#Medsky🧪 #IDsky #immunosky #publichealth Immune dysregulation in prolonged #LongCOVID is increasingly understood as a state of chronic, low-grade inflammation driven by a dysfunctional immune system rather than an active, high level viral infection.
#Medsky🧪 #IDsky #immunosky #publichealth
Growing evidence suggests that chronic disruption of mitochondrial function occurs in long COVID. Survivors of #COVID infection often report chronic symptoms such as fatigue, low tolerance to exercise, neurocognitive dysfunction,
#Medsky🧪 #pedsky #obsky #immunosky #IDsky #Vaccinematters #publichealth
The #COVID19pandemic has raised critical questions about the impact of maternal #SARSCoV2 infection during pregnancy on both passive immunity in newborns & subsequent child neurodevelopment.
NMCR-6, a novel nonmobile colistin resistance gene in Vibrio bacteria: full characterization and global perspective
Researchers identify NMCR-6 as a chromosomal #PolymyxinResistance determinant in #Vibrio species, mapping its global spread and drivers, offering insights to predict emerging #ColistinResistance threats.
#OpenAccess: doi.org/10.1016/j.dc...
#EpiSky #ImmunoSky #Bioinformatics #PublicHealth
A patient with three different autoimmune diseases has entered complete remission after undergoing an experimental treatment that effectively reset her immune system. #idsky #immunosky #medsky
⏰ 🏃➡️A quick reminder that the abstract submission & early bird registration deadline for AIRR Community Meeting VIII: Decoding and Recoding Immunity is April 15.
🔗 tinyurl.com/airrcmeeting8
#airrc8 #immunosky
Meet the editors: Kathryn Else @kathelse.bsky.social
My PhD was on the immunogenetics of Trichuris infection and I haven't looked back since! Over the last decade, I have been developing model systems that embrace the environmental variation to study immune responses to infection.
#ImmunoSky
There’s still time to register for the upcoming @eosinophilsoc.bsky.social webinar!
#immunosky #medsky 🧪 #scisky
Graphic abstract
#Medsky🧪 #IDsky #pedsky #immunosky #pedsky #publichealth Using random forest analysis, The study determined that myeloid CCR6 expression levels can identify pediatric #longCOVID with 79% accuracy.
#Medsky🧪 #immunosky #publichealth The advent of highly refined wheat products has reduced fiber consumption, which is associated with increased risk for IBD.
#Medsky🧪 #IDsky #immunosky #publichealth #Vaccinesmatter BNT162b2 vaccination provided substantial protection & robust antibody responses among LTC residents, including those of very advanced age, supporting the effectiveness of mRNA vaccination in highly vulnerable institutionalised populations
#Medsky🧪 #IDsky #immunosky #publichealth The E protein is known to localize to the ER & ERGIC membranes with M . Both E & M are required for viral budding, working together to induce membrane curvature and the budding off of them ERGIC membrane
High-fat #diet causes rapid loss of intestinal group 3 innate lymphoid cells through #microbiota -driven inflammation & mitochondrial stress
Dietary fats and microbes trigger ILC3 metabolic failure & death, disrupting intestinal homeostasis
www.sciencedirect.com/science/arti... #ImmunoSky #MicroSky
Acute and chronic infections drive distinct trajectories in human memory CD4+ T cell formation.
CD4⁺ T cell fates in #HCV differ by outcome, revealing distinct chronic, cleared, and cured memory paths.
www.sciencedirect.com/science/arti... #hepatitis #immunology #MicroSky #ImmunoSky
Men die more often from infections, while women are more prone to autoimmune diseases, partly due to sex hormones' effects on the immune system.
"Yet preclinical testing still relies heavily on single-sex inbred mice, collapsing human diversity into a single genetic line."
#immunosky
#Medsky🧪 #IDsky #episky #microsky #pedsky #immunosky #publichealth #Vaccinesmatter Vaccination prevents an estimated 4.5 mil deaths annually and has saved approximately 154 mil lives since the expanded programme on immunisation began over 50 years ago
#Medsky🧪 #IDsky #oncosky #immunosky #publichealth #vaccinesarematter @jama.com In a cohort of 76 807 patients with cancer, no significant elevation in overall risk of postacute sequelae compatible with long COVID was observed among those infected with the #SARSCoV’2
Man creates a bespoke mRNA vaccine to treat his dog's cancer with the help of AI.
