Human macrophage phagocytosis of lung cancer cells induced by CD47 blockade is augmented after knockdown of phagocytosis checkpoints mediated by siRNA-loaded lipid nanoparticles The present study demonstrates that siRNA-loaded lipid nanoparticles allow for effective in vitro transfection of human monocyte-derived macrophages and en

Kristian Antonsen and colleagues @au.dk report that "Human #Macrophage #Phagocytosis of #LungCancer cells induced by #CD47 blockade is augmented after knockdown of phagocytosis checkpoints mediated by siRNA-loaded #LipidNanoparticles"

In @jhumimmunity.org, Stejara A. Netea et al. @amsterdamumc.bsky.social present an infant with #macrophage activation syndrome as part of #KawasakiDisease, who was first treated with #canakinumab, followed by #methylprednisolone and intravenous immunoglobulins. rupress.org/jhi/article/...

Stejara A. Netea et al. @amsterdamumc.bsky.social present an infant with #macrophage activation syndrome as part of #KawasakiDisease, who was first treated with #canakinumab, followed by #methylprednisolone and intravenous immunoglobulins. rupress.org/jhi/article/...

Class A scavenger receptors promote tumor progression and induce a unique macrophage phenotype in a mouse model of spontaneous breast cancer Cellular and molecular approaches were used to demonstrate that SR-A specifically binds glycans on breast cancer cells and that SR-A-dependent interactions

New data from Behjatolah Monzavi-Karbassi and colleagues @uamshealth.bsky.social show that "Class A scavenger receptors promote tumor progression and induce a unique #Macrophage phenotype in a mouse model of spontaneous #BreastCancer"

Principles of resident tissue macrophages revealed by the eye Macrophages are no longer viewed as transient immune passersby but as integral tissue components that regulate physiological homeostasis. Many residen…

Cool new Tissue resident #macrophage demonstrated using the eye ecosystem as a model by Danny Saban and colleagues. Here is an insightful tutorial: x.com/sabanlab/sta...

Principles of resident tissue macrophages revealed by the eye

www.sciencedirect.com/science/chap...

Statins Combined with AAV8-TBG-LOX-1 Reduce the Vascular Lipid-driven Inflammatory Response and Inhibit Atherosclerosis

This study shows that combining statins with #AAV8 TBG #LOX1 holds promise for reducing lipid-driven #Inflammation, limiting #Macrophage deposition & inhibiting #Atherosclerosis, offering a new target for treatment in #CardiovascularDisease. #medsky
Read: doi.org/10.1007/s115...

#Macrophage anti-bacterial activity is controlled by adenylate kinase 4–mediated mitochondrial DNA synthesis. New study from Wei-Yao Chin, Shi-Chuen Miaw et al. (National Taiwan University): rupress.org/jem/article/...

#InnateImmunity #inflammation #InfectiousDisease #HostDefense #Mitochondria

#seminar on March 26 at noon by Sandrine Henri (Pathophysiology of lung infections team, @cepru1100.bsky.social, Tours)- #Neutrophil and #Macrophage Heterogeneity in Prostate #Cancer
institutcochin.fr/en/agenda/ne...
@cnrsbiologie.bsky.social @upcite.bsky.social @inserm.fr

The Odyssey of macrophages.

This issue spans immune regulation, #macrophage functions, T‑cell tolerance, #AI in infection, #cardiac repair, pelvic care, PDT #inflammation & diverse clinical studies.

www.sciencedirect.com/science/arti... #OpenAccess #ImmunoSky #MedSky

Postdoctoral Research Associate at The University of Edinburgh Discover an exciting academic career path as a Postdoctoral Research Associate at jobs.ac.uk. Don't miss out on this job opportunity - apply today!

Like #hemocytes? I'm advertising a 3 year, BBSRC #postdoc position, in #Edinburgh, using #Drosophila & human cells to understand sex differences in the regulation of #macrophage function, an exciting collaboration with the Bénézech and Wood labs. Please share! 🪰🏴󠁧󠁢󠁳󠁣󠁴󠁿

www.jobs.ac.uk/job/DQU604/p...

allowing #Tcell & #macrophage infiltration into the white matter. -Cytokines like IL-1β, IL-6, and TNF-α peak during the acute phase, leading to #perivenulardemyelination.
-Genetic Factors: Susceptibility is linked to specific Human Leukocyte Antigen (HLA) polymorphisms, such as HLA-DRB1*1501

New in @jem.org from Wei-Yao Chin, Shi-Chuen Miaw et al.: #macrophage Ak4 is vital for defense against bacteria. Ak4 fuels mtDNA synthesis ➡️ boosts mtROS production ➡️ kills pathogens. Loss of Ak4 leads to severe susceptibility. rupress.org/jem/article/...

#Immunology #Mitochondria #Ak4

New from Wei-Yao Chin, Shi-Chuen Miaw et al.: #macrophage Ak4 is vital for defense against bacteria. Ak4 fuels mtDNA synthesis ➡️ boosts mtROS production ➡️ kills pathogens. Loss of Ak4 leads to severe susceptibility. rupress.org/jem/article/...

#Immunology #Mitochondria #Ak4

Sensing of metabolic signals via GPR183 promotes occupation of lung #macrophage niches by #monocytes. New study from Laura Bub, Elza Evren, Stijn Verwaerde, Thomas Marichal, Bart Lambrecht, Tim Willinger @ki.se et al.: rupress.org/jem/article/...

