Reconstructing ancient protein alphabets: what can we truly infer?
#evolution #proteins #MicroSky
@cp-trendsgenetics.bsky.social
www.sciencedirect.com/science/arti...

Building the blocks of life Computational biologist Sergei Kotelnikov is working to develop new methods in protein modeling as part of the School of Science Dean’s Postdoctoral Fellowship. Origin...

#Profile #Staff #Graduate #postdoctoral #Awards #honors #and […]

[Original post on news.mit.edu]

🧠 How does the brain make #proteins exactly where they’re needed?

🎙️ @erin-schuman.bsky.social, Director at @mpibrain.bsky.social, shared how #neurons produce proteins locally at synapses, shaping plasticity and memory.

youtu.be/GFj__978bdg

📌Join #Excel4Pro & #PROTWIN on March 31 for a dynamic #webinar on #foodsafety, #novelfoods & alternative #proteins in Europe!

Discover the latest #regulatory updates, gain insights, and explore challenges & opportunities shaping tomorrow’s #foodsystems.

ℹ️ More info: excel4pro.eu/event/excel4...

Researchers Identify Protein Interaction Driving Alzheimer’s and Develop Compound to Halt It in Mice A research team led by Professor Hilmar Bading at Heidelberg University has uncovered a key biological mechanism behind Alzheimer's disease progression. The scientists identified a harmful interaction between two proteins—the NMDA receptor and the TRPM4 ion channel—that, when bound together, form a destructive protein complex. This complex triggers neuronal death and accelerates memory loss. Using a specially developed compound called FP802, the researchers successfully disrupted this toxic interaction in a mouse model of Alzheimer’s. The drug, described as a TwinF Interface Inhibitor, binds to the exact site where the two proteins connect, preventing the formation of the damaging complex. Mice treated with FP802 showed slower disease progression, preserved memory and learning abilities, and reduced brain damage. The treatment also lowered the accumulation of beta-amyloid plaques, a hallmark of Alzheimer’s pathology. Unlike traditional therapies focused solely on amyloid removal, this approach targets the downstream molecular mechanism responsible for neuronal death. The research suggests that FP802 may also have potential in treating other neurodegenerative diseases, such as ALS, that involve the same protein interaction. Although still in early preclinical stages, the discovery opens a promising path toward developing new therapies that protect brain cells and halt disease progression at its root. The team, collaborating with FundaMental Pharma, plans to refine FP802 and conduct safety and pharmacological studies before human trials.

Researchers Identify Protein Interaction Driving Alzheimer’s and Develop Compound to Halt It in Mice

🤖 IA: It's clickbait ⚠️
👥 Usuarios: It's clickbait ⚠️

#alzheimer's #neurodegeneration #proteins

View full AI summary:

New nanoparticle treatment helps brain to clear toxic Alzheimer’s proteins in mice The technique represents a new way of thinking about Alzheimer’s treatment.

#New #nanoparticle #treatment helps #brain to #clear #toxic #Alzheimer’s #proteins in #mice. Oct 15, 2025. #health #science #medicine #research #brain #proteins #senescence #aging #errors #DNA #thinking theconversation.com/new-nanopart...

Time to #clean up your #AACT!!!
.
#Switzerland's #blood #nanofilter
#removes #Alzheimer's #proteins in hours and reportedly #reverses #dementia.

‘Not all #proteins are created equal’: Inside PepsiCo’s approach to functional #ingredients www.fooddive.com/news/pepsico...

Structural modeling reveals phage proteins that manipulate bacterial immune signaling The genomes of phages—viruses that infect bacteria—are largely composed of "dark matter": genes that encode proteins whose functions remain unknown. Less than four years ago, a team led by Prof.…

Structural #modeling reveals #phage #proteins that manipulate #bacterial #immune signaling ...

| #bacteria | #MicroSky | #genomes | #virus | #immunesystems | Via @sciencex.bsky.social

Ferrero Group Expands Its Healthy Snack Portfolio with Bold Snacks Acquisition The Ferrero Group has successfully acquired Bold Snacks, strengthening their foothold in the health-conscious snack market in South America.

