A Molecular Shredder at the Source: How Trypanosomes Fine-Tune Their Surface Coat In the world of the African trypanosome—the parasite behind sleeping sickness—survival is a high-stakes game of molecular hide-and-seek.

(7/7) Curious about the "Aha!" moments and the messy reality of the discovery process? Read the team's 'Behind the Paper' story here: 🔗 communities.springernature.com/posts/a-mole... #Parasitology #RNAbiology #MolBio #Trypanosomes #YorkScience

Excited to highlight the new Special Issue of RNA showcasing advances in system-level RNA biology, from epitranscriptomics and RNA damage to deep learning–driven structure prediction and beyond #RNAbiology #Epitranscriptomics #RNAseq #ComputationalBiology #Genomics bit.ly/4tEQL9I

Direct RNA Sequencing Reveals Stress-Dependent and Pathway-Specific rRNA Modification Reprogramming during 50S Biogenesis Ribosomal RNA (rRNA) modification and processing are essential steps in the ribosome assembly. Using Oxford Nanopore direct RNA sequencing, we simultaneously detect and quantify N2-methyladenosine (m2...

Direct RNA Sequencing Reveals Stress-Dependent and Pathway-Specific rRNA Modification Reprogramming during 50S Biogenesis | Biochemistry 🦠 #rnasky #rnabiology pubs.acs.org/doi/10.1021/...

Graphic honoring Sir David Baulcombe as a Lasker Laureate for discovering tiny RNAs regulating gene function in plants and animals.

🎉 We're wishing Sir David Baulcombe of Cambridge University a very happy birthday! He won the 2008 #LaskerAward for his contributions to #RNABiology. His discoveries revealed an unanticipated world of tiny RNA that regulate gene function in plants and animals: http://ow.ly/Zigk50IA3yV

#SciSky 🧪

(7/7) If you want to hear about the messy reality and the "Aha!" moments behind the work, read our Behind the Paper story communities.springernature.com/posts/a-molecu… 
#Parasitology #RNAbiology

#RNAsky #RNAbiology

Portrait of Gary B. Ruvkun with a quote on the significance of tiny RNA revolution in non-mammalian genetic research, featuring microscopic worm imagery.

Happy birthday to Gary B. Ruvkun! He became a #LaskerLaureate for discoveries that revealed an unanticipated world of tiny RNA that regulates gene function in plants and animals. 🧪🌱🪱 #RNAbiology #Celegans Harvard Medical School

Read more here: https://ow.ly/IfZL50YmFle

Great energy at our inaugural Genome Dynamics & RNA Biology Axis symposium in Montpellier last week!

Inspiring talks, strong discussions, and a fantastic research community — proud of this first edition 👏

#Genomics #RNABiology

#RNAsky #RNAbiology #ViroSky #VirEvol

RNA is not just a messenger — structure matters.

In our review, we explore how RNA folding shapes translation, stability, protein binding and cellular function. #RNA #RNAstructure #mRNA #RNABiology

www.mdpi.com/1422-0067/21...

#RNAsky #RNAbiology

🚨 Preprint alert!

We solved the structure of human NSUN2 bound to Asp tRNA, revealing how it installs m⁵C and recognizes RNAs
#CryoEM #RNABiology

A collab between Casañal & Gullerova labs, with @miclass.bsky.social and me working side by side as co-first authors

🔗 doi.org/10.64898/202...
(0/7🧵)

#RNAsky #RNAbiology

Purification of post-transcriptionally modified tRNAs for enhanced cell-free translation systems Abstract. Transfer RNAs (tRNAs) are utilized by the ribosome to decode the nucleic acid alphabet. tRNA structure, stability, aminoacylation efficiency, and

Purification of native tRNAs from E. coli with their post-transcriptional modifications and translational activity 🦠 #rnasky #rnabiology academic.oup.com/nar/article/...

Modulating the cleavage and polyadenylation site: from research tools to therapeutic opportunities #RNAbiology #CRISPR bit.ly/4cwUlxf

Toxic RNA-protein interactions in myotonic dystrophy studied via live-cell NanoBRET. Scripps researchers screened compounds that disrupt CUG repeat-MBNL1 binding, rescue splicing, reduce nuclear foci in patient cells. Rare disease drug discovery application.

https://ow.ly/lUxM50YmzYz

#RNABiology

#RNASky #RNAbiology

🐟 We are hiring a postdoc!
Interested in RNA regulation, gene expression, and zebrafish embryogenesis? Join the Bazzini Lab at @stowersinstitute.bsky.social
www.stowers.org/labs/bazzini...
Please share! Details below 👇
#Postdoc #RNAbiology #zebrafish #devbio #Genomics

Amazing day @CNR-IEOMI, speaking about #RNAbiology. I felt welcomed from friends! Thank you for the nice scientific discussion e for the invitation.

