19 SKELETAL MUSCLE ANATOMY, STRUCTURE AND FUNCTION #50LAM_ANATOMY_ENG

youtube.com/shorts/WJWd6...

#Anatomy #SkeletalMuscles #MuscleStructure #MuscleFibers #Sarcomeres #Actin #Myosin #MuscleContraction #Physiology #MedicalScience

Bridging scales for cellular communities. Angela K.O. Lwin and Alpha S. Yap (The University of Queensland) discuss new work by Soffer et al. (rupress.org/jcb/article/...) in Spotlight: rupress.org/jcb/article/...

#Cytoskeleton #Spectrin #Actin #Myosin

Self-organization of cell-sized chiral rotating actin rings driven by a chiral myosin Understanding how microscopic interactions between proteins in cells produce large-scale organization and asymmetry is a fundamental question in cell biology. In a recent study, researchers from Japan investigated how actin and myosin create cell-scale structures using experimental setup. They found that Chara corallina myosin XI—a fast motor protein—drives actin filaments into large unidirectionally rotating rings. Their findings reveal physical principles of self-organization, inspiring new ways to design self-organizing biomimetic materials for biotechnological applications.

18-Feb-2026
#SelfOrganization
of cell-sized #chiral rotating actin rings driven by a chiral #myosin
Researchers explore how actin filaments and a motor protein can spontaneously give rise to cell-sized structures

https://www.eurekalert.org/news-releases/1116748

#science #nanoworld

Attention #MYOSIN fans!!! Have a look at this #OpenAccess #research #article in #CYOSKELETON. The Influence of #Drosophila Spire and Myosin V During Mid-Oogenesis Is Independent of Their Direct Interaction. onlinelibrary.wiley.com/doi/10.1002/...

Have you seen this #openaccess #research #article in #CYTOSKELETON? The Influence of #Drosophila Spire and #Myosin V During Mid‐Oogenesis Is Independent of Their Direct Interaction. Read it here: onlinelibrary.wiley.com/doi/full/10....

New paper out!
We show how mechanosensitive adherens junction proteins link actomyosin contractility to actin assembly using in vitro reconstitution.
Huge congrats to Aurélie Favarin, Rayan Said, & all authors!
In Science Advances: www.science.org/doi/10.1126/...
#actin #myosin #mechanobiology

High resolution mapping of the #actin fusion focus reveals #myosin V-dependent formin transport for aster formation. New study from Valentine Thomas (@valthomas.bsky.social), Sophie Martin (@sophiemartinlab.bsky.social) et al: rupress.org/jcb/article/...

#Cytoskeleton #Microbiology #Spombe #Yeast

Ren, Fujita et al. reveal that MYO18B, an unconventional #myosin II, positively regulates lysosomal #exocytosis by promoting focal #adhesion maturation. rupress.org/jcb/article/...

📕 Part of The Year In Cell Biology: rupress.org/jcb/collecti...
#CellBio2025

An 8-nm precise map in live cells, which revealed #actin aster formation by #myosin V-driven transport of #formin.

Happy to see this work now out! 😃

In collaboration with @kaksonen.bsky.social lab

#yeast #pombe #cell_fusion

@biology-unige.bsky.social

In @jcb.org, @valthomas.bsky.social et al. @sophiemartinlab.bsky.social provide a live, 8-nm precision map of the actin fusion focus for cell-cell fusion in S. #pombe. This reveals #actin aster formation by #myosin Myo52-driven transport of the formin Fus1 nucleator rupress.org/jcb/article/...

New work by @valthomas.bsky.social et al. in @sophiemartinlab.bsky.social provides a live, 8-nm precision map of the actin fusion focus for cell-cell fusion in S. #pombe. This reveals #actin aster formation by #myosin Myo52-driven transport of the formin Fus1 nucleator rupress.org/jcb/article/...

Mechanochemistry of Molecular Motors and Filaments. 8-9 May 2026 at University of Warwick.

Calling all #MotorsInQuarantine fans: Please join us for 1.5 days of science on motors and the cytoskeleton as we celebrate the career of Rob Cross. More info and sign-up here: tinyurl.com/mechanochemi... #kinesin #dynein #myosin #microtubules #actin #cytoskeleton

Yanyan Li, Hongchang Li al. reveal that Aurora A–mediated phosphorylation of Numb triggers its dissociation from the plasma membrane, thereby promoting #myosin I–dependent membrane-to-cortex adhesion required for mitotic cell rounding rupress.org/jcb/article/...

#Mitosis #CellDivision #Genetics

In @jcb.org, Yanyan Li, Hongchang Li al. reveal that Aurora A–mediated phosphorylation of Numb triggers its dissociation from the plasma membrane, thereby promoting #myosin I–dependent membrane-to-cortex adhesion required for mitotic cell rounding rupress.org/jcb/article/...

