#Aging might be slowed by a metabolic “brake”.
A Nature Aging (2026) study found that PEP acts as an immune checkpoint—reducing chronic inflammation (inflammaging).
It works by inhibiting the cGAS-STING pathway.
#Metabolism = key to aging.
Read:
www.nature.com/articles/s43...

#Longevity #Immunology

You’re Not Losing Fat, You’re Losing YOU: The Dark Side of Ozempic 💉 The Dark Side of the "Miracle Shot": Is Ozempic Melting Your Muscles? Are you trading your long-term vitality for a temporary reflection in the mirror? Most people jumping on the weight-loss medication bandwagon are chasing a number on the scale, but they don't realize they might be burning down their own house just to stay warm. Stay tuned to discover why the "easy way out" might be the hardest on your heart and bones. In this controversial episode, we dive deep into the biological price tag of Ozempic and Mounjaro when used for cosmetic quick fixes. While these drugs are medical breakthroughs for specific conditions, for the casual user, they often trigger a catabolic nightmare that leaves you "skinny fat" and metabolically fragile. 🔍 What’s Really Happening Inside Your Body? When you use GLP-1 agonists without a specific lifestyle strategy, your body doesn't just shed fat—it enters a state of rapid tissue destruction. We are witnessing the rise of the "smaller but weaker" physique, where individuals lose significant muscle mass and bone density in record time. In this episode, we break down: - ⚠️ The Catabolic Trap: Why your body begins destroying itself to fuel the weight loss. - 🔄 The Metabolic Rebound: The science of why users regain fat more easily once the injections stop. - 🛡️ Protective Protocols: Why high-protein diets and heavy resistance training are non-negotiable for anyone on these drugs. - 🌿 Natural Biohacks: How to trigger natural GLP-1 stimulation through fiber and strategic food sequencing for sustainable results. Don't let a pharmaceutical trend dictate your biological future. Whether you're currently using these medications or just curious, this is the essential manual you weren't given for protecting your strength and longevity. 🔥 Ready to reclaim your health the right way? If this episode challenged your perspective, please Rate, Review, and Subscribe! Share this link with someone who needs to hear the truth about the "miracle shot"—it’s time to prioritize your metabolism over a temporary trend! 🚀  

📣 New Podcast! "You’re Not Losing Fat, You’re Losing YOU: The Dark Side of Ozempic" on @Spreaker #biohacking #bonehealth #fatloss #fitnessmotivation #foodsequencing #glp1weightloss #healthwarning #highproteindiet #longevity #metabolichealth #metabolism #mounjaro #muscleloss #naturalweightloss

Close-up of fresh salmon fillet, eggs, and artichokes beside text about protein recommendations across the lifespan for health and clinical practice.

Submit your research to APNM on topics related to protein intake, performance, aging, and metabolic health to feature in this collection. Submissions close Nov. 30, 2026.

▶️ https://ow.ly/3Q8y50YrtuT

#NutritionResearch #AppliedPhysiology #Metabolism

MASH-GA: a manually curated cross-species transcriptomic database for metabolic-associated steatohepatitis Abstract. Metabolic dysfunction-associated steatohepatitis (MASH), formerly called NASH, is a progressive form of fatty liver disease closely linked to met

From #OUP 's #DATABASE journal | MASH-GA: a manually curated cross-species transcriptomic database for metabolic-associated steatohepatitis | #Metabolism #Bioinformatics #Genomics #OpenScience | 🧬 🖥️ 🧪 🔓
⬇️
academic.oup.com/database/art...

Lipid signaling networks in pancreatic cancer progression and therapeutic perspectives Pancreatic ductal adenocarcinoma (PDAC) remains one of the deadliest cancers, driven by aggressive biology, profound therapy resistance, and scarce treatment options. Beyond classical metabolic rewiring, recent discoveries reveal that lipid metabolism plays a central and previously underappreciated role in PDAC progression. Emerging evidence shows that fatty acids, cholesterol, lysophospholipids, sphingolipids, and oxidized lipid species actively shape oncogenic signaling, influence stromal and immune interactions, and contribute to metastasis and treatment evasion. In this review, we highlight these recent advances and discuss how lipid-driven circuits intersect with major oncogenic pathways, including KRAS effectors and phosphoinositide 3-kinase–AKT. By integrating mechanistic insights with therapeutic perspectives, we outline new opportunities to exploit lipid-based vulnerabilities in pancreatic cancer.

