Woman With 3 Autoimmune Diseases Enters Remission After Immune 'Reset' A patient with three different autoimmune diseases has entered complete remission after undergoing an experimental treatment that effectively reset her immune system.

A patient with three different autoimmune diseases has entered complete remission after undergoing an experimental treatment that effectively reset her immune system. #idsky #immunosky #medsky

⏰ 🏃‍➡️A quick reminder that the abstract submission & early bird registration deadline for AIRR Community Meeting VIII: Decoding and Recoding Immunity is April 15.
🔗 tinyurl.com/airrcmeeting8

#airrc8 #immunosky

Meet the editors: Kathryn Else @kathelse.bsky.social

My PhD was on the immunogenetics of Trichuris infection and I haven't looked back since! Over the last decade, I have been developing model systems that embrace the environmental variation to study immune responses to infection.

#ImmunoSky

There’s still time to register for the upcoming @eosinophilsoc.bsky.social webinar!

#immunosky #medsky 🧪 #scisky

Graphic abstract

#Medsky🧪 #IDsky #pedsky #immunosky #pedsky #publichealth Using random forest analysis, The study determined that myeloid CCR6 expression levels can identify pediatric #longCOVID with 79% accuracy.

#Medsky🧪 #immunosky #publichealth The advent of highly refined wheat products has reduced fiber consumption, which is associated with increased risk for IBD.

#Medsky🧪 #IDsky #immunosky #publichealth #Vaccinesmatter BNT162b2 vaccination provided substantial protection & robust antibody responses among LTC residents, including those of very advanced age, supporting the effectiveness of mRNA vaccination in highly vulnerable institutionalised populations

#Medsky🧪 #IDsky #immunosky #publichealth The E protein is known to localize to the ER & ERGIC membranes with M . Both E & M are required for viral budding, working together to induce membrane curvature and the budding off of them ERGIC membrane

High-fat diet causes rapid loss of intestinal group 3 innate lymphoid cells through microbiota-driven inflammation and mitochondrial stress Group 3 innate lymphoid cells (ILC3s) are key sensors of the intestinal environment, integrating dietary and microbial cues to maintain intestinal imm…

High-fat #diet causes rapid loss of intestinal group 3 innate lymphoid cells through #microbiota -driven inflammation & mitochondrial stress

Dietary fats and microbes trigger ILC3 metabolic failure & death, disrupting intestinal homeostasis
www.sciencedirect.com/science/arti... #ImmunoSky #MicroSky

Acute and chronic infections drive distinct trajectories in human memory CD4+ T cell formation.

CD4⁺ T cell fates in #HCV differ by outcome, revealing distinct chronic, cleared, and cured memory paths.

www.sciencedirect.com/science/arti... #hepatitis #immunology #MicroSky #ImmunoSky

Men die more often from infections, while women are more prone to autoimmune diseases, partly due to sex hormones' effects on the immune system.

"Yet preclinical testing still relies heavily on single-sex inbred mice, collapsing human diversity into a single genetic line."

#immunosky

#Medsky🧪 #IDsky #episky #microsky #pedsky #immunosky #publichealth #Vaccinesmatter Vaccination prevents an estimated 4.5 mil deaths annually and has saved approximately 154 mil lives since the expanded programme on immunisation began over 50 years ago

#Medsky🧪 #IDsky #oncosky #immunosky #publichealth #vaccinesarematter @jama.com In a cohort of 76 807 patients with cancer, no significant elevation in overall risk of postacute sequelae compatible with long COVID was observed among those infected with the #SARSCoV’2

Man creates a bespoke mRNA vaccine to treat his dog's cancer with the help of AI.
#Immunosky
🧪

#Medsky🧪 #Neurosky #immunosky #pedsky #publichealth The findings expand on those of the previous reported studies, by demonstrating that recessive variants in RNU2-2 cause a distinct & surprisingly prevalent disorder - recessive ReNU2 syndrome

Figure 1 from the paper: "Schematic representation of bioinformatics pipelines that implement computational modelling (mechanistic or Artificial Intelligence/Machine Learning driven) to develop Digital Twins for target identification and drug development for immune-mediated disorders. AI, artificial intelligence; DL, deep learning; DT, digital twins; ML, machine learning; ODE, ordinary differential equation."

🆕 review! Anna Niarakis and Philippe Moingeon explore how #DigitalTwin technology can accelerate precision medicine for immune-related pathologies. They highlight recent advances and outline future directions for the field.

