MET mutations boost #TumorImmunogenicity, enhance immune infiltration, and improve responses to #ImmuneCheckpointInhibitors, serving as independent #biomarkers for survival and guiding #PersonalizedImmunotherapy across cancers.
#OpenAccess: doi.org/10.1016/j.ge...

Graphic abstract

#Medsky🧪 #oncosky #pharmasky #publichealth #Immunecheckpointinhibitors improve cancer survival but can trigger immune related adverse events. Among these, #fulminantmyocarditis is an often fatal complication with limited therapies. This study makes a very important discovery

New review to read! Perioperative immune checkpoint inhibitor therapy across tumors.

➡️ Insights and shared lessons from a rapidly evolving field.
➡️ Major evolution in curative-intent oncology.

🔗 doi.org/10.1111/joim.70073

#adjuvanttherapy #immunecheckpointinhibitors #neoplasms

Immune Checkpoint Inhibitors in High-grade Gastroenteropancreatic Neuroendocrine Neoplasms Abstract. High-grade gastroenteropancreatic (GEP) neuroendocrine neoplasms (HG-NENs) comprise both highly proliferating well-differentiated NENs, called gr

Immune Checkpoint Inhibitors in High-grade Gastroenteropancreatic Neuroendocrine Neoplasms. Read more in #EndocrineReviews: bit.ly/44vELgI #HighGradeNeuroendocrineNeoplasms #ImmuneCheckpointInhibitors #Efficacy @endocrinesociety.bsky.social

Single-cell transcriptomic analysis reveals gut microbiota-immunotherapy synergy through modulating tumor microenvironment - Signal Transduction and Targeted Therapy Signal Transduction and Targeted Therapy - Single-cell transcriptomic analysis reveals gut microbiota-immunotherapy synergy through modulating tumor microenvironment

#GutMicrobiota synergizes with #ImmuneCheckpointInhibitors to reprogram the #TumorMicroenvironment by reshaping #macrophages and T cells, converting Spp1⁺ protumor TAMs into antigen-presenting Cd74⁺ TAMs and restoring CD8⁺ T cell function.

#OpenAccess #STTT: doi.org/10.1038/s413...

AMP just published!
"Immune Checkpoint Inhibitor-Induced Thyroidal, Pancreatic, and Pituitary Dysfunction: Diagnostic Challenges in a Cancer Patient"

Full paper here:
www.actamedicaportuguesa.com/revista/inde...

#endocrinediseases #immunecheckpointinhibitors #autoimmune #actamedicaportuguesa

Concomitant Immune Checkpoint Inhibitors Induced Central and Primary Adrenal Insufficiency: A Diagnostic Challenge. Read more in #JCEMCaseReports: bit.ly/42UM6pd #ImmuneCheckpointInhibitors #Hypophysitis #Adrenalitis

AMP just published!
"Immune-Mediated Diabetes Induced by Dostarlimab: A Case Report"

Full paper here:
www.actamedicaportuguesa.com/revista/inde...

#diabetesmellitus #DM1 #chemicallyinduced #endocrinediseases #immunecheckpointinhibitors #actamedicaportuguesa

New clues for treating immune cold tumors – BioNews Central Study explains how a tumor mutation blocks immune checkpoint inhibitors and identifies a way to restore sensitivity. ...

Study explains how a #TumorMutation blocks #ImmuneCheckpointInhibitors and identifies a way to restore sensitivity. 
#Immunotherapy #ImmunotherapyResponse

Intact #GutMicrobiota synergize with #ImmuneCheckpointInhibitors to enhance CD8⁺, CD4⁺, and γδ T cells, reprogram Spp1⁺ TAMs into Cd74⁺ antigen-presenting #macrophages, & activate the γδ T–APC–CD8⁺ axis via CD40–NF-κB signaling. #medsky

#STTT #OpenAccess: doi.org/10.1038/s413...

Impact of <i>Helicobacter pylori</i> on Immune Checkpoint Inhibition in Hepatocellular Carcinoma: A Multicenter Study <p xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" dir="auto" id="d7351057e459"> <b> <i>Introduction:</i> </b>...

