Current frameworks explain a lot through #ontogeny, niche accessibility, competition, #monocyte replacement, and time in tissue. But they do not fully explain whether self-maintenance becomes a durable population-level property under physiological conditions. 2/11

#Inflammation rewires the enteric nervous system through neurogenic #monocyte recruitment, say Sravya Kurapati, Changsik Shin, Krisztina Szabo, Milena Bogunovic @umasschan.bsky.social and colleagues: rupress.org/jem/article/...

#MucosalImmunology #Neuroinflammation #IBD

ICAM-1 and vascular matrices coordinate skin S1 macrophage formation from blood PDGFRα lineage monocyte Leukocyte-endothelial interface ICAM-1 structures (green) supports apical PDGFRα lineage (yellow) CD68+ (magenta) monocyte adhesion required for extravasat

Li and colleagues uncover new insights into skin #Macrophage formation - "#ICAM-1 and vascular matrices coordinate skin S1 macrophage formation from blood #PDGFRα lineage #Monocyte"

#Immunosky #Glycobiology #Infection #Monocyte

This study uncovers a novel CD14+#CXCL10+ #Monocyte subset driving #sJIA activity/recurrence & also identifies UBE2D1 as a key upstream modulator of NLR signaling, opening avenues for #Biomarker-guided monitoring & #TargetedTherapy. #medsky

#OpenAccess: www.sciencedirect.com/science/arti...

Lei Yuan, Chen Dong et al. reveal that ciliated cells play an immunoregulatory role in allergic #asthma by constitutively expressing IL-17D, which limits #monocyte recruitment to inflamed lungs. rupress.org/jem/article/...

📘 In #Cytokines collection rupress.org/jem/collecti...
#Cytokines2025

CCR2-driven monocyte recruitment is protective against radiotherapy-induced intestinal toxicity Radiotherapy (RT) is essential in treating abdominal and pelvic cancers but often damages the healthy tissues, particularly the intestines, leading to…

Wonderful to see this lovely data out in @mucosalimmunol.bsky.social! Congratulations to @nabinapun.bsky.social, @douglaspdyer.bsky.social & colleagues of @lydiabeckeriii.bsky.social & @mcrcellmatrix.bsky.social! 👏
#monocyte #radiotherapy #intestinal #toxicity
www.sciencedirect.com/science/arti...

Blood Count Abnormalities Predict Poor Outcomes in Advanced Systemic Mastocytosis Leukocytosis, monocytosis, and eosinophilia were consistently associated with advanced systemic mastocytosis, according to a recent study.

Elevated #Leukocyte, #Monocyte and #Eosinophil counts are adverse prognostic indicators in advanced #SystemicMastocytosis, correlating with additional mutations, specific disease subtypes and shorter overall survival. @jacionline.bsky.social

Read more: https://bit.ly/48eJtSO

#RareSky #MedSky

Lei Yuan, Chen Dong et al. reveal that ciliated cells play an immunoregulatory role in allergic #asthma by constitutively expressing IL-17D, which limits #monocyte recruitment to inflamed lungs rupress.org/jem/article/...

In #Macrophages and #DendriticCells collection 👉 rupress.org/jem/collecti...

Ciliated cell–derived IL-17D restrains allergic #asthma through controlling #monocyte recruitment, say Lei Yuan, Chen Dong et al. rupress.org/jem/article/...

#MucosalImmunology #Inflammation #Cilia

In @jem.org, Lei Yuan, Chen Dong et al. reveal that ciliated cells play an immunoregulatory role in allergic #asthma by constitutively expressing IL-17D, which limits #monocyte recruitment to inflamed lungs. rupress.org/jem/article/...

#MucosalImmunology #Inflammation #Cilia

Lei Yuan, Chen Dong et al. reveal that ciliated cells play an immunoregulatory role in allergic #asthma by constitutively expressing IL-17D, which limits #monocyte recruitment to inflamed lungs. rupress.org/jem/article/...

#MucosalImmunology #Inflammation #Cilia

✳️ Editor's Choice from Editor's Choice from Issue 6: Kimura et al. show how changes in #importin family receptors affect nuclear proteasomal degradation of cell cycle proteins during #monocyte to #macrophage differentiation.

➡️ doi.org/10.1002/1873-3468.70020

#NuclearTransport

Lovely seminar from @grizzlybeard.bsky.social the other day about systemic and local control of #monocyte derived cells in health and #Crohn’s disease. Thanks for visiting Andy! #ImmunoSky 🧪

Great to see the abstracts start to come in for EMDS2025.

We have over 20 short talk slots up for grabs - with dedicated slots for #ECRs (PhD and postdocs). So, if you want to showcase your work to Europe's #macrophage #monocyte and #dendriticcell community, be sure to submit your abstract ASAP.

the present study revealed that #monocyte count & NLR were significantly higher & #eosinophil count/% was higher in outpatients with #COVID vs those with #influenza A . These features may help significantly differentiate early
COVID & influenza A.

www.spandidos-publications.com/10.3892/etm....

Monocytes and their doppelgängers: An immunological crossroads Monocyte research reveals “doppelgänger” populations that resemble classical monocytes but differ in origin, function, or migration.

Up next in highlights from this month's #ScienceImmunology was a Focus commentary from Alexander Mildner and Simon Yona discussing the challenges of mapping the identities of recently described #monocyte subsets with different origins and functions.

Modeling Monocyte-to-#FoamCell transition
3D #EndothelialCell (SVEC-10) #SmoothMusclecell (MOVAS) #Monocyte (RAW264.7) collagen co-culture

+Glucose/LPS

SMC⏫
Mɸ Adhesion
Mɸ Transendothelial migration
Mɸ/SMC Foamy transition

#AdvBiol 2024
onlinelibrary.wiley.com/doi/10.1002/...

Highlight

#MedSky🧪#IDSky Qualitative & quantitative disturbances in #monocyte, #macrophage, #Bcell & #Tcells populations could predispose severe #COVID19 patients to develop the fungus #Aspergillus infection .

A 50-gene high-risk profile predictive of #COVID19 & Idiopathic Pulmonary Fibrosis mortality originates from a genomic imbalance in #monocyte & #Tcell subsets that reverses in survivors
with post-COVID-19 Interstitial Lung Disease
www.biorxiv.org/content/10.1...

The prize for the best poster at conference #ColorsOfSepsis about role of #neutrophils #monocyte during #sepsis - goes to @HortovaMarcela @FNUSA_ICRC and collaborators @MartinHelan. Thanks to whole team!!!

In 2020, we've shown how #monocyte subsets predict short‐term survival in patients with septic shock.Summarised here#sepsis #immunology #flowcytometry
@HortovaMarcela @el_deusu @CTM @FNUSA_ICRC @Fric_Immuno_Lab

fnusa-icrc.org/en/the-latest-… onlinelibrary.wiley.com/doi/10.1111/jc…