Online Now: Lipid signaling networks in pancreatic cancer progression and therapeutic perspectives #trends #endocrinology #metabolism

Flip the fuel, and the heat is on! Carnitine synthesis as a physiological mediator of fuel adaptation To what extent does de novo carnitine synthesis in tissues dictate their fuel preference? Recently, Auger et al. identified Solute Carrier 25A45 (SLC25A45) as a mitochondrial trimethyllysine importer for carnitine biosynthesis. SLC25A45 enables certain tissues to constitutively utilize fatty acids as fuel and, upon bioenergetic crisis, mediates a fuel switch that restores homeostasis.

Online Now: Flip the fuel, and the heat is on! Carnitine synthesis as a physiological mediator of fuel adaptation #trends #endocrinology #metabolism

Really cool new paper from the Rewtiz lab in @natureportfolio.nature.com on how #cholesterol sensing by nuclear receptor HR3 mediates #mTor signaling (via mechanisms possibly independent of its transcriptional function) by acting upstream of RAG GTPase to regulate growth.
#Drosophila #metabolism

Substrate supply, compartmentation, and utilization in hepatic de novo lipogenesis Hepatic de novo lipogenesis (DNL) is a fundamental process that supports energy storage, membrane biogenesis, and lipid signaling. However, chronically elevated hepatic DNL is a risk factor for insulin resistance and liver fat accumulation. If sustained, this can drive inflammation and fibrosis, with progression to cirrhosis and sometimes hepatocellular carcinoma, as well as numerous cardiometabolic comorbidities. Therefore, new discoveries on the basic mechanisms that control hepatic DNL may enable therapeutic modulation that improves major health outcomes. This review synthesizes recent advances in how the liver channels lipogenic substrates through mitochondrial and cytosolic pathways into DNL. It also highlights how these substrates regulate lipogenic flux by supplying cytosolic acetyl-CoA and NADPH.

Online Now: Substrate supply, compartmentation, and utilization in hepatic de novo lipogenesis #trends #endocrinology #metabolism

The Hidden Impact of Light on Your Mitochondria In today's episode we're investigating how modern environments, specifically light bulbs, impact your cellular health. Dr. Andrew Huberman highlights that incandescent bulbs emit long wavelengths that "charge" your mitochondria and improve vision, while common LEDs may damage them. We dive into the "Cell Danger Response," where cells enter a defensive survival mode and stop producing energy. Chronic illness can occur when this healing cycle gets stuck, causing systemic dysfunction and fatigue.  Restoring health requires shifting cellular signaling from danger to safety through restorative sleep and natural light. References: - https://www.vigilantfox.com/p/leading-neuroscientist-says-this Support our work. Make a small donation. This removes any advertisements and help us continue bringing more interesting topics and confronting mainstream narrative on health. Click the Link to support us: https://www.spreaker.com/podcast/foodnourish-deep-dives--6602003/support

📣 New Podcast! "The Hidden Impact of Light on Your Mitochondria" on @Spreaker #atp #biohacking #cells #cellular #chronic #energy #healing #health #incandescent #inflammation #led #light #metabolism #mitochondria #recovery #signaling #stress #survival #vision #wellness

Glucore helps support balanced blood sugar levels, improve metabolism, and boost daily energy. Its natural formula promotes overall wellness and helps maintain a healthier lifestyle.
Order Now :- eng-eng-glucore.com

#Glucore #BloodSugarSupport #GlucoseControl #EnergyBoost #Metabolism #HealthyLife

A new era in childhood obesity Advances in our understanding of hypothalamic control of energy homeostasis have resulted in the identification of genetic forms of obesity, both syndromic and nonsyndromic, with some precision treatments now being employed. In this review article, we examine the progress being made in identifying new genes involved in the hypothalamic leptin–melanocortin system and their possible implications in obesity, as well as other potential clinical features. We include an update on clinical trials in genetic obesity with specific pharmacological treatments, such as agonists for the melanocortin 4 receptor, and for glucagon-like peptide-1 receptor. The possibility of employing new precision drug targets in specific forms of obesity is modifying the approach to disease treatment in the pediatric clinic.

