Multifacet Roles of Cellular Senescence in Cancer: Mechanisms and Therapeutic Implications Cellular senescence shapes tumor progression through both antitumor and protumor mechanisms. Senescence triggered by telomere shortening restricts malignant transformation and limits tumor cell proli...

#Review in #MedComm_Oncology
Multifacet Roles of Cellular #Senescence in #Cancer: Mechanisms and #Therapeutic Implications doi.org/10.1002/mog2...

#SASP #ImmuneActivation

The Role of One‐Carbon Metabolism in Cancer and Its Therapeutic Significance One-Carbon metabolism in T-cell activation and tumor competition. T-cell activation shifts metabolic pathways, promoting anabolic metabolism and bioenergetic capacity. One-carbon metabolism plays a c...

#MedComm_Oncology
The Role of #One_Carbon #Metabolism in Cancer and Its Therapeutic Significance doi.org/10.1002/mog2...
Authors from Sichuan University

The #review highlights strategies to exploit specific #metabolic fragilities and proposes considerations for #biomarker-guided cancer #therapy.

Construction of a Prediction Model for Thyroid Nodules Based on Machine Learning Click on the article title to read more.

#Letter in #MedComm_Oncology

Construction of a #Prediction Model for #Thyroid #Nodules Based on #MachineLearning doi.org/10.1002/mog2...

#PapillaryThyroidCarcinoma #PTC #ArtificialIntelligence #AI

#Review in #MedComm_Oncology
Molecular Glue Degraders (#MGD) Redefining #Targeted #Therapies From Discovery to Therapeutic Applications doi.org/10.1002/mog2...

#cereblon #E3UbiquitinLigase #Undruggable #reprogramming #DrugDiscovery

RNA‐Binding Proteins and Ferroptosis in Cancer: Mechanism and Therapeutic Implications Ferroptosis critically influences cancer cell fate and represents a promising therapeutic strategy. Emerging evidence identifies RNA-binding proteins (RBPs) as key post-transcriptional regulators of ...

#Review in #MedComm_Oncology
#RNA-Binding Proteins (#RBP) and #Ferroptosis in #Cancer: Mechanism and Therapeutic Implications doi.org/10.1002/mog2...

#ClinicalPotential #SmallMolecule

SIRT7 Orchestrates Ligand‐Dependent ERα Signaling Rewiring to Drive Tamoxifen Resistance in ERα‐positive Breast Cancer In tamoxifen-sensitive breast cancer, SIRT7 deacetylates ERα at lysines 302 and 303, promoting CHIP-mediated, ubiquitin-dependent proteasomal degradation of ERα and thereby restraining estrogen-drive...

#Article in #MedComm_Oncology

Researchers from HunanUniversity find that #SIRT7 Orchestrates Ligand-Dependent ERα Signaling Rewiring to Drive #Tamoxifen Resistance in #ERα-positive #BreastCancer doi.org/10.1002/mog2...

#Deacetylation #DrugResistance

The Acetyl‐CoA‐NLRX1 Axis Acts as a Key Player in Mitophagy and Drug Resistance Click on the article title to read more.

#Highlight in #MedComm_Oncology
The #Acetyl-CoA-#NLRX1 Axis Acts as a Key Player in #Mitophagy and Drug #Resistance doi.org/10.1002/mog2...

The highlighted article in @nature.com ：https://doi.org/10.1038/s41586-025-09745-x

#Highlight in #MedComm_Oncology
#Metabolic Reprogramming of the Pre-Metastatic Niche: A Sweet Spot for Anti-#Tumor #Immunity doi.org/10.1002/mog2...

The highlighted article in @CellCellPress : doi.org/10.1016/j.ce...

#LowCarbohydrateDiet #Lung #Metastasis #macrophage #NKcell

Aging‐Derived Alterations in Genomic, Immune, and Metabolic Networks: Implications for Cancer Development and Therapy Ageing acts as a double-edged sword in cancer. In the elderly, open chromatin, immunosenescence, and chronic inflammation drive SASP (IL-6, MMPs), MDSC accumulation and T-cell suppression, fostering ....

#Review in #MedComm_Oncology
#Aging-Derived Alterations in #Genomic, #Immune, and #Metabolic Networks: Implications for Cancer Development and Therapy doi.org/10.1002/mog2...

#cancer #therapy #immunometabolism #TME

Local Anesthetics in Cancer: Mechanisms and Translational Perspectives Local anesthetics demonstrate multifaceted antitumor effects that collectively contribute to cancer suppression. Beyond canonical sodium channel blockade, these agents exert the following pharmacolog....

#Review in #MedComm_Oncology
Local #Anesthetics in #Cancer: Mechanisms and Translational Perspectives doi.org/10.1002/mog2...

#CancerBiology #ClinicalTranslation #Perioperative #management #TumorMicroenvironment #TME

#Review in #MedComm_Oncology
Targeting Tumor #Dormancy and #Recurrence: Molecular Mechanisms and #Peptide Therapeutic Delivery doi.org/10.1002/mog2...

#MolecularMechanism #Therapeutic #Delivery

Crosstalk Between Cancer‐Associated Fibroblasts and Immune Cells: Mechanisms and Therapeutic Implications Cancer-associated fibroblasts (CAFs) are widely engaged in tumor progression in the tumor microenvironment. CAFs interact actively with immunocytes including tumor-associated macrophages, T cells, ne....

#Review in #MedComm_Oncology
Crosstalk Between Cancer-Associated Fibroblasts and Immune Cells: Mechanisms and Therapeutic Implications doi.org/10.1002/mog2..., authored by a group from #SichuanUniversity

#CAFs #communication #immunocyte #therapy #TumorMicroenvironment #TME

Decreased M6A Modification Promotes Progression of Gastrointestinal Stromal Tumor and KIT‐Derived Imatinib Resistance Through FTO‐Regulated Axis The study identifies decreased m6A levels, FTO and lncRNA XIST as critical oncogenic molecules in gastrointestinal stromal tumor (GIST) progression and imatinib resistance, both in vitro and in vivo....

#Article in #MedComm_Oncology
Decreased M6A Modification Promotes Progression of Gastrointestinal Stromal Tumor and KIT-Derived #Imatinib Resistance Through FTO-Regulated Axis doi.org/10.1002/mog2...

#GIST #XIST #KIT #DrugResistance #N6_methyladenosine #FTO #lncRNA

#Article in #MedComm_Oncology

LncRNA SNHG5/miR-363-3p/USP28 Axis Promotes Lung Adenocarcinoma Progression Through Enhancing β-Catenin Stabilization doi.org/10.1002/mog2...

#lncRNA #LUAD #miR_363_3p #SNHG5 #USP28 #β_catenin #SingalingPathway

#Review in #MedComm_Oncology
Targeting Metabolic Reprogramming in Tumor: From Mechanisms to Precision Immunotherapies doi.org/10.1002/mog2...

#ImmuneResponse #immunotherapy #MetabolicReprogramming #TME

#Article in #MedComm_Oncology

Parkinson's Disease and Cancer: Mechanistic Insights and Therapeutic Opportunities From Cancer Neuroscience doi.org/10.1002/mog2...

#cancer #CancerNeuroscience #gliomas #NeurodegenerativeDisease #PD #Therapeutic #Neuroscience