In @jcb.org, Ming Sun, Yuan-Bin Liu, Pu-Yu Sun, Bao-Liang Song et al. show that newly synthesized #cholesterol is transported from the endoplasmic reticulum to the plasma #membrane via specialized COPII-independent vesicles. rupress.org/jcb/article/...
#ER_literature #lipids #trafficking
New @jem.org study from Mathew et al. @angelettilab.bsky.social (rupress.org/jem/article/...) shows that nasal tissue harbours T cells that ‘remember’ a pathogen long after infection is past. See @nature.com research highlight: www.nature.com/articles/d41...
In @jcb.org, @shyama13.bsky.social and Deepika Vasudevan show that #Drosophila #adipocytes transport select subcellular components across intercellular bridges with their neighbors, and that such transport is required for tissue resilience to various stressors. rupress.org/jcb/article/...
In @jcb.org, Océane Marescal, @iaincheeseman.bsky.social et al. show that quiescent cells disassemble their #centromeres through the transcriptional downregulation of most #centromere proteins while preserving those required to maintain centromere identity. rupress.org/jcb/article/...
Collective migration requires balancing force and flexibility. In @jcb.org, @vitoryang.bsky.social @polarityi3s.bsky.social et al identify RhoGAP15B as a local brake on RhoA-#myosin contractility in border cells, stabilizing front protrusions & coordinating group movement rupress.org/jcb/article/...
This letter @jhumimmunity.org on multigenerational #SOCS1 insufficiency from Cliodhna Murray et al. (Galway University Hospital) highlights diagnostic importance of considering monogenic immune dysregulation in complex allergic and #autoimmune diseases. rupress.org/jhi/article/...
#Atopy #Allergies
In @jhumimmunity.org, Stejara A. Netea et al. @amsterdamumc.bsky.social present an infant with #macrophage activation syndrome as part of #KawasakiDisease, who was first treated with #canakinumab, followed by #methylprednisolone and intravenous immunoglobulins. rupress.org/jhi/article/...
New study @jcb.org from @hp-tcj.bsky.social and colleagues reveals that cells in moving tissues strengthen their connections by actively shuttling #adhesion proteins along cell edges to vertices, enabling rapid responses to mechanical forces. rupress.org/jcb/article/...
#Development
In @jhumimmunity.org, Ghosh et al. describe a monoallelic dominant-negative PSMB10 variant that impairs immunoproteasome assembly & is associated with transient neonatal T #lymphopenia, highlighting a potentially dynamic & reversible form of early-life thymic dysfunction rupress.org/jhi/article/...
In @jem.org, Hepworth & Grencis discuss work by Forster et al (rupress.org/jem/article/...) reporting that Blimp-1 is a pivotal alarmin-activated transcription factor that is critical in controlling optimal effector cytokine secretion in ILC2 cells during type 2 immunity. rupress.org/jem/article/...
In @jcb.org, Fan and Yang et al. reveal that the SWR1 #chromatin remodeling complex plays a crucial, noncanonical role in preventing the vacuolar delivery of autophagy-related proteins in yeast. rupress.org/jcb/article/...
#Biochemistry #autophagy
In @icb.org, Shan Zhao, Jie Zhang, Chonglin Yang et al. reveal that PI(3)P-dependent recruitment of FGD at #endosome–mitochondrion contacts activates CDC42 to regulate mitochondrial networks through #actin organization and DRP-1 in #Celegans. rupress.org/jcb/article/...
#Development #Mitochondria
New in @jhumimmunity.org: Using single-cell RNA-seq, Manabu Wakamatsu, Hideki Muramatsu et al. @en.nagoya-u.ac.jp show that rhG-CSF suppresses IFNγ signaling and promotes B-cell differentiation in reticular dysgenesis, with potential benefits before #HSCT. rupress.org/jhi/article/...
