Front Psychol . 2021 Jul 1;12:687106. doi: 10.3389/fpsyg.2021.687106 Impact of Acute and Chronic Cannabis Use on Stress Response Regulation: Challenging the Belief That Cannabis Is an Effective Method for Coping Mustafa al'Absi 1,*, Alicia M Allen 2 PMCID: PMC8283823 PMID: 34276511 Abstract Although research has only recently started to examine the impact of cannabis use on stress response, there is some evidence that indicates acute and chronic impacts of cannabis on these processes. In this paper, we review processes involved in regulating the stress response and we review the influence of acute and chronic exposure to cannabis on patterns and regulation of the stress response. We also highlight the role of stress as a risk factor for initiation and maintenance of cannabis use. In this context, we examine moderating variables, including sex and life adversity. https://pmc.ncbi.nlm.nih.gov/articles/PMC8283823/

Although research has only recently started to examine the impact of #cannabis use on #stress response, there is some evidence that indicates acute and chronic impacts of cannabis on these processes. In this paper, we review processes involved in regulating […]

[Original post on mastodon.social]

Ageing promotes metastasis via activation of the integrated stress response - Nature Ageing reprograms the evolutionary trajectory of KRAS-driven lung adenocarcinoma, limiting primary tumour growth while promoting metastatic dissemination through epigenetic activation of the integrate...

This week #JournalClub @labsoap.bsky.social @nature.com #ageing #metastasis #stressresponse www.nature.com/articles/s41...

#FruitRes
Review highlights bZIP transcription factors as key regulators of plant stress, metabolism & development, offering insights for crop improvement.
Details: maxapress.com/article/doi/10.48130/fru...
#bZIP #StressResponse

Study finds stress-related nerves may fuel pancreatic cancer growth – BioNews Central New research has revealed that certain nerves involved in the body’s “fight or flight” stress response can support the growth of pancreatic cancer. ...

New research has revealed that certain #nerves involved in the body’s “fight or flight” #StressResponse can support the growth of #PancreaticCancer.
#SympatheticNerves #TumorGrowth #TumorMicroenvironment

Specific role of two NlpC/P60 endopeptidases in cell division and membrane vesicle formation in #Deinococcus radiodurans

www.sciencedirect.com/science/arti... #OpenAccess #stressresponse #MicroSky

🪱 We're delighted to share another interesting study focused on the characterization of GST-44 from our #Highlights2025 collection 👇

📕 Unraveling the functional dynamics of Caenorhabditis elegans stress-responsive omega class GST-44

Discover ➡️ buff.ly/Ts5w2LS

#Celegans #GST #stressresponse

⚡ We are delighted to share today’s #Highlights2025 article:

📕 In vivo modeling of lethal congenital contracture syndrome 1 suggests pathomechanisms in cellular stress responses

Discover the article, here ➡️ buff.ly/VFjwRCC

#embryonicdevelopment #neuralcrest #stressresponse #sympatheticneurons

Top: Subcellular localization of Cap1-GFP in wild-type background (top, tetO-CAP1-GFP/CAP1), Cap1-GFP with C446* (middle, TeO-CAP1C446*-GFP/CAP1) and wild-type Cap1-RFP (bottom, CAP1C446*/TeO-CAP1-RFP) in CAP1/CAP1C446* background. Scale bar, 5 μm. Bottom: Schematic of subcellular localization and transcription activation of CAP1 in wild-type (CAP1/CAP1, left) and CAP1/CAP1C446*. Figure generated with BioRender.

#Azole resistance in #Candida albicans poses a growing threat, and is linked to #StressResponse. @annaselmecki.bsky.social &co show that mutations in the oxidative stress TF Cap1 promote #DrugResistance while exposing a lethal vulnerability at high azole doses @plosbiology.org 🧪 plos.io/4rOrfOz

Top: Subcellular localization of Cap1-GFP in wild-type background (top, tetO-CAP1-GFP/CAP1), Cap1-GFP with C446* (middle, TeO-CAP1C446*-GFP/CAP1) and wild-type Cap1-RFP (bottom, CAP1C446*/TeO-CAP1-RFP) in CAP1/CAP1C446* background. Scale bar, 5 μm. Bottom: Schematic of subcellular localization and transcription activation of CAP1 in wild-type (CAP1/CAP1, left) and CAP1/CAP1C446*. Figure generated with BioRender.

