The Human DNA Virome Varies with Human Genes, Age, Gender, Circadian Patterns, and Smoking Many viruses have adapted to persist in infected humans for life1,2. Variable host control of their ongoing abundance (viral load) can lead to clearance or disease3–5. Here we analysed the viral DNA load of 31 common viruses in human blood and saliva using whole-genome sequencing data from UK Biobank (n = 490,401), All of Us (n = 414,817) and Simons Foundation Powering Autism Research for Knowledge (SPARK; n = 12,519). Viral DNA load varied markedly with age, time of day and season; most viruses were also present at greater abundance in men than in women. Human genetic variation at dozens of loci associated with DNA load of seven viruses: Epstein–Barr virus (EBV, 45 loci), human herpesvirus (HHV)-7 (37 loci), HHV-6B, Merkel cell polyomavirus and three anelloviruses.   Variation at the major histocompatibility complex (MHC) locus generated the strongest associations (P = 5.8 × 10–9 to 2.5 × 10–1459), which were specific to each virus. The HLA-B*08:01 allele also exhibited a host–virus genetic interaction with EBV subtype (P = 7.4 × 10–70). Other human genetic effects implicated genes encoding proteins that process peptides for antigen presentation, such as ERAP1 (HHV-7, P = 2.7 × 10–78) and ERAP2 (EBV, P = 4.6 × 10–111). Mendelian randomization analyses supported a strong causal effect of EBV DNA load on increased risk of Hodgkin’s lymphoma (P = 1.8 × 10–3), but not multiple sclerosis (P = 0.52). This suggests that higher chronic EBV load increases lymphoma risk, whereas associations of EBV infection with autoimmune conditions reflect host immune responses to particular viral epitopes. Analyses of biobank data show that human variation such as age, sex and genetics, particularly at the major histocompatibility complex locus, is associated with viral abundance and supports a causal link between abundance of Epstein–Barr virus and Hodgkin’s lymphoma.   Published in Nature (March 25, 2026): https://doi.org/10.1038/s41586-026-10288-y 

The study highlights multiple genetic and environmental associations that modulate viral load of persistent viruses associated to human disease, including autoimmune diseases and lymphomas. Variation at the MHC locus generated the strongest associations. #EBV #humanvirome

The Immunosuppression Paradox in Multiple Sclerosis: Are We Fueling the Fire by Suppressing Immunity in an Epstein–Barr Virus–Linked Disease? Abstract. Recent studies strongly implicate Epstein–Barr virus (EBV) as a necessary trigger for multiple sclerosis (MS). Longitudinal data show that EBV se

This review explores the paradox of using immunosuppression to treat Epstein–Barr virus–linked multiple sclerosis, suggesting future strategies may need EBV targeted therapies.🧠🦠 #MultipleSclerosis #EBV #Immunology #Neurovirology #Autoimmunity
📄 doi.org/10.1093/ofid...
👤 EVBC member: Anna Onisiforou

and ME/CFS, Professor Leonard Jason and colleagues have published a study that follows a group of college students — a population in which #EBV infection is common — over a 7-year period.

In Gedanken bei denen, für die es keinen anderen Weg mehr gab, als den Freitod … #MEcfs, #SeverveMEcfs,#LongCovid, #Lyme, #Borreliose, #EBV, #SARSCoV2, #Covid19

Incidence age is bimodal for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome, with higher severity burden for early onset disease Abstract. Myalgic Encephalomyelitis, or Chronic Fatigue Syndrome (ME/CFS), is a disease of uncertain origin. Studies of Norwegian health records have sugge

Incidence age is bimodal for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome, with higher severity burden for early onset disease
@simonmcg.bsky.social, Charles B Hillier , Joshua J Dibble , @tschei.bsky.social, Arild Angelsen , @aryback.bsky.social
#ME/CFS #DiseaseIncidence #EBV
#DiseaseOnset

NeuroVoices: Tanuja Chitnis, MD, on EBNA-1 Antibodies to Distinguish MS, MOGAD, and NMOSD | NeurologyLive - Clinical Neurology News and Neurology Expert Insights The division chief of neuroimmunology at Brigham and Women’s Hospital discusses longitudinal EBNA-1 antibody data and its potential role as a complementary biomarker to distinguish MS from related neu...

🧬 Could EBV antibodies help clarify #MS diagnoses?

Tanuja Chitnis, MD discusses research showing EBNA-1 antibodies are present in ~98–99% of patients with MS

Read more here: www.neurologylive.com/view/neurovo...

