How pancreatic cancer blocks immunotherapy – BioNews Central Researchers have uncovered a key reason why immunotherapy has largely failed in pancreatic cancer — and identified a promising strategy to overcome that resistance. ...

Researchers have uncovered a key reason why #immunotherapy has largely failed in #PancreaticCancer and have identified a promising strategy to overcome this resistance.
#PancreaticCancerTreatment #ImmunotherapyResistance

Mechanisms Underlying Immunotherapy Resistance in Microsatellite-stable Colorectal Cancer Microsatellite-stable colorectal cancer, which accounts for roughly 80–85% of cases, remains largely refractory to immune checkpoint inhibitors compared with microsatellite instability-high tumors. This review synthesizes current evidence on tumor-intrinsic and microenvironmental mechanisms underlying immune checkpoint inhibitor resistance in microsatellite-stable colorectal cancer—including low neoantigen burden and impaired antigen presentation, activation of Wnt/β-catenin and MAPK signaling that exclude T cells, an immunosuppressive cellular milieu (regulatory T cells, myeloid-derived suppressor cells, M2-like tumor-associated macrophages, cancer-associated fibroblasts), metabolic reprogramming, and gut microbiome dysbiosis—and evaluates translational strategies aimed at overcoming these barriers. Preclinical and early-phase clinical data indicate that rational, mechanism-guided combinations (vascular normalization, myeloid reprogramming, metabolic inhibitors, antigen-priming approaches, and microbiome modulation) can enhance immune infiltration and produce benefits in biomarker-defined subgroups. Moving the field forward will require biomarker-driven, adaptive clinical trials with embedded translational endpoints to optimize patient selection and manage toxicity.

🎗️ Why is MSS colorectal cancer so resistant to immunotherapy? This mini review unpacks tumor-intrinsic and microenvironmental barriers. @ascocancer.bsky.social
#ImmunotherapyResistance
🔗 www.xiahepublishing.com/2996-3427/On...

Exogenous #EBNA1 promotes #ImmunotherapyResistance by enhancing #ADAR1 translation via the IGF2BP3/EIF4G1 complex, suppressing #Interferon signaling and #ImmuneResponse in #EBV-associated cancers.

#STTT #OpenAccess: doi.org/10.1038/s413...

DNA copy-number changes help melanoma develop resistance to immunotherapy – BioNews Central Scientists have uncovered how melanoma, the deadliest form of skin cancer, evolves to resist immunotherapy and have identified a potential strategy to prevent or reverse that resistance. ...

Scientists have uncovered how #melanoma, the deadliest form of #SkinCancer, evolves to resist #immunotherapy and have identified a potential strategy to prevent or reverse that resistance.
#ImmunotherapyResistance #TherapyResistance

Impact of <i>Helicobacter pylori</i> on Immune Checkpoint Inhibition in Hepatocellular Carcinoma: A Multicenter Study <p xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" dir="auto" id="d7351057e459"> <b> <i>Introduction:</i> </b>...

🔬📄 'Impact of Helicobacter pylori on Immune Checkpoint Inhibition in Hepatocellular Carcinoma: A Multicenter Study' - a @kargerpublishers.bsky.social: #Gastroenterology article on #ScienceOpen -

🖇️ #HelicobacterPylori #HCC #ImmuneCheckpointInhibitors #ImmunotherapyResistance

Radiation therapy overcomes immunotherapy resistance in some cancers – BioNews Central New research shows that radiation therapy can make certain tumors that resist immunotherapy respond to treatment, leading to improved outcomes for patients. ...

New research shows that #RadiationTherapy can make certain #tumors that resist #immunotherapy respond to treatment, leading to improved #PatientOutcomes.
#ImmunotherapyResistance #Radiotherapy #CombinationTherapy