#Azole resistance in #Candida albicans poses a growing threat, and is linked to #StressResponse. @annaselmecki.bsky.social &co show that mutations in the oxidative stress TF Cap1 promote #DrugResistance while exposing a lethal vulnerability at high azole doses @plosbiology.org 🧪 plos.io/4rOrfOz

Top: Subcellular localization of Cap1-GFP in wild-type background (top, tetO-CAP1-GFP/CAP1), Cap1-GFP with C446* (middle, TeO-CAP1C446*-GFP/CAP1) and wild-type Cap1-RFP (bottom, CAP1C446*/TeO-CAP1-RFP) in CAP1/CAP1C446* background. Scale bar, 5 μm. Bottom: Schematic of subcellular localization and transcription activation of CAP1 in wild-type (CAP1/CAP1, left) and CAP1/CAP1C446*. Figure generated with BioRender.

#Azole resistance in #Candida albicans poses a growing threat, and is linked to #StressResponse. @annaselmecki.bsky.social &co show that mutations in the oxidative stress TF Cap1 promote #DrugResistance while exposing a lethal vulnerability at high azole doses @plosbiology.org 🧪 plos.io/4rOrfOz

Stress does not appear to release stored THC into the bloodstream A new study found that the physical stress of cold water immersion did not release fat-stored THC back into the blood. This suggests that moderate stress is unlikely to cause unexpected intoxication or failed drug tests.

Stress does not appear to release stored THC into the bloodstream #Science #HealthandMedicine #MentalHealth #THCResearch #StressResponse

www.psypost.org/stress-does-not-appear-t...

Impact of #noise on the #behaviour and biochemical parameters of the #crayfish Cherax quadricarinatus and Cherax destructor - #OpenAccess zslpublications.onlinelibrary.wiley.com/doi/10.1111/... #crustaceans #stressresponse @uhl-lab.bsky.social @elissazcameron.bsky.social @wileyecology.bsky.social

Body Language 8/10
Expansive posture increases confidence and optimism.
Closed posture amplifies fear and insecurity. 🔄
#EmotionalRegulation #StressResponse #MentalState

#EPI
DNA methylation and histone modifications are conserved epigenetic markers regulating gene expression, stress responses, and development in plants and animals! 🧬🌱
Details: www.maxapress.com/article/doi/10.48130/epi...
#epigenetics #geneexpression #stressresponse

Supporting Spine Recovery

Understanding how stress affects spinal healing helps guide better recovery habits.

#SpineWellness #HealingTimeline #StressResponse

Stress Response Quiz> Are You a Fighter, Freezer, Planner, or Avoider? How Do You React When Pressure Hits?

medium.com/storyangles/...

Stress Response Quiz> Are You a Fighter, Freezer, Planner, or Avoider?
How Do You React When Pressure Hits?

#stressresponse @quiz #PersonalityQuiz #medium ##PersonalityTypes #personality #stress #pressure

Surprising truth: Your brain’s “alert mode” is chemically controlled! 🤯🧠🌙⚡😊
Orexin helps explain stress, fear, learning, and why sleep matters so much! @mdpiopenaccess.bsky.social #Neuroscience #BrainChemistry #StressResponse #SleepDisorders #Anxiety
Explore the science → doi.org/10.3390/biom...

