Publishing in JEM enables authors funded by National Institutes of Health (NIH), Howard Hughes Medical Institute (HHMI), and other funders an easy pathway to compliance. Learn more:
👉 rupress.org/pages/nih-hh...
IFNγ-induced memory in human #macrophages is sustained by the durability of #cytokine signaling itself. From Aleksandr Gorin, Alexander Hoffmann and colleagues @ucla.edu: rupress.org/jem/article/...
📘 Part of JEM #Immunology collection 👉 rupress.org/jem/collecti...
#AAI2026
A PI3Kd-Foxo1-FasL signaling amplification loop rewires CD4+ T cell signaling and differentiation. From Dominic P. Golec, Pamela L. Schwartzberg and colleagues @niaidnews.bsky.social: rupress.org/jem/article/...
📘 Part of JEM #Immunology collection 👉 rupress.org/jem/collecti...
#AAI2026
Read our special collection of recent and exciting advances in #immunology, celebrating JEM’s long commitment to publishing outstanding basic as well as translational research.
👉 rupress.org/jem/collecti...
#AAI2026
🔬 From our April issue (rupress.org/jem/issue/22...): Representative immunohistochemistry for myeloid cells (white), cell outlines (green) and nuclei (blue) from the hearts of immune checkpoint inhibitor-treated mice. From Warrick et al.: rupress.org/jem/article-...
Nasal CD4⁺ tissue-resident memory T cells provide cross-protective immunity to #influenza. New study from Nimitha R. Mathew, Davide Angeletti @angelettilab.bsky.social and colleagues (University of Gothenburg): rupress.org/jem/article/...
#Virology #MucosalImmunology #InfectiousDisease #HostDefense
This collection highlights recent JEM studies investigating the adaptive and innate immune response induced by M. #tuberculosis and #HIV-1 infection. Explore new research to accompany @keystonesymposia.bsky.social meeting on HIV Vaccines 👉 rupress.org/jem/collecti...
#KSHIVVax26
New @jem.org study from Mathew et al. @angelettilab.bsky.social (rupress.org/jem/article/...) shows that nasal tissue harbours T cells that ‘remember’ a pathogen long after infection is past. See @nature.com research highlight:
www.nature.com/articles/d41...
Insights: Hepworth & Grencis discuss work by Forster et al. (rupress.org/jem/article/...) reporting that Blimp-1 is a pivotal alarmin-activated transcription factor that is critical in controlling optimal effector cytokine secretion in ILC2 cells during type 2 immunity. rupress.org/jem/article/...
See the accompanying Press Release: www.eurekalert.org/news-release...
Targeting conserved domains of hypoxia-inducible factors for cancer therapy. New study from Shaima Salman, Alexander D. MacKerell Jr. @univofmaryland.bsky.social, Gregg L. Semenza @jhu.edu and colleagues: rupress.org/jem/article/...
#SolidTumors #TumorImmunology
Inhibitory receptor agonists: Emerging strategies in immune modulation. New review form Kieran R. Adam, Aamir Suhail, Vijay K. Kuchroo @harvardmed.bsky.social, and
Dario A.A. Vignali (University of Pittsburgh School of Medicine):
rupress.org/jem/article/...
#Autoimmunity #LymphocyteBiology
Blimp-1 integrates alarmin signals in ILC2s and drives proinflammatory functions required for type 2 immunity. New study from Patrycja M. Forster, Christoph S.N. Klose and colleagues (Charité – Universitätsmedizin Berlin)
rupress.org/jem/article/...
#MucosalImmunology #Inflammation
CD4 tissue resident memory cells are established and persist in the upper airways after #influenza infection and protect from re-infection with drifted strains. New study by Nimitha Mathew et al. @angelettilab.bsky.social: rupress.org/jem/article/...
#Virology #MucosalImmunology #InfectiousDisease
Our April issue is here! rupress.org/jem/issue/22...
The cover depicts a confocal image of colonic myenteric plexus from tamoxifen- and DSS-treated NesER-CreR26-STOPf/ftdTomato (Cre+) mice at week 10 afer starting DSS. From Kurapati and Shin et al. (rupress.org/jem/article/...)
Targeting Mettl8-Tcf1 axis promotes CD8⁺ TPEX differentiation and antitumor immunity. New study from Jiaxi Song, Dan Cui, Qizhao Huang, Jia Li, Fengyin Li (University of Science and Technology of China) and colleagues:
rupress.org/jem/article/...
#TumorImmunology #Immunotherapy
IBD doesn’t just inflame the gut—it rewires it. New research by Milena Bogunovic, MD, PhD, of UMass Chan, published in @jem.org, shows how inflammation modifies the enteric nervous system, often referred to as the “second brain”: direc.to/o2Xp
#IBD #MucosalImmunology #muscosal #immunology
TIE2 links MEKK3–KLF2/4 and PI3K signaling in cerebral cavernous malformation. New study from Lun Li, Mark Kahn @pennmedicine.bsky.social and colleagues: rupress.org/jem/article/...
#CardiovascularBiology #stroke
3/ Yi-Hao Chan was first author on the papers in @jem.org and @nature.com reporting these groundbreaking findings, even making the cover of @jem.org! rupress.org/jem/article/...
www.nature.com/articles/s41...
See the accompanying Press Release: www.eurekalert.org/news-release...
Salman et al. develop the first dual HIF-1/2 inhibitors that bind to the most highly conserved domains of both proteins, show activity against a range of cancers, are orally bioavailable, & markedly improve responses to immune checkpoint blockade in mouse tumor models. rupress.org/jem/article/...
📰 #PressRelease: Researchers @jhu.edu and @univofmaryland.bsky.social have developed a set of novel, first-in-class drugs that inhibit hypoxia-inducible factors 1 and 2, a pair of transcription factors considered to be “master regulators” of cancer progression 👉 www.eurekalert.org/news-release...
#Basophils drive the resolution and promote #WoundHealing in adult and aged mice. New study from Julie Bex, Christophe Pellefigues and colleagues @upcite.bsky.social @cnrs.fr @inserm.fr:
rupress.org/jem/article/...
#InnateImmunity #inflammation
Local gene editing of #fibroblasts in tumors reveals a new cancer-associated fibroblast state. New study from Nicholas F. Kuhn, Matthew F. Krummel @maxkrummel.bsky.social @immunox.bsky.social and colleagues:
rupress.org/jem/article/...
#TumorImmunology #SolidTumors #TME #CAFs
Who gets the calories? An endothelial checkpoint for fat expansion. Luisa Iruela-Arispe @feinberg.northwestern.edu discusses new work by Wetternwald, Köck and colleagues @petrovalab.bsky.social (rupress.org/jem/article/...) in Insights: rupress.org/jem/article/...
#CardiovascularBiology #Metabolism
🎥 See a short video summary by Anna Köck: youtu.be/SGZ-5GiZvrI
MYCT1–IFITM2/3 interaction links endothelial endolysosomal trafficking to white #adipose tissue expansion. New study from Laureline Wetterwald, Anna Köck, Amélie Sabine @amelie-sabine-unil.bsky.social, Tatiana Petrova @petrovalab.bsky.social et al. @unil.bsky.social:
rupress.org/jem/article/...
New video summary on the study "DNA-PK interacts with cyclic dinucleotides and inhibits type I #interferon responses," from Isabelle K. Vila, Yasmine Messaoud-Nacer, @nadinelaguette.bsky.social and colleagues (rupress.org/jem/article/...)
Video by Yasmine Messaoud-Nacer 📽️ youtu.be/cYfmJvV_jjk
