We are looking forward to the LED3 Lecture by Peng Chen on April 23rd. He will talk about "Live-cell Protein Chemistry in Health and Disease"

If you are interested, make sure to come by!

www.universiteitleiden.nl/en/science/l...

#ChemBio #ChemSky #DrugDiscovery

Next-Gen Mass Spectrometer Breakthrough in Simultaneous Molecular Analysis

A new Science Advances paper introduces the MultiQ ion trap — a novel architecture that enables parallel ion processing instead of the traditional one-by-one approach.

www.ukisotope.com/next-gen-mas...

#MassSpectrometry #Proteomics #AnalyticalChemistry #DrugDiscovery #Innovation #ukisotope

🚀 Welcome to #FrontRowScience, highlighting research from our #CeMMResearchReport2025!

We kick off by featuring 3 CeMM PIs working on #DrugDiscovery: Stefan Kubicek, @supertifurgalab.bsky.social & @georgwinter.bsky.social.

Find out more below 🧵👇

A pathogenic Tau mutation drives autophagy-lysosome dysfunction that limits Tau degradation in a model of frontotemporal dementia - Nature Communications Researchers show that a disease-causing Tau mutation disrupts the autophagy-lysosome pathway in human neurons, leading to Tau accumulation, and that enhancing autophagy can partially restore protein c...

1/6 Can a single Tau mutation break the neuron’s recycling system? 🧠🔬
Our new study in Nature Communications links p.R406W Tau to multi-step autophagy failure, and points to a therapeutic path.
#Tauopathies #endFTD #DrugDiscovery #Neuroscience #Lysosomes www.nature.com/articles/s41...

Pipeline Overview Got 8 minutes? Let us show you how the Pipeline Drug Discovery platform can transform your research operations, reduce risk & costs, and improve communications & collaborations both inside and outside of the company. To learn more, contact us at pipeline@aspen.bio

Got 8 minutes? Let us show you how the Pipeline Drug Discovery platform can transform your research operations, reduce risk & costs, and improve collaboration.

Contact us at pipeline@aspen.bio

bit.ly/4uuHNwV

#DrugDiscovery #AI #Assays #PM #Chem #ProteinProduction #TargetManagement

Pipeline Overview Got 8 minutes? Let us show you how the Pipeline Drug Discovery platform can transform your research operations, reduce risk & costs, and improve communications & collaborations both inside and outside of the company. To learn more, contact us at pipeline@aspen.bio

Got 8 minutes? Let us show you how the Pipeline Drug Discovery platform can transform your research operations, reduce risk & costs, and improve collaboration.

Contact us at pipeline@aspen.bio

bit.ly/4uuHNwV

#DrugDiscovery #AI #Assays #PM #Chem #ProteinProduction #TargetManagement

Promotional graphic showing the front cover of the white paper.

In this free white paper, the validated, configurable protein–ligand docking software GOLD is used to compare predicted complex structures using AF2 predicted and X-ray determined protein structures.

🔗 ccdc-info.com/410P1vg

#DrugDiscovery #CompChemSky

Transforming Drug Discovery with AI
From target identification to toxicity prediction, innovation is reshaping healthcare.

Join us at AIIM 2026
May 04–05, 2026 | Boston, USA
🔗 ai-medicalcongress.com

#AIIM2026 #DrugDiscovery #AIinMedicine #HealthcareInnovation

The Cheat Code for Life: How AI Solved Biology’s Greatest Mystery 🧬 The 50-Year Mystery Is Over: Did AI Just Unlock the Cheat Code for Life? 🧬 What if I told you that the secret to curing every disease on Earth was hidden inside a puzzle we couldn’t solve for over half a century? For 50 years, the world’s most brilliant scientists were stumped by a single, mind-bending riddle: The Protein Folding Problem. It was the ultimate biological wall—until DeepMind’s AlphaFold 2 showed up and smashed through it like a digital sledgehammer. In this episode, we’re diving into the heart of the artificial intelligence revolution. We explore how AlphaFold 2 didn’t just guess the answers—it decoded the very biological blueprints of existence. We’re talking about a shift so massive it makes the discovery of DNA look like a warm-up act. Is it controversial to say machines now understand biology better than humans? Maybe. But the results speak for themselves. Inside this deep dive, we uncover: - 🚀 Beyond Human Intuition: How machine learning solved a 50-year-old puzzle that baffled Nobel laureates. - 💊 The End of 'Incurable': How AI is hyper-accelerating drug discovery for Alzheimer’s, Cancer, and malaria. - 🌍 Engineering the Future: Why this technology is the secret weapon for climate science and revolutionary material engineering. - 🔥 Exponential Progress: Why we have entered a new era where the 'impossible' is now just a manageable task. This isn't just about code and chemistry; it’s about the structural biology of you. We’re witnessing a moment where AI in healthcare moves from science fiction to the silent engine of human survival. Whether you're a tech enthusiast, a science nerd, or just curious about the future of the human race, this episode is a roadmap to the exponential technology reshaping our world. Don't get left behind in the old world. 🎧 Listen now to see how the code of life has finally been cracked! If this episode blew your mind, share it with one friend who needs to hear about the future, and hit that subscribe button to stay ahead of the curve! Let’s decode the future together. ✨  

📣 New Podcast! "The Cheat Code for Life: How AI Solved Biology’s Greatest Mystery" on @Spreaker #ai2026 #aigenerated #aihealthcare #alphafold2 #alphagenome #alzheimerscure #bioml #biotech #blueprintoflife #cancerresearch #deepmind #drugdiscovery #futureofmedicine #innovation #lifehacked

TREM2-mediated Macrophage Glycolysis Promotes Skin Wound Angiogenesis via the Akt/mTOR/HIF-1α Signaling Axis

This study finds that #TREM2⁺ #Macrophages drive # WoundRepair by linking #Glycolysis to #Angiogenesis via Akt/#mTOR/#HIF1α pathway, revealing #therapeutic targets for #TissueRegeneration. #medsky

Full article here: doi.org/10.1007/s115...
#WoundHealing #TherapeuticTargets #DrugDiscovery

Big news in drug discovery! We're diving deep into how large language models, like those powering ChatGPT, are now designing...

#Technology #BreachAndBuild #DrugDiscovery #mRNALanguageModels #AITherapies

breachandbuild.com/mrna-language-models-rev...

New Hope Against Superbugs: A Unique Antibiotic Family Targeting Untapped Bacterial Enzyme AntibioticResistance #Superbugs #DrugDiscovery #InfectionControl #DiabeticFootUlcer #McMasterResearch #AntimicrobialResistance diabeticfootonline.c...

Hello Bluesky! Migrating my focus on here. At Omega Infinity, we’re bridging the gap between drug discovery data and clinical success. The 'Summary' era is over; it's time for 'Structure'. Excited to share how our V12 Engine identifies topological gaps in scientific logic.

#Biotech #DrugDiscovery

Drug discovery is undergoing a paradigm shift—from static lock-and-key to systemic network modulation. This editorial unveils how multidisciplinary convergence reshapes cognition, technology, and ecosystem.
doi.org/10.59717/j.x...
#DrugDiscovery #ArtificialIntelligence

Looking for a better way of managing your drug discovery portfolio? The Ring of Fire is a new framework that combines data from biology, chemistry, clinical and commercial into a quantitative view of the project.

bit.ly/4s9rjZw

#DrugDiscovery #PPM #PM #PortfolioManagement

Looking for a better way of managing your drug discovery portfolio? The Ring of Fire is a new framework that combines data from biology, chemistry, clinical and commercial into a quantitative view of the project.

bit.ly/4s9rjZw

#DrugDiscovery #PPM #PM #PortfolioManagement

Anthropic Pays $400M for AI Drug Discovery Startup Anthropic acquires Coefficient Bio, an eight-month-old stealth startup with fewer than ten employees, in a $400M all-stock deal to push into pharmaceutical AI.

Anthropic Pays $400M for AI Drug Discovery Startup

awesomeagents.ai/news/anthropic-acquires-...

#Anthropic #Acquisition #DrugDiscovery

GitHub - K-Dense-AI/claude-scientific-skills: A set of ready to use Agent Skills for research, science, engineering, analysis, finance and writing. A set of ready to use Agent Skills for research, science, engineering, analysis, finance and writing. - K-Dense-AI/claude-scientific-skills

K-Dense released 134 scientific skills for AI coding agents, incl. #rdkit, molecular property prediction, VS, ADMET analysis, molecular docking. Open source, works with Claude Code/Cursor/Codex…

github.com/K-Dense-AI/claude-scientific-skills

#cheminformatics #RDKit #AIagents #drugdiscovery

A most excellent molecule with which to conclude the week #SynChem #BB #MedChem #DrugDesign #DrugDiscovery #chemsky 🧪
enaminestore.com/catalog/EN30...

Want to know all the ways that #biotechnology companies can benefit from bioinformatics? This short blog has the answers!
www.fiosgenomics.com/bioinformatics-applicati...

#bioinformatics #drugdiscovery #drugdevelopment

Hu et al. explore how integrating generative AI, like diffusion models, with rigorous physics-based validation prevents "structural hallucinations" and accelerates the translation of in silico peptide blueprints into viable clinical therapeutics.
doi.org/10.59717/j.x...
#DrugDiscovery #GenerativeAI

🧠 Can natural phytochemicals help target α-synuclein in Parkinson’s disease?

This in silico study highlights promising neuroprotective compounds using molecular docking & MD simulations.

📖 dr.clintile.com/article/doi/...

#Parkinsons #DrugDiscovery #Bioinformatics

💡 Most drug discovery tools look at biology in segments. Hyper-C is built to see diseases and drugs play out across systems. Explore Hyper-C's core components at 📍 delta4.ai/hyper-c
#DrugDiscovery #SystemsBiology #Biotech #TargetDiscovery #BiomarkerID #indicationExpansion

The Digital Transformation Roadmap - Improving Capital Efficiency & Velocity in Drug Discovery A Digital Transformation Roadmap can show you how to apply technologies like AI, automation and advanced analytics to improve the efficiency and velocity of your drug discovery operations. In this video, we take a look at some of the ways that these technologies can be applied to transform the way new medicines are discovered, and how a roadmap can help provide you with a plan for getting there. #digitaltransformation #drugdiscovery #ai #automation #analytics

Give us 10 minutes and we'll show you how Digital Transformation with AI and Automation can change your drug discovery operations.

bit.ly/4blEtN6

#DrugDiscovery #DigitalTransformation #AI #automation.

The Digital Transformation Roadmap - Improving Capital Efficiency & Velocity in Drug Discovery A Digital Transformation Roadmap can show you how to apply technologies like AI, automation and advanced analytics to improve the efficiency and velocity of your drug discovery operations. In this video, we take a look at some of the ways that these technologies can be applied to transform the way new medicines are discovered, and how a roadmap can help provide you with a plan for getting there. #digitaltransformation #drugdiscovery #ai #automation #analytics

Give us 10 minutes and we'll show you how Digital Transformation with AI and Automation can change your drug discovery operations.

bit.ly/4blEtN6

#DrugDiscovery #DigitalTransformation #AI #automation.

Computational and Structural Biotechnology Journal (CSBJ), a Science Partner Journal published in collaboration with AAAS, is inviting submissions for its upcoming special issue: “Advanced 3D Tissue Models for Improving Translational Pharmacology and Toxicology” For more info about the Call for Papers, please visit: https://spj.science.org/journal/csbj/si/advanced-3d-tissue-models

📢 Call for Papers: Advanced 3D Tissue Models for Improving Translational Pharmacology and Toxicology

⏳ Submission Deadline: 30 November 2026

🔗 Submit your work: spj.science.org/journal/csbj...

#CallForPapers #DrugDiscovery #Toxicology #3DTissueModels #Organoids #PrecisionMedicine #Pharmacology

Promotional graphic showing the front page of the white paper.

The GOLD algorithm is well established for protein-ligand docking — but how does it perform with peptides?

This white paper tests its performance with a set of linear peptide-protein complexes from the InterPep1 dataset.

Download it here: ccdc-info.com/4tsPClF

#DrugDiscovery #CompChemSky

Curious about using Biobanks to support your #drugdiscovery research? Here is everything you need to know: www.fiosgenomics.com/using-biobank-data-to-re... #biobanks #biobankdata #biobankresearch

Generare raises $23.2M to discover unknown molecules and advance new drugs - SiliconANGLE Generare raises $23.2M to discover unknown molecules and advance new drugs - SiliconANGLE

Generare raises $23.2M to discover unknown molecules and advance new drugs #Technology #Business #Startups #Funding #DrugDiscovery #Biotech

siliconangle.com/2026/04/02/generare-rais...

Is your #DrugDiscovery built on science or AI robot monkeys? 🐒🤖
You need a roadmap that reduces risk and increases velocity.

Watch: bit.ly/4rohQgC
Guide: bit.ly/4rOyVRj

#Biotech #Strategy