Epigenetics Update - Chromatin accessibility regulates age-dependent nuclear mechanotransduction bit.ly/4m0qhwH

Yawen Liao and G. V. Shivashankar from ETH Zurich in PNAS

#Epigenetics #Chromatin #Aging #Mechanotransduction
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Empower your research at epigenometech.com

The Stagnant Scale Do you feel stuck because the number on the scale isn't budging? 📉 Stop right there. Science says that narrative is “Scientifically Bankrupt.” 🧠The scale is a “fraudulent metric” because it can't measure how exercise acts like a “polypill” on your cells, repairing your heart and arteries regardless of your weight. 💊✨Stop measuring gravity and start measuring your metabolic health! ⚡️

📣 New Podcast! "The Stagnant Scale" on @Spreaker #advancedtraining #evidencebasedfitness #highthresholdfibers #hypertrophyscience #mechanicaltension #mechanotransduction #musclegrowth #musclephysiology #neuromuscularadaptation #nopainnogainmyth #progressiveoverload #scienceofstrength #zonethos

An overview of the reciprocal feedback between #Mechanotransduction & #Epigenetic remodeling, illustrating how these loops govern cellular fate & disease progression, and their role as #Biomarkers & #TherapeuticTargets.

#OpenAccess: doi.org/10.1016/j.ge...

Very thankful with this invitation to present our work Wichita State University Department of Chemistry and Biochemistry for the Chemistry Colloquium. Outstanding cadre of investigators, trainees, and great NMR and mass spec facilities! #Myofilament #Mechanobiology #Biophysics #Mechanotransduction

Experimental overview and measurement workflow. (A) Schematic of C. elegans body-wall musculature showing anterior (head), mid-body, and posterior (tail) regions analyzed. (B) Representative bright-field stills of worms during crawling on agar (left) and (C) swimming in liquid (right), illustrating posture and curvature over time (i–iii). (D,E) Confocal micrographs of phalloidin-stained mid-body myocytes from crawling and swimming animals, respectively. Actin filaments delineate sarcomeres used for morphometry. (F) Schematic diagram of C. elegans body-wall musculature styled after Gieseler et al. (2017). (G) Typical sarcomere arrangement in mammalian striated muscle compared with analogous structures in C. elegans (H).

Adina Fazyl, @andres-vidal-gadea.bsky.social & co show that swimming C. elegans develop shorter, denser #sarcomeres and elongated muscles compared to crawlers, revealing activity-dependent muscle remodelling. 🪱https://doi.org/10.1242/bio.062371

#MusclePlasticity #Locomotion #Mechanotransduction

Piezo1 suppresses bone marrow #Adipogenesis by inhibiting the c-Jun-Ccl2-NF-κB-Lcn2 inflammatory autocrine loop via CaMKII/Klf2, providing insights into the link between #Mechanotransduction, #Inflammation, and cell fate determination. #MedSky

#OpenAccess: doi.org/10.1038/s413...

Mechanosensitive genomic enhancers potentiate the cellular response to matrix stiffness Epigenetic control of gene expression and cellular phenotype is influenced by changes in the local microenvironment, yet how mechanical cues precisely influence epigenetic state to regulate transcript...

Mechanoenhancers regulate how cells translate mechanical cues into gene activity and functional behaviors ➡️ www.science.org/doi/10.1126/...
#enhancer #generegulation #mechanotransduction #extracellularmatrix

The #mechanosensitive channel #Piezo1 in #BMMSCs suppresses #BoneMarrow #adipogenesis and promotes #BoneFormation by blocking the Ccl2–Lcn2 inflammatory loop, linking #mechanotransduction to #inflammation control and bone strength.

#OpenAccess in #STTT: doi.org/10.1038/s413...

Our new review about RNA processing and mechanotransduction is out in Cell Reports! Link: lnkd.in/edApA4ZT. Proud of our very talented graduate student Gabrielle Bais and thankful to our institution and funding sources: UNC-Chapel Hill, NIH, NSF.
#mechanotransduction #RNA #alternativesplicing

How do neurons sense force? 🧠 Dr. Giorgia Demontis @unitrieste.bsky.social used #FluidFM to probe #PIEZO channel activation in DRG neurons via real‑time Ca2+ imaging, controlled mechanical stimuli, and repeated opposing‑force tests. At #CNR‑IOM Trieste. #Neuroscience #Mechanotransduction #SingleCell

4️⃣ Age-associated ECM remodeling signatures were linked to increased activity of #mechanotransduction regulators YAP/TAZ and TEAD, particularly in skin, lung, and liver. Immunofluorescence confirmed increased nuclear YAP in aged human skin ECs. 6/9

a cartoon character named stitch is sitting on a wooden surface ALT: a cartoon character named stitch is sitting on a wooden surface

For the second time- I’ve read a paper published this week claiming they’re altering #microtubule #mechanobiology / #mechanotransduction and they don’t cite the **primary papers**. Don’t do this…give credit to the authors who did the hard yards. Not sure which ones to cite? Just ask.

Activity-dependent development of the body’s touch receptors Santiago et al. report that the mechanosensitive ion channel Piezo2 is required for the transcriptional and structural maturation of the primary sensory neurons that detect gentle touch and that Piezo...

