New Epigenome Technologies Blog! bit.ly/4m4rZw

"Engineering Epigenetic Editors Takes Gene Silencing Platforms A Step Closer to Therapeutic Evaluations"

Based on a preprint from jdfev.bsky.social at scribetx.bsky.social

#Epigenetics #Blogs #EpigeneticEditors #CRISPR #DNAm

Epigenetics Update - A longitudinal DNA methylation atlas and its link to brain structure and mental health
go.nature.com/4vdyDWb

Tianye Jia and Sylvane Desrivières in Mol Psych

#Epigenetics #DNAm #Neurodevelopment
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Empower your research with hi-res epigenetic insights at epigenometech.com

🧬 Epigenetics controls gene expression without changing DNA!

Active chromatin = gene ON
Inactive chromatin = gene OFF
Driven by DNA methylation & histone modifications 🔬

📢 Epigenetics Congress 2026
📅 Oct 15–16, 2026 | 📍 Boston, USA (Hybrid)
🌐 epigeneticscongress.com

#Epigenetics #LifeSciences

Gene regulatory landscape dissected by single-cell four-omics sequencing - Nature Combining single-cell parallel profiling of genome conformation, histone modifications, chromatin accessibility and gene expression reveals dynamics and intranuclear spatial clustering of epigenome pr...

Epigenetics Update - Gene regulatory landscape dissected by single-cell four-omics sequencing go.nature.com/3PKiNSx

Yujie Chen/Zhiyuan Liu and Dong Xing from pku1898.bsky.social in Nature

#Epigenetics #SingleCell #Multiomics
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Perfect for cancer, immunology, and aging; epigenometech.com

The 2026 Epigenetic Inheritance Symposium (July 15–17, Baton Rouge, LA) brings together researchers and will highlight:
• Germline transmission
• RNA & chromatin-based pathways
• Developmental plasticity
• #Epigenetics in health & disease
More information: dknet.org/about/dknetn...
#genomics

Prof. Javier Rodriguez-Casariego's fascinating seminar, "Epigenetic Mechanisms of Rapid Environmental Plasticity in Reef-Building Corals", is now available for viewing on the CPGE YouTube channel. Enjoy!

#epigenetics #chromatin #genomics #corals #northwestern #reefs #science

youtu.be/lcp9TyW8UTs

Multiomic single-cell perturbation screens reveal critical lncRNA regulators of senescence - Nature Aging To dissect lncRNA functions in aging, here the authors perform a CRISPRi-based single-nucleus multiomics screen systematically perturbing 32 aging- and senescence-associated lncRNAs and measuring matc...

Epigenetics Update - Multiomic single-cell perturbation screens reveal critical lncRNA regulators of senescence go.nature.com/47Aev6m

Shouxuan Zhu / Sunyang Ying and Jing-Dong J. Han from @pku1898.bsky.social in Nature Aging

#Epigenetics #Multiomics #SingleCell #LncRNAs
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epigenometech.com

🧬 HIV-related epigenetic changes link environment & lifestyle to aging and disease. EWAS reveals key insights.

📅 Epigenetics Congress 2026 | Oct 15–16
📍 Boston, USA
🌐 epigeneticscongress.com

#Epigenetics #HIV

Epigenetics Update - Chromatin accessibility regulates age-dependent nuclear mechanotransduction bit.ly/4m0qhwH

Yawen Liao and G. V. Shivashankar from ETH Zurich in PNAS

#Epigenetics #Chromatin #Aging #Mechanotransduction
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Empower your research at epigenometech.com

Webinar with Danilo Buonsenso: How Long COVID Leaves Lasting Biological Imprints in Children – EPIVINF

🧬 What does long COVID look like in children? In our latest Epigenetics and Infectious Diseases webinar, Dr. Danilo Buonsenso explained that even children with mild COVID-19 can develop long-term symptoms.

Read further 👇
epivinf.eu/2026/03/30/w...

#LongCOVID #Epigenetics

This prestigious award celebrates researchers across Australasia who are driving innovation and impact in our field, continuing the legacy of Professor Susan Clark.

