ICIs transformed oncology—but ICIs-myocarditis is rare & fatal.

This review challenges the “troponin-centric” model and proposes a dynamic risk approach.

🔗 dr.clintile.com/article/doi/...

#CardioOncology #Immunotherapy #Myocarditis #Biomarkers

Abstract 2443: Urinary pesticide biomarkers and liver disease risk in Thailand: A machine-learning-based risk-prediction model AbstractBackground. Building on evidence linking urinary glyphosate to chronic liver disease (CLD) and hepatocellular carcinoma (HCC), we developed urinary pesticide profiling integrated with machine ...

#ecology #health #agedcare #publichealth #gerontology #epidemiology #SDGs #biomarkers #hepatology #exposome #pathology #rural #foodsystems #NAFLD #MASLD #NCDs #aging

Significant association between
urinary pesticides

and chronic liver disease
and liver cancer
.
aacrjournals.org/cancerres/ar...

Association between serum organophosphorus pesticides and the risk of incident chronic kidney disease: findings from Dongfeng-Tongji cohort Although chronic kidney disease (CKD) represents a significant worldwide public health concern, evidence linking organophosphorus pesticides (OPPs) to…

#ecology #health #agedcare #publichealth #biomarkers #nephrology #aging #epidemiology

In a cohort study with 1902 participants
with a mean age of 64
blood levels of
organophosphorus pesticides
were significantly associated with
risk of
chronic kidney disease.
.
www.sciencedirect.com/science/arti...

Metals exposure and biomarkers of liver damage: a systematic review and meta-analysis of observational studies Introduction Environmental exposure to metals represents a significant global health concern, yet the hepatotoxic potential of these contaminants remains incompletely characterized. This systematic re...

#health #publichealth #ecology #gerontology #aging #exposome #SDGs #gerontology #pathology #primaryhealthcare #geriatrics #biomarkers #ecotoxicology #NCDs

Arsenic (As),
cadmium (Cd)
mercury (Hg),
and lead (Pb)

are significantly associated with
liver damage.
.
www.degruyterbrill.com/document/doi...

#health #ecology #agedcare #Alzheimers #publichealth #gerontology #biomarkers #SDGs #menopause #primaryhealthcare #exposome #ecotoxicology #healthinformatics #aging #ecotoxicology

Significant association between

mixtures of toxic metals
and reduced
cognitive score
.
www.nature.com/articles/s41...

#Hair-thin #fiberoptic #sensors could #detect #cancer by reading #multiple #biomarkers

Microscopic sensors that are as thin as a strand of hair but capable of taking multiple measurements simultaneously could revolutionize diagnosis and monitoring scitechupdates.com/h...

Identification of platelet-derived biomarker in a cohort of Parkinson's disease

#Platelet modules mirror #SubstantiaNigra changes in #ParkinsonsDisease, with CRLF3 and LRRC37A2 emerging as non-invasive #biomarkers linking chromatin and immune pathways, advancing PD diagnosis and #Neurodegeneration insights. @pku1898.bsky.social
Read: doi.org/10.1016/j.ge...

Exposure to titanium and nickel as the novel risk factors for PCOS: Evidence from a case control study in Xiamen, China Polycystic ovary syndrome (PCOS) is a common cause of female infertility. While heavy metal exposure is a suspected risk factor, the role of trace ele…

#ecology #health #publichealth #gynecology #womenshealth #biomarkers #endocrinology #ecotoxicology #exposome #pathology

Elevated nickel (Ni)
and titanium (Ti)

are associated with
an increased risk of
PCOS.
.
www.sciencedirect.com/science/arti...

#health #nutrition #ecology #publichealth #gerontology #healthliteracy #SDGs #biomarkers #pathology #healthinformatics #menopause #aging #epidemiology #exposome

21 urinary metals were measured.

Seafood and rice
are associated with
elevated toxic metals.
.
www.sciencedirect.com/science/arti...

Serum and Hair Nickel Levels and Breast Cancer: Systematic Review and Meta-Analysis - Biological Trace Element Research Several studies have investigated the relationship between serum and hair nickel (Ni) concentration and breast cancer, but the results were inconsistent. Thus, we conducted a systematic review and meta-analysis to evaluate the association between serum and hair nickel levels and breast cancer. Nine studies determining the serum nickel levels and six studies evaluating the hair nickel levels were identified in a systematic search of PubMed, China Knowledge Resource Integrated Database, Wanfang, and China Biomedical Literature Service System databases. Based on a random-effects model, standard mean differences (SMD) and the corresponding 95% confidence intervals (CI) were pooled to compare the nickel levels between different groups. Compared with healthy controls, the serum nickel levels in breast cancer were significantly higher (SMD (95% CI) 1.76 (0.82, 2.70)), as well as in those post-treated cases (SMD (95% CI) 2.56 (1.18, 3.94)). For breast cancer cases, the treatment made no significant decrease in serum nickel levels (SMD (95% CI) −0.29 (−1.17, 0.59)). In hair, the nickel levels in breast cancer were slightly higher than in controls, but not significant (SMD (95% CI) 0.16 (−1.08, 1.40)). In conclusion, high serum nickel levels were associated with breast cancer, and nickel exposure might be a risk factor for breast cancer.

