It is with great sadness that I'm sharing the news that Dr. Don Moerman passed away this weekend. He was such a legend in the #Celegans and Canadian science community.
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#Celegans
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In #GENETICS, Hamrick et al. used a #Celegans meiosis model to identify that the unpaired chromosomes undergo more double-stranded breaks than previously thought in conditions where homologous associations are disrupted. buff.ly/rbYVkg7
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mission logo for NG24
Launch is late this week (4/9-10) from Cape Canaveral / Kennedy Space Center. Watch live on NASA+. I'll post updates and a live link as we get closer, and when the worms come home. 🪱 🚀 🦠 🧬 🚀
www.nasa.gov/news-release...
#WormsinSpace #Celegans #Microbiome #ISS #CBIOMES #Artemis #spaceX
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None of this happens without model organism biology. Decades of basic research on a 1mm #Celegans worm built the foundation for #space #microbiome experiments in 2026. Investment in fundamental science is an investment in future treatments and discoveries.
www.nytimes.com/2024/10/17/s...
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The worms launch in culture bags and microfluidic chips, live on the station for ~6 days, then get imaged, frozen and returned to Earth for analysis. A matching ground experiment runs simultaneously so we can isolate what impact of microgravity.
#Celegans #SpaceBiology #microbiome #cbiomes 🚀 🦠
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Think of #Celegans as a mini version of ourselves, but with a transparent body, short lifespan and simpler microbiome. What we learn about gut-microbiome interactions in worms often applies broadly, including in humans. That's the power of basic biology.
www.sciencedirect.com/science/arti...
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Preflight microscopic image of C. elegans worm expressing fluorescent proteins in gut microbiome, plus reporting on changes in gut, nerve, and muscle function as part of C. elegans Biological Investigation on Microbiome Effect in Space (CBIOMES).
The worms are called C. elegans. About 1mm long, with a lot of physiology that works like ours. Scientists have used them to make Nobel Prize-winning discoveries about genetics, aging, and disease. Now they're taking a trip to space.
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#Celegans #spacebiology
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CBIOMES team - Buck Samuel, Monica Driscoll, Shilpa Akella, Atiyya Soroyia, Siva Vanapalli, Ciara Hosea and Bushra Rhaman. Not pictured: Dana Blackburn. Collaboration between Baylor College of Medicine, Texas Tech and Rutgers University.
#Artemis is circling the Moon right now. And later this week, our team's experiment launches to the #ISS. Tiny worms. Defined gut microbiomes. Here's why the two are connected. 🧵
#WormsinSpace #CBIOMES #Celegans 🧪 🪱 🧬 🚀
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Shan Zhao, Jie Zhang, Chonglin Yang et al. reveal that PI(3)P-dependent recruitment of FGD at #endosome–mitochondrion contacts activates CDC42 to regulate mitochondrial networks through #actin organization and DRP-1 in #Celegans. rupress.org/jcb/article/...
#Development #Organelles #Mitochondria
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In @icb.org, Shan Zhao, Jie Zhang, Chonglin Yang et al. reveal that PI(3)P-dependent recruitment of FGD at #endosome–mitochondrion contacts activates CDC42 to regulate mitochondrial networks through #actin organization and DRP-1 in #Celegans. rupress.org/jcb/article/...
#Development #Mitochondria
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Beautiful #microscopy 😍
#celegans
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Latest study in #GENETICS from @wbderry.bsky.social and colleagues reports a stress-dependent role for the core ensemble of cleavage and polyadenylation factor CFIM-1 in #Celegans germline integrity. buff.ly/NOdKWKT
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Check out this review in #GENETICS from @gotworms.bsky.social, @cgc-worms.bsky.social, and others describing the first release in the Curated Special Collections for #Celegans, highlighting protein degradation systems and how to achieve targeted protein deletion in #nematode #worms. buff.ly/lEaf2T2
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Congratulations to the legendary scientist Judith Kimble!!!
We stand on the shoulders of giants.
#womeninSTEM #celegans
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In #GENETICS, @ravijanagal.bsky.social and @jogender-singh.bsky.social determine the role of RHY-1 as both a regulatory and effector component of the #hypoxia response pathway that mediates cellular protection against thiol reductive stress in #Celegans. buff.ly/81sTGYZ
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⚒️ NEW TOOLBOX for #Celegans researchers 🪱
Theresa Gibney and Ariel Pani developed a method that allows for a standardized workflow to generate N-terminal and internal tags in any background and without the need for genetic balancers.
