PDK1 promotes #BreastCancer progression by stabilizing #HIF1α through #Ser451 phosphorylation, reducing its #ubiquitination, enhancing transcriptional activity, and forming a positive feedback loop that drives #TumorGrowth and metabolic reprogramming.
Read: doi.org/10.1016/j.ge...
Bruceine A stabilizes #NR4A1 by blocking K48-linked #ubiquitination to suppress NF-κB-driven #inflammation, establishing a protein-stabilization therapeutic paradigm that advances nuclear receptor targeting & opens avenues for #KidneyDrug development.
#STTT: doi.org/10.1038/s413...
This review outlines #ubiquitination as a key regulator of #cellularhomeostasis, its dysregulation in major diseases, and emerging therapeutic strategies including #PROTACs, molecular glues, and clinical advances targeting this pathway.
#OpenAccess in #STTT: doi.org/10.1038/s413...
Hot off the press!
New #metanalysis from Ikerbasque Research Professor Ugo_Mayor ‘s lab (Nerea Osinalde, Unai Alduntzin, @gorka-ehu.bsky.social) on protein abundance and #ubiquitination changes.
➡️ buff.ly/uDE9kzu
Progranulin deficiency contributes to postmenopausal osteoporosis by enhancing ubiquitination of estrogen receptor α.
#Progranulin #Osteoporosis #EstrogenReceptor #Ubiquitination #BoneHomeostasis #PostmenopausalHealth
doi.org/10.1016/j.ge...
A meta-analysis of published di-Gly #ubiquitomics vs general #proteomics doi.org/10.1002/2211... shows that protein levels do NOT inversely correlate with ubiquitination levels. So, please do not assume that a reduction in your POI abundance is caused by #ubiquitination, unless you have detected so.
⏰ New Issue alert: Our January Issue 2 is online!
🤿 Dive into Reviews, Commentary, Original articles
'📚 and Hidden Gem' articles published in The FEBS Journal in 2023 and 2024 that members of our Editorial Board deemed particularly notable.
➡️ buff.ly/VS6XZAx
#Ubiquitination #Researchhighlights
An overview of #Ubiquitination and its role in the cardiovascular system, highlighting the links between specific #E3Ligases, DUBs, and #Ubiquitin-like modifiers with #CardiovascularDiseases, opportunities and challenges.
#OpenAccess: doi.org/10.1016/j.ge...
Congratulations to João Mello-Vieira on his important contribution to @natrevimmunol.nature.com, providing an in-depth analysis of how #ubiquitination and #autophagy coordinate host-pathogen interactions, spanning immune surveillance mechanisms to antimicrobial #immunity. 👏
This review examines how protein arginine #methyltransferases drive #cancer progression through crosstalk between #ArginineMethylation and #ubiquitination, shaping #DNADamage responses, protein stability, immune escape and signaling.
#OpenAccess: doi.org/10.1016/j.ge...
This review summarizes the #Ubiquitination & #Deubiquitination mechanisms, exploring their signaling crosstalk and multilayered regulatory functions in health & disease, while highlighting the clinical potential of their therapeutic targeting.
#OpenAccess: doi.org/10.1038/s413...
Exploring the role of #Ubiquitination & #Deubiquitination in regulating #TumorCells, #ImmuneCells, & non-immune cells within the #TumorMicroenvironment, while discussing the prospect of ubiquitin-related enzyme inhibitors for #CancerTherapy.
#OpenAccess: doi.org/10.1016/j.ge...
Induced ubiquitination bypasses canonical ERAD to drive ER protein degradation
Deol, K. K. et al.
Paper
Details
#ERAD #Ubiquitination #ProteinDegradation
Bruceine A confers renoprotection in mesangial proliferative #Glomerulonephritis by binding to the NR4A1 ligand-binding domain & blocking its #Ubiquitination, thereby stabilizing it to suppress NF-κB-driven #Inflammation.
#OpenAccess: doi.org/10.1038/s413...
#Research
Histone methyltransferase KMT2D targets the SPOP-G3BP1 axis to enhance AR stability and drive castration-resistant prostate cancer progression doi.org/10.1186/s435...
#AndrogenReceptor #CastrationResistant #Methylation #Signaling #Ubiquitination
🫣 Can you believe that we are at the last day of #AusUb2025?!?!
