweet 200 extra dollars in cold tax credit. That's a government that really values baby making and not just saying it does. I for one am planning on buying a single package of diapers with it, lol.

You have the best taste in movies. The fear street prom one was a good recommendation and I'm pumped about this one too. Love the troma stuff.