Discover how Novogene's RNA-seq decoded neuronal, microglial & complement pathways in a lupus model, pinpointing C1q & Nr4a1 in synaptic loss. A fresh take on neuropsychiatric lupus mechanisms. #SLE #RNAseq #Neurogenomics https://tinyurl.com/3wk848fp

New preprint 🧠🧬
Post-stroke gene activity follows a genome hierarchy:
• New TADs scaffold transcription
• Loops work only in permissive TADs
• Compartments guide noncoding RNAs
🔗 www.biorxiv.org/content/10.6...
#4DNucleome #Chromatin #Stroke #HiC #Neurogenomics

Discover how Novogene's RNA-seq decoded neuronal, microglial & complement pathways in a lupus model, pinpointing C1q & Nr4a1 in synaptic loss. A fresh take on neuropsychiatric lupus mechanisms. #SLE #RNAseq #Neurogenomics https://bit.ly/3BwaXFr

Optimistic and pessimistic cognitive judgement bias modulates the stress response and cancer progression in zebrafish - Translational Psychiatry Translational Psychiatry - Optimistic and pessimistic cognitive judgement bias modulates the stress response and cancer progression in zebrafish

doi.org/10.1038/s413...
#SPEetologia
#SPEmembers

#CognitiveBias #StressResponse #Zebrafish #DiseaseResilience #BehavioralTrait #Neurogenomics

Divergent sensory transcriptomic profiles in positive and negative learning in Bicyclus Anynana butterflies - Journal of Comparative Physiology A Journal of Comparative Physiology A - Mate preference learning, where individuals learn to prefer or avoid specific phenotypes during mate selection, is pervasive across animal taxa and influences...

🚨 New paper out in #JCP-A @springernature.com "Divergent sensory transcriptomic profiles in positive and negative learning in Bicyclus Anynana butterflies" by Yi Teng Ter & Erica Westerman #Neurogenomics #VisualLearning #Lepidoptera 🧪🧠🦋
↘️ link.springer.com/article/10.1... ↙️

Call for Applications: Fully Funded PhD Scholarships in Systems Medicine - Human Technopole Are you passionate about science and ready to take the next step in your research journey? Human Technopole is offering up to 9 fully funded PhD scholarships through the highly regarded SEMM PhD Progr...

🎓 Just graduated and passionate about Computational #Biology, Structural Biology, #Genomics or #Neurogenomics? Apply by 8 Sept for 1 of 9 fully funded PhD scholarships via the SEMM Program at HT in Milan!

👉 humantechnopole.it/en/news/call... #PhDlife

Neurogenomics Market Growth to $5.48 Billion by 2032 Fueled by Technological Innovations The neurogenomics market is set to expand to $5.48 billion by 2032, growing at 17% CAGR, driven by lower sequencing costs and advanced diagnostic technologies.

Neurogenomics Market Growth to $5.48 Billion by 2032 Fueled by Technological Innovations #USA #Redding #Precision_Medicine #Sequencing #Neurogenomics

Recent Discoveries: The Molecular Complexity of Our Brain’s Decision-Maker

#PrefrontalCortex #Neuroscience #BrainResearch #CellularDiversity #Neurobiology #BrainCircuits #Neuromodulation #MentalHealth #Neurogenomics #CognitiveScience

youtube.com/shorts/tIYGc...

China Neurogenomics Market - Opportunity Analysis and Industry Forecast (2024-2031) China Neurogenomics Market is expected to reach $562.1 million by 2031 from an estimated $162.1 million in 2024, at a CAGR of 19.4% during the forecast period from 2024 to 2031.

Neurogenomics in China expands via precision medicine, better tech, and R&D, though costs and ethical concerns remain barriers.

Read More:
www.meticulousresearch.com/product/chin...

#Neurogenomics #PrecisionMedicine #GeneSequencing #Biotech #GenomicsInnovation #NeurologicalDisorders #Healthcare

We're looking for a new colleague! If you're excited by 2D and 3D neural models for neurodegenerative disease and want to join a fantastic lab, apply!!! 👇

Sharing would be great as well 🙏

#postdoc #jobs #neurogen #neurogenomics

Comparative characterization of human accelerated regions in neurons | Nature Human accelerated regions (HARs) are conserved genomic loci that have experienced rapid nucleotide substitutions following the divergence from chimpanzees1,2. HARs are enriched in candidate regulatory regions near neurodevelopmental genes, suggesting their roles in gene regulation3. However, their target genes and functional contributions to human brain development remain largely uncharacterized. Here we elucidate the cis-regulatory functions of HARs in human and chimpanzee induced pluripotent stem (iPS) cell-induced excitatory neurons. Using genomic4 and chromatin looping information, we prioritized 20 HARs and their chimpanzee orthologues for functional characterization via single-cell CRISPR interference, and demonstrated their species-specific gene regulatory functions. Our findings reveal diverse functional outcomes of HAR-mediated cis-regulation in human neurons, including attenuated NPAS3 expression by altering the binding affinities of multiple transcription factors in HAR202 a