New in @jhumimmunity.org: Paul E. Gray, @sethlucianmasters.bsky.social, & Edwin P. Kirk argue that the lack of large association studies between Yao-associated variants & clinical phenotypes mean that the diagnosis should not be used in the literature or in the clinic
CD4 tissue resident memory cells are established and persist in the upper airways after #influenza infection and protect from re-infection with drifted strains. New study in @jem.org by Nimitha Mathew et al. @angelettilab.bsky.social: rupress.org/jem/article/...
#Virology #MucosalImmunology
New in @jgp.org: Behringer et al. @tuda.bsky.social review how coarse-grained computational methods uncover long-range mechanical connectivities in HCN channels. Together with high-res #cryoEM structures, these methods provide insights into their allosteric regulation. rupress.org/jgp/article-...
In @jcb.org, Shan Wang et al @tsinghuauniversity.bsky.social reveal how nanoscale polarity emerges at mechanosensory ciliary tips. A #kinesin-8 motor, Kif19A, drives localized transport that is stabilized by region-specific receptor binding, counteracting rapid diffusion rupress.org/jcb/article/...
@jem.org's April issue is here! rupress.org/jem/issue/22...
The cover depicts a confocal image of colonic myenteric plexus from tamoxifen- and DSS-treated NesER-CreR26-STOPf/ftdTomato (Cre+) mice at week 10 afer starting DSS. From Kurapati and Shin et al. (rupress.org/jem/article/...)
@jcb.org's April issue is here! rupress.org/jcb/issue/22...
Image shows immunofluorescence whole-mount staining of cortical F-#actin networks with phalloidin in alI-#spectrin deficient newborn mouse #epidermis. From Soffer, Bhosale et al. rupress.org/jcb/article/...
Park, Liu, Sun, Roll-Mecak et al. present the crystal structure of an RPGR–TTLL5 co-complex, which reveals TTLL recognition paradigms for non-tubulin substrates and sheds light on disease mechanism for retinal dystrophies caused by TTLL5 and RPGR mutations. rupress.org/jcb/article/...
#Cilia
See the accompanying Press Release: www.eurekalert.org/news-release...
@jem.org: Salman et al develop the 1st dual HIF-1/2 inhibitors that bind to the most highly conserved domains of both proteins, show activity vs. a range of cancers, are orally bioavailable & markedly improve responses to immune checkpoint blockade in mouse tumor models rupress.org/jem/article/...
See the original study from Salman et al. published in @jem.org 👉 doi.org/10.1084/jem....
📰 #PressRelease: Researchers @jhu.edu and @univofmaryland.bsky.social have developed a set of novel, first-in-class drugs that inhibit hypoxia-inducible factors 1 and 2, a pair of transcription factors considered to be “master regulators” of cancer progression 👉 www.eurekalert.org/news-release...
📰 #PressRelease: Researchers in China have provided the first proof-of-principle study demonstrating that targeting a receptor on the surface of anti-inflammatory regulatory T cells (Tregs) can restore their function and alleviate #asthma in mice.
www.eurekalert.org/news-release...
In @jgp.org, Levitt, Benninger et al. @cuanschutz.bsky.social investigate how loss of #GapJunctions under diabetogenic environments and their protection influence subpopulations of #insulin-producing β-cells rupress.org/jgp/article/...
#Diabetes
In this review @jem.org, Adam, Suhail, Kuchroo, and Vignali highlight the challenges and novel approaches to developing agonistic inhibitory receptor (IR)-targeted therapies to treat #autoimmunity and inflammatory disorders.
rupress.org/jem/article/...
#CancerFocus #LymphocyteBiology
In @jgp.org, Muñoz, @lfsantana68.bsky.social et al. show that beat-locked cytosolic and mitochondrial ATP transients in sinoatrial node myocytes sort into high-gain, low-gain, or consumption-dominant modes aligned with superior–inferior vascular–mitochondrial gradients. rupress.org/jgp/article/...
@jem.org: Forster et al identify the transcriptional network controlling effector functions of ILC2s downstream of the IL-33 receptor: the Blimp-1–IRF4 axis regulates IL-5 & IL-13 production, driving either worm expulsion or eosinophilia during allergic lung inflammation rupress.org/jem/article/...