#MultipleSclerosis #EBV #Neurology #EpsteinBarrVirus

#MultipleSclerosis progression insights via #proteomic profiling: New study on MS reveals anti-viral response as a continuous disease driver, implicating #EBV infection beyond just a trigger. Highlights include sex-specific pathways for injury, repair & resilience.

rdcu.be/e7ZWe
#MSResearch

A new long COVID paper suggests that, in a subset of patients, the picture may involve circulating microaggregates, impaired capillary flow, and - EBV-related immune activation🧵 A study describes a subgroup of patients who had so called microaggregates in blood, along with stronger T-cell responses to EBV. The main idea is that, in some patients, long COVID may involve a mix of impaired microcirculation and immune activation linked to latent herpesviruses.

🚨🧵by Zdenek Vrozina on XTwitter:

"A new long COVID paper suggests that, in a subset of patients, the picture may involve circulating microaggregates, impaired capillary flow, and - EBV-related immune activation🧵"

21 tweets 🧵:
threadreaderapp.com/thread/20336...

#LongCovid #EBV #Reactivation

contrast, only about one-third of those with moderate or lingering symptoms at 6 months still had ME/CFS 7 years later.

Conclusion: These findings indicate that #ME/CFS following IM tends to persist over the long term, particularly among those whose illness was more severe at onset.
#EBV #IM

Eradication of latent Epstein-Barr virus by hydroxyurea alters the growth-transformed cell phenotype - PubMed The hallmark of infection by human herpesviruses, life-long persistence in the host, is unaffected by current antiviral therapies effective against replication of virus. In vitro studies indicated that low concentrations of the ribonucleotide reductase inhibitor, hydroxyurea, completely eliminated E …

Eradication of latent Epstein-Barr virus by hydroxyurea alters the growth-transformed cell phenotype #EBV #MECFS #LongCovid

pubmed.ncbi.nlm.nih.gov/9593003/

Participantes en la reunión intermedia del proyecto WildINTEL (https://wildintel.eu/) en el RJB, 4 de marzo de 2026

Participante en la reunión intermedia del proyecto WildINTEL (https://wildintel.eu/) en el RJB, 4 de marzo de 2026

Participantes en la reunión intermedia del proyecto WildINTEL (https://wildintel.eu/) en el RJB, 4 de marzo de 2026

Hoy en WildINTEL (wildintel.eu) 📸 en el RJB:
⛲ Fuentes de datos
🛰️ LiDAR de alta resolución
🌍 GEE‑PICX para índices de vegetación
📊 Parámetros ecológicos y #EBV
💽 Recogida de datos
🔢 Propuesta de conjunto estándar de análisis
📸 Funciones y flujo de trabajo con camtrapR
📦 BON‑in‑a‑Box... y más

Steckt in vielen von uns: Forscher finden Hauptursache für Multiple Sklerose Fast alle Menschen tragen das Epstein-Barr-Virus in sich. Doch nur wenige entwickeln eine Multiple Sklerose. Forscher haben jetzt einen entscheidenden Mechanismus entschlüsselt.

#Epstein-Barr-Virus #EBV #MultipleSklerose #MS

Kurze Darstellung des #Mechanismus 👇❗❗❗

www.t-online.de/gesundheit/a...

Promising #EpsteinBarrVirus #EBV development @fredhutch.org: human monoclonal #antibodies #mAbs that block viral entry & protect humanized mice. Could be a big step toward preventing post-transplant lymphoproliferative disorder PTLD. #Immunology #TransplantMedicine
www.linkedin.com/posts/drmelv...

Scientists develop first-of-its-kind antibody to block Epstein Barr virus Fred Hutch Cancer Center scientists reached a crucial milestone in blocking Epstein Barr virus (EBV), a pathogen estimated to infect 95% of the global population that is linked to multiple types of…

First-of-its-kind #antibody to block #Epstein Barr #virus developed ...

| #EpsteinBarrvirus | #infection | #EBV | #pathogen | Via @sciencex.bsky.social

New method estimates Epstein-Barr virus in blood using standard genome sequencing data The Epstein-Barr virus (EBV) can cause certain types of cancer or autoimmune diseases, but how the body controls this common viral infection is largely unknown. Researchers at the University Hospital…

New method estimates Epstein-Barr #virus in #blood ...

| #EpsteinBarr | #infection | #EBV | #cancer | #sequencing | Via @sciencex.bsky.social

The virus nearly everyone has and its possible role in MS | The-14 Nearly everyone carries Epstein-Barr virus, but research suggests it may trigger multiple sclerosis, opening new paths for prevention and treatment.

The virus nearly everyone has and its possible role in MS
#Health #MultipleSclerosis #MS #EpsteinBarrVirus #EBV #Neurology #Immunology #BrainHealth #Autoimmune #Science #PublicHealth #Inflammation #BCells #TCells #Healthcare #DiseasePrevention
the-14.com/the-virus-ne...

Immune cells that target EBV may be driving MS

Immune cells that target EBV may be driving MS.

A type of immune cell that has received little attention in multiple sclerosis (MS) research may play an important role in how the condition develops.

Click the link to find out more.

ms-uk.org/news/immune-...

#MS #MultipleSclerosis #EBV

Crystal Chhan and the McGuire lab at @fredhutch.org reached a crucial milestone in blocking Epstein Barr virus (#EBV) in mice. 🐭

Their work with EBV also validated an innovative a new approach for discovering protective antibodies against other pathogens: https://bit.ly/4qI8riI

Scientists develop first-of-its-kind antibody to block Epstein Barr virus

Scientists at @fredhutch.org Cancer Center Seattle have done it again! My chronic illness journey began 30 yrs ago when I got sick w/ #EBV. It’s been a wild ride but manageable until 1 mild case of delta #Covid. That’s when the wheels fell off & my life crashed. This is such hopeful happy news!

Fred Hutch scientists reached a crucial milestone in blocking Epstein Barr virus (#EBV), a common pathogen linked to multiple types of #cancer, neurodegenerative diseases and other chronic health conditions. https://bit.ly/4anRs0m

Original post on social.adlerweb.info

RE: https://med-mastodon.com/@jeneralist/116063720006024901

Oops. USA (FDA) haben offenbar die Zulassung für Grippeimpfung auf mRNA-Basis ausgesetzt. Die Entwicklung ähnlicher Impfstoffe zu Gürtelrose, Epstein-Barr und Herpes wurden vom Hersteller daher eingestellt. Ja, komplett. Ohne den […]

The Daily Press, Virginia, US.
12th February 1987.

#ebv #chronicfatiguesyndrome #cfs #MyalgicEncephalomyelitis #myalgice #mecfs #cfsme.

Integrated transcriptomic and methylome analysis reveals retinoic acid pathway activation after decitabine treatment in EBV-associated gastric cancer | mBio EBV+ gastric cancer contains hypermethylated DNA, and despite this distinct molecular phenotype, there are currently no Epstein–Barr virus (EBV)-specific treatments available. Using an FDA-approved in...

Excited to share our new study: Integrated transcriptomic and methylome analysis reveals retinoic acid pathway activation after decitabine treatment in EBV-associated gastric cancer | mBio #EBV #Epigenetics #CancerResearch #GastricCancer #DNAme #Transcriptomics
journals.asm.org/doi/10.1128/...

A new study in @natcomms.nature.com re-analyzed WGS data from ~750k individuals to find viral "dark matter". By mapping viral reads, researchers linked persistent #EBV to #chronicdiseases like Lupus and Dementia. Large-scale omics are key to unlocking new disease #biomarkers

Article: rdcu.be/e2cAt

The Daily News Leader, Virginia, US.
10th February 1988.

#mecfs #ebv #myalgice #epsteinbarr #cfsme #myalgicencephalomyelitis

Population-scale sequencing resolves determinants of persistent EBV DNA - Nature Population-scale WGS reveals genetic determinants of persistent EBV DNA, linking immune regulation—especially antigen processing and MHC class II variation—to EBV persistence and heterogeneous di...

chronic diseases following infection with a common virus.

@nature.com
#EBV #Genetics #ChronicDiseases

Wie das #Epstein-Barr-Virus bei manchen Menschen Multiple Sklerose auslöst …

| #MS | #Infektion | Epstein-Barr | #Herpes | #Krebs | Via @deutschewelle.dw.com

Wann kommt endlich die Impfung gegen #EBV ?

#ImmunologyNews The study points to an unexpected role for CD8+ “killer” T cells in the disease...#immunology #EBV

Read more here: https://ow.ly/1cqA50Yb6ie

Chicago Tribune, US.
8th February 1987.

#ebv #myalgice #myalgicencephalomyelitis #chronicfatiguesyndrome #cfs #cfsme #mecfs.

17) 📣 If you find this information relevant, sharing it or following the page helps it reach those who may need it.

#EBV #HLA #Autoimmunity #MECFS #LongCOVID