Explore Human Accelerated Regions (HARs) with 100+ rapid substitutions since chimpanzee divergence. Insights into neurodevelopmental gene regulation. #NeuroGenomics PMID:40011774, Nature 2025, @Nature https://doi.org/10.1038/s41586-025-08622-x #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

An oligodendrocyte silencer element underlies the pathogenic impact of lamin B1 structural variants | Nature Communications The role of non-coding regulatory elements and how they might contribute to tissue type specificity of disease phenotypes is poorly understood. Autosomal Dominant Leukodystrophy (ADLD) is a fatal, adult-onset, neurological disorder that is characterized by extensive CNS demyelination. Most cases of ADLD are caused by tandem genomic duplications involving the lamin B1 gene (LMNB1) while a small subset are caused by genomic deletions upstream of the gene. Utilizing data from recently identified families that carry LMNB1 gene duplications but do not exhibit demyelination, ADLD patient tissues, CRISPR edited cell lines and mouse models, we have identified a silencer element that is lost in ADLD patients and that specifically targets expression to oligodendrocytes. This element consists of CTCF binding sites that mediate three-dimensional chromatin looping involving LMNB1 and the recruitment of the PRC2 transcriptional repressor complex. Loss of the silencer element in ADLD identifies a rol

Discover how an oligodendrocyte silencer element affects ADLD, a demyelinating disorder. Links with LMNB1 duplications & deletions. #Neurogenomics PMID:39910058, Nat Commun 2025, @NatureComms https://doi.org/10.1038/s41467-025-56378-9 #Medsky #Pharmsky #RNA 🧪

🥺 Actor Peter Gallagher's mother suffered from Alzheimer's for much of his life. 🌟You can make a difference. 🧠 Take the memory test. Change the future. Participate to help us understand how the brain performs at different ages to prevent diseases like dementia. #MindCrowd #neurogenomics

🥺 Actor Peter Gallagher's mother suffered from Alzheimer's for much of his life.

🌟You can make a difference.

🧠 Take the memory test. Change the future. Participate to help us understand how the brain performs at different ages to prevent diseases like #dementia.

#MindCrowd #neurogenomics

🔬 2/4: Looking at brain regions, we saw a strong genetic risk for #schizophrenia enriched in the hippocampus and amygdala. This suggests that these regions are important to the etiology of the disorder. #BrainMapping #PsychiatricResearch #Genetics #BrainResearch #neurogenomics

I’m still trying to figure this thing out. Do we have a “starter pack” for a list of people to follow for #neurodegeneration #neurogenomics #Alzheimer #Parkinson #als #ftd

Don't miss the talk from our BMC group leader @silvianeuro.bsky.social at the #neurogenomics #conference on May 19-21, 2025 ⬇️ ⬇️ ⬇️
#neurodevelopment / #disorders / #neurobiology

🗓️ Mark your calendar: May 19-21, 2025
There will be a great #neurogenomics conference @humantechnopole.bsky.social in Milan (@harschnitz.bsky.social ‬ is one of the organizers). Grateful to have been invited alongside (some joined 🦋 recently):
@silvianeuro.bsky.social @sergiuppasca.bsky.social 1/

Scientists uncover cerebrospinal fluid markers for Alzheimer's detection and treatment Researchers map the unique genetic regulation of proteins in human cerebrospinal fluid, identifying potential targets for Alzheimer’s treatments.

Scientists uncover cerebrospinal fluid markers for Alzheimer's detection and treatment 🧬🧠🔬 www.news-medical.net/news/2024111... #Alzheimers #Genomics #Proteomics #BrainHealth #CSFresearch #Neuroscience #GeneticMapping #DrugDiscovery #Biomarkers #Neurogenomics

Navigating the pitfalls of applying machine learning in genomics Nature Reviews Genetics - Machine learning is widely applied in various fields of genomics and systems biology. In this Review, the authors describe how responsible application of machine learning...

This was a great talk by @jmschreiber91! Paper here:| Ty @sj_marzi @ImperialBrains for hosting another great seminar. I really recommend this #neurogenomics seminar series btw!

x.com/sj_marzi/statu… nature.com/articles/s4157…

Prof Naomi Wray from @IMBatUQ and @QldBrainInst now talking aboutcommon complex diseases in the #neurogenomics session #agta18 #agta2018