Ferrero Group Expands Its Healthy Snack Portfolio with Bold Snacks Acquisition #Brazil #Proteins #Ferrero_Group #Bold_Snacks #Divinópolis

@mariaweyh.bsky.social from the @klanglab.bsky.social gave an interesting talk at #Biochemistry2026 under the title: "Accessing defined protein-protein conjugates via in-cellulo native chemical ligation".

#Biochemistry #Chemistry #ChemBio #Ligation #Peptides #Proteins

What are proteins made of? A. Fatty acids B. Sugars C. Amino acids D. Nucleotides #proteins #bioche What are proteins made of? A. Fatty acids B. Sugars C. Amino acids D. Nucleotides #proteins #bioche

What are proteins made of?
A. Fatty acids
B. Sugars
C. Amino acids
D. Nucleotides
#proteins #biochemistry #chemistry #questionandanswer ... Continue to: www.facebook.com/113009240922...

Fantastic fungi found with ability to freeze water Can fungi influence the weather? Turns out, they just might. An international group of researchers that includes Virginia Tech's Xiaofeng Wang and Boris A. Vinatzer discovered the identity of fungal…

Fantastic #fungi found with ability to #freeze #water ...

| #fungal | #proteins | #Clouds | #ICE | By @virginiatech.bsky.social via @sciencex.bsky.social

Fascinating nuclear pores: a new high-definition view reveals the machine in action.

"Every nuclear pore complex is constructed from hundreds of #proteins, of around 30 different types."
🧪 #Science #Biology
Disorder Drives One of Nature’s Most Complex Machines
www.quantamagazine.org/disorder-dri...

Yesterday Felix Willmund from @unimarburg.bsky.social visited us to talk about the features of heat-induced aggregation of #chloroplast #proteins in #algae Chlamydomonas reinhardtii. Great seminar und discussion!
Thanks to Adrian Nievergelt for organizing the event.

Last chance to submit an abstract or save £50 on registration fees! Deadline tomorrow! #proteins

100gr of tofu is enough for two.

Store the 2/3 of tofu that will be used later in water in a punnet, closed with lid, keep in the fridge. Change water daily. Use within 4/5 days

I cut 100 gr of tofu (1/3 of packet) in slices. Into a flat bowl, sprinkle cayenne pepper, cumin, coriander, turmeric, ginger powders, (whatever you like). Add tamari or soy sauce (about 2 spoons)

Mix delicately, let it soak, then add into dish 3mn before end of cooking.

For people who learn to leave meat, adding pulses, nuts, a bit of cheeses and eggs, tempe and tofu in every meal will bring enough #proteins.

How to keep tofu once the pocket is open? In a punnet in water in the fridge, change water every day.

How to make #tofu tasty? Soak in spices and tamari.

Researchers Develop Light-Controlled Protein Evolution for Dynamic Cellular Functions Scientists at the Ecole Polytechnique Fédérale de Lausanne have developed a novel method called 'optovolution' that uses light to guide the evolution of proteins with dynamic behaviors. Unlike traditional directed evolution, which favors proteins that remain constantly active, optovolution allows proteins to switch between states in a controlled manner. Using engineered yeast cells, researchers made cell survival dependent on proteins switching at the right time. Light pulses were applied to force proteins to alternate between active and inactive states during the yeast cell cycle, creating a fast and automatic selection process for the best-performing variants. This approach generated new light-sensitive proteins capable of responding to multiple colors and improved existing optogenetic systems. Additionally, the team evolved a transcription factor that acts as a simple logic gate, activating genes only when two signals—a light and a chemical—are present simultaneously. Optovolution could transform synthetic biology, biotechnology, and fundamental research by enabling the design of smarter cellular circuits, multi-state protein behaviors, and color-specific optogenetic tools.

Researchers Develop Light-Controlled Protein Evolution for Dynamic Cellular Functions

🤖 IA: It's not clickbait ✅
👥 Usuarios: It's not clickbait ✅

#proteins #optogenetics #evolution

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Five projects share £100m UK-US Cancer Grand Challenges fund Five scientific teams will receive up to £20m each in a new round of funding under the UK and US Cancer Grand Challenges initiative.