Online Now: A new era in childhood obesity #trends #endocrinology #metabolism

Metabolic consequences of naturally occurring mitochondrial heteroplasmy in bivalves Abstract. Oxidative phosphorylation, the cornerstone of mitochondrial energy production, is a tightly regulated process that relies on the strict interacti

Our latest study on mitochondrial heteroplasmy and its impact on energy metabolism across sexes is finally out in ProcB @royalsocietypublishing.org!! 🎉🦪🧬

Kudos to Ariane and the Breton Lab for this marvellous work.
#mitochondria #heteroplasmy #metabolism

Check it out!

doi.org/10.1098/rspb...

An IL6 variant -174 G-C alters cardiac hypertrophy but not cardiometabolic responses to HFD in mice - npj Metabolic Health and Disease npj Metabolic Health and Disease - An IL6 variant -174 G-C alters cardiac hypertrophy but not cardiometabolic responses to HFD in mice

How do genetic variants of #interleukin-6 (#IL6) contribute to #cardiometabolic disease? With help from Promethion #Metabolic Cages, scientists tested a knock-in mouse model of the IL6 promoter variant #rs1800795. 🧪

buff.ly/GDBusEN

#Respirometry #Metabolism #CVD #HFD

An IL6 variant -174 G-C alters cardiac hypertrophy but not cardiometabolic responses to HFD in mice Chronic elevations in interleukin-6 (IL6) signaling have been shown to exacerbate features of cardiometabolic disease. A common variant in the IL6 promoter (location -174 G/C, identifier rs1800795) is...

How do genetic variants of #interleukin-6 (#IL6) contribute to #cardiometabolic disease? With help from Sable Promethion #Metabolic Cages, scientists tested a knock-in mouse model of the IL6 promoter variant #rs1800795.

buff.ly/GDBusEN

#Respirometry #Metabolism #Inflammation #Adipose #CVD #HFD

The immunoregulatory role of progesterone during embryo implantation and pregnancy Progesterone (P4), the ‘pregnancy hormone’, plays a pivotal role in the establishment and maintenance of pregnancy by modulating maternal immune responses, thereby promoting immune tolerance toward the semi-allogeneic fetus. In this review, we examine the key pathways through which P4 mediates its effects on maternal immune systems. We elucidate P4's immunomodulatory functions, with a focus on how altered P4 signaling may affect immune tolerance toward the fetus and contribute to the pathogenesis of pregnancy complications. We further discuss the potential role of P4 supplementation in improving embryo implantation and preventing miscarriage, as well as its role in modulating immune-mediated pathological conditions during pregnancy, while emphasizing unresolved questions and directions for future investigation.

Online Now: The immunoregulatory role of progesterone during embryo implantation and pregnancy #trends #endocrinology #metabolism

U01.01.079 Vitamin B7  Test your knowledge of U01.01.079 Vitamin B7. Practice identifying the "ABC" enzymes of biotin-dependent carboxylation and the clinical triad of dermatitis, alopecia, and enteritis with this expert-curated MCQ set.

🥚 The Carboxylation Key: Mastering Vitamin B7 (Biotin)! 🥚Biotin is the essential carrier of activated carbon dioxide ($CO_2$) for the body's carboxylation reactions. #USMLEStep1 #MedEd #MedicalStudent #Biochemistry #VitaminB7 #Biotin #Step1Prep #HighYield #MedSchool #Metabolism #Gluconeogenesis #N

I’m thrilled to co-organize the 2nd #AdiposeBiology with @sunglab.bsky.social, Jacqueline Beaudry, and @sablesys.bsky.social in Montreal on Oct 7-9 2026!🇨🇦
🔗 Register now – adiposebiology.com
Hope to see you there! #ABC2026 #Metabolism #Energybalance #ObesityResearch @mcgillgci.bsky.social

Who gets the calories? An endothelial checkpoint for fat expansion. Luisa Iruela-Arispe @feinberg.northwestern.edu discusses new work by Wetternwald, Köck and colleagues @petrovalab.bsky.social (rupress.org/jem/article/...) in Insights: rupress.org/jem/article/...

#CardiovascularBiology #Metabolism

U01.01.077 Vitamin B5 Test your knowledge of U01.01.077 Vitamin B5. Practice identifying the role of Pantothenic Acid in acetyl group transfer, heme synthesis, and the biochemical consequences of B5 deficiency with this expert-curated MCQ set.

