Distinct metabolic signatures of Alzheimer's and Parkinson's disease revealed through genetic overlap AD and PD are shaped by fundamentally distinct metabolic-genetic architectures. Metabolically targeted interventions, particularly those modulating lipid, amino acid, and proglucagon pathways, may require disease-specific and genetically informed strategies for prevention and treatment of neurodegenerative diseases.

Metabolic dysfunction is a risk factor for neurodegeneration, but do Alzheimer’s and Parkinson’s share the same underlying biology? 🧠 New research suggests they do not, pointing to fundamentally different metabolic-genetic architectures. #Alzheimers #ParkinsonsDisease #Neurodegeneration

Systematic discovery of disease-modifying targets by prediction from knowledge graph-based AI model and experimental validation: Parkinson’s disease case The development of disease-modifying therapies (DMTs) for Parkinson’s disease (PD) remains a critical unmet need. Despite extensive research efforts, no therapy capable of slowing or halting PD progre...

A new AI-driven study identified and experimentally validated disease-modifying targets for Parkinson's Disease.

Offering a smarter path to understanding ASyn aggregation. Research conducted using rPeptide's Alpha-Synuclein.

t.ly/tRDKu

#Parkinsons #AlphaSynuclein #Neuroscience #Neurodegeneration

Alzheimer's starts with stalled cargo trucks. Electric fields freeze kinesin motors hauling supplies along your neurons—blocking transport keeping brain cells alive. Průša & Cifra (2019) https://doi.org/10.1038/s41598-019-56052-3 #academicsky #neurodegeneration

Identification of platelet-derived biomarker in a cohort of Parkinson's disease

#Platelet modules mirror #SubstantiaNigra changes in #ParkinsonsDisease, with CRLF3 and LRRC37A2 emerging as non-invasive #biomarkers linking chromatin and immune pathways, advancing PD diagnosis and #Neurodegeneration insights. @pku1898.bsky.social
Read: doi.org/10.1016/j.ge...

fundraising time! any useful biomedical angel investor resources or links floating around these parts? our focus is novel biomarkers of epilepsy & neurodegenation #investing #startup #startups #biomedical #neuromedical #medicine #biotech #biomed #neuroscience #epilepsy #neurodegeneration #biomarker

#askfedi any useful biomedical angel investor resources or links floating around these parts? our focus is novel biomarkers of epilepsy & neurodegenation #investing #startup #startups #biomedical #neuromedical #medicine #biotech #biomed #neuroscience #epilepsy #neurodegeneration #biomarker

8/9 Final card: STING agonists (Flagship preview)
9/9 #TAC #Alzheimers #Neurodegeneration

A new The Scientist feature revisits the long, strange history of Annovis’ lead drug candidate as its Phase 3 Alzheimer’s trial moves forward.

Link as first comment.

#longevity #alzheimers #neurodegeneration #biotech #clinicaltrials

🚨 Last chance to register for the LC Meeting 2026!

Registration closes April 15th. Rooms at the conference venue are first come, first served. Late registration is open until end of May.

Register: www.uibk.ac.at/de/congress/...

#LocusCoeruleus #Neuroscience #Neurodegeneration #LCMeeting2026

From Heatwaves to Brainwaves: Climate-Driven Microplastics Promote Epstein–Barr Virus Reactivation and Female-Biased Risk for Alzheimer’s Disease and Multiple Sclerosis Background Climate change accelerates plastic degradation, increasing human exposure to microplastics and their associated endocrine-disrupting additives, thereby reshaping the chemical exposome. Many of these compounds, including bisphenols and phthalates, act as xenoestrogens capabl...

Climate‑driven #microplastic exposure may intersect with Epstein–Barr virus biology and endocrine pathways, potentially increasing female‑biased risk for Alzheimer’s and MS. 🌍🦠#EBV #Exposome #ClimateChange #Neurodegeneration
📄https://doi.org/10.21203/rs.3.rs-8928857/v1
👤EVBC member: Anna Onisiforou

A new @cellcellpress.bsky.social study of 2,279 brain samples reveals deep molecular diversity in #Neurodegeneration. By mapping #Proteomics & PTMs, we move closer to #PrecisionMedicine and improved stratification between seemingly similar neurodegenerative diseases.
www.cell.com/cell/fulltex...

A promotion for the 2026 ARVO+Genentech closing keynote in Denver, Colorado featuring a photo of the speaker, Sally Temple, PhD, Scientific Director at the Neural Stem Cell Institute. The event details are Thursday, May 7, from 10:15 to 11:30 am. Her presentation topic is “Modeling, Targeting and Healing: Stem Cell Strategies to Combat Neurodegeneration in the Brain and Eye.” The ARVO.org/keynotes webpage is listed for more information.

