✨New issue✨

Check out the latest in #Metabolism research from across all disciplines.

Read about #AdiposeTissue, #EVs, #Incretins, #Immune cells, #LiverMetabolism, #MitochondrialMetabolism, #SpatialOmics, #Tumorbiology and many more topics! 🧪

http://dlvr.it/TRmC3C

🧬 Which organ is primarily responsible for protein metabolism? #protein #metabolism #bodyfacts ... Continue to: www.youtube.com/watch?v=k8vg...

Scientists discover a hidden system that turns brown fat into a calorie burner Scientists have identified a key biological system that helps brown fat burn energy by building the networks it needs to function. A protein called SLIT3 splits into two parts, with each piece guiding...

#mwgic #2026 #Metabolism #Fat #BrownFat

www.sciencedaily.com/releases/202...

RobinReach

⚠️ Are insulin spikes physically deleting your drive? Learn what causes these spikes, how they impact your energy and motivation, and ways to support a steadier day. Watch now ▶️ https://youtu.be/-wFY31D4hwo
#Metabolism #Energy #Wellness #Health

Explanation for why we don't see two-foot-long dragonflies anymore fails https://arstechni.ca #metabolism #physiology #breathing #Science #Biology #insects #trachea

Calories vs Macronutrients: The Real Science of Body Composition. Is body transformation just about calories, or is there a deeper biological system at play?In this episode, we break down the relationship between energy balance and macronutrients from a scientific perspective.We explore how calories determine body weight, while macronutrients influence body composition, performance, and recovery.We also cover protein intake (1.6–2.5 g/kg), metabolic signaling, and nutritional periodization strategies to optimize results. Calories control weight. Macros control body composition.In this episode, discover the science behind fat loss, muscle gain, and how to structure your nutrition for real results.

📣 New Podcast! "Calories vs Macronutrients: The Real Science of Body Composition." on @Spreaker #biohacking #fitnessscience #healthexpert #longevity #metabolism #musclequality #nutrition #vo2max

Improving incretin-mediated body weight loss via energy expenditure Incretin-based therapies have transformed obesity and type 2 diabetes treatment. While current therapeutics safely reduce food intake and lower body weight, a compensatory drop-in basal metabolic rate represents a barrier to sustainable weight loss. Current efforts aim to incorporate energy expenditure (EE) stimulation with the anorectic actions currently available in the clinic. Glucagon receptor agonism, for instance, has demonstrated the benefit of a multipronged increase in EE; however, compensatory challenges persist. We detail peripheral mechanisms that can increase EE independent of activity and the key central mechanisms controlling them. Understanding the complex interplay between these mechanisms and their central modulation is critical for a coordinated engagement of EE pathways to complement and improve current weight loss treatments.

Online Now: Improving incretin-mediated body weight loss via energy expenditure #trends #endocrinology #metabolism

People who stay naturally slim often have slower metabolisms than average #Metabolism #Health

Does this surprise you?

#Astronomy #JamesWebb #DeepSpace #OceanFacts #Universe

Polyamines Polyamines are small, positively charged metabolites ubiquitous in living organisms, with putrescine, spermidine, and spermine as the main types in mammalian cells. They act as critical substrates for protein synthesis and key signaling molecules, essential for tissue homeostasis and regulating immune cell proliferation, differentiation, and function. Additionally, polyamines are involved in fundamental processes such as aging and tumor progression, underscoring their broad physiological and pathophysiological significance.

Online Now: Polyamines #trends #endocrinology #metabolism

🔬🧪🧠⚡Now also out as a detailed protocol.
#brain glucose #metabolism #MRI
#NeuroSky ⏬⏬

journals.plos.org/plosone/arti...

Acetate Acetate/acetic acid (CH3COO−/CH3COOH) acts as intracellular metabolic and extracellular signaling molecules. Intracellular concentration is an order of magnitude lower than that in the plasma, with the latter mostly supplied by gut microbiota. In animal cells, acetate is not a major end product of metabolism but is continuously produced by protein deacetylation, metabolic stress-induced acetyl-CoA overflow, peroxisomal lipid oxidation, and ethanol metabolism. It is rapidly reconverted to acetyl-coenzyme A (CoA) and utilized as the substrate for the tricarboxylic acid (TCA) cycle (mitochondria), as well as for fatty acid and cholesterol synthesis (cytosol and endoplasmic reticulum).

Online Now: Acetate #trends #endocrinology #metabolism

#METPHYS - The Metabolic Physiology Meeting The Metabolic Physiology Meeting 2024 overview, speakers, agenda, hotel reservation and registration information. #metphys2024

Last call to register for #METPHYS2026 -- The #Metabolic #Physiology Meeting 2026 (April 27-30, 2026)! Join leading researchers at the beautiful Sonesta Resort, Hilton Head Island, SC, USA to discuss the latest advances in the field.

buff.ly/djLXeU7

#Conference #Metabolism

Endocrine control of one-carbon metabolism in cachexia Cancer cachexia lacks effective therapies due to an incomplete understanding of its upstream drivers. A recent study by Morigny et al. identifies one-carbon metabolism as a conserved endocrine–metabolic program that links tumor signals to skeletal muscle hypermetabolism and systemic energy imbalance, highlighting methyl-donor pathways as actionable targets for treating cachexia.