The second ‘Mechanisms in #Ubiquitination’ session had a focus on deubiquitinases #DUB.
Fine-Tuning Immunity: The Role of Ubiquitination in T cell Activation
Fine-Tuning #Immunity: The Role of #Ubiquitination in T cell Activation 🔬
A new study by researchers at #HelmholtzMunich reveals how two molecular players, LUBAC and TRAF6, work together to fine-tune immune signaling in #Tcells.
👉 t1p.de/ejpf7
New paper from Dr. @kuldeep-verma.bsky.social Lab @lid-cdfd.bsky.social at CDFD, in BMC Biology on a new paradigm in Rab biology.
@navyaka.bsky.social
Read for more: bmcbiol.biomedcentral.com/articles/10....
#RabGTPase #Selfassociation #Multivesicularbodies #Ubiquitination #Entamoebahistolytica
New paper published in iScience journal from the lab of Dr. Subbareddy Maddika on protein interaction mapping of LisH domain proteins.
Read the paper: cell.com/iscience/ful...
#proteomics #LisH #ARIH2 #ubiquitination #regulatoryaxis
@devanshigupta.bsky.social
This review examines the regulatory roles of #Ubiquitination and #Deubiquitination in the #TumorMicroenvironment and discusses the potential of targeting ubiquity-related #Enzymes for #CancerTherapy. #medsky
#OpenAccess: www.sciencedirect.com/science/arti...
Src inhibitors reverse MCL-1 accumulation induced by MCL-1 inhibitors in #AcuteMyeloidLeukemia (AML) cells, by promoting degradative #Ubiquitination, disrupting STAT-3-mediated transcription, and inducing NOXA-mediated MCL-1 degradation.
#STTT #OpenAccess: doi.org/10.1038/s413...
This study finds #Progranulin as a key mediator of estrogen in #BoneMetabolism, showing that its loss after menopause promotes #Osteoporosis by increasing #ERα #Ubiquitination & decreasing expression, opening avenues for novel therapies. #medsky
#OpenAccess: www.sciencedirect.com/science/arti...
#Highlight
Decoding LAG3 activation: ubiquitination liberates immunosuppressive motif to license checkpoint function doi.org/10.1186/s435...
The highlighted article in Cell @cellpress.bsky.social ：https://doi.org/10.1016/j.cell.2025.02.014
#LAG3 #TCRsignaling #ubiquitination #checkpoint
A research team reported their findings in Horticulture Research. The study identifies VviPUB19as a critical factor undermining grapevine resilience to cold stress.
#Ubiquitination system #Cold stress
Details: doi.org/10.1093/hr/u...
Stellar flash talk and poster presentation on #ubiquitination regulators in #KRAS inhibitor resistance by our own #CassieMarkham @faseborg.bsky.social Protein Phosphorylation! @yalecancer.bsky.social
Drs Zhongshou Wu & Shaojie Han highlight Xuan Wang & colleagues’ @theplantcell.bsky.social article on a #nematode #effector targeting #NRC4 pathway to hijack #plant #immunity. #Ubiquitination
authors.elsevier.com/a/1lRGZ5Eb1x...
📣 Online now - the Review "The ribosome ubiquitination code: fine-tuning translation under stress" from
Haleigh Wooters, Neil Nimmagadda, Alicia Darnell, and @thesilvalab.bsky.social .
#Ubiquitination #TranslationalReprogramming #StressResponse
Read it here: authors.elsevier.com/a/1lPPS3S6Gf...
Online now - the Spotlight "Modifying the modifiers: ubiquitination of ADP-ribosylation in human cells" from @kfeijszaja.bsky.social and colleagues.
#ADPribosylation #ubiquitination #MARUbylation #crosstalk
authors.elsevier.com/sd/article/S...
Just dropped on bioRxiv! Our team has assembled a data-driven map of the human E3 ligome. Check out our preprint! #E3_ligome #ubiquitination #dataIntegration #metriclearning www.biorxiv.org/content/10.1...
Key roles of ubiquitination in regulating critical regulators of cancer stem cell functionality
This review details the role of #ubiquitination molecules, E3 Ub ligases, #deubiquitinases, & transcription factors in regulating #CancerStemCells (CSC) and describe how the Ub-proteasome system modulates the signaling pathways governing CSC maintenance. #medsky
#OpenAccess:
