NANBIOSIS launches an integrated service to develop antibody-functionalized nanoconjugates, bridging diagnostics and nanomedicine innovation.
Read more: www.nanbiosis.es/biofunctiona...

#ICTSnews #CEBS #CEBiomedS #NanbiosisExpertise #Nanomedicine #Diagnostics #Biosensors #Biotechnology #Innovation

Learn more about advances in anaerobic #microbiology at EMBO Practical Course "Breathless Microbes: Life With No Oxygen" in #Nijmegen, NL, 6–10 July 2026. 🧪

Deadline: 15 April

https://meetings.embo.org/event/26-breathless-microbes
#EMBObreathless #EMBOevents #MicroSky #biotechnology #biochemistry

Chromosomal instability drives convergent and divergent evolution toward advantageous inherited traits in mammalian CHO bioproduction lineages - PubMed Genetic instability of Chinese hamster ovary (CHO) cells is implicated in production inconsistency through poorly defined mechanisms. Using a multi-omics approach, we analyzed the variations of CHO lineages derived from CHO-K1 cells. We identify an equilibrium between random genetic variation of the …

🧬 Chromosomal instability drives convergent and divergent evolution toward advantageous inherited traits in mammalian CHO bioproduction lineages.
iScience(2022)
#Biotechnology #Science

Advanced Biotech For Sustainability (AB4S) Coalition Unveils “The Molecule Manifesto,” Pinpointing Four Key Pathways to a $1.1 Trillion Biotech Economy renewable-carbon.eu/news/?p=175275 #biobased #biochemicals #biotechnology #fermentation #peptides #proteins #terpenes #RenewableCarbon

An automated high inoculation density fed-batch bioreactor, enabled through N-1 perfusion, accommodates clonal diversity and doubles titers - PubMed An important consideration for biopharmaceutical processes is the cost of goods (CoGs) of biotherapeutics manufacturing. CoGs can be reduced by dramatically increasing the productivity of the bioreactor process. In this study, we demonstrate that an intensified process which couples a perfused N-1 s …

💊 An automated high inoculation density fed-batch bioreactor, enabled through N-1 perfusion, accommodates clonal diversity and doubles titers.
Biotechnology progress(2024)
#Biotechnology #Science

Differential Effects of Endocannabinoids on Amyloid-Beta Aggregation and Toxicity - PubMed The regulation and metabolism of the endocannabinoid system has received extensive attention for their potential neuroprotective effect in neurodegenerative diseases such as Alzheimer's disease (AD), which is characterized by amyloid β (Aβ) -induced cell toxicity, inflammation, and oxidative stress. …

💻 Differential Effects of Endocannabinoids on Amyloid-Beta Aggregation and Toxicity.
International journal of molecular sciences(2023)
#Biotechnology #Science

Greenberg Traurig Advises Entera Bio in $10 Million Funding Round Led by BVF Partners Greenberg Traurig has guided Entera Bio through a $10 million private placement led by BVF Partners, enhancing its funding for key clinical studies.

Greenberg Traurig Advises Entera Bio in $10 Million Funding Round Led by BVF Partners #Israel #Tel_Aviv #biotechnology #Greenberg_Traurig #Entera_Bio

Akari Therapeutics Partners with WuXi XDC on ADCs Akari Therapeutics' Apr 6, 2026 ADC tie-up with WuXi XDC could accelerate preclinical timelines as the ADC market is projected at ~13.8% CAGR to 2030 (Grand View Research, 2024).

Akari Therapeutics Partners with WuXi XDC on ADCs: Akari Therapeutics' Apr 6, 2026 ADC tie-up with WuXi XDC could accelerate preclinical timelines as the ADC market is projected at ~13.8% CAGR to 2030 (Grand View… 👈 Read full analysis #AkariTherapeutics #WuXiXDC #ADCs #Biotechnology #Pharmaceuticals

https://pubmed.ncbi.nlm.nih.gov/35164242/

💻 Synthetic Diphenylacetylene-Based Retinoids Induce DNA Damage in Chinese Hamster Ovary Cells without Altering Viability.
Molecules (Basel, Switzerland)(2022)
#Biotechnology #Science

The future of medicine is being reshaped by nanotechnology

Join WCNN 2026 in Barcelona, Nov 5-6.
Early Bird ends Apr 24.
📩 gunashekar@sciinovhealth.com

nanotech-summit.com

#Nanotech #WCNN2026 #Innovation#Nanoscience #Innovation #WCNN2026 #FutureOfMedicine #Biotechnology

Biogen Signals $34 Million Deal-Related Charge as It Reshapes Earnings Strategy Biogen warns of a $34M charge tied to licensing and research deals, underscoring the rising cost and volatility of its deal-driven strategy.

Biogen Signals $34 Million Deal-Related Charge as It Reshapes Earnings Strategy

#biogen #biotechnology #earnings #deal #pharma

Optimizing VLP production in gene therapy: Opportunities and challenges for in silico modeling - PubMed Over the past decades, virus-like particle (VLP)-based gene therapy (GT) evolved as a promising approach to cure inherited diseases or cancer. Tremendous costs due to inefficient production processes remain one of the key challenges despite considerable efforts to improve titers. This review aims to …

🧬 Optimizing VLP production in gene therapy: Opportunities and challenges for in silico modeling.
Biotechnology journal(2023)
#Biotechnology #Science

Evaluation of site-specific methylation of the CMV promoter and its role in CHO cell productivity of a recombinant monoclonal antibody - PubMed We previously demonstrated that increased monoclonal antibody productivity in dihydrofolate reductase (DHFR)-amplified CHO cells correlates with phosphorylated transcription factor-cytomegalovirus (CMV) promoter interactions. In this article, we extend the characterization to include CMV promoter me …

🔬 Evaluation of site-specific methylation of the CMV promoter and its role in CHO cell productivity of a recombinant monoclonal antibody.
Antibody therapeutics(2022)
#Biotechnology #Science

Exploring the limits of conventional small-scale CHO fed-batch for accelerated on demand monoclonal antibody production - PubMed In the field of therapeutic antibody production, diversification of fed-batch strategies is flourishing in response to the market demand. All manufacturing approaches tend to follow the generally accepted dogma of increasing titer since it directly increases manufacturing output. While titer is infl …

📚 Exploring the limits of conventional small-scale CHO fed-batch for accelerated on demand monoclonal antibody production.
Bioprocess and biosystems engineering(2022)
#Biotechnology #Science

A billionaire-backed startup, R3 Bio, has been pitching investors on a controversial idea of creating “brainless clones” of human bodies for future transplants.

#TechNews #Biotechnology #FutureTech #Science #Innovation

Five takeaways for US policymakers about China’s new five-year development plan Chinese leaders are much more focused on their nation’s strengths than its weaknesses, and they are feeling bullish about the future.

#Biotechnology #China #USA
Five takeaways for US policymakers about China’s new five-year development plan
www.atlanticcouncil.org/dispatches/f...

[...]
Until now, leading on biotechnology innovation was a stretch goal for China. For example, the Made in China 2025 plan (the ten-year industrial...

Ascendis Pharma Posts Positive Week 52 Phase 2 Data Ascendis (ASND) reported positive Week 52 data from its Phase 2 New InsiGHTS trial on Apr 4, 2026, marking one-year durability but full metrics are pending.

Ascendis Pharma Posts Positive Week 52 Phase 2 Data: Ascendis (ASND) reported positive Week 52 data from its Phase 2 New InsiGHTS trial on Apr 4, 2026, marking one-year durability but full metrics are… 👈 Read full analysis #AscendisPharma #Phase2Trial #EndocrineHealth #ClinicalTrials #Biotechnology

Efficiency and scalability in harvesting mammalian cell cultures: A scale-down approach to continuous centrifugation - PubMed Continuous centrifugation is a well-established method for clarifying mammalian cell cultures, but traditional batch-based approaches often fall short of modern biomanufacturing's scalability and flexibility demands. Increasing variability in product volumes and manufacturing setups calls for adapta …

🔬 Efficiency and scalability in harvesting mammalian cell cultures: A scale-down approach to continuous centrifugation.
Journal of biotechnology(2026)
#Biotechnology #Science

Happy Easter greeting above a cluster of decorated Easter eggs.

Happy Easter from the Department of Chemical Engineering and Biotechnology 🍫

🧪⚙️🌱🔋

#ChemicalEngineering #Biotechnology #CambridgeUniversity

Qiagen Upgraded to Buy After 30% Drop Deutsche Bank upgraded Qiagen (QGEN) to Buy on Apr 2, 2026 after a roughly 30% share drop; institutional investors should weigh primary research before repositioning.