Optimistic and pessimistic cognitive judgement bias modulates the stress response and cancer progression in zebrafish - Translational Psychiatry Translational Psychiatry - Optimistic and pessimistic cognitive judgement bias modulates the stress response and cancer progression in zebrafish

doi.org/10.1038/s413...
#SPEetologia
#SPEmembers

#CognitiveBias #StressResponse #Zebrafish #DiseaseResilience #BehavioralTrait #Neurogenomics

⚠️ Stress, sleep & vigilance share one hub! 🩺🧠⚡ Orexin signaling shapes anxiety, arousal & autonomic balance! @mdpiopenaccess.bsky.social #Neuroscience #PeptidergicSignaling #StressResponse #Anxiety #SleepDisorders
👉 Explore clinical implications
doi.org/10.3390/biom...

Your Brain Releases a Chemical Surge When Plans Fall Apart All the science news you can handle in a single feed

Your Brain Releases a Chemical Surge When Plans Fall Apart #Science #HealthandMedicine #MentalHealth #StressResponse #BrainChemistry

#ForestryRes
🌿UGT enzymes crucial for plant growth, stress response, and secondary metabolites! 🌱 Study reveals their roles in glycosylation, essential for adapting to climate change.
Details: www.maxapress.com/article/doi/10.48130/for...
#stressresponse #ugt

#MentalHealthMatters
#WomensWellbeing
#NervousSystemHealing
#SurvivalMode
#ChronicStress
#TraumaInformed
#EmotionalHealth
#InnerHealing
#WomenSupportWomen
#StressAwareness
#MindBodyConnection
#HealingJourney
#YouAreNotAlone
#StressResponse
#FightFlightFreeze
#MentalWellness
#HealingIsPossible

Top left: Schematic derived from WormPaths showing methionine salvage and arginine-derived metabolic pathways. Information regarding gene level and H3K4me3 status from Control, sams-1 or sams-4 animals in basal or heat-shocked conditions is marked in legend. Data is from Godbole and colleagues eLife 2023. Bottom left: Schematic showing connections between SAM and PC synthesis to trafficking of PC to and within the mitochondria. Right: Transmission electron micrograph of normal mitochondria (blue, top) compared to those with low levels of the phospholipid phosphatidylcholine (pink, bottom) from C. elegans intestinal cells, showing collapse of the mitochondrial network and accumulation along the intestinal lumen. Image taken by Dr. Maria Ericsson

S-adenosylmethionine synthases (SAMS) have distinct roles in #StressResponse & #mitochondrial metabolism in #Celegans. @akw-lab.bsky.social &co show that SAMS-1 supports broad metabolic functions (e.g. PC synthesis), while SAMS-4 aids protein transmethylation @plosbiology.org 🧪 plos.io/4rvQvtt

Top left: Schematic derived from WormPaths showing methionine salvage and arginine-derived metabolic pathways. Information regarding gene level and H3K4me3 status from Control, sams-1 or sams-4 animals in basal or heat-shocked conditions is marked in legend. Data is from Godbole and colleagues eLife 2023. Bottom left: Schematic showing connections between SAM and PC synthesis to trafficking of PC to and within the mitochondria. Right: Transmission electron micrograph of normal mitochondria (blue, top) compared to those with low levels of the phospholipid phosphatidylcholine (pink, bottom) from C. elegans intestinal cells, showing collapse of the mitochondrial network and accumulation along the intestinal lumen. Image taken by Dr. Maria Ericsson

S-adenosylmethionine synthases (SAMS) have distinct roles in #StressResponse & #mitochondrial metabolism in #Celegans. @akw-lab.bsky.social &co show that SAMS-1 supports broad metabolic functions (e.g. PC synthesis), while SAMS-4 aids protein transmethylation @plosbiology.org 🧪 plos.io/4rvQvtt

Top left: Schematic derived from WormPaths showing methionine salvage and arginine-derived metabolic pathways. Information regarding gene level and H3K4me3 status from Control, sams-1 or sams-4 animals in basal or heat-shocked conditions is marked in legend. Data is from Godbole and colleagues eLife 2023. Bottom left: Schematic showing connections between SAM and PC synthesis to trafficking of PC to and within the mitochondria. Right: Transmission electron micrograph of normal mitochondria (blue, top) compared to those with low levels of the phospholipid phosphatidylcholine (pink, bottom) from C. elegans intestinal cells, showing collapse of the mitochondrial network and accumulation along the intestinal lumen. Image taken by Dr. Maria Ericsson