#Epigenetics #ResearchExcellence #AEpiA #ScienceAwards #AcademicResearch #Conference2026

Learn how we used Droplet Paired-Tag to assess RNA expression and histone modifications in individual brain cells and PBMCs to identify novel cell-type-specific CREs and heritability factors linked to AD

#Epigenetics #SingleCell #DropletPairedTag #PairedTag #Multiomics #Alzheimers

bit.ly/4kgWMF3

We are thrilled to share our latest work uncovering a completely novel pathway in plants, where Pol II elongation factor SPT6L recruits AGO4 to guide mRNA methylation 🌿🔬
www.biorxiv.org/content/10.6...
#PlantSci #Epigenetics #RNA #Preprint #epitranscriptomics

Epigenetics News - Why No Individual Is Like Another

News bit.ly/48dgHAQ Study - bit.ly/411Z8zS

Denis Meuthen and David L.J. Vendrami / Joachim Kurtz

#Epigenetics #News
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Perfect for cancer, immunology, and aging research; epigenometech.com

Plant-Based Dietary Patterns Linked to Slower Epigenetic Aging - Aging-US Authors A new research paper was published in Volume 18 of Aging-US on March 20, 2026, titled “Plant-based dietary patterns are associated with slower epigenetic aging.”

🔆 #PaperSpotlight:
This #research paper was #published in Volume 18, titled "Plant-based dietary patterns are associated with slower epigenetic aging."

#PressRelease ⬇️
aging-us.net/2026/03/31/p...

#Aging #Epigenetics #Diet #Longevity #HealthyAging #Longevity #Press #OA #Publishing

Epigenetics Update - Stage-specific epigenetic priming amplifies gene activation during lineage commitment bit.ly/4s3qDnN

Arion Foertsch and Asifa Akhtar in PNAS

#Epigenetics #StemCells #NPCs
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Gain deeper insights into gene regulation; epigenometech.com

🆕 ADVANCE ONLINE 🆕

RESEARCH PAPER: Bypass of blocking lesions by RNAPII reveals a novel stress induced by DNA damage
By Bañuelos et al. and Ramiro Verdun
➡️ https://ow.ly/ZfMy50YAOS1


#chromatin #histone #epigenetics #cellstress #chemotherapy

🔆 #PaperSpotlight:
A new #research paper was #published on March 20, titled “Plant-based dietary patterns are associated with slower epigenetic aging.” @uwepidemiology.bsky.social

🔗 doi.org/10.18632/agi...

#Aging #Quote #Epigenetics #PlantBasedDiet #Longevity #HealthyAging #Publishing #OA

🎥 #AgingShort:
Abstract #video about this #research paper, titled “Plant-based dietary patterns are associated with slower epigenetic aging.” @uwepidemiology.bsky.social

🔗 doi.org/10.18632/agi...

#Aging #PaperSpotlight #Epigenetics #EpigeneticAging #PlantBasedDiet #Longevity #NutritionScience #OA

Download our poster to learn how we used single-cell CUT&Tag and Droplet Paired-Tag to profile PBMCs, generating over 70,000 single-cell profiles and identifying vast numbers of cis-regulatory elements.

#Epigenetics #SingleCell #DropletPairedTag #PairedTag #Multiomics

bit.ly/4kgWMF3

🧬 New work revisits an old favorite: hydrochloric acid-based #histone extraction! Simple, reliable, and compatible with SDS, 2D gels, and mass spec—making histone prep easier for downstream #analyses. #Epigenetics #HistoneResearch #MolecularBiology
https://ow.ly/vAp550Yh28O

As a medical school professor, I taught that aging was caused by DNA mutations accumulating over time.
A landmark study from my friend Dave Sinclair's team in... www.cell.com/cell/fulltext/S0092-8674...

#Epigenetics #Longevity #AgingResearch #MetabolicHealth #HealthLongevitySecrets

Systemic epigenetic dysregulation as a driver of ageing and a therapeutic target - Nature Reviews Molecular Cell Biology This Review presents a systems-level framework of how epigenetic dysregulation drives ageing, including through deterioration of nuclear architecture, dysregulation of epigenetic memory, nucleosome al...