#Immunosky

#Medsky🧪 #IDsky #immunosky #episky #publichealth
Nearly 5 years after #COVID began ~ 5.3% of 🇺🇸 adults were experiencing #LongCOVID ; 1-in-4 of them consistently report significant activity limitations from its symptoms Disability accounts for most LC diseases burden,

@cleeterichter.bsky.social will present this preprint today in #preprinthub2! ⚡️🚦🐁 #immunosky @ucsdhealthsci.bsky.social

New Journal for ImmunoTherapy of Cancer article: "Intratumoral PD-1-directed IL-2 expression via oncolytic vaccinia virus elicits superior antitumor effects with enhanced safety" https://jitc.bmj.com/content/14/3/e011340🧪

New Journal for ImmunoTherapy of Cancer article: "Intratumoral PD-1-directed IL-2 expression via oncolytic vaccinia virus elicits superior antitumor effects with enhanced safety" jitc.bmj.com/content/14/3...

#JITC #immunosky

Infographic

#Medsky🧪#IDsky #immunosky #publichealth The study find different individual #Mycobacterium #tuberculosis antigens induce distinct #Tcell responses, with important implications for TB #vaccine development.
@insight.jci.org
insight.jci.org/articles/vie...

#Medsky🧪 #IDsky #Immunosky #publichealth PDLIM2, a PDZ-LIM domain-containing protein expressed highest in the lung and immune cells, serves as a unique tumor suppressor & immune modulator,

#Medsky🧪 #iDsky #immunosky #Publichealth This trial addresses a critical gap in #LongCOVID management by providing the largest source of evidence to guide medical care for #POTS in LC patients
- Specific Interventions & Their Rationale
N

FEBS Press Using 1H NMR metabolomics, we measured polar and lipid metabolites from human blood neutrophils from people with frailty (n = 31, mean age 84Y), people with rheumatoid arthritis (n = 16, mean age 55Y...

New paper from @gnna.bsky.social investigating altered neutrophil metabolism in healthy ageing & frailty. We found signatures of neutrophil activation, lipid metabolism & oxidative stress. #immunosky
@vivensa.bsky.social @livuni-ilcams.bsky.social

febs.onlinelibrary.wiley.com/doi/10.1111/...

Glibenclamide attenuates neuronal #pyroptosis by modulating KATP channels in the hippocampus of palmitic acid-induced lipotoxic mice

www.sciencedirect.com/science/arti... #OpenAccess #inflammasome #inflammation #immunology #ImmunoSky #MedSky

Disease-Attenuated Pneumococcal Biosynthesis Gene Mutants Invade the Mucosal Epithelium and Induce Innate Immunity Mutations in Streptococcus pneumoniae biosynthesis genes had impacts on virulence, oxidative stress, and metabolism. Mutants retained their microinvasive a

Epithelial host pathogen interactions are complex!

Happy to have contributed to this work, showing how mutations in Streptococcus pneumoniae biosynthesis genes results in divergent phenotyoic effects and host transcriptional responses (the bit I did!)

#IDSky #immunosky

@jidjournal.bsky.social

Call for reviewers. Become an ad hoc reviewer for the BSI journals. British Society for Immunology. Oxford University Press.

Discover benefits available when you become a peer reviewer for the @britsocimm.bsky.social journals, including a chance work with immunology experts to advance research.

🔗 oxford.ly/4sz3vPa

#ImmunoSky @ceijournal.bsky.social @imtadvances.bsky.social @discovimmunol.bsky.social

#Medsky🧪 #IDsky #Immunosky #publichealth #Longcovid & inflammation .
Across the retrieved evidence, there is clear support for a mechanistic link between elevated BMI, reduced gray matter volume (GMV), and peripheral inflammation in #postCOVID condition (PCC).

#Medsky🧪 #IDsky #immunosky #publichealth This study reveals that #SARSCoV2 nonspike structural proteins— specifically the Envelope (E), Membrane (M) & Nucleocapsid (N) proteins—directly hijack mucosal epithelial cell fate through a "double hijack" mechanism.

Early Detection and Surveillance of the SARS-CoV-2 ... This report describes early detection and surveillance ...

#Medsky🧪 #IDsky #immunosky The #SARSCoV2 variant BA.3.2, a highly divergent lineage of the Omicron variant, was first detected in South Africa .it has been reported in at least 23 countries worldwide, following a notable ⏫️ in detections starting in Sep 2025.

www.cdc.gov/mmwr/volumes....

Here here for retiring an often overgeneralized M1-M2 binary phenotypic framework. #macrophages express an incredible large array of sensome receptors that allow them to tailor their phenotype and reactions to the needs of incredibly local environments. #neuroskyence #immunosky #glia