🔬📄 'Impact of Helicobacter pylori on Immune Checkpoint Inhibition in Hepatocellular Carcinoma: A Multicenter Study' - a @kargerpublishers.bsky.social: #Gastroenterology article on #ScienceOpen -

🖇️ #HelicobacterPylori #HCC #ImmuneCheckpointInhibitors #ImmunotherapyResistance

Bispecific Antibodies VS Immune Checkpoint Inhibitors in Oncology: Mechanisms, Clinical Progress, and Future Directions - OncoDaily Explore how bispecific antibodies and checkpoint inhibitors differ in mechanism, efficacy, toxicity, and resistance in modern cancer immunotherapy.

Bispecific Antibodies VS Immune Checkpoint Inhibitors in Oncology: Mechanisms, Clinical Progress, and Future Directions

oncodaily.com/oncolibrary/...

#OncoDaily #Oncology #Cancer #Health #Medicine #MedEd #MedOnc #MedNews #BispecificAntibodies #ImmuneCheckpointInhibitors #ICIs #IO #Immunotherapy

Increased risk of muscle damage when combining immunotherapy and chemoradiation in rectal cancer More about the recent study!

📌 #ImmuneCheckpointInhibitors are revolutionising #cancertreatment:

A #MedUniVienna study, conducted at #CCCVienna, shows: In #rectalcancer, combining #immunotherapy with #chemoradiotherapy can surprisingly often cause severe #myositis. Further information on the study! ⬇️

Clash Of Drugs Impedes Lung Cancer Treatment, Lowers Survival - Drugs.com MedNews TUESDAY, July 7, 2025 Two drugs used in lung cancer treatment appear to be tripping over each other, reducing patients chances for a cure, a new study says. Cor

New study: Steroids commonly given to lung cancer patients may reduce immunotherapy effectiveness by preventing T-cells from maturing. Patients on steroids had 2-4x higher risk of shorter remission. #ImmuneCheckpointInhibitors #CancerTreatment www.drugs.com/news/clash-i...

Machine Learning Model Integrating CT Radiomics of the Lung to Predict Checkpoint Inhibitor Pneumonitis in Patients with Advanced Cancer
@journals.sagepub.com @tcrtcancer.bsky.social

journals.sagepub.com/doi/10.1177/...

#artificialintelligence #adverseevent #immunecheckpointinhibitors #openaccess

What Are the Signs That Immunotherapy Is Working? - OncoDaily Signs immunotherapy is working may include tumor shrinkage, stable scans, or symptom relief. Learn what to expect and how to recognize if treatment is effective.

What Are the Signs That Immunotherapy Is Working?

oncodaily.com/oncolibrary/...

#OncoDaily #Oncology #Cancer #Health #Medicine #MedEd #MedOnc #MedNews #Immunotherapy #IO #ImmuneCheckpointInhibitors #ImmuneRelatedSideEffects #ICIs #Pseudoprogression

Stanford's Fauzia Riaz & others found poor outcomes for hospitalized cancer patients treated with #ImmuneCheckpointInhibitors. Caution is advised for inpatient use.

Analysis of New Colorectal Cancer Immunotherapy Shows More Treatment Options | Newswise A team of researchers from Cleveland Clinic Genomic Medicine share insights from an early set of 19,000 patients to receive immune checkpoint inhibitor treatments for colorectal cancer in the U.S. ...

Analysis of New Colorectal Cancer Immunotherapy Shows More Treatment Options
www.newswise.com/articles/ana...
#Cancer #colorectalcancer #immunology #ImmuneCheckpointInhibitors #metastaticcancer

Microbiotica unveils new data on MB097 at AACR IO meeting - PharmaTimes Data presented in Los Angeles showcases therapy’s potential

#Microbiotica #personalisedmedicine #microbiome #microbiomebasedtherapeutics #MB097 #MB097therapy #precisionmicrobiomemedicine #KEYTRUDA #pembrolizumab #immunecheckpointinhibitors #melanoma #MB097bacteria #livebiotherapeuticproducts #LBPs #humanmicrobiome
pharmatimes.com/news/microbi...

Real life management of elevated troponin in patients treated with immune checkpoint inhibitors Immune checkpoint inhibitors (ICIs) have revolutionized the clinical outcomes of cancer. Nevertheless, their use may lead to myocardial injury. The 20…

#Medsky🧪 #oncosky #cardioncology In real life Diagnosis and management of #Immunecheckpointinhibitors -induced #myocarditis following #cancertherapy
www.sciencedirect.com/science/arti...