Control of retrotransposon-driven activation of the interferon response by the double-stranded RNA binding protein DGCR8 Abstract. The type I interferon (IFN) response is the main innate immune pathway against viruses in mammals. This pathway must be tightly regulated to prev

I'm so happy to share our latest paper! Now out in @narjournal.bsky.social 🥳

Did you know that transposable elements embedded in mRNAs can form dsRNA and activate innate immunity? 🧬🦠 Have a look! academic.oup.com/nar/article/...

#TEsky #RNAsky #RNAbiology #immunity #NAR

Scientist Joan Steitz in a white blazer sitting in a dimly lit room with large windows and vintage furniture (top). Below, a black and white picture of a young Steitz lecturing in a classroom.

This #WomensHistoryMonth and beyond, how do we fight for equality for #WomenInSTEM? “Communally,” says #LaskerLaureate Joan Steitz.

🧬🧪 Steitz was recognized for her leadership in #RNAbiology and in scientific mentorship: http://ow.ly/rjRL50N961h

codon usage About the Conference Codon usage bias—the preference for certain synonymous codons—is a key factor in genome regulation. Codon usage and synonymous codon mutations have been shown to influence gene ex...

Just a reminder - Please Register for the 3rd Codon Usage Conference in Montreal, Canada from May 31- June 3, right after the RNA Society Meeting.

Even if you can't go, please share! #RNA #RNAsky #RNAbiology

sites.google.com/view/codonus...

Global dissemination of npmA mediated pan-aminoglycoside resistance via a mobile genetic element in Gram-positive bacteria - Nature Communications The authors investigate the distribution of the aminoglycoside resistance gene npmA in Gram-positive bacteria via a mobile genetic element, highlighting its global presence and cross-species transfer ...

multi resistance dissemination with rRNA modification enzyme on mobile genetic element 🦠 #AMR #RNAbiology #rnasky

Ribosomal RNA expansion segments mediate the oligomerization of inactive animal ribosomes
www.science.org/doi/full/10....
From Erin Schuman's lab @erin-schuman.bsky.social
#RNAbiology

#RNASky #RNAbiology

New study reveals how glycyl-tRNA synthetase binding boosts Mengovirus RNA #translation, offering fresh insights into RNA–protein interactions and virus gene expression. 📈#Virology #RNAbiology
📄 https://doi.org/10.1093/nar/gkaf1451
👤 EVBC: Markus Fricke, Muriel Ritsch, Manja Marz, Michael Niepmann

Cleavage of host tRNAs by mycoplasma membrane-associated nuclease Abstract. Mycoplasmas are pathogens causing infectious diseases in various animals, including humans. They are also common contaminants of cell culture. Al

🦠 #rnasky #rnabiology

TlyA is a 23S and 16S 2′-O-methylcytidine methyltransferase important for ribosome assembly in Bacillus subtilis Abstract. Ribosomal RNA (rRNA) methylation is conserved across biology, yet the effect of rRNA methylation on ribosome function is poorly understood. In th

accumulation of the 50S subunit in delta-tlyA with cold sensitive phenotype and resistance to aminoglycosides 🦠 #RNAmodifications #RNAbiology #rnasky

Synonymous codon usage defines functional gene families - BMC Biology Background The degeneracy of the genetic code is increasingly recognized for roles in regulating translation rate, protein folding, and cell response. However, the functional genomics of codon usage p...

Signature codon usage patterns define functional gene families, this is in yeast and could be also very informative for bacteria and link with tRNA modifs #rnasky #codonusage #rnabiology #rnamodifications

📢 Rfam 15.1 is here!

✨ 50 new RNA families including riboswitch candidates, plastid ncRNAs, snoRNAs, plant xrRNAs and more.
🧬 10 families updated with 3D structures
🖥️ Brand new interactive alignment viewer

Take a look xfam.wordpress.com/2026/01/08/r...

#RNA #Bioinformatics #RNAbiology