🔑 The Universal Component: Mastering Vitamin B5 (Pantothenic Acid)! 🔑
#USMLEStep1 #MedEd #MedicalStudent #Biochemistry #VitaminB5 #PantothenicAcid #Step1Prep #HighYield #MedSchool #Metabolism #CoenzymeA #Nutrition #USMLE #FutureDoctor #StudyGram #MedTwitter

The 3M roles of the gut microbiome in pharmacotherapy for diabetes: mediator, modifier, and marker The rising global prevalence of type 2 diabetes mellitus (T2DM) presents major challenges to healthcare systems; thus, more effective treatment strategies are urgently needed. In this context, the growing recognition of the gut microbiome’s role in T2DM pharmacotherapy has shifted attention toward integrating microbiome-derived mechanisms to optimize drug response. This review proposes a structured ‘3M’ framework that classifies the gut microbiome’s roles in T2DM pharmacotherapy into three translational categories: mediator of drug action, modifier of therapeutic response, and marker for predicting efficacy or intolerance, based on recent clinical and mechanistic insights. Together, these insights support a translational framework that may guide the integration of microbiome-informed strategies into future T2DM pharmacotherapy.

Online Now: The 3M roles of the gut microbiome in pharmacotherapy for diabetes: mediator, modifier, and marker #trends #endocrinology #metabolism

How Sunlight Penetrates the Human Body to Boost Your Vision In today's episode we're diving into new science showing how infrared sunlight passes through your skin and clothing to improve your health. Researchers found that just 15 minutes of light on a person's back can sharpen their vision by up to 16%, even if their eyes are completely covered. This works by boosting mitochondria, the tiny power plants in our cells, to produce more energy. We also look at why modern LED bulbs might be bad for us since they lack these healing infrared wavelengths. It’s time to rethink our relationship with the sun. References: - https://doi.org/10.1038/s41598-025-09785-3 - https://petermcculloughmd.substack.com/p/new-study-sunlight-penetrates-the Support our work. Make a small donation. This removes any advertisements and help us continue bringing more interesting topics and confronting mainstream narrative on health. Click the Link to support us: https://www.spreaker.com/podcast/foodnourish-deep-dives--6602003/support

📣 New Podcast! "How Sunlight Penetrates the Human Body to Boost Your Vision" on @Spreaker #atp #biology #cells #energy #evolution #eyes #healing #health #infrared #led #light #metabolism #mitochondria #nature #radiation #science #sunlight #systemic #vision #wellness

Cardio Slim Tea is a herbal blend that supports heart health and weight management. Rich in antioxidants, it boosts metabolism, improves circulation, and enhances energy,
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#CardioSlimTea #HeartHealth #WeightLoss #HerbalTea #Metabolism #Wellness

Sugar Defender helps maintain healthy blood sugar levels with a natural blend of ingredients. It supports metabolism, reduces cravings, and promotes energy balance.
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#SugarDefender #BloodSugar #Metabolism #HealthyLiving #WeightSupport #Wellness

Citrate-mediated control of chromatin and mitosis Citrate metabolism remains poorly understood during mitosis, raising unresolved questions about citrate dynamics, compartmentalization, and targeting in cancer. Here, we propose a comprehensive model to explain how ATP-citrate lyase degradation at mitotic onset induces a transient citrate peak, promoting histone H3 phosphorylation and mitotic progression, while mitotic exit relies on acetate-driven lipogenesis.

Online Now: Citrate-mediated control of chromatin and mitosis #trends #endocrinology #metabolism

Scientists discover sleep switch that builds muscle, burns fat, and boosts brainpower Deep sleep does far more than rest the body — it activates a powerful brain-driven system that controls growth hormone, fueling muscle and bone strength, metabolism, and even mental performance. Scien...

#mwgic #2026 #Sleep #Metabolism #Strength #Focus

www.sciencedaily.com/releases/202...

Metabolic interactions shape ecosystems

Looking very much forward to contributing to this exciting symposium at @embl.org in Heidelberg on one of my favorite research topics. Many thanks for the kind invitation! I highly recommend registering and joining us. #metabolism #microbiome #interactions

#MicroSky 🧪

www.embl.org/about/info/c...

Reprogramming the mitochondrial–circadian energy code with incretins Mitochondrial dysfunction, circadian disruption, and the accumulation of senescent cells converge to impair metabolic flexibility, a unifying phenotype of obesity and aging. We frame obesity as a nutrient-driven and aging as a time-driven expression of a disrupted mitochondrial–circadian energy code, with shared outputs: impaired substrate switching and flattened energy rhythms. This opinion argues that restoring code integrity, indexed clinically by gains in metabolic flexibility, should guide therapy. Beyond appetite and glycemia, GLP-1 (glucagon-like peptide-1) and dual GLP-1/GIP (glucose-dependent insulinotropic polypeptide) agonists may enhance mitochondrial efficiency, support circadian alignment, and temper prosenescent signaling across target tissues (muscle, liver, adipose, islets, and brain). We outline how node-specific and combination strategies (senolytics/senomorphics, mitophagy/NAD+ support, and chrono-entrainment) could reprogram systemic energy coordination, improve durability of response, and delay age-related metabolic decline.