Qiagen Upgraded to Buy After 30% Drop: Deutsche Bank upgraded Qiagen (QGEN) to Buy on Apr 2, 2026 after a roughly 30% share drop; institutional investors should weigh primary research before repositioning. 👈 Read full analysis #Qiagen #Investing #StockMarket #DeutscheBank #Biotechnology

N-1 Perfusion Platform Development Using a Capacitance Probe for Biomanufacturing - PubMed Fed-batch process intensification with a significantly shorter culture duration or higher titer for monoclonal antibody (mAb) production by Chinese hamster ovary (CHO) cells can be achieved by implementing perfusion operation at the N-1 stage for biomanufacturing. N-1 perfusion seed with much higher …

🦠 N-1 Perfusion Platform Development Using a Capacitance Probe for Biomanufacturing.
Bioengineering (Basel, Switzerland)(2022)
#Biotechnology #Science

Factors and Mechanisms Affecting the Secretion of Recombinant Protein in CHO Cells - PubMed The market demand for recombinant therapeutic proteins (RTPs) has promoted the development of various protein expression host and bioprocessing technologies. Since mammalian cells have the unique advantage of being able to direct the correct folding of proteins and provide post-translational process …

📚 Factors and Mechanisms Affecting the Secretion of Recombinant Protein in CHO Cells.
Current pharmaceutical biotechnology(2023)
#Biotechnology #Science

Stress-induced increase of monoclonal antibody production in CHO cells - PubMed Monoclonal antibodies (mAbs) are of great interest to the biopharmaceutical industry due to their widely used application as human therapeutic and diagnostic agents. As such, mAb require to exhibit human-like glycolization patterns. Therefore, recombinant Chinese hamster ovary (CHO) cells are the fa …

💻 Stress-induced increase of monoclonal antibody production in CHO cells.
Engineering in life sciences(2022)
#Biotechnology #Science

The colorful world of GMOs | Modified From glowing petunias to purple tomatoes - this episode is a roundup of some of the lesser known GMO crops that are nonetheless out there in our world.    Key references   Glowing plants I Bought a G...

www.modifiedpod.com/e/the-colorf...

Episode 15 out now - A roundup of some of the lesser known GMO crops in our world.

#science #biotechnology #GMOs

Recent Advances in Engineering the Unfolded Protein Response in Recombinant Chinese Hamster Ovary Cell Lines - PubMed Chinese hamster ovary (CHO) cells are the most common protein production platform for glycosylated biopharmaceuticals due to their relatively efficient secretion systems, post-translational modification (PTM) machinery, and quality control mechanisms. However, high productivity and titer demands can …

🤖 Recent Advances in Engineering the Unfolded Protein Response in Recombinant Chinese Hamster Ovary Cell Lines.
International journal of molecular sciences(2025)
#Biotechnology #Science

A gene-editing therapy delivers functional cures for sickle cell The analysis highlights immune-oncology advances, ocean stress signals, and risks from media and alcohol.

🔬 CRISPR/Cas12a therapy delivered functional cures in 27 of 28 severe sickle cell cases—showing real progress in gene-editing treatment.

scienceecho.com/en/2026/04/gene-editing-... #biotechnology #health

Incorporating shaken 24-deep-well plate fed-batch culture shortens CHO cell line development time - PubMed In conventional Chinese hamster ovary (CHO) cell line development, static culture is used for early-stage screening, whereas suspension culture is generally used for the manufacturing process. Shaken flask (SF) fed-batch culture allows evaluation with culture mode, which is closer to the final proce …

💊 Incorporating shaken 24-deep-well plate fed-batch culture shortens CHO cell line development time.
Cytotechnology(2025)
#Biotechnology #Science

🔬 Bioprocess Optimization: Driving Efficiency in Modern Biotechnology

🌍 Join us at the Biocatalysis and Biotransformation Congress 2026
📅 21–22 October, 2026
📍 San Francisco, California, USA

#BioprocessOptimization #Biocatalysis #Biotransformation #Biotech #GreenChemistry #Biotechnology

LncRNA analysis of mAb producing CHO clones reveals marker and engineering potential - PubMed Long non-coding RNAs (lncRNAs) are a potential new cell line engineering tool for improvement of yield and stability of CHO cells. In this study, we performed RNA sequencing of mAb producer CHO clones to study the lncRNA and protein coding transcriptome in relation to productivity. First, a robust l …

🔬 LncRNA analysis of mAb producing CHO clones reveals marker and engineering potential.
Metabolic engineering(2023)
#Biotechnology #Science

Unveiling the CHO surfaceome: Identification of cell surface proteins reveals cell aggregation-relevant mechanisms - PubMed Chinese hamster ovary (CHO) suspension cells are the main production hosts for biopharmaceuticals. For the improvement of production processes, it is essential to understand the interaction between CHO cells and their microenvironment. While the cellular membrane is the crucial surface barrier betwe …

🦠 Unveiling the CHO surfaceome: Identification of cell surface proteins reveals cell aggregation-relevant mechanisms.
Biotechnology and bioengineering(2021)
#Biotechnology #Science