A novel catalytic radiopharmaceutical nanoplatform remodels tumor metabolism and induces systemic immune memory, thereby establishing a new research paradigm for overcoming the bottlenecks of solid tumor therapy.
#tumormetabolism #ferroptosis

Congrats to co-authors Jenny Jin, Jiachen Hu, Mingyue Li, Wei Gu, and Xuejun Jiang on publication of our new review on #ferroptosis as an approach to leverage #cancer #metabolism in Trends in Cell Biology! It is freely available: authors.elsevier.com/sd/article/S...

Inhibin beta A drives colorectal cancer progression through macrophage M2 polarization and mitochondria-dependent ferroptosis suppression.
Tumor–immune crosstalk meets cell death control.
doi.org/10.1038/s413...
#ColorectalCancer #TumorImmunology #MacrophagePolarization #Ferroptosis #Mitochondria

Riboflavin metabolism shapes FSP1-driven ferroptosis resistance - Nature Cell Biology After performing a focused CRISPR–Cas9 screen, Skafar et al. identify riboflavin (vitamin B2) as a regulator of FSP1 stability that modulates phospholipid peroxidation and ferroptosis sensitivity in c...

☕After performing a focused CRISPR–Cas9 screen, Skafar et al. identify riboflavin (vitamin B2) as a regulator of FSP1 stability that modulates phospholipid peroxidation and #ferroptosis sensitivity in #cancer cells.
bit.ly/4t91gm1

#EchinocysticAcid inhibits #BladderCancer by inducing #ferroptosis and suppressing proliferation, invasion, and migration via AKT1/GSK3β/β‑catenin inhibition, synergizing with #gemcitabine as a safe therapeutic option.

#OpenAccess: doi.org/10.1016/j.ge...

ZNF750 functions as a #TumorSuppressor in #ESCC by regulating #PUFA metabolism via FADS1, and its loss drives lipid remodeling, malignant progression, and #ferroptosis sensitivity through ACSL4, spotlighting PUFA metabolism and ferroptosis as targets.

Read: doi.org/10.1016/j.ge...

honored to deliver the William E.M. Lands Lecture. Dr. Lands’ pioneering work on the Lands cycle and PL remodeling continues to shape how we think about lipid biology, #ferroptosis and its roles in health and disease.
Thank you U of Michigan for the warm welcome and good luck in the Final Four!!

New preprint from the lab! Close collaboration with Silvia von Karstedt @vonkarstedtlab.bsky.social and her lab. We find that #SCLC cells are strikingly dependent on exogenous cysteine #LungCancer #CancerMetabolism #Ferroptosis 🧵
biorxiv.org/content/10.64898/2026.03.27.714827v1

Ferroptosis by nanomaterials targeting cancer stem cells
www.scienceopen.com/hosted-docum...
#Ferroptosis #Nanomaterials #CancerStemCells #TargetedTherapy #CancerResearch

Marcus Conrad Receives German Cancer Award 2026

Prof. Marcus Conrad, #HelmholtzMunich & TU München, receives the German Cancer Award 2026 for pioneering #ferroptosis research opening new avenues in cancer therapy. 👏

👉 t1p.de/rpctg

@krebsgesellschaft.bsky.social @tum.de
#CellDeath #CancerResearch #Ferroptosis

Peritumoural adipose tissue promotes ferroptosis resistance by 3-hydroxykynurenine-mediated suppression of ferritinophagy - Nature Cell Biology Zhang, Han, Tan, Lu, Ma et al. report that kynurenine derived from peritumoural adipose tissue is hijacked by cancer cells to mediate ferroptosis resistance, a process that could potentially be target...

☕Zhang, Han, Tan, Lu, Ma et al. report that kynurenine derived from peritumoral #adipose tissue is hijacked by #cancer cells to mediate #ferroptosis resistance, a process that could potentially be targeted with immunotherapy to inhibit tumor growth.
bit.ly/4uWc73X

Researchers developed P8D NPs as a chemo-photothermal synergistic platform to ignite systemic #AntitumorImmunity via #Ferroptosis, providing a potent approach to enhance therapeutic efficacy against "cold" tumors.

#STTT #OpenAccess: doi.org/10.1038/s413...

In this study, researchers developed a conductive coordination #Nanozyme prodrug that triggers synergistic #Pyroptosis, #Cuproptosis, and #Ferroptosis to elicit potent in situ #CancerVaccination and systemic #AntitumorImmunity.

#STTT #OpenAccess: doi.org/10.1038/s413...

Frontiers | A feedback loop between cell proliferation and ROS regulates ferroptosis sensitivity BackgroundFerroptosis is a form of regulated cell death characterized by iron-dependent lipid peroxidation and membrane rupture. While cellular populations r...

Ever wondered how cellular #metabolism, #ROS, cellular confluence and #Ferroptosis are connected? Read our new study with theoretical physicist Johannes Berg @unicologne.bsky.social @cecad.bsky.social @uniklinikkoeln.bsky.social @dtg-cologne.bsky.social
www.frontiersin.org/journals/cel...

🍔➡️🧬 High-fat, high-sugar diets can wreak havoc on the #liver—but NEDD4L overexpression flips the switch, reducing #ferroptosis and preventing MAFLD-related liver #damage. Targeting this pathway could inspire new therapies! #MetabolicHealth
https://ow.ly/Q6VS50Yh223

👋Our March issue is out!
Cover: #Adipose – #tumor in #immune escape

👉Reviews on: #metabolism #hematopoiesis ; #amnion ; #brain #lipids
🔬 #mitochondria #LipidDroplets #aging #autophagy #mechanobiology #neurodegeneration #ferroptosis #chromatin #metastasis & more!
www.nature.com/ncb/volumes/...

