SIRT7 Orchestrates Ligand‐Dependent ERα Signaling Rewiring to Drive Tamoxifen Resistance in ERα‐positive Breast Cancer In tamoxifen-sensitive breast cancer, SIRT7 deacetylates ERα at lysines 302 and 303, promoting CHIP-mediated, ubiquitin-dependent proteasomal degradation of ERα and thereby restraining estrogen-drive...

#Article in #MedComm_Oncology

Researchers from HunanUniversity find that #SIRT7 Orchestrates Ligand-Dependent ERα Signaling Rewiring to Drive #Tamoxifen Resistance in #ERα-positive #BreastCancer doi.org/10.1002/mog2...

#Deacetylation #DrugResistance

A #research team of #UniMainz and @unifr identified mechanisms to restore #myelin sheaths after injury or in #MultipleSclerosis www.uni-mainz.de/presse/aktuell/11912_ENG... #neurobiology #neurons #deacetylation #CentralNervousSystem #PeripheralNervousSystem...