#CancerGrandChallenges #CRUK #NCI #UK #USA #oncology #cancer #ATLAS #INSERM #autoantibodies #tumours #REWIRECAN #UCLCancerInstitute #ILLUMINE #NetherlandsCancerInstitute #darkproteome #proteins #immunotherapies #antigenicmarkers #CAUSE #InteroCANCEption #FrancisCrickInstitute
zurl.co/P9eTF

TALE Homeodomain Proteins in Plant Reproductive Development and Environmental Stress Resilience This review provides a comprehensive synthesis of the Three Amino acid Loop Extension (TALE) homeodomain gene family, integrating recent advances in structure, evolution, and mechanism to illuminat...

TALE #Homeodomain #Proteins in Plant #Reproductive Development and #Environmental Stress #Resilience

onlinelibrary.wiley.com/doi/10.1111/...

#PlantScience #CropScience #StressBiology #PlantStress #AbioticStress #Agriculture @plecevo.bsky.social @plantcmb.bsky.social @plantenergy.bsky.social

Democratizing Nanoscale Imaging at Molecular Resolution Discover a practical expansion imaging approach that reveals protein shape and spatial organization at the nanoscale using standard fluorescence...

#Proteins are ~10 nm.
#Fluorescence #microscopes were never meant to see them beyond a single dot.
On March 11 I’ll discuss how #ONEmicroscopy pushes #imaging toward true #molecular #scale.
Hosted by @leicamicrosystems.bsky.social
Register today: events.bitesizebio.com/democratizin...

Why ‘quantum proteins’ could be the next big thing in biology Fluorescent proteins with a quantum upgrade could offer unprecedented views inside cells.

Why ‘ #quantum #proteins’ could be the next big thing in #biology

www.nature.com/articles/d41...

New developments in #GPCR assay technologies now enable faster and more precise discovery of therapeutics across #oncology, #immunology, pain and #inflammatory disorders. See how we can support your drug and antibody development

🔗https://tinyurl.com/ytnp3hk4

#antibodies #proteins #lifesciences

📣 We're pleased to announce the reintroduction of the taxonomy restriction feature.
Sequence searches can now be restricted to specific taxonomic groups, allowing more control over which species are included in the results.
#bioinformatics #hmmer #proteins

In-person training. 7th UK Workshop on Membrane Proteins. Birmingham, UK. 15-17 April 2026. Includes Biochemical Society logo, image of scientists in lab coats, in a lab, and event logo.

There are still a few places left for the 7th UK Workshop on Membrane #Proteins! Join us from 15-17 April at Aston University to understand the basics of membrane protein purification using cutting edge methods 🧪 ow.ly/rx0B50YbAUt

Power in the Proteins Test your knowledge with this fun trivia challenge! Source link #Power #Proteins

Power in the Proteins

Test your knowledge with this fun trivia challenge! Source link #Power #Proteins

🎉Just appeared online in #JCTC @pubs.acs.org "Improving Conformational Ensembles of Folded #Proteins in #GōMartini" @maksimkalutskii.bsky.social @maxotubule.bsky.social @carterjwilson.bsky.social pubs.acs.org/doi/10.1021/...

Are there living microbes on Mars? Check the ice, researchers say | Penn State University If living microbes were present on Mars, they’d most likely be found in Martian ice, not soil, according to a new study by researchers at NASA and Penn State. By recreating Mars-like conditions in the...

Check Martian ice for remains of #microbes dormant for very long [via Penn St.] 🧪🥼🔴🌑🦠🧊

"fragments of the #molecules that make up #proteins in E. coli bacteria, if present in Mars’s #permafrost and #ice caps, could remain intact for over 50 million years"

www.psu.edu/news/earth-a...

#Mars #life

🎤🍕Cafe Synthetique is back! Mon 2 Mar,6pm

Join Gabriela Guedes, Joel Roca & Gorjan Stojanovski for talks on #proteins #nanomedicine #plastic-eatingenzymes 🧫

🎟️Sign up: www.tickettailor.com/events/engin...

@hollfelderlab.bsky.social @lauraitzhaki.bsky.social @cambiochem.bsky.social @phar.cam.ac.uk

Moss Medicines: The Next Revolution in Biotech? Plant biotechnologists are favoring moss factories over other models to produce certain valuable proteins.

Moss Medicines: The Next Revolution in #Biotech?
Plant biotechnologists are favoring #moss factories over other models to produce certain valuable #proteins.
Great article based on an interview with yours truly.
www.the-scientist.com/moss-medicin...