What music should we play to our cells? This was the start of an amazing journey from @ivaskalab.bsky.social at @turkubioscience.bsky.social with Jasmin Kaivola and collaborators @sarawickstrom.bsky.social and others to explore larynx cancer mechanosensitivity!
www.nature.com/articles/s41...
Incredibly bright 🌈
Delighted to share our latest preprint "Filopodia-mediated trans-endocytosis"
www.biorxiv.org/content/10.6...
Work driven by many people including Hanna, Marcela, Sujan, Marie-Catherine, Anna and Monika. Fantastic collaboration with Johanna Englund, Emilia Peuhu, and Eija Jokitalo
A TRPV4-dependent calcium signaling axis regulates lamellipodial actin architecture to promote cell migration: Current Biology www.cell.com/current-biol...
My personal obituary for Richard Hynes now live on the Manchester Cell-Matrix Centre website. www.manchester-matrix.org/news/profess...
Last night @museeorsay.bsky.social we saw fluorescence images of cells or protein filaments seemingly grow along the internal structures of the ceiling of the main hallway. It was mesmerising I loved it Science is Art! More of this please! Congratulations @manuelthery.bsky.social very cool 🤩🤓
🚨 We are hiring TWO postdocs to join the Cell Migration Lab (cellmig.org) 🇫🇮 as part of the new Centre of Excellence in Immune–Endothelial Interfaces (IMMENs).
Join us to decode immune regulation & develop next-gen imaging tools! 🧪🔬
Details in thread 🧵👇
#ScienceSky #Postdoc #AcademicJobs Please RT🫶
It provides a summary of our ongoing research to understand the binary switches built into the synaptic scaffold protein talin, and how these switch patterns change when synapses are stimulated.
Check out our new Talin Infographic!
The poster summarises why we think there is a binary code in animals.
Great artwork made by Josh Hawley @golgigraphics.bsky.social
Excited to share our new preprint! and the surprising finding that the second integrin-binding site (IBS2) does not bind integrin.
IBS2 can be better explained as talin-talin interactions mediated via a cryptic talin-binding site in R11.
We also show a new role for vinculin as a mechano-chaperone
When R11 unfolds it exposes a cryptic Aggregation Prone Region, which we call APR1. This motif mediates talin-talin oligomerisation. Excitingly vinculin binding resolves these talin oligomers revealing that vinculin acts as a mechano-chaperone to maintain mechanotransduction through talin.
Great collaboration with Vesa Hytonen and Jie Yan's teams and led by Neil Ball in my lab @liverpooluni.bsky.social
Excited to share our new preprint! and the surprising finding that the second integrin-binding site (IBS2) does not bind integrin.
IBS2 can be better explained as talin-talin interactions mediated via a cryptic talin-binding site in R11.
We also show a new role for vinculin as a mechano-chaperone
Coming 2027...
Delighted to share the latest paper from the lab
"Fast label-free live imaging with FlowVision reveals key principles of cancer cell arrest on endothelial monolayers"
Amazing work driven by @follainga.bsky.social with contributions from many.
link.springer.com/article/10.1...
New paper out!
We show how mechanosensitive adherens junction proteins link actomyosin contractility to actin assembly using in vitro reconstitution.
Huge congrats to Aurélie Favarin, Rayan Said, & all authors!
In Science Advances: www.science.org/doi/10.1126/...
#actin #myosin #mechanobiology
I will be recruiting two postdocs early next year.
- One image analyst
- one biologist interested in working on lymphatics!
Reach out if you are interested 👍
Latest from the lab "Filopodome proteomics identifies CCT8 as a MYO10 interactor critical for filopodia functions
"
www.biorxiv.org/content/10.6...
Work driven by @anagracanin.bsky.social
A great collaboration with @ivaskalab.bsky.social and @bengoult.bsky.social
🎉
Gutted I missed this. Glad it went well.
This title has "very lethal" energy
spicy!
genesdev.cshlp.org/content/33/2...
🧵
Optogenetic control of mechanotransduction based on light-induced homodimerization of talin url: journals.biologists.com/jcs/article-...
@livuni-ismib.bsky.social and @lincneurosci.bsky.social
🧠 Fully funded 4-year PhD studentship 🧠 Please repost
BBSRC NWD project with @parikki.bsky.social and @iamabyron.bsky.social
Come join us to look at how mechanical and oxidative stress signalling pathways converge on the synaptic scaffold protein talin.
www.findaphd.com/phds/project...
Vinculin is a simple adapter protein right? Wrong!
That’s been the prevailing view for the 46 years since it was discovered.
Here we provide a new paradigm and show that vinculin is a complex mechanosensor itself, containing 6 binary switch domains.
www.science.org/doi/10.1126/...
Both ridiculous.