#Mitosis #Genetics

With an in-vitro fast system, we found that even small temperature increases (1-2°C) are sensed by different immune cells. This rapid and reversible thermo-response depends on Myosin II activity, revealing a conserved thermokinetic mechanism for immune cell motility 🔥

#immunecell #cellbio #myosin

🚨 New paper alert! 🧬
Excited to share our latest preprint from the @michellepeckham.bsky.social lab 🎉

We reveal the structure of human non-muscle myosin 2A — showing how ionic interactions control auto-inhibition ⚡ and how disease mutations disrupt it 💪

👉 tinyurl.com/4fkxfv4e

#cryoEM #myosin

Grech, @jimenezruizlab.bsky.social @meissnerlab.bsky.social show that #Toxoplasma gondii tepsin interacts with the AP4 adaptor complex & #clathrin to mediate #actin- and #myosin F–dependent vesicle trafficking from the trans-#Golgi to the parasite’s #lysosome-like PLVAC rupress.org/jcb/article/...

In @jcb.org, Grech, @meissnerlab.bsky.social et al. show that #Toxoplasma gondii tepsin interacts with the AP4 adaptor complex & #clathrin to mediate #actin- and #myosin F–dependent vesicle trafficking from the trans-#Golgi to the parasite’s #lysosome-like PLVAC rupress.org/jcb/article/...

Resolving zone-specific regulation of cardiac #myosin. Shane Nelson @uvmvermont.bsky.social provides commentary on work from Pilagov et al. (rupress.org/jgp/article/...) that explores role of MyBP-C in regulation of the myosin SRX state in cardiac muscle. rupress.org/jgp/article/...

#Myofilaments

Resolving zone-specific regulation of cardiac myosin | Journal of General Physiology | Rockefeller University Press Pilagov and colleagues explore role of MyBP-C in regulation of the myosin SRX state in cardiac muscle.

Commentary published by Shane Nelson, Ph.D., faculty scientist in the Warshaw Lab at #UVMLarnerMed, Department of Molecular Physiology and Biophysics doi.org/10.1085/jgp.... @uvmvermont.bsky.social #physiology #myosin

Commentary @jgp.org from Shane Nelson @uvmvermont.bsky.social: new study from Pilagov and colleagues (rupress.org/jgp/article/...) explores role of MyBP-C in regulation of the #myosin SRX state in cardiac muscle. rupress.org/jgp/article/...

Commentary from Shane Nelson @uvmlarnermed.bsky.social: new study from Pilagov and colleagues (rupress.org/jgp/article/...) explores role of MyBP-C in regulation of the #myosin SRX state in cardiac muscle. rupress.org/jgp/article/...

Theoretical treatment of tension transients in muscle following sudden changes in orthophosphate concentration: implications for energy transduction - Journal of Muscle Research and Cell Motility The relative timing of the force-generating power stroke and release of the ATP-hydrolysis product orthophosphate (Pi) in actomyosin energy transduction is debated. It may be explored by studying the ...

Original manuscript by Alf Månsson #onlinefirst
Theoretical treatment of tension transients in muscle following sudden changes in orthophosphate concentration: implications for energy transduction

doi.org/10.1007/s109...

#myoblue #myosin #tension

Differential impact of substrates on myosin heavy and light chain expression in human stem cell-derived cardiomyocytes at single-cell level - Journal of Muscle Research and Cell Motility To fully exploit the potential of human pluripotent stem cell-derived cardiomyocytes, ideally they should acquire a mature, adult ventricular-like phenotype. Predominant expression of the β-isoform of...

Highlights 🧵 (3/4)

Original #manuscript by Osten et al.: Differential impact of substrates on myosin heavy and light chain expression in human stem cell-derived cardiomyocytes at single-cell level

link.springer.com/article/10.1...

#myoblue #muscle #myosin #iPSC #single-cell

In @jcb.org, Kim, Andrew et al. report on Arc, a large PDZ domain–containing cell membrane–associated protein that controls #Drosophila salivary gland architecture by modulating Crumbs and non-muscle #myosin II. rupress.org/jcb/article/...

#Development #Trafficking

Kim, Andrew et al. report on Arc, a large PDZ domain–containing cell membrane–associated protein that controls #Drosophila salivary gland architecture by modulating Crumbs and non-muscle #myosin II. rupress.org/jcb/article/...

#Development #Trafficking

Myosin makes the moves to keep cell processes humming along Washington University in St. Louis and Duke University researchers show how directed motions combined with protein interactions influence phase separation and the maintenance of biomolecular...

Vroom vroom, let's learn about those myosin motors as part of the continuing partnership between @washu.bsky.social and @dukemedschool.bsky.social to understand the rules governing biomolecular condensates. #myosin #PlantScience 🌱🧪 #CellBiology

engineering.washu.edu/news/2025/My...

Cargo adaptors use a handhold mechanism to engage with #myosin V for #organelle transport, say Hye Jee Hahn, Natalya Pashkova, Michael Cianfrocco, & Lois Weisman @umlifesciences.bsky.social
rupress.org/jcb/article/...

#Microbiology #Organelles #Trafficking

Resolving the kinetics of an ensemble of muscle #myosin motors via a temperature-dependent fitting procedure royalsocietypublishing.org/doi/10.1098/... | #JRSocInterface #Biomechanics #Biophysics

This goes will with this gem, showing a high-speed AFM-video of a myosin V walking along an actin track.
www.nature.com/articles/nat...
I remember seeing this work at the OIST SPDC 2014 workshop in Okinawa & being blown away. 🤯
#AFM #Cytoskeleton #Actin #Myosin #Microscopy #Bioimaging