Online Now: Reprogramming the mitochondrial–circadian energy code with incretins #trends #endocrinology #metabolism

Please wait whilst we redirect you All content on this site: Copyright © 2026 Elsevier B.V., its licensors, and contributors. All rights are reserved, including those for text and data mining, AI training, and similar technologies. For all open access content, the relevant licensing terms apply.

🔬 Mitochondria produce and export lactate to help limit oxidative stress.

Finally done—deeply grateful to an incredible team.

Read more here:
🔗 authors.elsevier.com/c/1mpvh5WXUl...

#Mitochondria #Metabolism #Science #Bioenergetics

Is Your Workout Making You Fat? (The High Cortisol Trap) 🚨 STOP: Is Your 5 AM Workout Actually Making You Fat? 🏃‍♂️💨 Ever pulled an all-nighter only to drag yourself to the gym, thinking you're a "warrior"? Spoiler alert: You’re actually sabotaging your metabolism. 😱 In this episode, we’re deconstructing the dangerous myth that you can "grind" your way through exhaustion. We reveal why your body isn't a simple calorie calculator, but a highly sensitive chemical laboratory. When you’re sleep-deprived, your cortisol levels spike, and your insulin sensitivity plummets, putting your body into a "Code Red" survival mode. In this state, your biology perceives a threat and begins storing fat as a protective mechanism, making that high-intensity workout not just hard, but biologically counterproductive. Why you’ll want to listen to the end: We’re sharing the exact metabolic recovery protocol to flip the switch from fat storage to fat burning without stepping foot on a treadmill. 🧪 What We’re Diving Into: - The Cortisol Trap: Why high-intensity exercise after poor sleep is a recipe for weight gain and hormonal chaos. - Biological Wisdom: How to make your body feel "safe" enough to release stored fat by prioritizing nervous system regulation. - The Caffeine Mistake: Why that immediate morning coffee is wrecking your metabolic health and what to do instead. - Nasal Breathing & Sunlight: The low-tech biohacking secrets that clear blood sugar and reset your internal clock. Forget the "no pain, no gain" mantra. It’s time to stop the punishment and start listening to your biology. Sustainable fat loss isn't about force; it's about biological safety and recovery. 🌿 ✨ Ready to transform your metabolism and master your sleep? Hit that Follow button and share this episode with a friend who needs to stop the 5 AM madness. Let’s choose wisdom over willpower! 🎧👇  

📣 New Podcast! "Is Your Workout Making You Fat? (The High Cortisol Trap)" on @Spreaker #biohacker #biohacking #burnoutrecovery #circadianrhythm #cortisolhealth #fatloss #fitnessmyths #healthtips #healthyhabits #hormones #liss #lowcortisol #metabolichealth #metabolism #nervoussystemregulation

Targeting ferroptosis to halt MASLD and MASH Metabolic dysfunction–associated steatotic liver disease (MASLD) is a global epidemic, with its inflammatory form, metabolic dysfunction–associated steatohepatitis (MASH), driving cirrhosis and hepatocellular carcinoma. Ferroptosis, an iron-dependent form of programmed cell death, is a central pathogenic mechanism in MASLD and MASH. The core drivers of ferroptosis include dysregulated iron metabolism, an increase in peroxidation-susceptible phospholipids, and impaired antioxidant defenses. These changes promote hepatocyte death via a so-called ‘ferroptotic explosion’ triggered by an increase in FerroLipid, thus driving the transition from a profibrotic state to overt fibrosis. Notably, targeting ferroptosis with iron chelators and ferroptosis inhibitors shows promise as a therapeutic strategy by restoring redox and lipid homeostasis. Furthermore, systemic crosstalk between the liver, adipose tissue, and gut microbiota modulates ferroptotic susceptibility, revealing new avenues for developing precision-targeted therapies.

Online Now: Targeting ferroptosis to halt MASLD and MASH #trends #endocrinology #metabolism