Anti-aging vitamin B3 derivatives help pancreatic cancer cells survive and resist chemotherapy – BioNews Central Popular anti-aging vitamin B3 derivatives—nicotinamide mononucleotide, nicotinamide riboside, and nicotinamide—may reduce the effectiveness of chemotherapy in pancreatic cancer patients. ...

Popular #AntiAging #VitaminB3 derivatives— #NicotinamideMononucleotide, #NicotinamideRiboside, and #nicotinamide —may reduce the effectiveness of #chemotherapy in #PancreaticCancer patients. 
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U01.01.076 Vitamin B3 Test your knowledge of U01.01.076 Vitamin B3. Practice identifying the role of Niacin in ATP production, its use in treating hyperlipidemia, and the diagnostic hallmarks of Pellagra with this expert-curated MCQ set.

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🔥Hot Off the Press | ❓Could a common #vitamin hold the key to treating rare genetic disease? 🧬👇
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research puts #VitaminB3 (niacin) in the spotlight:
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Fuel the System. Not Just the Symptoms.

Energy, digestion, and balance start at the cellular level — and Vitamin B3 is doing more work than most people realize

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Supplement Inspektor: Vitamin B3 (niacin) boosts energy metabolism, supports DNA repair & skin health, and can help manage cholesterol. Facts on benefits & proper dosing. #SupplementInspektor #VitaminB3 https://supplementinspektor.de/vitamin-b3/

Supplement Inspektor analysiert Vitamin B3 (Niacin): Essenziell für Energiestoffwechsel, DNA-Reparatur und Hautgesundheit. Kann Cholesterinspiegel verbessern und Müdigkeit reduzieren. #SupplementInspektor #VitaminB3 https://supplementinspektor.de/vitamin-b3/

Vitamin B3 can help protect against skin cancer. Here's who may benefit Dermatologists often recommend nicotinamide — a form of Vitamin B3 — following skin cancer. A study of nearly 34,000 veterans finds this supplement reduces the risk of skin cancer recurrence.

#VitaminB3 can help protect against #skincancer. Here's who may benefit

www.npr.org/2025/09/17/n...

Supplement Inspektor analysiert Vitamin B3 (Niacin): Schlüsselrolle im Energiestoffwechsel, Hautgesundheit und DNA-Reparatur. Vegavero als Testsieger mit flush-free Formel empfohlen. #SupplementInspektor #VitaminB3 https://supplementinspektor.de/vitamin-b3/

Vitamin B3 supplement may reduce your risk of skin cancer | The-14 A new study shows that nicotinamide, a form of vitamin B3, may significantly reduce the risk of skin cancer, offering a simple, low-cost option for prevention.

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the-14.com/vitamin-b3-s...

This Vitamin B3 Supplement Could Cut Your Skin Cancer Risk by up to 54% A new large-scale study has found that nicotinamide, a common vitamin B3 supplement, may significantly reduce the risk of skin cancer recurrence. Dermatologists have been recommending the supplement nicotinamide...

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This Over-the-Counter Vitamin B3 Supplement May Help Prevent Skin Cancer Vitamin B3 pill shows promise in preventing skin cancer, large VA study suggests. A common over-the-counter form of vitamin B3, nicotinamide, also known as niacinamide, may help prevent certain skin cancers,...

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Vitamin B3 can help protect against skin cancer. Here's who may benefit A new study shows B3 supplements helped reduce the risk of non-melanoma skin cancer recurrences.

The biggest reduction was seen among people who began taking the supplement after being diagnosed with their first #SkinCancer. #VitaminB3 #nicotinamide

Supplement Inspektor analysiert Vitamin B3: Schlüsselrolle im Energiestoffwechsel & DNA-Reparatur. Fördert Hautgesundheit, reduziert Müdigkeit und kann Cholesterin verbessern. #VitaminB3 #Niacin https://supplementinspektor.de/vitamin-b3/

Nicotinic acid levels found crucial for yeast fermentation and wine quality, study shows Research highlights risks of vitamin B3 deficiency in grape must and suggests targeted supplementation to maintain fermentation efficiency

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Nicotinic acid levels found crucial for yeast fermentation and wine quality, study shows Research highlights risks of vitamin B3 deficiency in grape must and suggests targeted supplementation to maintain fermentation efficiency

