Shen, Shah, Jain et al. @pennmedicine.bsky.social demonstrate that #lamin A/C reduction alters peripheral genome organization in human cardiomyocytes through cytoskeletal forces transmitted by the LINC complex. rupress.org/jcb/article/...
#laminopathies #cytoskeleton #microtubules
Congratulations Megan King @luskinglab.bsky.social
OptoTAT reveals #microtubule acetylation as a rapid trigger for GEF-H1–mediated cell migration. New tool developed by Abhijit Deb Roy, Takanari Inoue @jhu.edu and colleagues:
rupress.org/jcb/article/...
#Cytoskeleton #Technology #Optogenetics
I’m so happy to join the Editorial Board of JCB! I look forward to handling your manuscripts
Publishing in JCB enables authors funded by National Institutes of Health (NIH), Howard Hughes Medical Institute (HHMI), and other funders an easy pathway to compliance. Learn more: rupress.org/pages/nih-hh...
Stage-specific #transcriptomics of a leader cell reveals cell machineries driving collective invasion. New study from Priti Agarwal @pritiagarwal.bsky.social,
Ronen Zaidel-Bar and colleagues (Tel Aviv University): rupress.org/jcb/article/...
#Migration #Motility #Development #Trafficking #Celegans
Happy and honored to be part of JCB's newest editorial board additions. Looking forward to new and exciting cell biology!
Read 📄 "Cytoplasmic ribosomes on mitochondria alter the local membrane environment for protein import" from the Grotjahn lab: hubs.la/Q0442jjR0
“This recognition feels especially significant because we strive to integrate structural detail with broader cell biological understanding.” — Dr. Danielle Grotjahn (@nanigrotjahn.bsky.social). Learn more. hubs.la/Q0442hKP0
Review: Brenda Cesar and Yumi Kim @jhu.edu review how the synaptonemal complex assembles and serves as a dynamic signaling platform that coordinates meiotic recombination.
rupress.org/jcb/article/...
#Genetics #CellCycle #CellDivision #Meiosis
@cohenlaboratory.bsky.social @carajgottardi.bsky.social @kkarbstein.bsky.social @susannarosi.bsky.social @septinlab.bsky.social @mattwelchlab.bsky.social
JCB is pleased to introduce the newest members of our editorial board. We are grateful to these and all of our board members for their contributions to JCB and service to the cell biology community. rupress.org/jcb/article/...
🌈 Download JCB's CELLULAR DIVERSITY poster! 📩 Sign up to receive our future special collections and download this beautiful artwork by Bianca Dunn to display at home or in the lab 👉 info.rupress.org/jcb-collecti...
A PTPN23-dependent #ESCRT pathway is essential for constitutive secretion in mammalian cells, say Danièle Stalder, Conceição Pereira, David C. Gershlick @dgershlick.bsky.social and colleagues @thecimr.bsky.social:
rupress.org/jcb/article/...
#Trafficking #Biochemistry #Golgi
We miss you!
What a fun surprise to open this app and find that our work had been featured in a @jcb.org spotlight!! Many thanks to @cpeselj.bsky.social and Nora Vögtle for the great write up!
Spotlight: Sidney Whiteheart @universityofky.bsky.social highlights recent work by Ambrosio et al. (rupress.org/jcb/article/...), which provides new insights into endosomal transport and biogenesis of platelet α-granules. rupress.org/jcb/article/...
#Physiology #Trafficking
Spotlight: @cpeselj.bsky.social & Nora Vögtle discuss work by Yan et al. of the @nieminm.bsky.social lab (rupress.org/jcb/article/...) that provides a quantitative framework for measuring the strength & targeting efficiency of various #mitochondria targeting presequences rupress.org/jcb/article/...
Spotlight: Hiba Baaziz and Daniela Cimini @virginiatech.bsky.social discuss recent work from Zych et al. (rupress.org/jcb/article/...), showing that low RCC1 levels impair protein export in #micronuclei, causing overgrowth and rupture. rupress.org/jcb/article/...
The cell biology community mourns the loss of Catherine Rabouille, an exceptional scientist whose determination, innovation, and fearless engagement with ideas reshaped how we think about cellular organization. #InMemoriam from @adamgrieve.bsky.social and colleagues: rupress.org/jcb/article/...
Bridging scales for cellular communities. Angela K.O. Lwin and Alpha S. Yap (The University of Queensland) discuss new work by Soffer et al. (rupress.org/jcb/article/...) in Spotlight: rupress.org/jcb/article/...
#Cytoskeleton #Spectrin #Actin #Myosin
Collective migration is not just about leaders at the front, but about coordination across the group.
Always exciting to see these dynamics visualized.
Many thanks to @jcb.org for featuring our work 🐸🔬🌹
🔬 From our March issue (rupress.org/jcb/issue/22...): Epithelial neural collectives undergoing #chemotaxis, stained for phospho-#myosin (magenta), #actin (cyan), and nuclei (yellow). From @jorgediazfuentes.bsky.social and @mayorlab.bsky.social: rupress.org/jcb/article/...
🌈 Download JCB's CELLULAR DIVERSITY poster! 📩 Sign up to receive our future special collections and download this beautiful artwork by Bianca Dunn to display at home or in the lab 👉 info.rupress.org/jcb-collecti...
Leader cell behaviour during invasion in C. elegans!
Stress-induced nucleolar rejuvenation via chaperone-mediated segregation in a filamentous fungus. New report from Audra M. Rogers, Martin J. Egan and colleagues @uarkansas.bsky.social:
rupress.org/jcb/article/...
Deb Roy, Inoue et al. @jhu.edu introduce an #optogenetics tool to rapidly induce #microtubule acetylation in living cells and show that this triggers release of the RhoGEF GEF-H1 from #microtubules, thereby driving persistent directional cell migration. rupress.org/jcb/article/...
#Cytoskeleton
@pritiagarwal.bsky.social, Zaidel-Bar et al. define the stage-specific gene expression programs of a leader cell that drives collective tissue invasion during organ #development, identifying membrane #trafficking as a central regulator of leader cell behavior. rupress.org/jcb/article/...
#Migration
#Tetraspanin CD82 shapes #EGFR signaling outcomes through nanoscale receptor organization. New study from Sebastian Restrepo Cruz, Jennifer M. Gillette and colleagues @unm.edu: rupress.org/jcb/article/...
#Cancer #Biophysics #Membrane #Lipid #CellSignaling
Stalder, Pereira, @dgershlick.bsky.social et al. @thecimr.bsky.social uncover new regulators of #Golgi-to-plasma membrane transport, showing that a PTPN23-dependent #ESCRT pathway is essential for secretion of membrane & soluble cargoes, including hormones & antibodies. rupress.org/jcb/article/...