#health #ecology #agedcare #womenshealth #gerontology #biomarkers #primaryhealthcare #pathology #oncology #endocrinology #exposome #menopause #aging #ecotoxicology #SDGs

High blood levels of
metalloestrogens, such as
nickel (Ni)

are associated with
breast cancer
.
link.springer.com/article/10.1...

Frontiers | Association of metalloestrogens exposure with depression in women across reproductive lifespan BackgroundExposure to metal could impact women’s depression risk. However, the connection and mechanisms between metalloestrogens exposure and depression are...

#health #agedcare #ecology #publichealth #gerontology #neurology #SDGs #biomarkers #mentalhealth

Significant association between

mixtures of metalloestrogens, such as
antimony (Sb)
barium (Ba)
lead (Pb) and
tin (Sn)

and risk of depression in women
.
www.frontiersin.org/journals/psy...

$30,000 award backs research that improves donor organ assessment and shows how redox biology edging closer to real-world longevity medicine.

Link as first comment.

#longevity #geroscience #redox #transplant #biomarkers

Professor Emer McGrath, Associate Professor in Medicine, University of Galway and Consultant Neurologist, Galway University Hospital. Photo: Aengus McMahon

Higher vitamin D levels may be linked to lower levels of Alzheimer’s biomarkers www.universityofgalway.ie/about-us/new...

#Alzheimers #dementia #biomarkers #science #neuroscience #NeuroSkyence

#DepressionResearch #BipolarDisorder #Biomarkers
@crosellcardona.bsky.social @kittelschneider.bsky.social @uni-wuerzburg.de @goetheuni.bsky.social @elsevierhms.bsky.social

Watch Novogene's free on-demand webinar: A Beginner's Guide to Proteomics Using Olink Panels. Learn about Olink Reveal & Explore HT, targeted proteomics, workflows and data analysis. #Proteomics #Biomarkers #Olink #Webinar https://tinyurl.com/5cfkhdhz

Paper | A metabolomics and lipidomics atlas of pulmonary large cell neuroendocrine carcinoma | #Metabolomics #Lipidomics #CancerMetabolism #LungCancer #LCNEC
#Biomarkers #LCMS #SystemsBiology #Oncometabolites #OpenScience | doi.org/10.1016/j.bi...

This World Health Day, we bring attention to one of the biggest challenges in neurodegenerative diseases: late and uncertain diagnosis.
🧠 PREDICTFTD aims to transform FTD diagnosis by overcoming the current 3.6-year diagnostic delay!

#WorldHealthDay #FTD #Biomarkers #EUProjects

Can EEG detect early Alzheimer’s progression? 🧠🔍

Using our #Enobio, this study shows decreasing fast-band and increasing slow-band connectivity from SCD to MCI+, highlighting a dual biomarker signature.

Full thesis: upcommons.upc.edu/server/api/c...

#EEG #Alzheimers #Biomarkers

AI Study Identifies Gut Biomarkers for Early Detection of Gastrointestinal Diseases Researchers at the University of Birmingham have identified a set of gut microbiome and metabolome markers that could improve early detection of gastrointestinal diseases such as gastric cancer, colorectal cancer, and inflammatory bowel disease. Using advanced AI and machine learning tools, the study revealed that certain gut bacteria and chemical metabolites are linked not only to individual diseases but also to overlapping disease patterns, suggesting shared biological pathways. For example, bacteria from the Firmicutes and Bacteroidetes groups were associated with gastric cancer, while Fusobacterium and Enterococcus were linked to colorectal cancer. Some metabolites, like taurine and nicotinamide, were also indicative across multiple conditions. The researchers conducted simulations to study microbial growth and metabolite flow, confirming clear metabolic differences between healthy and diseased individuals. The study emphasizes the potential for non-invasive diagnostics and personalized therapies, allowing earlier detection and targeted treatment of these conditions. Future plans include validating these findings in larger patient populations and exploring additional applications of these biomarkers in clinical settings.

