This study provides a comprehensive overview of #Nanoparticle-based #Phototherapy systems, detailing their molecular mechanisms and diverse clinical applications in #Oncology to enhance #PrecisionMedicine. @dalhousie.bsky.social

#STTT #OpenAccess: doi.org/10.1038/s413...

This #STTT study reveals that the Spi-1 #ProtoOncogene regulates mRNA hypertranscription to drive malignant progression in #HNSCC, offering a novel #TherapeuticTarget for hypertranscriptional HNSCC subtypes.

#OpenAccess: doi.org/10.1038/s413...

m6A-modified circArhgap26 attenuates cardiac I/R injury by suppressing plakophilin-1 palmitoylation, maintaining desmosome integrity and #Cardiomyocyte survival, offering a novel #TherapeuticTarget in #MyocardialInjury.

#STTT #OpenAccess: doi.org/10.1038/s413...

Researchers developed P8D NPs as a chemo-photothermal synergistic platform to ignite systemic #AntitumorImmunity via #Ferroptosis, providing a potent approach to enhance therapeutic efficacy against "cold" tumors.

#STTT #OpenAccess: doi.org/10.1038/s413...

DUSP6 ablation rescues CAR T-cell dysfunction impaired by CD58 loss by activating AP-1 signaling, thereby providing a potent genetic strategy to enhance the efficacy of adoptive cellular #Immunotherapy.

#STTT #OpenAccess: doi.org/10.1038/s413...

In this study, researchers developed a conductive coordination #Nanozyme prodrug that triggers synergistic #Pyroptosis, #Cuproptosis, and #Ferroptosis to elicit potent in situ #CancerVaccination and systemic #AntitumorImmunity.

#STTT #OpenAccess: doi.org/10.1038/s413...

This #STTT review discusses the molecular mechanisms and therapeutic landscape of #MitochondrialDiseases, highlighting how targeted interventions in mitochondrial function provide a promising avenue for clinical treatment.

#OpenAccess: doi.org/10.1038/s413...

This study presents a low-input redoxomics platform to identify metabolic regulators of #OxidativeStress in the gut, highlighting how advanced #MetabolicProfiling improves the detection of redox-active molecules.

#STTT #OpenAccess: doi.org/10.1038/s413...

This #STTT review examines the regulation and therapeutic potential of pattern recognition receptors, highlighting targeting innate immune sensing as a potential therapeutic strategy in inflammatory & immune-related diseases.

#OpenAccess: doi.org/10.1038/s413...

An overview of the mucosal #ImmuneResponse in health and disease, highlighting how modulation of mucosal immunity is a promising avenue for novel disease prevention and therapeutic interventions. #Vaccines

#STTT #OpenAccess: doi.org/10.1038/s413...

An overview of how dysregulated epigenetic networks influence #CancerTherapy resistance and how targeting #Epigenetic regulators in combination with conventional therapies is a potential therapeutic strategy.

#STTT #OpenAccess: doi.org/10.1038/s413...

This #STTT study reviews how the regulatory reforms and global alignment have accelerated innovative drug development in China, improving approval efficiency and expanding its role in global pharmaceutical innovation.

#OpenAccess: doi.org/10.1038/s413...

A phase I #ClinicalTrial evaluating the efficacy & safety of IBI351 monotherapy in Chinese patients with KRASG12C-mutated #Metastatic #ColorectalCancer shows a manageable safety profile. highlighting its potential as a #TherapeuticTarget.

#STTT #OpenAccess: doi.org/10.1038/s413...

This phase 2 #ClinicalTrial evaluates genetic subtype-guided immunochemotherapy for relapsed diffuse large B cell lymphoma, highlighting how molecular stratification improves clinical outcomes and survival rates in patients.

#STTT #OpenAccess: doi.org/10.1038/s413...

Dysregulated astrocytic #GABA signaling contributes to #PTSD pathology while pharmacological inhibition of MAOB restores GABA balance and improves fear-extinction behavior in experimental models.

#STTT #OpenAccess: doi.org/10.1038/s413...