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Natural Compound Combo Restores Aging Brain Cells **Summary:** Scientists have identified a natural compound combination that reverses aging-related brain cell decline and removes harmful Alzheimer’s-linked proteins. The treatment, combining nicotinamide (vitamin B3) and the green tea antioxidant epigallocatechin gallate, restores guanosine triphosphate (GTP) levels—critical for neuronal energy and protein cleanup. In aged neurons, the restored energy boosted protein clearance, reduced oxidative stress, and reactivated key cell trafficking pathways. The findings suggest a potential non-drug strategy for combating Alzheimer’s, though more work is needed to optimize delivery. **Key Facts** * **Energy Restoration:** Nicotinamide and green tea antioxidant revived GTP levels in aged neurons to youthful levels. * **Protein Clearance Boost:** Treatment improved the brain’s ability to remove toxic amyloid beta aggregates. * **Non-Pharmaceutical Potential:** Findings point to a supplement-based approach for Alzheimer’s prevention or therapy. **Source:** UC Irvine **Researchers at the University of California, Irvine have identified a promising nonpharmaceutical treatment that rejuvenates aging brain cells and clears away the buildup of harmful proteins associated with Alzheimer’s disease.** In a paper published recently in the journal _GeroScience_ , the UC Irvine team reports that a combination of naturally occurring compounds – nicotinamide (a form of vitamin B3) and epigallocatechin gallate (a green tea antioxidant) – can reinstate levels of guanosine triphosphate, an essential energy molecule in brain cells. “We found that restoring energy levels helps neurons regain this critical cleanup function.” Credit: Neuroscience News In tests on neurons in a dish, the treatment reversed age-related cellular deficits and improved the brain cells’ ability to clear damaging amyloid protein aggregates, an Alzheimer’s hallmark. “As people age, their brains show a decline in neuronal energy levels, which limits the ability to remove unwanted proteins and damaged components,” said lead author Gregory Brewer, adjunct professor of biomedical engineering at UC Irvine. “We found that restoring energy levels helps neurons regain this critical cleanup function.” The researchers used a genetically encoded fluorescent sensor called GEVAL to track live guanosine triphosphate levels in neurons from aged Alzheimer’s model mice. They discovered that free GTP levels declined with age – particularly in mitochondria, the cells’ energy hubs – leading to impaired autophagy, the process by which cells eliminate damaged components. But when aged neurons were treated for just 24 hours with nicotinamide and epigallocatechin gallate, GTP levels were restored to those typically seen in younger cells. This revival triggered a cascade of benefits: improved energy metabolism; activation of key GTPases involved in cellular trafficking, Rab7 and Arl8b; and efficient clearance of amyloid beta aggregates. Oxidative stress, another contributor to neurodegeneration, was also reduced. “This study highlights GTP as a previously underappreciated energy source driving vital brain functions,” Brewer said. “By supplementing the brain’s energy systems with compounds that are already available as dietary supplements, we may have a new path toward treating age-related cognitive decline and Alzheimer’s disease.” He cautioned, “More work is going to be required to find the best way to administer this treatment, since a recent clinical trial involving UC Irvine researchers showed that oral nicotinamide was not very effective because of inactivation in the bloodstream.” Brewer’s collaborators were Ricardo Santana, a UC Irvine associate specialist in biomedical engineering, and Joshua McWhirt, a UC Irvine junior specialist who’s now a Ph.D. candidate at the Medical University of South Carolina. **Funding:** Funding was provided by the National Institutes of Health and the UC Irvine Foundation. ## About this supplements and brain aging research news **Author:**Brian Bell **Source:**UC Irvine **Contact:** Brian Bell – UC Irvine **Image:** The image is credited to Neuroscience News **Original Research:** Open access. “Treatment of age-related decreases in GTP levels restores endocytosis and autophagy” by Gregory Brewer et al. _GeroScience_ * * * **Abstract** **Treatment of age-related decreases in GTP levels restores endocytosis and autophagy** Age-related declines in neuronal bioenergetic levels may limit vesicular trafficking and autophagic clearance of damaged organelles and proteins. Age-related ATP depletion would impact cognition dependent on ionic homeostasis, but limits on proteostasis powered by GTP are less clear. We used neurons isolated from aged 3xTg-AD Alzheimer’s model mice and a novel genetically encoded fluorescent GTP sensor (GEVAL) to evaluate live GTP levels in situ. We report an age-dependent reduction in ratiometric measurements of free/bound GTP levels in living hippocampal neurons. Free GTP colocalized in the mitochondria decreased with age accompanied by the accumulation of free GTP-labeled vesicular structures. The energy dependence of autophagy was demonstrated by depletion of GTP with rapamycin stimulation, while bafilomycin inhibition of autophagy raised GTP levels. Twenty-four-hour supplementation of aged neurons with the NAD precursor nicotinamide and the Nrf2 redox modulator EGCG restored GTP levels to youthful levels and mobilized endocytosis and lysosomal consumption for autophagy via the respective GTPases Rab7 and Arl8b. This vesicular mobilization promoted the clearance of intraneuronal Aβ aggregates, improved viability, and lowered protein oxidative nitration in AD model neurons. Our results reveal age- and AD-related neuronal GTP energy deficits that impair autophagy and endocytosis. GTP deficits were remediated by an external NAD precursor together with a Nrf2 redox modulator which suggests a translational path. Join our Newsletter Thank you for subscribing. Something went wrong. I agree to have my personal information transferred to AWeber for Neuroscience Newsletter ( more information ) Sign up to receive our recent neuroscience headlines and summaries sent to your email once a day, totally free. We hate spam and only use your email to contact you about newsletters. You can cancel your subscription any time.

