Anti-aging vitamin B3 derivatives help pancreatic cancer cells survive and resist chemotherapy – BioNews Central Popular anti-aging vitamin B3 derivatives—nicotinamide mononucleotide, nicotinamide riboside, and nicotinamide—may reduce the effectiveness of chemotherapy in pancreatic cancer patients. ...

Popular #AntiAging #VitaminB3 derivatives— #NicotinamideMononucleotide, #NicotinamideRiboside, and #nicotinamide —may reduce the effectiveness of #chemotherapy in #PancreaticCancer patients. 
#ChemotherapyResistance #AntiAgingSupplements

JAMA Dermatology editorial: "Nicotinamide for Skin Cancer Chemoprevention" by Sarah T. Arron, MD, PhD. Published online September 17, 2025. Includes links to author affiliations and article information.

Editorial: #Nicotinamide shows significant promise as a chemopreventive agent to reduce skin cancer risk in those with a history of the disease, advocating for its integration into routine secondary prevention alongside sun protection.

ja.ma/4rqHguA

Graph comparing skin cancer-free survival rates of patients exposed to Nicotinamide vs. unexposed. The Y axis shows "overall skin cancer-free survival" from 0 to 1.0, and the X axis represents "time, y" from 0 to 10.0. Log-rank P < .001.

The use of #nicotinamide is associated with a reduced risk of developing skin #cancer, particularly when initiated after the first skin cancer. ja.ma/48cXn5V

#Nicotinamide #N-methyltransferase inhibition is shown to improve limb function in experimental #peripheral #artery disease in male mice.
doi.org/10.14814/phy...
#Ischemia #SkeletalMuscle

Nicotinamide supplementation is associated with reduced skin cancer #science #nicotinamide #health

More details at klaustownsend.com/september-re...

Vitamin B3 supplement may reduce your risk of skin cancer | The-14 A new study shows that nicotinamide, a form of vitamin B3, may significantly reduce the risk of skin cancer, offering a simple, low-cost option for prevention.

Vitamin B3 supplement may reduce your risk of skin cancer
#Health #VitaminB3 #SkinCancer #HealthNews #Vitamin #CancerPrevention #Nicotinamide #Dermatology #Wellness #VitaminSupplements #HealthResearch #MedicalNews #CancerAwareness
the-14.com/vitamin-b3-s...

Nicotinamide May Cut Skin Cancer Recurrence Risk Up to 54%

A study of 33,000 U.S. veterans found that 500 mg nicotinamide twice daily cut skin‑cancer recurrence risk by up to 54% (overall 14% reduction). Read more: getnews.me/nicotinamide-may-cut-ski... #nicotinamide #skincancer #veterans

Nicotinamide, Vitamin B3, Pills Prevent Skin Cancer. Taking the pill form of Vitamin B3, nicotinamide, can cut a risk of skin cancer by more than half. #skincancer #nicotinamide #squamouscell #basalcell

A Nutritional Hedge Against Skin Cancer's Return A form of vitamin B3, nicotinamide, seems to reduce risk of recurrence of basal cell carcinoma and other skin cancers by over 50 percent.

A Nutritional Hedge Against Skin Cancer's Return
A form of vitamin B3, nicotinamide, can reduce risk of recurrence of basal cell carcinoma and other skin cancers by over 50%. bit.ly/46NFycW @vanderbilt.edu #B3 #Nicotinamide #skincancer @jamadermatology.com #Niacinamide @skincancerorg.bsky.social

Nicotinamide for Skin Cancer Chemoprevention This cohort study examines the clinical efficacy of nicotinamide supplementation for skin cancer prevention in the general population and among solid organ transplant recipients.

En pacientes tratados con nicotinamida hay un menor riesgo de cáncer de piel, siendo mayor el efecto cuando se inicia luego de la primera neoplasia de piel #skincancer #nicotinamide jamanetwork.com/journals/jam...

Daily vitamin B3 dose cuts skin cancer risk by up to 54% A common, over-the-counter form of vitamin B3 has emerged as an inexpensive ally in protecting us from skin cancer, lowering the risk by an average of 14% and increasing to a massive 54% for anyone wh...

