A PTPN23-dependent #ESCRT pathway is essential for constitutive secretion in mammalian cells, say Danièle Stalder, Conceição Pereira, David C. Gershlick @dgershlick.bsky.social and colleagues @thecimr.bsky.social:
rupress.org/jcb/article/...
#Trafficking #Biochemistry #Golgi
In @jcb.org, Stalder, Pereira, @dgershlick.bsky.social et al. uncover new regulators of #Golgi-to-plasma membrane transport, showing that a PTPN23-dependent #ESCRT pathway is essential for secretion of membrane & soluble cargoes, including hormones & antibodies. rupress.org/jcb/article/...
Stalder, Pereira, @dgershlick.bsky.social et al. @thecimr.bsky.social uncover new regulators of #Golgi-to-plasma membrane transport, showing that a PTPN23-dependent #ESCRT pathway is essential for secretion of membrane & soluble cargoes, including hormones & antibodies. rupress.org/jcb/article/...
Rsp5/NEDD4 and #ESCRT regulate TDP-43 toxicity and turnover via an endolysosomal clearance mechanism. New study from Aaron Byrd, Lucas J. Marmorale, Ross Buchan and colleagues @uarizona.bsky.social: rupress.org/jcb/article/...
#ProteinHomeostasis #Genetics #Trafficking #Neuroscience #ALS
Byrd, Marmorale, Buchan et al. @uarizona.bsky.social conducted a yeast genome-wide screen to identify genes affecting TDP-43 clearance in #ALS cell models. They found that #ESCRT complex genes and the #ubiquitin ligase Rsp5/NEDD4 facilitate TDP-43 endolysosomal clearance. rupress.org/jcb/article/...
In @jcb.org, Byrd, Marmorale, Buchan et al. conducted a yeast genome-wide screen to identify genes affecting TDP-43 clearance in #ALS cell models. They found that #ESCRT complex genes and the #ubiquitin ligase Rsp5/NEDD4 facilitate TDP-43 endolysosomal clearance. rupress.org/jcb/article/...
Coordination between #ESCRT function and Rab conversion during #endosome maturation
Anne Spang and colleagues @biozentrum.unibas.ch show that early ESCRT complexes shepherd cargoes towards sites of intraluminal vesicle formation in a key step of endosome maturation
www.embopress.org/doi/full/10....
Ariadna Gonzales Solis from the Otegui lab is bringing #ESCRT complex to our attention. We hardly heard about them so far! Beautiful microscopy coupled with awesome biology!!! #plantproteolysis2025 otegui.cellimaging.wisc.edu
Very glad to see our story on the choreography of #ESCRT proteins in #archaeal cell division finally published in mBio - Junfeng Liu et al "A relay race of ESCRT-III paralogs drives cell division in a hyperthermophilic archaeon" journals.asm.org/doi/10.1128/...
Can we exploit the #ESCRT pathway to develop new broad-spectrum #antivirals ? Let’s see where this new adventure will take us 🧪
#ENPER2024: first #ESCRT talk by M-K Nagel about non-endosomal ESCRT-III functions in Arabidopsis!
Perfect calli: stable transformation of #barley #ESCRT lines. Big thanks to Madeleine, our PhD student, for optimizing the protocol! 😎
We know eukaryotes and bacteria encode #ESCRT proteins, but what about viruses? Our new preprint suggests they do!
doi.org/10.1101/2024...
🧵 on HCMV's pUL71 novel VPS4 recruitment motif, plus figures from the paper reimagined by Taylor Swift because, well, why not?