Great to see a complementary screen from the @fda.gov identify #ferroptosis inhibition as critical for expanding human 🩸 #stemcells in @moltherapy.bsky.social: www.cell.com/molecular-th...
Nicely supports our prior findings: www.nature.com/articles/s41...

Porphyromonas gingivalis Induces Chronic Kidney Disease through Crosstalk between the NF-κB/NLRP3 Pathway and Ferroptosis in GMCs

This study shows that P. gingivalis induces #CKD in mice via #NFκB/#NLRP3 crosstalk & #Ferroptosis in #Mesangial cells, highlighting the contribution of #Periodontitis to CKD pathogenesis, underscoring the importance of #PeriodontalTherapy. #medsky

To read: doi.org/10.1007/s115...

A bioactive ginsenoside alleviates hepatocellular ferroptosis induced by oxidized phospholipid accumulation in nonalcoholic steatohepatitis Schematic representation showing that 20 (S)-Rg3 improves mouse NASH. 20(S)-Rg3 reduces OxPLs levels and ameliorates ferroptosis in the liver of NASH mice. Mechanistically, 20(S)-Rg3 activates SPOP. ...

👏 Targeting ferroptosis in NASH

🧐 A bioactive ginsenoside alleviates hepatocellular ferroptosis induced by oxidized phospholipid accumulation in nonalcoholic steatohepatitise.
#NASH #Ferroptosis #LiverDisease #Metabolism
onlinelibrary.wiley.com/doi/10.1002/...

Osteocytic Lipocalin-2 regulates bone formation locally through iron-dependent ferroptosis and Wnt suppression - Cell Death Discovery Cell Death Discovery - Osteocytic Lipocalin-2 regulates bone formation locally through iron-dependent ferroptosis and Wnt suppression

How does the #cytokine #Lipocalin-2 (#LCN2) link #bone and #EnergyHomeostasis? With help from Sable Promethion #Metabolic Cages, scientists revealed how LCN2 modulates bone remodeling by driving #ferroptosis & suppressing #Wnt signaling.

buff.ly/uMp5AmZ

#SLC22A17 #IndirectCalorimetry #Respirometry

New research from MSK investigates harnessing the power of #ferroptosis to spread cell death; reports how an MSK artificial intelligence (AI) model could help improve patient safety; and uses #AI to reveal country-specific drivers of global cancer outcomes. Learn more: https://bit.ly/47hDB9N

Happy to share our new paper in @febsj.bsky.social! With
@ondrej-kuda.bsky.social & @fedorovalab.bsky.social we show how #LipidDroplets reshape the lipidome of PUFA-exposed cells, but can also shift function within the same cell, revealing a context-dependent role in #ferroptosis. shorturl.at/TyRl1

RNA‐Binding Proteins and Ferroptosis in Cancer: Mechanism and Therapeutic Implications Ferroptosis critically influences cancer cell fate and represents a promising therapeutic strategy. Emerging evidence identifies RNA-binding proteins (RBPs) as key post-transcriptional regulators of ...

#Review in #MedComm_Oncology
#RNA-Binding Proteins (#RBP) and #Ferroptosis in #Cancer: Mechanism and Therapeutic Implications doi.org/10.1002/mog2...

#ClinicalPotential #SmallMolecule

Dual SHP2/MEK inhibition in #PDAC triggers mitochondrial remodeling and #LipidPeroxidase dependency, creating a #ferroptosis vulnerability; combining #GPX4 blockade or withaferin A enhances #tumor suppression across PDAC subtypes.

#STTT: doi.org/10.1038/s413...

Inhibin beta A drives colorectal cancer progression through macrophage M2 polarization and mitochondria-dependent ferroptosis suppression.
Tumor–immune crosstalk meets cell death control.
doi.org/10.1038/s413...
#ColorectalCancer #TumorImmunology #Ferroptosis #TumorMicroenvironment

#CLL cells accumulate lipid peroxides & iron, predisposing them to #ferroptosis; #BTK inhibition raises #TFRC and sensitizes cells, while combining #ibrutinib with #GPX4 blockade enhances efficacy, with TFRC and #ACSL1 emerging as targets.

#OpenAccess #STTT: doi.org/10.1038/s413...

Researchers map the interplay of #ProgrammedCellDeath after #IschemicStroke, showing early #ferroptosis and #necroptosis followed by #apoptosis, with iron driving both—highlighting the potential of concurrently targeting multiple death mechanisms.

Read: doi.org/10.1016/j.ge...

Upregulated STIM1 enhances SOCE in #sorafenib-resistant #HCC, activating CaN-NFAT to drive #SLC7A11 transcription, boost GSH, and suppress #ferroptosis; blocking this axis with SKF96365 restores sorafenib sensitivity.

#OpenAccess: doi.org/10.1016/j.ge...

🚨 New Issue Alert! 🚨

We're delighted to share that the fourth issue of The FEBS Journal is now online.

Discover our latest Issue, here ➡️ buff.ly/5wZasfQ

#macrophage #ferroptosis #machinelearning #herpesvirus #platelet

Pleased to share this review by our talented trainee, Geena! Check it out for the latest on #ferroptosis as a treatment target following #stroke 🧠