Explore #StemCell strategies to combat #neurodegeneration in the brain and eye with @arvoinfo.bsky.social+@genentech.bsky.social closing keynote Sally Temple, PhD (Neural Stem Cell Institute). Don't miss it on May 7 at #ARVO2026. Learn more: https://bit.ly/41Eg6EC

⭐️April is #GraduateStudentAppreciation Month! Highlighted 👉 Enna Selmanovic! Enna led @sinaitbi.bsky.social's "Late Effects of #TraumaticBrainInjury Project" w/ Dr. Kristen Dams-O'Connor. Now, in the Hof Lab, she investigates long term effects of TBI on cognition & post-traumatic #Neurodegeneration.

Review @jci.org @crick.ac.uk
Lysosomal homeostasis at the crossroads of #neurodegeneration
www.jci.org/articles/vie...

Researchers use AI to redesign antibody fragments that work inside human cells, opening a new angle on Alzheimer’s and neurodegeneration.

Link as first comment.

#longevity #geroscience #alzheimers #neurodegeneration #biotech

@universityofessex.bsky.social

Alpha-Synuclein Preformed Fibrils Buy high-quality Alpha-Synuclein Preformed Fibrils (PFF) for research use. rPeptide offers recombinant peptides and proteins ideal for scientific and laboratory research studies.

Check out our Alpha-Synuclein Preformed Fibrils (ASF-1001) for your research needs!

t.ly/DrNEI

#Neuroscience #AlphaSynuclein #Fibrils #PFF #ParkinsonsResearch #Neurodegeneration #rPeptide

Excited to share this collaborative work with Ward and Petrucelli Labs!

We show that two major genetic risk factors for #neurodegeneration and cognitive decline converge on TMEM106B fibrils accumulating within lysosomes.

A LOT of work packed in here 🧠🔬

Preprint: www.biorxiv.org/content/10.6...

This review highlights #mitochondrialDNAdamage as a driver of #neurodegeneration and explores emerging base editing tools, including #ZFNs and DdCBE, as promising strategies for studying and treating mitochondrial and #NeurodegenerativeDiseases.

#OpenAccess: doi.org/10.1016/j.ge...

#Tubulin #prevents toxic #protein #clumps in the brain, fighting back against #neurodegeneration

A potential new way may fight against #Alzheimer's & #Parkinson's diseases, linked to the toxic accumulation of Tau & alpha synuclein protein clumps... scitechupdates.com/t...

Company Updates: Spring 2026 | StressMarq StressMarq’s product development is driven by an ongoing dialogue between our scientists & the research community. Learn about our new products for Spring 2026.

🌱 StressMarq is excited to welcome spring with a fresh lineup of #AlphaSynuclein, #Tau, and #AmyloidBeta products.

🔎 Discover our approach to product innovation, upcoming conferences, and our ongoing commitment to advancing #neurodegeneration research worldwide 🌸 https://bit.ly/40VPtLf

This review highlights how #GlutathioneSTransferases regulate detoxification and #homeostasis, with dysregulation or polymorphisms driving #cancer, #neurodegeneration, and #chemoresistance, highlighting them as precision therapeutic targets. @qu_uni

Read: doi.org/10.1016/j.ge...

MedChemExpress: Master of Bioactive Molecules | Inhibitors, Screening Libraries & Proteins MedChemExpress (MCE) provides 50,000+ selective Inhibitors and Recombinant Proteins with high purity and quality. Cited in 30,000+ publications by worldwide scientists.

This study was supported by a range of high-quality reagents from MedChemExpress, including:
#Lecanemab, #BafilomycinA1, #Chloroquine, #Pitstop2, DC-LC3in-D5, as well as multiple antibodies and recombinant proteins. www.medchemexpress.com

#AlzheimersDisease #Neurodegeneration

Disease-derived extract strongly activates TDP-43 aggregate seeding in a sensitive FRET-based biosensor. Top: The HEK293FRET cell line stably expressing the TDP-43 C-terminal domain (CTD, amino acids 262-414) fused to mClover3 and mRuby3 FRET pairs was used as a reporter of TDP-43 aggregation upon seeding with FTD extract, prepared as in S1A Fig. Image created in BioRender, Ayala, Y. (2026). Middle: de novo CTD aggregation in HEK293FRET cells treated with FTD seeds visualized by confocal fluorescence microscopy. As control, cells were treated with neurologically unaffected tissue extract. Bottom: High resolution images of aggregates in cells treated with FTD seeds as z-stacks with DAPI overlay generated with stimulated emission depletion (STED) microscopy. The white box corresponds to the enlarged region. Scale bar for microscopy images, 10 μm.