S-adenosylmethionine synthases (SAMS) have distinct roles in #StressResponse & #mitochondrial metabolism in #Celegans. @akw-lab.bsky.social &co show that SAMS-1 supports broad metabolic functions (e.g. PC synthesis), while SAMS-4 aids protein transmethylation @plosbiology.org 🧪 plos.io/4rvQvtt

Trauma history shapes how the brain adaptively responds to new stress A new study reveals that brain networks associated with a person’s history of traumatic experiences can temporarily quiet down when confronted with a new, mild stressor. This finding, published in the...

Trauma history shapes how the brain adaptively responds to new stress #Science #HealthandMedicine #MentalHealth #BrainHealth #StressResponse #MentalHealthAwareness

Researchers uncover key mechanism behind chemotherapy-induced nerve damage – BioNews Central The discovery that a stress response in specific immune cells triggers chemotherapy-induced nerve damage suggests new ways to prevent or treat this side effect. ...

The discovery that a #StressResponse in specific #ImmuneCells triggers #chemotherapy -induced #NerveDamage suggests new ways to prevent or treat this #SideEffect.
#PeripheralNeuropathy

Your amygdala can’t tell the difference between an angry boss and a bear. Good luck with your corporate wilderness survival.

#StressResponse #NeuroScience #WorkLife

“Molecular bodyguard” helps infections persist Key protein helps bacteria survive in the body and points to strategies for fighting persistent infections.

🛣️ Bypass a molecular bodyguard to stop persistent bacterial infections:
IceLab researcher Kemal Avican and team show how the protein RfaH helps them resist stress and persist — and how its network could be a new antimicrobial target.
🔗 www.umu.se/en/news/mole...
#scicomm #stressresponse

The transcriptional mechanism behind Mimosa pudica leaf folding in response to mechanical disturbance - Planta Main conclusions Repeated stress in Mimosa pudica reduces photosystem efficiency, alters gene expression, shifting from flavonoid biosynthesis to stress resistance pathways, offering insights for sustainable plant stress defense strategies. Abstract Mimosa pudica is a plant known for its ability to fold leaves in response to mechanical disturbances, which serves as a visible phenotypic stress marker. Leaf folding response occurs with a timing and an intensity that vary depending on the stimulus. This adaptive behavior may function as a defense mechanism, helping plant resist herbivores and environmental stressors. In this study, we investigated the gene regulatory networks underlying M. pudica leaf closure following single and multiple mechanical disturbances (whole pot drops). Chlorophyll fluorescence was measured as fast phenotypic indicator of transient or permanent photochemical damage, and transcriptional responses were measured to identify the key genes regulating phenotypic changes after single or multiple drops. A progressive reduction of the quantum yield of PSII revealed a lower electron transport rate in leaves subjected to one or more drops, which may indicate the onset of energy shortage, potentially caused by limited ATP availability that constrains both leaf movement and photosynthesis. The transcriptomic profiles revealed larger differences when plants were subjected to multiple drops than to a single drop, with respect to unstressed controls. Interestingly, following a single drop, the majority of up-regulated genes were associated with the flavonoid biosynthetic pathway. After multiple drops, however, genes associated with biotic and abiotic stress resistance pathways were predominantly up-regulated. These findings provide new insights into the gene regulatory networks driving stress-induced movements in M. pudica leaves and lay the groundwork for developing sustainable strategies for plant stress defense.

🌿 Our new paper out in Planta @springernature.com !
doi.org/10.1007/s004... 🌱🧬
We uncover the gene networks driving Mimosa pudica leaf closure after single vs multiple stimuli, revealing distinct stress-response pathways.
#Transcriptomics #MimosaPudica #StressResponse