Apolipoproteins L involvement in immunity. New Perspective from Etienne Pays @ulbruxelles.bsky.social: rupress.org/jhi/article/...
#Infections #autoantibodies #InbornErrorsOfImmunity #ImmunologicalPhenotypes
New research from @umcutrecht.bsky.social & @amsterdamumc.bsky.social shows #longCOVID may be driven by #autoantibodies. Patient IgG triggered persistent pain symptoms in mice (even years later) highlighting a lasting, immune-driven mechanism. #COVID #immunology www.linkedin.com/posts/drmelv...
#CancerGrandChallenges #CRUK #NCI #UK #USA #oncology #cancer #ATLAS #INSERM #autoantibodies #tumours #REWIRECAN #UCLCancerInstitute #ILLUMINE #NetherlandsCancerInstitute #darkproteome #proteins #immunotherapies #antigenicmarkers #CAUSE #InteroCANCEption #FrancisCrickInstitute
zurl.co/P9eTF
Exciting news! 🇪🇺 Novartis has received a positive CHMP opinion for Remibrutinib in Chronic Spontaneous Urticaria (CSU).
We are proud to have collaborated with the Novartis team on the autoantibody analysis presented at #AAAAI2026 (Abstract #022). www.jacionline.org/article/S009...
#autoantibodies
Infographic on Islet Autoantibody Standardization Program 2024: Interlaboratory Evaluation of Multiplex Islet Autoantibody Assays. Includes sections on advantages & challenges such as nonstandardized methods and variability, study design details like 11 new-onset type 1 diabetes samples and two-tier testing strategies, and results showing a wide specificity range across different percentages.
Multiplex islet autoantibody assays demonstrated high performance in distinguishing type 1 diabetes cases from controls: results from the IASP 2024 workshop #autoantibodies #assays #T1D
Read here ➡️ doi.org/10.2337/dc25-1326
Effect of #Steroids on #Antinephrin #Autoantibodies and B cells in Minimal Change Disease #MCD
#VisualAbstract by Priya John
www.kireports.org/article/S2468-0249(26)00...
#Autoantibodies neutralizing type 1 #interferons in two cohorts of people with #HIV. New study from Julie A. Jensen, Jean-Laurent Casanova @casanovalab.bsky.social, Trine H. Mogensen @au.dk and colleagues: rupress.org/jhi/article/...
@esidsociety.bsky.social
#Medsky🧪 #Neurosky #Immunosky #pharmsky #publichealth #Autoantibodies that block type I interferons (IFNs) have recently been recognized as major causes of a growing number of life-threatening viral infections. The study report that these autoantibodies also
Increased prevalence of #autoantibodies neutralizing IFNλ2/3 in young individuals with #CysticFibrosis. New report from Kevin Groen, Emanuela Bruscia, Marc Emmenegger, Benjamin Hale @benhale.bsky.social and colleagues: rupress.org/jhi/article/...
#Autoimmunity #Infections
In @jhumimmunity.org: Groen, @benhale.bsky.social et al. identify interferon-λ #autoantibodies in 11.8% of those with #CysticFibrosis, a prevalence >10-fold higher than expected. In vitro & clinical analyses suggest the antibodies may impact mucosal pathology. rupress.org/jhi/article/...
Groen, @benhale.bsky.social et al. @virology.uzh.ch identify interferon-λ #autoantibodies in 11.8% of those with #CysticFibrosis, a prevalence >10-fold higher than expected. In vitro & clinical analyses suggest the antibodies may impact mucosal pathology. rupress.org/jhi/article/...
#Medsky🧪 #IDSky #pedsky #publichealth #Acuterheumaticfever (ARF) & associated rheumatic heart disease are serious sequelae after infection with group A Streptococcus (Strep A). #Autoantibodies are thought to contribute to pathogenesis,
@insight.jci.org
insight.jci.org/articles/vie...
Research Article
Anti-Integrin αvβ6 Autoantibodies as a Biomarker for Ulcerative Colitis in Patients With Axial Spondyloarthritis
📖 www.jrheum.org/cgi/content/...
@schroeder-uhn.bsky.social @uhn.ca @uoftmedicine.bsky.social
#AnkylosingSpondylitis #Autoantibodies
www.scilit.com/publications...
An indirect ELISA was developed using the multi-epitope ACE2 antigen to quantify anti-ACE2 #autoantibodies in serum samples. This assay was applied to blood samples from individuals with newly diagnosed T1DM from #postCOVID ,
Mendelian susceptibility to mycobacterial disease: Clinical, immunological, and genetic study in India. New study from Aparna Dalvi, Manisha Madkaikar (Indian Council of Medical Research National Institute of Immunohaematology) and colleagues: rupress.org/jhi/article/...
#Infections #Autoantibodies
This study shows that the anti-CD38 #antibody #CM313 is well tolerated in #SystemicLupusErythematosus & delivers dose-dependent benefits, reduced #autoantibodies, and improved complement levels, supporting further clinical development.
#FeaturedArticle #STTT: doi.org/10.1038/s413...
Predisposición genética elevada a diabetes tipo 1 medida c/escala de riesgo genético a partir de polimorfismos de nucleótido único se asocia c/positividad a autoanticuerpos del islote y diabetes tipo 1 presintomática en adultos #T1D #adults #autoantibodies www.thelancet.com/journals/lan...
