An enhanced domestication method for uncultured bacteria Abstract. When environmental bacteria transition to laboratory conditions, a process termed domestication, the shift from the native habitat to a culture m

Most bacteria remain uncultured with vast microbial ‘dark matter’ awaiting discovery.. to address this am excited to share EDEN - an enhanced domestication method to grow uncultured bacteria & new diversity. Using EDEN we isolate a new species active against MDR pathogens..

doi.org/10.1093/isme...

Happy to share our latest work, 'Integrating targeted genome mining and structure-guided modeling reveals unexplored 7-deazapurine-containing pathways.' 1/n

www.biorxiv.org/content/10.6...

My super department @warwicklifesci.bsky.social is hiring 6 assistant profs in the wake of recent retirements. We're looking for people in microbiology/infection, cellular disease / immunity; environmental biology; and plant/crop science. #MicroSky warwick-careers.tal.net/vx/lang-en-G...

The @jgi.doe.gov is an amazing partner! I am grateful they have accepted some of our proposals as it has helped us immensely.

This maybe one of the few times I am OK with bringing back the middle ages! Looks like awesome work.

Come to #Microbio26 poster 094 to hear all about natural product antimocrobial discovery from @tosinorababa.bsky.social and me #MicroSky

Tetracenomycin Y, a plant growth-promoting tetracenedione from a rare actinomycete of the genus Acrocarpospora The Journal of Antibiotics - Tetracenomycin Y, a plant growth-promoting tetracenedione from a rare actinomycete of the genus Acrocarpospora

Tetracenomycin Y, a plant growth-promoting tetracenedione from a rare actinomycete of the genus Acrocarpospora | The Journal of Antibiotics rdcu.be/fc3BP

Now out in @acs.org JACS Au, the manuscript by #BarbaraTerlouw et al. describing PARAS, a high-accuracy machine-learning algorithm to predict substrate specificities of nonribosomal peptide synthetase (NRPS) adenylation domains, key for estimating natural product structures from BGC sequence. 1/n

Hacking 3D printers as laboratory robots The emergence of affordable and reliable 3D printers has enabled laboratories to optimize setups, print custom parts, accelerate research, and rapidly prototype. A new movement has emerged in the past...

How to make your own robot!
A review of people making awesome lab robots out of commercial 3D printers. Thank you @vsaggiomo.bsky.social and Sander for inviting me to help write this paper in @digital-discovery.rsc.org.

Beep boop! 🤖 #chemsky
doi.org/10.1039/D5DD...

Any chance they are offered as sweatshirts too?

Skull and spine of presumably a deer in leaf litter

Seen on our walk today. I believe I am too far north for the #Chupacabra so cougar?

NIGMS is signed onto the F31 NOFO. grants.nih.gov/grants/guide...

Highlights of cyanobacterial metabolites reported between 2021–2024 Covering: 2021 to 2024This review highlights cyanobacteria secondary metabolites reported between 2021 and 2024. Those compounds are categorised into major classes, including peptides, alkaloids, lipi...

Our highlight review on recently isolated cyanobacterial metabolites is out @natprodreports.rsc.org !🥳 Covers isolation, structure elucidation (analytical techniques, biosynthesis and total synthesis). Great work with @elisabethjanssen.bsky.social!
@chem.uzh.ch

pubs.rsc.org/en/content/a...

It was great to work with @nicoleavalonlab.bsky.social @danudwary.secondarymetabolism.com @eustaquiolab.bsky.social and Jimmy O @ucsdpharmacy.bsky.social colleagues Bill G and Arnaud T @jgi.doe.gov Drew D, and UF colleagues Yousong D and Hendrik L as well as @oregonstate.edu Shaz S (from our lab)

Green genes from blue greens: challenges and solutions to unlocking the potential of cyanobacteria in drug discovery Cyanobacteria are prolific producers of biologically active compounds that are important in influencing ecology, behavior of interacting organisms, and as leads in drug discovery efforts. Here we…

🔓Don't miss this #OpenAccess Viewpoint by @philmuslab.bsky.social & co. discussing the challenges & solutions to unlocking the potential of cyanobacteria in drug discovery #secmet #natprod

Check it out in full below👇

2 x Assistant Professor in Chemistry University of Warwick - Department of Chemistry.

📍 Location: University of Warwick, UK
📅 Start date: AY 2026/2027
⏰ Deadline to apply: 8th April 2026

warwick-careers.tal.net/vx/appcentre...