🚨 Check out this excellent #review by Nacho Melero and Maria Aggelakopoulou from @oxcio.bsky.social on the role of cDC1 in #cross-priming CD8+ Tcells in tumors and how strategies like FLT3L, which boost cDC1, may support immunotherapy success.
👇🔬
#CancerImmunotherapy #DCs #ImmuneCheckpointInhibitors

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In patients with cancer, the presence and abundance of cDC1s in the tumour microenvironment is markedly associated with the level of T cell infiltration and responsiveness to #immunecheckpointinhibitors.

Comprehensive analysis of immune subtype characterization on identification of potential cells and drugs to predict response to immune checkpoint inhibitors for hepatocellular carcinoma

A new study reveals the cell types that potentially affect #ImmuneCheckpointInhibitors (ICIs) and identifies potential drugs by combining bulk sequencing and single-cell sequencing, thus providing hope for ICI treatment in #HCC.

#OpenAccess: https://buff.ly/4h2ocgy

Acute Allograft Rejection in Kidney Transplant Recipients Treated With Immune Checkpoint Inhibitors: An Educational Case Report - Steven A. Morrison, Amanda J. Vinson, 2024 Rationale: Kidney transplant (KT) recipients have an increased risk of malignancy due to chronic immunosuppression. The emerging use of immune checkpoint inhibi...

Acute Allograft Rejection in Kidney Transplant Recipients Treated With Immune Checkpoint Inhibitors: An Educational Case Report

DOI:
doi.org/10.1177/2054...

#Transplant
#ImmuneCheckpointInhibitors
#AcuteAllograftRejection

@cjkhd.bsky.social
@csnscn.bsky.social
@dalhousieu.bsky.social

Proton Pump Inhibitors, Immune Checkpoint Inhibitors, and AKI  | Docwire News A study assessed acute kidney injury (AKI) risk with proton pump inhibitor (PPI) use in patients with cancer who received immune checkpoint inhibitors.

The findings of a recent study emphasize the need to carefully monitor and evaluate kidney function in patients treated with proton pump inhibitors and immune checkpoint inhibitors. #nephrology #nephsky #kidney #PPIs #protonpumpinhibitors #immunecheckpointinhibitors

Comprehensive analysis of immune subtype characterization on identification of potential cells and drugs to predict response to immune checkpoint inhibitors for hepatocellular carcinoma

A new study reveals the cell types that potentially affect #ImmuneCheckpointInhibitors (ICIs) and identifies potential drugs by combining bulk sequencing and single-cell sequencing, thus providing hope for ICI treatment in #HCC.

#OpenAccess: www.sciencedirect.co...

Amy Moore: PD-1/VEGF combos are a strategy to watch in lung cancer - OncoDaily Amy Moore: PD-1/VEGF combos are a strategy to watch in lung cancer / Amy Moore, cancer, Immune Checkpoint Inhibitors, Keiju Aokage, Lung cancer, Masahiro

PD-1/VEGF combos are a strategy to watch in lung cancer - Amy Moore
@acmoorephd.bsky.social

oncodaily.com/insight/amy-...

#Cancer #ImmuneCheckpointInhibitors #LungCancer #Health #NSCLC #OncoDaily #Oncology #Medicine

The evolving posology and administration of immune checkpoint inhibitors: subcutaneous formulations Immune checkpoint inhibitors (ICIs) have transformed cancer care. Recently, atezolizumab gained its first global approval in a subcutaneous (SC) formulation by the UK medicines regulator, being notable as the first time an FDA- and/or European Medicines Agency (EMA)-approved ICI has been licensed via this administration route. Here, we discuss this approval, other SC ICIs in development, and the benefits and challenges of this administration route, including potential implications for patient care.

Our thoughts on the evolving #posology of #Immunecheckpointinhibitors in
@trends in #Cancer

www.cell.com/trends/cance...

abstract

MedSky🧪 #Immunotherapy #Gutmicrobiome & #Cancerimmunotherapy The #gutmicrobiota influences anti-tumor #immunity & can induce or inhibit response to #immunecheckpointinhibitors

MedSky🧪#Drugsdevelopment Various #immunecheckpointinhibitors are approved as adjuvant therapies for high-risk #melanoma (stage IIB–IV), but disease recurrence remains common.