Left: −log10(P value) of the log-binomial regression for the presence of plasma MTBD-tau IgG autoantibodies for 276 disorders according to ICD-10 codes and adjusted for age and sex. Triangles pointing upwards and downwards: positive and negative coefficients, respectively; gray dashed line: P < 0.05 after Bonferroni correction (here and henceforth). P values significant after Bonferroni adjustment are labeled with the ICD codes. Right: −log10(P value) of the log-binomial regression for the presence of plasma MTBD-tau IgG autoantibodies and clinical laboratory parameters P values significant after Bonferroni adjustment are labeled with the clinical laboratory parameters. eGFR CKD-EPI 2009: estimated glomerular filtration rate using the Chronic Kidney Disease Epidemiology Collaboration 2009 equation; eGFR BIS1: estimated glomerular filtration rate using the older adults Berlin Initiative Study 1 equation. INR: international normalized ratio. LDL: low-density lipoprotein. HDL: high-density lipoprotein.
What is the role of anti-tau autoantibodies in disease? A screen of 40,497 human plasma samples reveals that anti- #tau #autoantibodies are highly prevalent, increase with age, and are associated with #kidney & #urinary disorders but not #neurological disease @plosbiology.org 🧪 plos.io/43XXwsZ
Left: −log10(P value) of the log-binomial regression for the presence of plasma MTBD-tau IgG autoantibodies for 276 disorders according to ICD-10 codes and adjusted for age and sex. Triangles pointing upwards and downwards: positive and negative coefficients, respectively; gray dashed line: P < 0.05 after Bonferroni correction (here and henceforth). P values significant after Bonferroni adjustment are labeled with the ICD codes. Right: −log10(P value) of the log-binomial regression for the presence of plasma MTBD-tau IgG autoantibodies and clinical laboratory parameters P values significant after Bonferroni adjustment are labeled with the clinical laboratory parameters. eGFR CKD-EPI 2009: estimated glomerular filtration rate using the Chronic Kidney Disease Epidemiology Collaboration 2009 equation; eGFR BIS1: estimated glomerular filtration rate using the older adults Berlin Initiative Study 1 equation. INR: international normalized ratio. LDL: low-density lipoprotein. HDL: high-density lipoprotein.
What is the role of anti-tau autoantibodies in disease? A screen of 40,497 human plasma samples reveals that anti- #tau #autoantibodies are highly prevalent, increase with age, and are associated with #kidney & #urinary disorders but not #neurological disease @plosbiology.org 🧪 plos.io/43XXwsZ
Left: −log10(P value) of the log-binomial regression for the presence of plasma MTBD-tau IgG autoantibodies for 276 disorders according to ICD-10 codes and adjusted for age and sex. Triangles pointing upwards and downwards: positive and negative coefficients, respectively; gray dashed line: P < 0.05 after Bonferroni correction (here and henceforth). P values significant after Bonferroni adjustment are labeled with the ICD codes. Right: −log10(P value) of the log-binomial regression for the presence of plasma MTBD-tau IgG autoantibodies and clinical laboratory parameters P values significant after Bonferroni adjustment are labeled with the clinical laboratory parameters. eGFR CKD-EPI 2009: estimated glomerular filtration rate using the Chronic Kidney Disease Epidemiology Collaboration 2009 equation; eGFR BIS1: estimated glomerular filtration rate using the older adults Berlin Initiative Study 1 equation. INR: international normalized ratio. LDL: low-density lipoprotein. HDL: high-density lipoprotein.
What is the role of anti-tau autoantibodies in disease? A screen of 40,497 human plasma samples reveals that anti- #tau #autoantibodies are highly prevalent, increase with age, and are associated with #kidney & #urinary disorders but not #neurological disease @plosbiology.org 🧪 plos.io/43XXwsZ
"My #RedBloodCell count was also lower than my baseline, so the #orthopedic team decided to give me a #BloodTransfusion. As always, finding a single pack of blood for me is difficult as I am O negative with #autoantibodies.": buff.ly/xwPghb1
#surgery
"In summary, #SLE-associated #autoantibodies are present in patients with other immunological diseases, especially [ #SjogrensSyndrome ] patients, and have a major impact on diagnostic efficiency.": buff.ly/1HtFAz4
#SjogrensDisease #lupus #MedSky
via @nature.com
In @jhumimmunity.org, Gervais, Borghesi, Casanova, and Zhang review how #autoantibodies neutralizing antiviral type I IFNs underlie a small but growing number of severe #arboviral diseases. Genetic defects of type I IFN immunity may underlie other unexplained cases. rupress.org/jhi/article/...
Gervais, @esibor.bsky.social, @casanovalab.bsky.social, and Zhang review how #autoantibodies neutralizing antiviral type I IFNs underlie a small but growing number of severe #arboviral diseases. Genetic defects of type I IFN immunity may underlie other unexplained cases. rupress.org/jhi/article/...
The study’s authors call for further research to investigate the function of these #autoantibodies and their potential for diagnostic or therapeutic applications.
🔑 findings:
- The study identified #autoantibodies targeting arginine-rich (poly-R) peptides in human proteins with sequences similar to
#Medsky🧪 #IDsky #immunology #publichealth This exploratory study identify #autoantibodies directed against EBV mimicking arginine rich sequences in human proteins,suggesting a potential role for molecular mimicry in the pathogenesis of PCS / #Longcovid & ME/CFS.
www.frontiersin.org/journals/imm...
can lead to the formation of #autoantibodies that attack kidney tissue. This can trigger new-onset autoimmune kidney diseases like #vasculitis.
- Direct viral infection: The virus enters kidney cells through the ACE2 receptor,
#Medsky🧪 #IDsky #immunosky #publichealth A study investigated host autoreactivities in #COVID & their links with severe #COVID & the neutralising antibody response. It found circulating #autoantibodies in the serum of unvaccinated #COVID patients .
Today’s question!
Check out the answer on the next slide along with its explanation.
#AcquiredHemophiliaA #BleedingDisorders #Autoantibodies #ThrombinGeneration #Hematology #RareDiseases @rarediseasectn.bsky.social @rarediseasesint.bsky.social @vjhemonc.bsky.social @bsochaem.bsky.social