#Metabolism #MucosalImmunology #inflammation

🌅 #Research #Alert
RETN exacerbates #sepsis by GBP5/NLRP3 #signaling #pathway-mediated #pyroptosis of #macrophage

@springernature.com #Genes & #immunity
👉 Access paper here: www.nature.com/articles/s41...

New paper in Biology by @mdpiopenaccess.bsky.social 🧬

The authors from present the Chamber Gap Assay, a simple and visual method to study #macrophage migration ᯓ➤ toward #pancreaticcancer cells using the ibidi Culture-Insert 2 Well in a µ-Dish 35 mm

🧐Read more: zurl.co/VqO5T

#publication

Research Advancements in the Interplay between T3 and Macrophages

This review summarizes how the #thyroidhormone #T3 regulates #macrophage phenotype and function, shaping immune responses and #TissueRepair, and highlights mechanisms underlying endocrine–immune crosstalk, offering insights for future research.

Read: doi.org/10.1007/s115...

New study from the labs of Willinger, Lambrecht, Marichal and colleagues found that #cholesterol metabolites recognized by the receptor GPR183 attract #monocytes to repopulate depleted lung #macrophage niches. rupress.org/jem/article/...

#Metabolism #MucosalImmunology #InnateImmunity #inflammation

New study @jem.org from the labs of Willinger, Lambrecht, Marichal and colleagues found that #cholesterol metabolites recognized by the receptor GPR183 attract #monocytes to repopulate depleted lung #macrophage niches. rupress.org/jem/article/...

#Metabolism #MucosalImmunology #InnateImmunity

#Highlight in #MedComm_Oncology
#Metabolic Reprogramming of the Pre-Metastatic Niche: A Sweet Spot for Anti-#Tumor #Immunity doi.org/10.1002/mog2...

The highlighted article in @CellCellPress : doi.org/10.1016/j.ce...

#LowCarbohydrateDiet #Lung #Metastasis #macrophage #NKcell

Sticky memories of an activated #macrophage. Luca Frosio and Renato Ostuni @ostunilab.bsky.social @unisr.bsky.social discuss new findings by Gorin et al. (rupress.org/jem/article/...) in Insights: rupress.org/jem/article/...

#InnateImmunity #inflammation

🧬 In our latest issue, Deng et al. utilized scRNA-seq to uncover the potential of a specific macrophage population in kidney injury.
'Single-cell RNA sequencing reveals the protective role of renal Cx3cr1+ macrophages in cisplatin-induced acute kidney injury' ➡️ buff.ly/ooEodld
#scRNAseq #macrophage

Lovely to see the imaging by @lizihegarty.bsky.social making the front cover of @mucosalimmunol.bsky.social. Instead is our work on #macrophage heterogeneity & dynamics in health & inflammation. We also did a short podcast to discuss the main findings. @edinuni-irr.bsky.social @uofgsii.bsky.social

Immunomodulatory Effects of Hyoscine Butylbromide on Mammalian Macrophages Hyoscine butylbromide (HB), popularly known as Buscopan, is a common anticholinergic antispasmodic used worldwide for gastrointestinal disorders. While the interaction between the cholinergic system ...

Now available:
Immunomodulatory Effects of Hyoscine Butylbromide on Mammalian Macrophages
#fundamental #clinical #pharmacology #buscopan #cytokine #macrophage #antispasmodic #immune #inflammatory @wileyhealth.bsky.social @sfpt-fr.org
onlinelibrary.wiley.com/doi/10.1111/...

VAMP7-dependent late endosomal secretion of ER and mitochondrial proteins impacts the tumor microenvironment and macrophage engagement - Nature Communications The SNARE VAMP7 is essential for an unconventional secretory pathway based on late endosomal secretion. Here the authors show that this secretion functions as an organelle quality-control and stress-c...

#VAMP7-dependent late endosomal #secretion of #ER and #mitochondrial proteins impacts the #tumor #microenvironment and #macrophage engagement
www.nature.com/articles/s41...

ICAM-1 and vascular matrices coordinate skin S1 macrophage formation from blood PDGFRα lineage monocyte Leukocyte-endothelial interface ICAM-1 structures (green) supports apical PDGFRα lineage (yellow) CD68+ (magenta) monocyte adhesion required for extravasat

Li and colleagues uncover new insights into skin #Macrophage formation - "#ICAM-1 and vascular matrices coordinate skin S1 macrophage formation from blood #PDGFRα lineage #Monocyte"

🚨 New Issue Alert! 🚨

We're delighted to share that the fourth issue of The FEBS Journal is now online.

Discover our latest Issue, here ➡️ buff.ly/5wZasfQ

#macrophage #ferroptosis #machinelearning #herpesvirus #platelet

XPR1 regulates fetal liver #macrophage development, identity and pyrenocyte clearance. From Sebastian Stifter, Melanie Greter and colleagues: rupress.org/jem/article/...

📘 In #Hematopoiesis and #Myeloid Cells collection: rupress.org/jem/collecti...

#KSMyeloid26 #KSHemato26

Pauci-Immune #Endocapillary Proliferative #Glomerulonephritis With Glomerular M2 #Macrophage Infiltration

#VisualAbstract by Abdul Qader

www.kireports.org/article/S2468-0249(26)00...

@mlmlmlmlmlmlml.bsky.social

⏰ New preprint from @lizihegarty.bsky.social, @erinwatson.bsky.social, @bainlab.bsky.social & @doctoremmerson.bsky.social shows that 1hr in PFA-based fixative allows detection of #macrophage subsets in the #salivarygland, #pancreas & #kidney while preserving #epithelial & #endothelial architecture