Automated genome mining predicts structural diversity and taxonomic distribution of peptide metallophores across bacteria Automated detection of metallophore biosynthesis reveals that metal-chelating non-ribosomal peptides are widespread, chemically diverse, and deeply rooted in bacterial evolution.

Automated genome mining predicts structural diversity and taxonomic distribution of peptide metallophores across bacteria

@elife.bsky.social by Zachary Reitz and Bita Pourmohsenin et al from @marnixmedema.bsky.social and @nadineziemert.bsky.social

elifesciences.org/articles/109...

ACTION ITEM-----ACTION ITEM

Because of overwhelming demand, NIH has new links for the Strategic Plan webinars

March 16, 2026 12:30 - 1:30 pm | www.scgcorp.com/strategicpla...

April 8, 2026 2:30 - 3:30 pm | www.scgcorp.com/strategicpla...

NOTE: YOU HAVE TO RE-REGISTER IS YOU REGISTERED BEFORE

Rethinking Natural Product Discovery: A Complex Epistemological Approach Linking Chemical Ecology and Pharmacognosy Global challenges such as health crises, biodiversity loss, and climate change demand a rethinking of natural product discovery. Despite advances in dereplication, metabolomics, and genomic sequencing...

Rethinking Natural Product Discovery: A Complex Epistemological Approach Linking Chemical Ecology and Pharmacognosy | Journal of Natural Products pubs.acs.org/doi/10.1021/...

Now out in @natcomms.nature.com :
versions 2.0 of both BiG-SCAPE and BiG-SLiCE! With significant speed and accuracy increases, as well as new interactive functionalities.
Read the full paper here #openaccess:
www.nature.com/articles/s41...

Come join us again in a next round of this massive online open science community effort! 💪
Sign up using the link in the thread.
It’s great fun, and really helps the scientific community. What more can you ask? 🙂

The MIBiG 5.0 Annotathon is coming soon, and registration is now open!

🧬 Does your research involve biosynthetic gene clusters? Do you love natural product biosynthesis? Do you have an interest in rare & exotic enzymes? We can use your help & expertise.

Register here 👉 forms.gle/C1cWcLHtrjT2...

A set of genetic tools for use in Clostridioides difficile and related species The Clostridia are a phylogenetically diverse group of anaerobic, spore-forming bacteria that include species of medical, veterinary and industrial importance. The last two decades have seen major adv...

New paper from us.

If you're interested in genetic manipulation of Clostridia, we have a few new tools for you! 36 new plasmids - all available from @addgene.bsky.social

www.microbiologyresearch.org/content/jour...

#microsky

OK. Serious question. How many plant species do you work on? Everyday I swear I see a new leaf!

I am SO incredibly excited to announce the launch of a global list of Inspiring Black Scientists. You can use this list to nominate and connect with researchers. Please share and join us in highlighting these outstanding scientists for #BlackHistoryMonth and beyond!

www.wiley.com/en-us/resear...

I'd watch a muppet show movie where the muppets infiltrate an academic conference.

Phylogeny‐Aware Metabologenomics Accurately Assigns Natural Products to Biosynthetic Gene Clusters We report a statistical approach for associating biosynthetic gene clusters with their cognate metabolites and demonstrate its unprecedented power for scalable natural product discovery. Notably, it ...

Phylogeny-­ Aware Metabologenomics Accurately Assigns
Natural Products to Biosynthetic Gene Clusters

@microbiotech.bsky.social by Judith Boldt et al from Ulrich Nübel and @drrolfmueller.bsky.social

enviromicro-journals.onlinelibrary.wiley.com/doi/pdf/10.1...

This position is still open. The Weisberg lab is recruiting a postdoc or Ph.D. student to study horizontal gene transfer in plant-associated microbial communities. Please see the job ad for more information and feel free to contact me if you have any questions!

The image is the logo of the RABID (Research and training in global Arthropod-Borne Infectious Diseases) program.

Very proud to announce that my baby is finally here!
This new program at UTMB will support a variety of training opportunities in medical and veterinary entomology. It will also focus on developing a broad network of partners interested in vector biology and ecology across the state of Texas.

Graduate school application season: Tip #3

In the current funding climate, find a program with 3-4 people you would be happy to complete your thesis with. Changes at the NIH have created instability. Minimize your risk.