Mechanically evoked neuronal activity via Piezo2 and Nav channels is essential for the development and structural maturation of mechanosensory end-organs underlying gentle touch. #Mechanotransduction #Piezo2 www.cell.com/neuron/fullt...

Anisotropic hydrogel degradation enhances 3D collective mesenchymal stromal cell alignment, mechanotransduction and osteogenic differentiation Tissue engineering involves assembling cells and mimicking the complex anisotropic architecture of biological tissues to perform specific functions. T…

After a long journey, finally published in @ActaBio: beautiful work by #ClaudiaGarrido showing how #anisotropic #hydrogel degradation enhances #collective cell behavior, #mechanotransduction and #osteogenic differentiation 👉 bit.ly/3J98HHG. Congratulations! @ChariteBerlin @biogipuzkoa @Ikerbasque

Tubulin with a twist: Acetylated highways at the immune synapse. Srishti Mandal & Sudha Kumari @sudha-kumari.bsky.social discuss new work (rupress.org/jcb/article/...) from Aceitón, Riobó, @fadelvalle.bsky.social, Yuseff and colleagues: rupress.org/jcb/article/...

#Mechanotransduction #Immunology

In @jcb.org, Srishti Mandal & @sudha-kumari.bsky.social highlight new work from Aceitón and colleagues (rupress.org/jcb/article/...), describing mechanisms underlying the effect of #mechanotransduction in B cells on antigen extraction & presentation at the immune synapse rupress.org/jcb/article/...

Srishti Mandal & @sudha-kumari.bsky.social highlight new work from Aceitón and colleagues (rupress.org/jcb/article/...), describing mechanisms underlying the effect of #mechanotransduction in B cells on antigen extraction & presentation at the immune synapse rupress.org/jcb/article/...

#Immunology

PDLIM5, a protein that senses mechanical changes, promotes osteogenesis in adipose-derived stem cells by altering the cell’s internal structure (microfilaments). doi.org/10.1016/j.ge...
#StemCells #BoneBiology #PDLIM5 #Mechanotransduction

⚙️ Isn’t it “touching” when cells communicate via #mechanotransduction? 🤝 Sampietro et al. explore mechanosensation in #Bcells and #leukemia:

➡️ doi.org/10.1002/1873-3468.70071

#mechanobiology #immunology

By enabling controlled, repeated stimulations with opposing pressures, FluidFM® advances #singlecell #mechanotransduction research.
👇

4/ This groundbreaking partnership opens new doors in #cancerresearch 🎗️, #mechanotransduction studies, and time-resolved #transcriptomics!

11/11
These findings have broad implications for understanding cell–cell interactions, such as those between immune cells and target cells.
#CellAdhesion #Mechanotransduction #Microtubules #Dynein #Integrin #IntegrinAffinity #FluidSubstrates #CellSpreading

Polyunsaturated fatty acids suppress PIEZO ion channel mechanotransduction in articular chondrocytes Chondrocytes sense mechanical signals from their environment via ion channels such as TRPV4 and Piezo1. The mechanosensitivity of these channels is altered by the presence of polyunsaturated omega-3 ...

Congrats to Gabi Marushack and @alisavadipour.bsky.social & team for our latest @Guilak_Lab paper showing that polyunsaturated fatty acids alter cell membrane properties & inhibit chondrocyte #mechanotransduction by #Piezo1 and #TRPV4. faseb.onlinelibrary.wiley.com/doi/10.1096/...

Dynamic duo at the cell's edge: Caveolae and the actin cytoskeleton work together to sense and respond to mechanical stress. Caveolae buffer tension, while actin provides structure and force. Ultimate biomechanics team. #CellBiology #Mechanotransduction

How does the cell use the actin cytoskeleton to co-ordinate its functions? #fluorescencefriday

As I begin to teach lectures on #mechanotransduction, I am reminded of the remarkable ability of the cell to read the external environment, converting mechanical signals into biochemical responses.

Differentiating erythroblasts adapt to mechanical stimulation by upregulation of cholesterol biosynthesis via S1P/SREBP-induced HMGCR expression - Scientific Reports Scientific Reports - Differentiating erythroblasts adapt to mechanical stimulation by upregulation of cholesterol biosynthesis via S1P/SREBP-induced HMGCR expression

Looks like SREBP, triglycerides and cholesterol synthesis is a general #mitochondrial #mechanotransduction response to both ECM elasticity (Romani+Bertolio 2019, Romani 2024) and shear stress
www.nature.com/articles/s41...

I really want to highlight this paper and 🧵by @bengoult.bsky.social for the #Mechanotransduction community, linking the #MeshCODE theory to pathophysiological implications in Alzheimer's disease. Congratulations Ben, fantastic paper and discussion section🤯:

Hey, do you think anyone could help me with this?

" I want to know, do any of my
#cytoskeletal #cellbiology #mechanotransduction educators pals have any good interactive, video and/or podcast resources they like to use to help their UG teaching? Thank you - pls share #cellbio #academichatter"

🧪Very interesting findings with implications in #cancermetastasis 👇

#mechanotransduction
#cancerresearch
#ECMatrix
#integrins

Happy #FluorescenceFriday !

Here is a 3D self-assembly bioengineered bladder cancer model with mechanical forces signal in the urothelium (top) and collagen signal in the stroma (bottom)

#microscopy #mechanobiology #mechanotransduction