Epigenetics Review - Systemic epigenetic dysregulation as a driver of ageing and a therapeutic target go.nature.com/4s3quRh

A. Doğa Yücel and Vadim N. Gladyshev @harvard.edu in Nat Rev Mol Cell Biol

#Epigenetics #Review #Aging
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Discover the breakthrough at epigenometech.com

Epigenetics Update - An EGFR co-amplified lncRNA HELDR promotes glioblastoma malignancy through KAT7-driven gene programs go.nature.com/3Pxyuwl

Xiaozhou Yu and Bo Hu/Shi-Yuan Cheng (Northwestern University) in Nat Cell Biol

#Epigenetics #KAT7A #Glioblastoma #lncRNAs
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epigenometech.com

In the most recent episode we talked with Michaela Frye from the German Cancer Research Center (DKFZ) in Heidelberg about her work on the role of RNA modifications and RNA binding proteins in gene expression and cancer development. #podcast #epigenetics

Listen here: activemotif.com/podcasts-mic...

Wrapping up a wonderful week at #IADR2026. Had a great time meeting colleagues and friends, making new connections and above all, watching these girls shine at their poster sessions - #proudmentor 😍 🦷 🧬 🧪 🔬 💪🏻
#uiowadentistry #cleftlipandpalate #epigenetics #uicod #womeninscience #AADOCR #IADR2026

Not just mutations: inbreeding depression persists without genetic variation Abstract. Inbreeding depression (ID)—the reduction in fitness with increasing parental relatedness—is classically attributed to the expression of recessive

Not just mutations: inbreeding depression persists without genetic variation - new results suggest a role for #epigenetics in #inbreeding depression. Hypothesis is under investigation. Stay tuned… and read first this: academic.oup.com/evlett/artic...

#history #archaeology #medicine #ethics #epidemiology #ecotoxicology #MS #autoimmunity #autism #forensic #pathology #childhoodcancer #epigenetics #ecology #histology #publichealth #health #agedcare #SDGs

Patients'
parents'
and grandparents'

liver concentrations of pollutants
need to be documented.

Genome sequencing uncovers the history of the Russian desman’s gradual population decline and contributes to the evolutionary history of Talpidae - BMC Ecology and Evolution Background The Russian desman (Desmana moschata) is a critically endangered, elusive semi-aquatic mammal. While understanding its historical population dynamics is crucial for conservation, genomic data on its evolutionary and demographic history remain scarce. Results Here, we present a comprehensive whole-genome phylogenetic analysis of Desmana moschata within the Talpidae family, including heterozygosity assessments and inferred population size changes, as determined by PSMC and MSMC analyses. Our results demonstrate that, similar to its closest relative the Pyrenean desman (Galemys pyrenaicus), this species has undergone a long-term population decline preceding significant human influence. The phylogenetic component of our study involved a multigene analysis based on over 2,000 exons, producing a well-resolved, dated phylogeny of the Talpidae family at the tribal level. Conclusions Although anthropogenic factors have undoubtedly contributed to recent declines, our data reveal that the reduction in the desman population is primarily an ancient process driven by natural causes. This has resulted in persistent declines in both effective population size and geographic range and then subsequent evolutionary extinction of ancient taxa with limited adaptive capabilities. These findings lay the groundwork for future genomic conservation studies, incorporating expanded sampling and targeted investigation of specific genomic features.

A study in BMC Ecology and Evolution presents the first comprehensive genomic analysis of the endangered Russian desman and finds that the long-term decline in its population is primarily an ancient process driven by natural causes that began millennia before human impact.

#Epigenetics

Benchmarking of chromatin profiling methods (ChIP-Seq, CUT&Tag) in the Pacific oyster Magallana gigas Chromatin Immunoprecipitation sequencing (ChIP-seq) is the method of choice to generate chromatin landscapes across genomes. The scarcity of literatur…

#ChIP-seq in #non-model species? We compared at #IHPE 4 chromatin profiling methods in the Pacific #oyster and found that #CUT&Tag delivers the most robust, low-background, and reproducible results.
A step forward for epigenomics in marine organisms #Epigenetics www.sciencedirect.com/science/arti...