neurosciencenews.com/natural-compound-brain-a...
#neuroscience #news #alzheimers #nicotinamide #VitaminB3
#EpigallocatechinGallate #antioxidant #GreenTea

Natural Compound Combo Restores Aging Brain Cells - Neuroscience News Scientists have identified a natural compound combination that reverses aging-related brain cell decline and removes harmful Alzheimer’s-linked proteins.

neurosciencenews.com/natural-comp...
#neuroscience #news #alzheimers #nicotinamide #VitaminB3
#EpigallocatechinGallate #antioxidant #GreenTea

WholisticResearch's Niacin Dosage Calculator provides your exact mg dose based on body weight. Get mild, moderate, and strong dosage options tailored specifically to you. Calculate your optimal B3 dose now! #Niacin #VitaminB3 #Supplements www.wholisticresearch.com/dosage-calculator/niacin...

Vitamin B3 Pill Rewinds Premature Aging in Groundbreaking Human Trial A breakthrough clinical trial in Japan reveals that nicotinamide riboside (NR), a vitamin B3 derivative, significantly improves symptoms of the rare premature aging disease Werner syndrome. Patients saw...

Vitamin B3 Pill Rewinds Premature Aging in Groundbreaking Human Trial #Science #HealthandMedicine #Nutrition #VitaminB3 #AgingResearch #HumanTrial

Vitamin B Guide: Health Benefits, Deficiency Symptoms, and Top Food Sources Explained! Discover the types, benefits, deficiency symptoms, food sources, and prevention tips of essential B vitamins for better health and energy.

Learn about #Vitamin B types, benefits, deficiency symptoms, and the best #food sources to stay #healthy and #energized.

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Vitamin B3 (Niacin): Supplement Inspektor analysiert die vielfältigen Vorteile für Energiestoffwechsel, Hautgesundheit und Cholesterinspiegel. Fundierte Einblicke zu Dosierung, Anwendung und wissenschaftlichen Erkenntnissen. #SupplementInspektor #VitaminB3 https://supplementinspektor.de/vitamin-b3/

NEW #clinicaltrial finds faster recovery from #COVID19 through targeted use of high-dose #VitaminB3 #nicotinamide in the gut. No relevant safety signals are observed. www.nature.com/articles/s42...

Vitamin B3 (Niacin): Essenziell für Energiestoffwechsel und Zellgesundheit. Supplement Inspektor erklärt, wie es Hautgesundheit fördert und Cholesterinspiegel senkt. Mit Testsieger-Empfehlung! #SupplementInspektor #VitaminB3 https://supplementinspektor.de/vitamin-b3/

Niacin boosts memory and focus while protecting against cognitive decline. Wholistic Research breaks down how this essential B vitamin enhances brain function, proper dosages, and ideal supplement combinations. #VitaminB3 #BrainHealth #Nootropics https://wholisticresearch.com/niacin/

Vitamins and Minerals to Use with Caution In today's health-conscious society, many individuals are drawn to nutritional supplements, believing they are a shortcut to achieving optimal well-being. While supplements can provide benefits, there is a less visible danger lurking in their overconsumption. This can lead to unpleasant side effects such as nausea and headaches, and, over time, may contribute to more serious health complications. Striking a balance in nutrient intake is essential; an excess can disturb this harmony.

READ FULL ARTICLE BY CLICKING LINK BELOW: #Nutrition #Supplements #Health #Vitamins #Minerals #Wellness #Diet #HealthyLiving #PreventiveHealth #Potassium #Calcium #VitaminA #VitaminB3 #Niacin #VitaminD #VitaminE #Iron #OverdoseRisks #HealthcareProfessional #DietaryBalance

Does this mean that it is very important to keep a good level of #vitaminD and #vitaminB3 all life long ?
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