Paper in #GENETICS:🔗 buff.ly/wXMml3x
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Caenorhabditis Intervention Testing Program: the anticonvulsant leviteracetam does not extend lifespan in nematodes. #micropublication #biology #data #caltechlibrary #Celegans #Caenorhabditisbriggsae micropublication.org/journals/biology/micropu...
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Swimming exercise during early-life starvation enhances adult stress resistance in Caenorhabditis elegans #micropublication #biology #data #caltechlibrary #Celegans #ModelsOfHumanDisease #NewFinding micropublication.org/journals/biology/micropu...
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The 🆕 #omics report in the March issue of #G3journal presents #RNAseq and phenotypic analysis from multiple #Celegans mutant strains, which facilitates the dissection of genetic epistasis mechanisms in larval starvation resistance.🪱
🔗 Read the paper: buff.ly/uhXrEmX
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It’s great to see our latest microPublication go live!
Four undergraduate researchers worked with grad student Kat Yamamoto to demonstrate a correlation between fat storage and survival of #Celegans on pathogenic bacteria!
Congrats Alan, Grace, Tiffany, and Daniel! #undergradinthelab #proudPI
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Suppression of the fat storage defect of C. elegans dbl-1/BMP signaling mutants correlates with improved survival on a bacterial pathogen #micropublication #biology #data #caltechlibrary #Celegans #Ph micropublication.org/journals/biology/micropu...
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Stage-specific #transcriptomics of a leader cell reveals cell machineries driving collective invasion. New study from Priti Agarwal @pritiagarwal.bsky.social,
Ronen Zaidel-Bar and colleagues (Tel Aviv University): rupress.org/jcb/article/...
#Migration #Motility #Development #Trafficking #Celegans
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Portrait of Gary B. Ruvkun with a quote on the significance of tiny RNA revolution in non-mammalian genetic research, featuring microscopic worm imagery.
Happy birthday to Gary B. Ruvkun! He became a #LaskerLaureate for discoveries that revealed an unanticipated world of tiny RNA that regulates gene function in plants and animals. 🧪🌱🪱 #RNAbiology #Celegans Harvard Medical School
Read more here: https://ow.ly/IfZL50YmFle
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Representative immunostaining of anti-glutamylated tubulin (rMAb-GT335) in C. elegans hermaphrodites. Glutamylated tubulin is detected in labial and cephalic cilia (bracket) and the middle segments (MS) of amphid channel cilia. Scale bar=2μm.
Recombinant monoclonal antibodies to detect tubulin post-translational modifications work beautifully in #celegans neurons and cilia.
@kjverhey1.bsky.social shared ONE ML of each rMAb!
www.micropublication.org/journals/bio...
Blasius...Verhey 2025 Cytoskeleton: 10.1002/cm.70011. PMID: 40650552
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LIVEtools: an R Package for Visualizing C. elegans Embryo Cell Tracking Data #micropublication #biology #data #caltechlibrary #Celegans #Software #PhenotypeData #Methods #ImagingSoftware #ExpressionDa micropublication.org/journals/biology/micropu...
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A new #GENETICS study from @katzlab.bsky.social, @bscarp84.bsky.social, and colleagues explores the relationships between histone modifications, nucleosome remodeling, and transcriptional repressors, which play an important role in maternal reprogramming in #Celegans. buff.ly/tHiFtAr
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Recombinant monoclonal antibodies for labeling tubulin post-translational modifications in Caenorhabditis elegans #micropublication #biology #data #caltechlibrary #Celegans #Biochemistry #ExpressionDa micropublication.org/journals/biology/micropu...
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In #GENETICS, @uncnondpy.bsky.social et al. present a comprehensive mapping of genetic interactions among all #Celegans Wnt and its receptor genes, identifying how these interactions regulate the polarity of asymmetrically dividing stem cells. buff.ly/WIUus96
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#Xenopus #Celegans #DevelopmentalBiology #ExperimentalModels #Organoids #AnimalCaps #Review
bsky.app/profile/nico...
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