In @jhumimmunity.org, Stejara A. Netea et al. @amsterdamumc.bsky.social present an infant with #macrophage activation syndrome as part of #KawasakiDisease, who was first treated with #canakinumab, followed by #methylprednisolone and intravenous immunoglobulins. rupress.org/jhi/article/...

Stejara A. Netea et al. @amsterdamumc.bsky.social present an infant with #macrophage activation syndrome as part of #KawasakiDisease, who was first treated with #canakinumab, followed by #methylprednisolone and intravenous immunoglobulins. rupress.org/jhi/article/...

The multiple-hit rat model is a model of structural etiology drug-resistant infantile epileptic spasms syndrome (IESS).
doi.org/10.1002/epi4...

#epilepsy #ilae #epilepsiaopen #Sivelestat #fingolimod #methylprednisolone #topiramate #insulingrowthfactor

6/ As with anything in medicine, the answer is “It Depends.” Depends on severity:
👉 If asymptomatic, can even continue infusions
👉 If mild, can follow
👉 If severe, can treat with #methylprednisolone 1g x 5 days, and 🛑 future infusions
👉 If with herniation, would treat as any other #ICP crisis