⚠️Correction
#nicotinamide #vitamin B3
I just found this article. It's a bit more detailed.
That's why I'll start taking vitamin B3 soon. (Next week [one week after the skin graft], I'll have the stitches removed.)
newatlas.com/cancer/vitamin-b3-skin-c...

Daily vitamin B3 dose cuts skin cancer risk by up to 54% A common, over-the-counter form of vitamin B3 has emerged as an inexpensive ally in protecting us from skin cancer, lowering the risk by an average of 14% and increasing to a massive 54% for anyone wh...

I just found this article. It's a bit more detailed.
That's why I'll start taking vitamin B3 soon. (Next week [one week after the skin graft], I'll have the stitches removed.)
#nicotinamide
newatlas.com/cancer/vitamin-b3-skin-c...

Nicotinamide for Skin Cancer Chemoprevention This cohort study examines the clinical efficacy of nicotinamide supplementation for skin cancer prevention in the general population and among solid organ transplant recipients.

#Nicotinamide
I read an old study on #vitamin B3 and skin #cancer because I stumbled across the new veterans study in an article.

Is there a scientist here who can evaluate these studies?
What do you think of these papers?
/2
jamanetwork.com/journals/jamadermatology...

Vitamin B3 (Nicotinamide) Linked to Lower Risk of New Skin Cancers

Analyzing over 33,000 U.S. veterans, researchers found that 500 mg nicotinamide twice daily cut new skin‑cancer risk by 14%, and by 54% when started after a first cancer. getnews.me/vitamin-b3-nicotinamide-... #nicotinamide #skincancer

Study reveals early nicotinamide use reduces risk of aggressive skin cancers A large U.S. Department of Veterans Affairs cohort study found that Nicotinamide use was associated with a 14% lower risk of new keratinocyte skin cancers, driven by a 22% reduction in cSCC and no red...

Starting nicotinamide early after a first skin cancer could sharply cut future cancer risk, according to a real-world VA study of over 33,000 patients. 🧴🩺📊 www.news-medical.net/news/2025091... #SkinCancer #Nicotinamide @jamadermatology.com

Vitamin B3 can help protect against skin cancer. Here's who may benefit A new study shows B3 supplements helped reduce the risk of non-melanoma skin cancer recurrences.

The biggest reduction was seen among people who began taking the supplement after being diagnosed with their first #SkinCancer. #VitaminB3 #nicotinamide