TDP-43 is implicated in #neurodegeneration, but how does its aggregation relate to dysfunction? @ayalalab.bsky.social &co develop a reporter & cellular model based on #TDP-43 aggregate seeding that captures both TDP-43 aggregation & loss of protein function @plosbiology.org 🧪 plos.io/4sxw0g9

Disease-derived extract strongly activates TDP-43 aggregate seeding in a sensitive FRET-based biosensor. Top: The HEK293FRET cell line stably expressing the TDP-43 C-terminal domain (CTD, amino acids 262-414) fused to mClover3 and mRuby3 FRET pairs was used as a reporter of TDP-43 aggregation upon seeding with FTD extract, prepared as in S1A Fig. Image created in BioRender, Ayala, Y. (2026). Middle: de novo CTD aggregation in HEK293FRET cells treated with FTD seeds visualized by confocal fluorescence microscopy. As control, cells were treated with neurologically unaffected tissue extract. Bottom: High resolution images of aggregates in cells treated with FTD seeds as z-stacks with DAPI overlay generated with stimulated emission depletion (STED) microscopy. The white box corresponds to the enlarged region. Scale bar for microscopy images, 10 μm.

TDP-43 is implicated in #neurodegeneration, but how does its aggregation relate to dysfunction? @ayalalab.bsky.social &co develop a reporter & cellular model based on #TDP-43 aggregate seeding that captures both TDP-43 aggregation & loss of protein function @plosbiology.org 🧪 plos.io/4sxw0g9

Research Showcase - Dr Sarah Faber - Music, Mathematics and the Ageing Brain Research Showcase - Dr Sarah Faber - Music, Mathematics and the Ageing Brain

Research Showcase - Dr Sarah Faber - Music, Mathematics and the Ageing Brain
Wednesday, Apr 8, 12:00 PM - 12:45 PM PDT

What can music and math tell us about how the brain adapts to ageing and #neurodegeneration.

Watch Online: communities.dementiaresearcher.nihr.ac.uk/c/events/res...

Discover the latest in MND research, clinical advances, and patient perspectives.

A must-attend for clinicians and neuroscientists looking to deepen their translational understanding.

Register here - www.bna.org.uk/events/mnd-m...

#Neuroscience #MotorNeuronDisease #Neurodegeneration

New preclinical data suggest Galimedix may have found more practical way to deliver Alzheimer’s treatment through a next-gen oral candidate.

Link as first comment.

#longevity #geroscience #alzheimers #oraltherapy #neurodegeneration

Disease-derived extract strongly activates TDP-43 aggregate seeding in a sensitive FRET-based biosensor. Top: The HEK293FRET cell line stably expressing the TDP-43 C-terminal domain (CTD, amino acids 262-414) fused to mClover3 and mRuby3 FRET pairs was used as a reporter of TDP-43 aggregation upon seeding with FTD extract, prepared as in S1A Fig. Image created in BioRender, Ayala, Y. (2026). Middle: de novo CTD aggregation in HEK293FRET cells treated with FTD seeds visualized by confocal fluorescence microscopy. As control, cells were treated with neurologically unaffected tissue extract. Bottom: High resolution images of aggregates in cells treated with FTD seeds as z-stacks with DAPI overlay generated with stimulated emission depletion (STED) microscopy. The white box corresponds to the enlarged region. Scale bar for microscopy images, 10 μm.

TDP-43 is implicated in #neurodegeneration, but how does its aggregation relate to dysfunction? @ayalalab.bsky.social &co develop a reporter & cellular model based on #TDP-43 aggregate seeding that captures both TDP-43 aggregation & loss of protein function @plosbiology.org 🧪 plos.io/4sxw0g9

This review explores the regulatory mechanisms of biomolecular condensates in cellular homeostasis and diseases, highlighting the therapeutic potential of "C-mods" in targeting these structures in #Cancer and #Neurodegeneration.

#STTT #OpenAccess: doi.org/10.1038/s413...

Last Friday we hosted Jens Christian Schwamborn (LCSB, Luxembourg) at Achucarro for a seminar on patient-specific in vitro models of neurodegeneration with brain organoids and assembloids. Thank you for sharing your research 👏.

#AchucarroSeminars #Neuroscience #Neurodegeneration #BrainResearch