Online Now: Endocrine control of one-carbon metabolism in cachexia #trends #endocrinology #metabolism

U01.01.076 Vitamin B3 Test your knowledge of U01.01.076 Vitamin B3. Practice identifying the role of Niacin in ATP production, its use in treating hyperlipidemia, and the diagnostic hallmarks of Pellagra with this expert-curated MCQ set.

⚡ The Redox Regulator: Mastering Vitamin B3 (Niacin)! ⚡
#USMLEStep1 #MedEd #MedicalStudent #Biochemistry #VitaminB3 #Niacin #Step1Prep #HighYield #MedSchool #Pellagra #Metabolism #Tryptophan #USMLE #FutureDoctor #StudyGram #MedTwitter

U01.01.075 Vitamin B2 Test your knowledge of U01.01.075 Vitamin B2. Practice identifying the role of Riboflavin in redox reactions, its connection to FADH2 production, and the diagnostic hallmarks of Ariboflavinosis with this expert-curated MCQ set.

🟡 The Golden Cofactor: Mastering Vitamin B2 (Riboflavin)! 🟡
#USMLEStep1 #MedEd #MedicalStudent #Biochemistry #VitaminB2 #Riboflavin #Step1Prep #HighYield #MedSchool #Metabolism #TCAcycle #Nutrition #USMLE #FutureDoctor #StudyGram #MedTwitter

Amino acids compensate for MPC metabolism in hepatocytes, BCAAs & pyruvate share similarities, & PPM1K phosphorylation ↑ in obese livers. Mouse CRISPR model insights! 🎨 Dr. Brian Finck, PhD at WashU #Metabolism #BCAA #LiverMetabolism #MetabolicResearch #MedEd @beineff.bsky.social

U01.01.071 Vitamins: Water soluble Test your knowledge of U01.01.071 Water-Soluble Vitamins. Practice identifying enzyme cofactors, deficiency manifestations, and the biochemical roles of B-vitamins and Vitamin C with this expert-curated MCQ set.

💧 Energy and Metabolism: Mastering the Water-Soluble Vitamins! 💧
#USMLEStep1 #MedEd #MedicalStudent #Biochemistry #Nutrition #Step1Prep #HighYield #MedSchool #VitaminB12 #Folate #VitaminC #Metabolism #USMLE #FutureDoctor #StudyGram #MedTwitter

📣 Call for Papers: Dietary Manipulations for Health & Disease Prevention

Topics of interest include:
🔬 Metabolism
🥗 Dietary interventions
🧬 Chronic disease prevention

Learn more now➡️ buff.ly/sUQHcJD
#NutritionResearch #HealthScience #Metabolism #DietAndHealth

Exploring cell types and their dynamic states in adipose tissue The functional versatility of adipose tissue is mediated by various cell types and their capacity to transition between distinct functional states upon pathophysiological stimuli. Recent advances in single-cell transcriptomics have enabled the identification of novel and numerous cell types and states of adipocytes, adipose stem and progenitor cells, immune cells, vascular cells, and mesothelial cells. Significant efforts have been made to understand the key features and underlying processes of the cell subpopulations and to elucidate the cellular mechanisms of adipose tissue plasticity. In this review, we describe current knowledge of heterogeneous cell types and states in adipose tissue and emerging techniques to characterize them, offering fundamental knowledge for studying adipose tissue in the single-cell era.

Online Now: Exploring cell types and their dynamic states in adipose tissue #trends #endocrinology #metabolism

Adipose tissue-derived extracellular vesicles as drivers of endothelial dysfunction in obesity Obesity and (white) adipose tissue (AT) inflammation are closely linked to endothelial dysfunction (ED) and neurological conditions associated with an impaired blood–brain barrier (BBB). AT-derived extracellular vesicles (AT-EVs), cell-derived particles involved in intercellular and interorgan communication, have emerged as active mediators of this process, yet the underlying mechanisms remain largely elusive. Molecular and functional profiling of AT-EVs’ cargo has revealed obesity-related changes in miRNAs, proteins, and lipids that drive ED, primarily by activating proinflammatory signaling in endothelial cells. Importantly, these cargo changes in AT-EVs suggest a broader role, potentially modulating the neurovascular unit, thereby linking AT-EVs to brain pathologies. Collectively, these insights highlight AT-EVs as critical players in obesity-related ED and support their causal role in promoting neurological disease progression.

Online Now: Adipose tissue-derived extracellular vesicles as drivers of endothelial dysfunction in obesity #trends #endocrinology #metabolism

Time-Restricted Eating Fails to Improve Metabolic Health in New Study A new study challenges the health benefits of time-restricted eating, finding no metabolic improvements despite controlled calorie intake.