Natural Compound Combo Restores Aging Brain Cells **Summary:** Scientists have identified a natural compound combination that reverses aging-related brain cell decline and removes harmful Alzheimer’s-linked proteins. The treatment, combining nicotinamide (vitamin B3) and the green tea antioxidant epigallocatechin gallate, restores guanosine triphosphate (GTP) levels—critical for neuronal energy and protein cleanup. In aged neurons, the restored energy boosted protein clearance, reduced oxidative stress, and reactivated key cell trafficking pathways. The findings suggest a potential non-drug strategy for combating Alzheimer’s, though more work is needed to optimize delivery. **Key Facts** * **Energy Restoration:** Nicotinamide and green tea antioxidant revived GTP levels in aged neurons to youthful levels. * **Protein Clearance Boost:** Treatment improved the brain’s ability to remove toxic amyloid beta aggregates. * **Non-Pharmaceutical Potential:** Findings point to a supplement-based approach for Alzheimer’s prevention or therapy. **Source:** UC Irvine **Researchers at the University of California, Irvine have identified a promising nonpharmaceutical treatment that rejuvenates aging brain cells and clears away the buildup of harmful proteins associated with Alzheimer’s disease.** In a paper published recently in the journal _GeroScience_ , the UC Irvine team reports that a combination of naturally occurring compounds – nicotinamide (a form of vitamin B3) and epigallocatechin gallate (a green tea antioxidant) – can reinstate levels of guanosine triphosphate, an essential energy molecule in brain cells. “We found that restoring energy levels helps neurons regain this critical cleanup function.” Credit: Neuroscience News In tests on neurons in a dish, the treatment reversed age-related cellular deficits and improved the brain cells’ ability to clear damaging amyloid protein aggregates, an Alzheimer’s hallmark. “As people age, their brains show a decline in neuronal energy levels, which limits the ability to remove unwanted proteins and damaged components,” said lead author Gregory Brewer, adjunct professor of biomedical engineering at UC Irvine. “We found that restoring energy levels helps neurons regain this critical cleanup function.” The researchers used a genetically encoded fluorescent sensor called GEVAL to track live guanosine triphosphate levels in neurons from aged Alzheimer’s model mice. They discovered that free GTP levels declined with age – particularly in mitochondria, the cells’ energy hubs – leading to impaired autophagy, the process by which cells eliminate damaged components. But when aged neurons were treated for just 24 hours with nicotinamide and epigallocatechin gallate, GTP levels were restored to those typically seen in younger cells. This revival triggered a cascade of benefits: improved energy metabolism; activation of key GTPases involved in cellular trafficking, Rab7 and Arl8b; and efficient clearance of amyloid beta aggregates. Oxidative stress, another contributor to neurodegeneration, was also reduced. “This study highlights GTP as a previously underappreciated energy source driving vital brain functions,” Brewer said. “By supplementing the brain’s energy systems with compounds that are already available as dietary supplements, we may have a new path toward treating age-related cognitive decline and Alzheimer’s disease.” He cautioned, “More work is going to be required to find the best way to administer this treatment, since a recent clinical trial involving UC Irvine researchers showed that oral nicotinamide was not very effective because of inactivation in the bloodstream.” Brewer’s collaborators were Ricardo Santana, a UC Irvine associate specialist in biomedical engineering, and Joshua McWhirt, a UC Irvine junior specialist who’s now a Ph.D. candidate at the Medical University of South Carolina. **Funding:** Funding was provided by the National Institutes of Health and the UC Irvine Foundation. ## About this supplements and brain aging research news **Author:**Brian Bell **Source:**UC Irvine **Contact:** Brian Bell – UC Irvine **Image:** The image is credited to Neuroscience News **Original Research:** Open access. “Treatment of age-related decreases in GTP levels restores endocytosis and autophagy” by Gregory Brewer et al. _GeroScience_ * * * **Abstract** **Treatment of age-related decreases in GTP levels restores endocytosis and autophagy** Age-related declines in neuronal bioenergetic levels may limit vesicular trafficking and autophagic clearance of damaged organelles and proteins. Age-related ATP depletion would impact cognition dependent on ionic homeostasis, but limits on proteostasis powered by GTP are less clear. We used neurons isolated from aged 3xTg-AD Alzheimer’s model mice and a novel genetically encoded fluorescent GTP sensor (GEVAL) to evaluate live GTP levels in situ. We report an age-dependent reduction in ratiometric measurements of free/bound GTP levels in living hippocampal neurons. Free GTP colocalized in the mitochondria decreased with age accompanied by the accumulation of free GTP-labeled vesicular structures. The energy dependence of autophagy was demonstrated by depletion of GTP with rapamycin stimulation, while bafilomycin inhibition of autophagy raised GTP levels. Twenty-four-hour supplementation of aged neurons with the NAD precursor nicotinamide and the Nrf2 redox modulator EGCG restored GTP levels to youthful levels and mobilized endocytosis and lysosomal consumption for autophagy via the respective GTPases Rab7 and Arl8b. This vesicular mobilization promoted the clearance of intraneuronal Aβ aggregates, improved viability, and lowered protein oxidative nitration in AD model neurons. Our results reveal age- and AD-related neuronal GTP energy deficits that impair autophagy and endocytosis. GTP deficits were remediated by an external NAD precursor together with a Nrf2 redox modulator which suggests a translational path. Join our Newsletter Thank you for subscribing. Something went wrong. I agree to have my personal information transferred to AWeber for Neuroscience Newsletter ( more information ) Sign up to receive our recent neuroscience headlines and summaries sent to your email once a day, totally free. We hate spam and only use your email to contact you about newsletters. You can cancel your subscription any time.

