Anti-aging vitamin B3 derivatives help pancreatic cancer cells survive and resist chemotherapy – BioNews Central Popular anti-aging vitamin B3 derivatives—nicotinamide mononucleotide, nicotinamide riboside, and nicotinamide—may reduce the effectiveness of chemotherapy in pancreatic cancer patients. ...

Popular #AntiAging #VitaminB3 derivatives— #NicotinamideMononucleotide, #NicotinamideRiboside, and #nicotinamide —may reduce the effectiveness of #chemotherapy in #PancreaticCancer patients. 
#ChemotherapyResistance #AntiAgingSupplements

Cholesterol-lowering drug can overcome chemotherapy resistance in triple-negative breast cancer – BioNews Central Pitavastatin, a common cholesterol-lowering drug, counteracts chemotherapy resistance in triple-negative breast cancer cells by directly blocking the anti-apoptotic protein Mcl-1. ...

#Pitavastatin, a common #CholesterolLoweringDrug, counteracts #ChemotherapyResistance in #TripleNegativeBreastCancer cells by directly blocking the anti-apoptotic protein Mcl-1.
#Statins #BreastCancer #BreastCancerTreatment

NADK tetramer defective mutants affect lung cancer response to chemotherapy via controlling NADK activity

Insights into the mechanisms regulating NADK activity and identification of mutant NADK phenotypes that either enhance tumor progression and #ChemotherapyResistance or suppress tumor growth while increasing #chemotherapy sensitization. #medsky

#OpenAccess: www.sciencedirect.co...

NADK tetramer defective mutants affect lung cancer response to chemotherapy via controlling NADK activity

This study shows that the presence of an additional N-terminal domain in human NADK tetramer regulates the tetramer conformation critical for its activity, while NADK mutants confer #ChemotherapyResistance in #LungCancer.

#OpenAccess: https://buff.ly/4hidwdA