#Immunosky
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#Medsky🧪 #Neurosky #immunosky #pedsky #publichealth The findings expand on those of the previous reported studies, by demonstrating that recessive variants in RNU2-2 cause a distinct & surprisingly prevalent disorder - recessive ReNU2 syndrome
Figure 1 from the paper: "Schematic representation of bioinformatics pipelines that implement computational modelling (mechanistic or Artificial Intelligence/Machine Learning driven) to develop Digital Twins for target identification and drug development for immune-mediated disorders. AI, artificial intelligence; DL, deep learning; DT, digital twins; ML, machine learning; ODE, ordinary differential equation."
🆕 review! Anna Niarakis and Philippe Moingeon explore how #DigitalTwin technology can accelerate precision medicine for immune-related pathologies. They highlight recent advances and outline future directions for the field.
#Immunosky
#Medsky🧪 #IDsky #immunosky #episky #publichealth
Nearly 5 years after #COVID began ~ 5.3% of 🇺🇸 adults were experiencing #LongCOVID ; 1-in-4 of them consistently report significant activity limitations from its symptoms Disability accounts for most LC diseases burden,
@cleeterichter.bsky.social will present this preprint today in #preprinthub2! ⚡️🚦🐁 #immunosky @ucsdhealthsci.bsky.social
New Journal for ImmunoTherapy of Cancer article: "Intratumoral PD-1-directed IL-2 expression via oncolytic vaccinia virus elicits superior antitumor effects with enhanced safety" https://jitc.bmj.com/content/14/3/e011340🧪
New Journal for ImmunoTherapy of Cancer article: "Intratumoral PD-1-directed IL-2 expression via oncolytic vaccinia virus elicits superior antitumor effects with enhanced safety" jitc.bmj.com/content/14/3...
#JITC #immunosky
Infographic
#Medsky🧪#IDsky #immunosky #publichealth The study find different individual #Mycobacterium #tuberculosis antigens induce distinct #Tcell responses, with important implications for TB #vaccine development.
@insight.jci.org
insight.jci.org/articles/vie...
#Medsky🧪 #IDsky #Immunosky #publichealth PDLIM2, a PDZ-LIM domain-containing protein expressed highest in the lung and immune cells, serves as a unique tumor suppressor & immune modulator,
#Medsky🧪 #iDsky #immunosky #Publichealth This trial addresses a critical gap in #LongCOVID management by providing the largest source of evidence to guide medical care for #POTS in LC patients
- Specific Interventions & Their Rationale
N
New paper from @gnna.bsky.social investigating altered neutrophil metabolism in healthy ageing & frailty. We found signatures of neutrophil activation, lipid metabolism & oxidative stress. #immunosky
@vivensa.bsky.social @livuni-ilcams.bsky.social
febs.onlinelibrary.wiley.com/doi/10.1111/...
Glibenclamide attenuates neuronal #pyroptosis by modulating KATP channels in the hippocampus of palmitic acid-induced lipotoxic mice
www.sciencedirect.com/science/arti... #OpenAccess #inflammasome #inflammation #immunology #ImmunoSky #MedSky
Epithelial host pathogen interactions are complex!
Happy to have contributed to this work, showing how mutations in Streptococcus pneumoniae biosynthesis genes results in divergent phenotyoic effects and host transcriptional responses (the bit I did!)
#IDSky #immunosky
@jidjournal.bsky.social
Call for reviewers. Become an ad hoc reviewer for the BSI journals. British Society for Immunology. Oxford University Press.
Discover benefits available when you become a peer reviewer for the @britsocimm.bsky.social journals, including a chance work with immunology experts to advance research.
🔗 oxford.ly/4sz3vPa
#ImmunoSky @ceijournal.bsky.social @imtadvances.bsky.social @discovimmunol.bsky.social
