This study finds #Progranulin as a key mediator of estrogen in #BoneMetabolism, showing that its loss after menopause promotes #Osteoporosis by increasing #ERα #Ubiquitination & decreasing expression, opening avenues for novel therapies. #medsky

#OpenAccess: www.sciencedirect.com/science/arti...

#ERα #breastcancer #sustainability

The combined effects of
multigenerational exposure to
mixtures of endocrine-disrupting chemicals, such as
bisphenol A/F/S, benzophenone-1,
BDE-47, DEHP, PAHs, PCBs, PFAS,
pesticides, polystyrene microplastics,
and toxic metals (cadmium),
need to be investigated.

Drug Interaction Report: cimetidine, cyproheptadine, metformin, spironolactone View detailed report of drug-drug and drug-food interactions for cimetidine, cyproheptadine, metformin, spironolactone

One of the things nirmatrelvir in Paxlovid does is interfere with #ERα reducing immune suppression by Tregs.

Cimetidine is an H2 antagonist.

Cyproheptadine is an H1 antagonist (antihistamine).

eg. cimetidine + cyproheptadine + metformin + spironolactone

www.drugs.com/interactions...

Medical Treatment Can Unintentionally Alter the Regulatory T-Cell Compartment in Patients with Widespread Pathophysiologic Conditions Regulatory T cells (Tregs) are non-redundant mediators of immune tolerance that are critical to prevent autoimmune disease and promote an anti-inflamm…

www.sciencedirect.com/science/arti...

"Inhibition of estrogen receptor (ER) α with a specific antagonist impaired the tumor-infiltrating Tregs by blocking FOXP3 expression, thereby inhibiting their function." #ERα

Medical Treatment Can Unintentionally Alter the Regulatory T-Cell Compartment in Patients with Widespread Pathophysiologic Conditions Regulatory T cells (Tregs) are non-redundant mediators of immune tolerance that are critical to prevent autoimmune disease and promote an anti-inflamm…

Medical Treatment Can Unintentionally Alter the Regulatory T-Cell Compartment in Patients with Widespread Pathophysiologic Conditions #FOXP3 #ERα #EBV #CMV #VZV #HSV #MECFS #LongCovid

www.sciencedirect.com/science/arti...