neurosciencenews.com/natural-compound-brain-a...
#neuroscience #news #alzheimers #nicotinamide #VitaminB3
#EpigallocatechinGallate #antioxidant #GreenTea

Natural Compound Combo Restores Aging Brain Cells - Neuroscience News Scientists have identified a natural compound combination that reverses aging-related brain cell decline and removes harmful Alzheimer’s-linked proteins.

neurosciencenews.com/natural-comp...
#neuroscience #news #alzheimers #nicotinamide #VitaminB3
#EpigallocatechinGallate #antioxidant #GreenTea

Nicotinamide This is a brief extract from a professional article talking about Nicotinamide, which is an effective skincare ingredient

Have you heard about Nicotinamide? 🌱 It's an incredible ingredient that can elevate your skincare! Read more about its benefits for your skin here: wix.to/5Lw5j3G #Skincare #Nicotinamide

NEW #clinicaltrial finds faster recovery from #COVID19 through targeted use of high-dose #VitaminB3 #nicotinamide in the gut. No relevant safety signals are observed. www.nature.com/articles/s42...

Risk of Major Adverse Cardiovascular Events Following Nicotinamide Exposure This cohort study evaluates whether nicotinamide use resulted in an increase of major cardiovascular events.

Exposición a nicotinamida no aumenta el riesgo de eventos CV adversos mayores #nicotinamide #MACE jamanetwork.com/journals/jam...

Nicotinamide This is a brief extract from a professional article talking about Nicotinamide, which is an effective skincare ingredient

Discover the power of Nicotinamide in skincare! This incredible ingredient helps brighten and hydrate your skin. Want to know more? Check out the full article here: wix.to/CaZEhPx #SkincareTips #Nicotinamide #Beauty

Nicotinamide This is a brief extract from a professional article talking about Nicotinamide, which is an effective skincare ingredient

Nicotinamide: An effective skincare ingredient that can do wonders for your skin! Don't miss out on the benefits it offers. Read more about it in this article! wix.to/W8Ey12j #skincare #Nicotinamide #SkinPerfection #Beauty

Nicotinamide This is a brief extract from a professional article talking about Nicotinamide, which is an effective skincare ingredient

Unlock the secret to flawless skin with Nicotinamide! This amazing ingredient can work wonders for your skincare routine. Check out this latest article for tips! #Nicotinamide #SkincareSecrets #GlowingSkin
www.skinperfection.co.uk/post/nicotin...

Nicotinamide trial for Alzheimer’s disease shows no clear benefit in reducing tau proteins A high dose of nicotinamide, tested as a treatment for early-stage Alzheimer’s, showed no significant impact on reducing harmful tau proteins in the brain.

A high dose of nicotinamide, tested as a treatment for early-stage Alzheimer’s, showed no significant impact on reducing harmful tau proteins in the brain. #Alzheimers #Nicotinamide #TauProteins #HealthResearch #Neurology

Saving a Life by Recognizing the Rash: Niacin (Vitamin B3) Deficiency in Hartnup Disease With a Clinical Debut in Adulthood | Annals of Internal Medicine: Clinical Cases Tryptophan deficiency can lead to a critical shortness of niacin (vitamin B3), causing photosensitive dermatitis and a range of neurologic symptoms. The most common cause is severe protein malnutritio...

Have always taught about Hartnup Disease in courses but nice to have a solid case study presentation w skin & neurological manifestations & clinical responsiveness to #nicotinamide supplementation @annalsofim.bsky.social
#metabolism

www.acpjournals.org/doi/10.7326/...

Muscle stem cells in regeneration and aging

#Medsky🧪#publichealth #Musclebiology Could #Nicotinamide and #pyridoxine stimulate muscle #stemcell expansion and enhance regenerative capacity during aging ?
@jci-insight.bsky.social

www.jci.org/articles/vie...

www.jci.org/articles/vie...