A large-scale single-cell #Transcriptome atlas reveals the complex immune landscape of #BacterialPneumonia, identifying distinct macrophage and neutrophil dynamics that contribute to #LungInflammation and repair.

#STTT #OpenAccess: doi.org/10.1038/s413...

This #STTT study explores how fatty-acid signaling modulation restores #Allopregnanolone homeostasis, highlighting lipid-mediated pathways as potential targets for regulating GABAergic signaling and treating #Anxiety disorders.

#OpenAccess: doi.org/10.1038/s413...

This #STTT study shows that activation of the cGMP–PKG signaling pathway attenuates #AorticValveCalcification by promoting ULK1-mediated #Autophagy, which suppresses #Osteogenic differentiation in valvular interstitial cells.

#OpenAccess: doi.org/10.1038/s413...

This review explores the regulatory mechanisms of biomolecular condensates in cellular homeostasis and diseases, highlighting the therapeutic potential of "C-mods" in targeting these structures in #Cancer and #Neurodegeneration.

#STTT #OpenAccess: doi.org/10.1038/s413...

This #STTT review elucidates the applications of radiopharmaceuticals in #MolecularImaging & targeted #RadionuclideTherapy, discussing how recent advancements in ligand design enhance diagnostic & therapeutic outcomes. #Medsky

#OpenAccess: doi.org/10.1038/s413...

Summarizing the mechanisms underlying ferroptosis and the cellular defence systems that limit lipid peroxidation, highlighting the role of NADPH-dependent antioxidant pathways and their implications in cancer and neurodegenerative diseases.

#STTT #OpenAccess: doi.org/10.1038/s413...

This #STTT review delineates the critical signaling pathways of #NuclearReceptors in human health and disease, discussing the emerging pharmaceutical strategies to modulate these targets for diverse clinical applications.

#OpenAccess: doi.org/10.1038/s413...

This #STTT review outlines #ImmuneEvasion mechanisms in #Cancer, including checkpoint activation and #TumorMicroenvironment-mediated suppression, and discusses emerging therapeutic approaches for enhancing anti-tumor immunity.

#OpenAccess: doi.org/10.1038/s413...

This review examines the origin, functional diversity, and disease relevance of cytotoxic CD4+ T cells and discusses their emerging potential as #Immunotherapeutic targets in #Cancer, infectious, and #AutoimmuneDiseases.

#STTT #OpenAccess: doi.org/10.1038/s413...

This phase 1 pilot study shows that a combinatorial #AAV8-hFVIII-V3 and tacrolimus-#Glucocorticoid achieves therapeutic FVIII activity in severe #HemophiliaA, with reduced bleeding rates & effective immune modulation.

#STTT #OpenAccess: doi.org/10.1038/s413...

This study investigates how USP11-mediated stabilization of KDM5B drives #Chemoresistance in #OvarianCancer by repressing DUSP4, uncovering a novel #Epigenetic mechanism with potential therapeutic implications.

#STTT #OpenAccess: doi.org/10.1038/s413...

This #STTT study demonstrates that combining irreversible electroporation with GPC3-targeted CAR-NK cells reshapes the tumor microenvironment and synergistically enhances antitumor efficacy in #HepatocellularCarcinoma models.

#OpenAccess: doi.org/10.1038/s413...

A nature-inspired confined cascade enzyme #Nanoreactor integrating multiple #Nanozyme activities within a #Biomimetic platform modulates inflammatory plaque microenvironments and inhibits #FoamCell formation in #Atherosclerosis.

#STTT #OpenAccess: doi.org/10.1038/s413...

This study highlights the efficacy of #Claudin18.2-targeted IL-7/XCL1 armored CAR-T cells, demonstrating enhanced tumor regression and immune remodeling in preclinical and clinical #DigestiveTractCancer models.

#STTT #OpenAccess: doi.org/10.1038/s413...

This review summarizes the molecular drivers of #Osteoarthritis and highlights innovative therapeutic strategies, including #GeneTherapy and stem cell interventions, to enhance joint regeneration and improve disease outcomes.

#STTT #OpenAccess: doi.org/10.1038/s413...