📍Time-Restricted Eating Fails to Improve Metabolic Health in New Study.

A new study challenges the health benefits of time-restricted eating, finding no metabolic improvements despite controlled calorie intake.

#Health #WeightLoss #Metabolism #Diet

factide.com/time-restric...

Interplays and functional divergences of one-carbon metabolic shunts One-carbon (1C) metabolism serves as a central hub governing anabolism-supporting and epigenetic modification processes through its shunts, the tetrahydrofolate (THF) cycle, and the methionine cycle. The 1C shunts exhibit divergent characteristics in mammalian cells in terms of methyl sources, regulatory networks, and supporting functions. Under specific physiological and pathological contexts, 1C metabolic shunts exhibit distinct biological functions and orchestrate metabolic crosstalk between cells and across organs. These findings have significantly advanced our understanding of systemic compartmentalization and functional cooperation between the divergent 1C shunts. In this review, we explore the intricate interplays and divergent biological roles between the THF and methionine cycles at the molecular, cellular, and systemic levels and further propose innovative avenues for research and clinical applications.

Online Now: Interplays and functional divergences of one-carbon metabolic shunts #trends #endocrinology #metabolism

(2) Maria Correia studied the effects of #microbiota produced #metabolites, particularly short-chained fatty acids (butyrate) on #mitochondria, whole animal #metabolism and cold tolerance, via experimental supplement. Massive amount of data collected, super well done!

🆕 ADVANCE ONLINE 🆕

RESEARCH PAPER: A brain-specific microRNA, miR-1000, regulates lipid homeostasis via neuropeptide-like precursor 1 in Drosophila melanogaster
By Verma et al. and David Van Vactor
➡️ https://ow.ly/sCFM50YyTsG

Harvard Medical School
#Drosophila #lipid #metabolism #lifespan #miRNA

Frontiers | A feedback loop between cell proliferation and ROS regulates ferroptosis sensitivity BackgroundFerroptosis is a form of regulated cell death characterized by iron-dependent lipid peroxidation and membrane rupture. While cellular populations r...

Ever wondered how cellular #metabolism, #ROS, cellular confluence and #Ferroptosis are connected? Read our new study with theoretical physicist Johannes Berg @unicologne.bsky.social @cecad.bsky.social @uniklinikkoeln.bsky.social @dtg-cologne.bsky.social
www.frontiersin.org/journals/cel...

SLIT3 fragments orchestrate neurovascular expansion and thermogenesis in brown adipose tissue - Nature Communications Brown adipocytes are embedded within an intricate network of blood vessels and sympathetic nerves that support their development and thermogenic function. This study shows that adipocyte progenitor ce...

Really happy to share new work from our lab, led by Tamires Serdan, with Heidi Cervantes and Benji Frank. They uncover an elegant evolutionary design where adipocyte progenitors don’t just make fat, they help wire it. www.nature.com/articles/s41... #obesity #metabolism @nyupress.bsky.social

Nature has already run billions of biological experiments.

Stowers scientist @batevodevo.bsky.social, Ph.D. joined @npr.org's All Things Considered to discuss how researchers study unusual species—like bats and pythons—to uncover clues about #metabolism, disease, and human health. 🦇

🎧 n.pr/4c2mlbj

Mitochondrial NADP(H) integrates redox and metabolism The compartmentalization of NAD(H) and NADP(H) is fundamental to cellular metabolism, enabling precise coordination of redox balance, biosynthetic reactions, and energy homeostasis. Within mitochondria, NADP(H) has long been viewed as a redox buffer supporting antioxidant defense and reductive biosynthesis. Emerging evidence, however, reveals that mitochondrial NADP(H) also drives oxidative metabolism and metabolic flexibility. Loss of the mitochondrial NAD kinase, which phosphorylates NAD(H) to generate mitochondrial NADP(H), disrupts NADP(H)-dependent pathways that sustain oxidative metabolism and systemic energy balance. These advances reposition mitochondrial NADP(H) as an integrative regulator that links redox homeostasis with energy metabolism across cellular and systemic levels, with broad implications for metabolic disease.

Online Now: Mitochondrial NADP(H) integrates redox and metabolism #trends #endocrinology #metabolism

Outstanding new article coauthored by Elad Noor:

‘Metabolic thermodynamics: pertinent reference state and energy potentials’

tinyurl.com/38xsxse2

#WIS

#PlantandEnvironmentalScience

#Metabolism

#Thermodynamics

#Energy

#ChemicalPotential

#pH

#StandardChemicalPotential

Elad

Gut Microbes Turn Low-Protein Diets Into Fat-Burning Mode In mice, specific gut bacteria convert protein restriction into a metabolic signal that transforms energy-storing fat into energy-burning tissue.

The #GutMicrobiome is the missing element here in converting "white fat" to "brown fat" —

japanresearchreport.substack.com/p/gut-microb...

#GutMicrobiome #Metabolism #BrownFat #Obesity #JapanResearchReport