AI Study Identifies Gut Biomarkers for Early Detection of Gastrointestinal Diseases

🤖 IA: It's not clickbait ✅
👥 Usuarios: It's not clickbait ✅

#gutmicrobiome #biomarkers #gastrointestinaldiseases

View full AI summary:

Association of a five-metabolite and early-symptom profile with Parkinson's disease and its clinical progression - PubMed Parkinson's disease (PD) urgently requires blood-based markers that flag pathology before disabling motor decline. This study measured absolute concentrations of 144 plasma metabolites in 20 neurologically healthy adults and in 40 PD patients clinically classified as intermediate (PD-I) or progressi …

April is Parkinson’s Awareness Month 💙🧠
New research suggests a five-metabolite blood signature may help support earlier Parkinson’s detection—before motor symptoms appear. Explore more here:
pubmed.ncbi.nlm.nih.gov/41565969/#Pa... #ParkinsonsDisease #Metabolomics #Biomarkers

👏Happy having collaborated on this study led by @bergerslab.bsky.social lab!
🔥Particularly glad that they could successfully #reverse #translate and #validate our #human #glioblastoma #tolerogenic T cell #biomarkers published in Sci Transl Med @science.org
Checkout: www.science.org/doi/abs/10.1...

MET mutations boost #TumorImmunogenicity, enhance immune infiltration, and improve responses to #ImmuneCheckpointInhibitors, serving as independent #biomarkers for survival and guiding #PersonalizedImmunotherapy across cancers.
#OpenAccess: doi.org/10.1016/j.ge...

Tissue-specific bioaccumulation and hepatotoxicity of 6PPD and 6PPD-Quinone in zebrafish Tire additive 6PPD and its transformation product 6PPD-Quinone have garnered substantial attention due to their association with mass salmon mortality…

#gerontology #ecotoxicology #biomarkers #publichealth #neurology #hepatology #forensic #pathology #health #oncology #aging #geriatrics #SDGs

Toxic chemicals released from tyres

6PPD accumulates in the liver and gut.
6PPD-Q accumulates in the liver and brain.
.
www.sciencedirect.com/science/arti...

Want to know how to identify #biomarkers associated with gene dependency? 🤔
In this blog, we explain how we identify transcriptional, copy number, and mutational changes associated with BRAF dependency.
www.fiosgenomics.com/how-to-identify-biomarke...

C-reactive Protein-Albumin-Lymphocyte (CALLY) Index in Chronic Kidney Disease and Mortality: Insights into Inflammation, Nutrition, and Immune Status Introduction: The C-reactive protein-albumin-lymphocyte (CALLY) index represents a novel composite biomarker integrating inflammatory, nutritional, and immune parameters. We aim to examine the relati...

#CKD #Immunefunction #Nutritionalstatus #Inflammation #biomarkers #Populationbasedstudy

www.archivesofmedicalscience.com/C-reactive-P...

We invite you to read this paper published in Proteomes: Proteomic Profiling of Non-Muscle Invasive Bladder Cancer Reveals Stage-Specific Molecular Signatures and Prognostic Biomarkers 🧬🖥️🧫🥼

www.mdpi.com/2227-7382/13...

#proteomes #proteomics #proteoforms #biomarkers

How AI and Longevity Biotechnology are Revolutionizing Healthcare for Healthier, Longer Lives - Aging-US Research Aging research has made significant progress in recent years by combining disciplines like biology, technology, and medicine to tackle the challenges of extending healthspans and reducing age-related ...

✅ Read our #blog post about the #research paper, "Longevity biotechnology: bridging AI, biomarkers, geroscience and clinical applications for healthy longevity."

#Summary ⬇️
aging-us.org/2024/11/how-...

#aging #summary #longevity #ai #biomarkers #lifespan #healthspan #geroscience

Complement regulatory proteins are associated with progression rate of geographic atrophy secondary to age-related macular degeneration - PubMed The online version contains supplementary material available at 10.1186/s12979-026-00562-y.

New study reveals complement regulators—not just activation—shape GA progression in AMD, enabling functional patient stratification and precision care. #AMD #Ophthalmology #Immunology #PrecisionMedicine #Biomarkers buff.ly/JQ7bdR5

🧬 Health3 v1.11.0 is live!

New: Lifestyle Journal - log medication changes, new routines, or sleep shifts and see them plotted right on your biomarker graphs. Connect what you do with what your labs show.

#health #biomarkers #longevity #quantifiedself

The review of Wong et al. highlights the most promising #PTSD #biomarkers that could be targeted by novel #treatments and proposes a map for future research work. #NeuroscienceBulletin See here: doi.org/10.1007/s122...